http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Choi, Jinhyang,Ko, Eunjung,Chung, Hye-Kyung,Lee, Jae Hee,Ju, Eun Jin,Lim, Hyun Kyung,Park, Intae,Kim, Kab-Sig,Lee, Joo-Hwan,Son, Woo-Chan,Lee, Jung Shin,Jung, Joohee,Jeong, Seong-Yun,Song, Si Yeol,Cho Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P>Nanoparticulation of insoluble drugs improves dissolution rate, resulting in increased bioavailability that leads to increased stability, better efficacy, and reduced toxicity of drugs. Docetaxel (DTX), under the trade name Taxotere™, is one of the representative anticancer chemotherapeutic agents of this era. However, this highly lipophilic and insoluble drug has many adverse effects. Our novel and widely applicable nanoparticulation using fat and supercritical fluid (NUFS™) technology enabled successful nanoscale particulation of DTX (Nufs-DTX). Nufs-DTX showed enhanced dissolution rate and increased aqueous stability in water. After confirming the preserved mechanism of action of DTX, which targets microtubules, we showed that Nufs-DTX exhibited similar effects in proliferation and clonogenic assays using A549 cells. Interestingly, we observed that Nufs-DTX had a greater in vivo tumor growth delay effect on an A549 xenograft model than Taxotere™, which was in agreement with the improved drug accumulation in tumors according to the biodistribution result, and was caused by the enhanced permeability and retention (EPR) effect. Although both Nufs-DTX and Taxotere™ showed negative results for our administration dose in the hematologic toxicity test, Nufs-DTX showed much less toxicity than Taxotere™ in edema, paralysis, and paw-withdrawal latency on a hot plate analysis that are regarded as indicators of fluid retention, peripheral neuropathy, and thermal threshold, respectively, for toxicological tests. In summary, compared with Taxotere™, Nufs-DTX, which was generated by our new platform technology using lipid, supercritical fluid, and carbon dioxide (CO<SUB>2</SUB>), maintained its biochemical properties as a cytotoxic agent and had better tumor targeting ability, better in vivo therapeutic effect, and less toxicity, thereby overcoming the current hurdles of traditional drugs.</P>
최운성,주정화,임창수,이훈갑,박상덕 대한신경외과학회 1983 Journal of Korean neurosurgical society Vol.12 No.2
Cerebral herniations were successfully produced in experimental animals during the expansion of intracranial balloon or laminaria. Visualizing structures deep in the brain, cat's heads were instantaneousely frozen with liquid nitrogen and were sectioned in the midline longitudinally. The cerebral herniations were assessed by measuring the distance between parts of various anatomical structures on the brain in mid-sagittal sectional plane. Transtentorial rostrocaudal herniation of the brain stem was evident and more marked in the group of bilateral parietal lesions than in the groups of frontal and temporal lesions. Infratentorial lesions produced transtentorial upward herniation of a part of anterior cerebellar vermis and downward herniation of the cerebellar tonsil through the foramen magnum. The risk of brain herniation was noted to be greater in rapid expanding lesions with balloon than the more slowly developing lesions with laminaria.
Hybrid Scaffolds Composed of Hyaluronic Acid and Collagen for Cartilage Regeneration
( Hyun Jung Kim ),( Kab Keun Kim ),( Il Kyu Park ),( Baek Sun Choi ),( Jae Ho Kim ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.2
Hybrid scaffolds composed of hyaluronic acid (HA) and collagen was prepared and evaluated for cartilage regeneration. The hybrid scaffolds prepared by adding 0.1, 0.3 or 0.5 wt.% collagen to HA had a three-dimensional structure with interconnected pores and showed an increase in tensile strength with increasing collagen concentration. The degradation period of the hybrid scaffolds in vitro increased with increasing collagen concentration and that the cell growth in the hybrid scaffolds increased with increasing collagen concentration for 2 weeks of cell culture. After the hybrid scaffolds with different collagen concentrations were implanted into cartilage defects of rabbit ears for 6 months, the GAG concentration of the hybrid scaffolds was higher than the HA scaffold itself, suggesting that cartilage tissue was easily formed in the collagen-containing scaffolds although the GAG concentration in the hybrid scaffolds decreased with increasing collagen concentration. Therefore, it is concluded that the collagen- containing porous scaffolds can be effectively used for cartilage regeneration.
COM 기반 프로그램 맞춤을 이용한 설계자 전용 해석 애플릿 개발
전갑진(Kab-Jin Jun),박태원(Tae-Won Park),박찬승(Chan-Seung Park),전용호(Yong-Ho Jeon),최성훈(Seong-Hoon Choi),김정범(Jung-Bum Kim) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10
Many designers have difficulty to use the existing commercial program because of their complicated and numerous functions. This problem causes that the engineer spend more time to learn the commercial program than the actual design. Therefore, it’s very necessary a program which focused on the designer’s convenience. This paper presents that the development of an applet for designers customizing the existing COM(Component Object Model) based program. The COM component is so excellent in reusability and expandability. Therefore, the development can be easily applied to various requirements. The applet represented in this study can be effective to the designers by simplifying the user interface and analysis procedure.
수중의 Pb<SUP>2+</SUP> 흡착을 위한 Graphene oxide/Polyacrylic acid/Alginate Beads 제조
최정원(Jung-Weon Choi),김윤갑(Yoon-Kab Kim),김명균(Myung-Gyun Kim) 한국환경관리학회 2020 環境管理學會誌 Vol.26 No.1
본 연구는 수중의 Pb<SUP>2+</SUP>를 흡착하기 위해 GO와 PAA로 이루어진 IPN구조의 알지네이트 비드인 GO/Ca-Alg₂-PAA를 합성하고자 하였다. 합성된 GO/Ca-Alg₂-PAA beads의 물성을 평가하기 위해, FT-IR, TGA, BET 분석을 실시하였다. 흡착제는 등온흡착실험을 통해 높은 흡착능을 갖고 있음을 확인하였으며, Langmuir 흡착 모델과의 높은 적합성으로 단일 흡착임을 확인하였다. GO/Ca-Alg₂-PAA의 최대흡착량은 기존 연구들로부터 개발된 흡착제와 비교하여 높은 값을 가졌다. 또한 beads형태의 GO/Ca-Alg₂-PAA는 칼럼을 이용한 대량의 폐수처리를 가능하게 하고 쉬운 합성방법과 추가적인 분리공정이 불필요하여 흡착 후 처리가 간단하다는 장점을 가짐을 확인하였다. 또한, 높은 Pb<SUP>2+</SUP> 제거율을 갖는 흡착제 GO/Ca-Alg₂-PAA는 여러 가지 분석들을 통해 합성이 성공적으로 되었음을 확인했다. 따라서 실제 Pb<SUP>2+</SUP>가 오염된 폐수처리에 활용될 수 있을 것으로 사료된다. In this study, GO/Ca-Alg₂-PAA composite which is an alginate bead with IPN (Interpenetrating Polymer Network) structure consisted of GO (Graphene Oxide) and PAA (Polyacrylic acid) was synthesized to adsorb Pb<SUP>2+</SUP> from aqueous solution. By FT-IR, TGA and BET analysis, it was identified that GO and PAA co-exist in homogenous structure and it has a significant thermal stability. In addition, monolayer adsorption mechanism was also identified as the isotherm experimental data was fitted well with Langmuir isotherm model (R²=0.987). It can be concluded that the GO/Ca-Alg₂-PAA can be an good adsorbent for the removal of Pb<SUP>2+</SUP> in aqueous solution with the maximum adsorption capacity (qm) of 1.424 m㏖/g. Also, through the evaluation of pH effect for Pb<SUP>2+</SUP> adsorption experiment, it is confirmed that the GO/Ca-Alg₂-PAA adsorbs at broad range of pH of 3-11. Therefore, these results show that the GO/Ca-Alg₂-PAA beads were suitable to Pb<SUP>2+</SUP> adsorption and separation with solution with high adsorption capacity.