십이지장 결핵 2예의 내시경적 고찰

장린,박충기,민영일,장영운,우정택,방익수,최학림,장주희 대한소화기내시경학회 1985 Clinical Endoscopy Vol.5 No.1

Today, the duodenal tuberculosis is a very rare disease. Final diagnosis of duodenal tuberculosis is difficult due to inconsistent symptoms and nonspecific duodenal lesions. We found 2 cases of duodenal tuberculosis by gastrascopy. In gastroscopic findings, there were undetermined ulcers and irregular nodular mucosal changes.

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

흉부 X선촬영 기술의 변천에 관한 연구

이창엽,조평곤,김지닐,최소영,김창균,최종학,김정민,김유현 高麗大學校 倂設 保健大學 保健科學硏究所 2002 保健科學論集 Vol.28 No.2

To find elements which enable improving Quality of image of chest radiography, we attempted to make comparison between chest radiography used currently with that of the past, and following conclusion was reached: 1) It could be confirmed that a dependance on chest radiography was declining, because proportion of chest radiography against overall radiography decreased. 2) There was a change of kVp to a high voltage in a chest radiography, and use of high kVp became a generalization 3) Exposure time was reduced and exposure dose was curtailed accordingly. 4) Apparatus was mainly comprised of 3-phase rectifier circuit and inverter type. 5) It could be confirmed that frequency of applying additional filters for high kVp radiography was insufficient. 6) There was almost no difference in the condition of exposure between hospitals using film/screen and hospitals using CR. But when CR is used for radiography, it was increase in exposure dose due to increase in tube current and it will be necessary to have continuous study on exposure dose by an increase use of CR in the future.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

대학주도의 사회교육 모형을 위한 실천적 연구 -새마을 대학의 개설과 운영을 중심으로-

최학주/ 김성회 / 박용진 / 한상각 / 이창섭 공주교육대학교 초등연구원 1977 公州敎大論叢 Vol.13 No.2

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經骨骨折의 經皮金屬釘 및 石膏固定

崔昌都,金學賢 순천향대학교 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

脛骨骨折의 經皮金屬釘 및 石膏固定

崔昌郁,金學賢 순천향의과대학 1978 Journal of Soonchunhyang Medical Science Vol.1 No.1

There are few fractures arouse more controversy in their therapeutic principles as tibial fractures. The method of treatment have change almost from decade to decade, swings of opinion from the closed method of the 1930~40's to the more use of open reduction in 1950~60's These somewhat totalitarian approach appear to have become aware of the hazards and many authors,recently,recommend some form of conservative treatment but would always be prepared to resort to internal fixation in specific situation. As always when there is the choice of treatment ,none of them are completely ideal as a routine method-every fracture has an individual problem-considerration must be given not only to local factors but also to the patient's general condition and socioeconomic states. Consequently, there is always a place for conservative as well as operative means. Roughly there are three degrees of fixation appropriate to different types of fractures : rigid intenal fixation, approximate fixation and casual fixation. The transfixing-pins method is probably a compromise maneuver between rigid and appoximate fixation. We report our experiences with transfixing-pins method for 32 tibial shaft fractures, consisted Kirschner wire of Steinmann pins through the tibia, closed trduction of the fracture and incorporation of the wires or pins into plaster-of-Paris cast. 1. This is a compromise method of internal fixation yet eliminated the risk of open teduction. 2. It prevented excessive shortening and angulation in unstable fracture, and if after the initial reduction shows some residual angulation , wedging cast may resolve it.

醫學映像檢査에 대한 臨床的 統計의 分析

최종학,이창엽 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

This study was to analyze statistical data to find the distribution of the latest medical imaging technology in the field of Computed Tomography(CT), Ultrasonography and Magnetic Resonance Imaging(MRI). The data were obtained from diagnostic radiology, Korea University Hospital in the recent 5 years(l993-1997). The results were as follows. 1. The total number of patients examined using CT were 44,990. According to the order of examination items, brain examination had the most patients among various diagnostic areas followed by abdomen(12,101), chest(3,176), pelvis(2,207), neck(2,118) and spine(l,848) in sequence. 2. There were 62,090 patients examined by ultrasonography. According to the order of examination items, upper abdomen region had the most patients(50,630) followed by lower abdomen region(2,925), biopsy and aspiration(l,971), duplex(l,431), breast(972) and sonoguided P.EJ.(950) in sequence. 3. The total number of patients examined using MRI were 16,827. According to the order of examination items, brain showed the highest cases(8,270 patients) followed by lumbar vertebra(2,631), chest · mediastinum · lung(l,124), cervical vertebra(l,221), thoracic vertera(752) and knee joint(567). 4. The monthly distribution of patients for medical imaging ware 2,296 on the average. The number of patients did not show significant change according to mouths and four seasons. 5. In terms of time shift for examination, the most patients were examined during 9 to 10 AM(33.0%), followed by 11-12 AM(20.1%), 1-2 PM(11.3%), 3-4 PM(11.2%), 7-8 AM(7.7%) and 5-6 PM(6.1%) in sequence. 6. The age distribution of patients in medical imaging, 55-59 years had a more than majority(15.5%) followed by 40-44 years(10.6%), 50-54 years(10.3%), over 70 years(9.0%), 45-49 years(8.5%) and 60-64 years(8.2%) in sequence. 7. For sex distribution, male patients showed a higher percentage(56.4%) for examination than female patients(43.6%). 8. In relation to referral departments for 3 fields, emergency medicine made the most referrals for CT followed by gastrointestinal internal medicine, otorhinolaryngology, general surgery, neurosurgery, hematooncology and neurology in sequnce. Additionaly, ultrasonography had a different distribution compared with CT, shoring the most referrals from gastrointestinal internal medicine, general surgery, emergency medicine, nephrology, family medicine, pediatrics and pulmonology. For MRI, neurosurgery had the most cases of referrals followed by neurology, orthopedic surgery, rehabilitation medicine, psychiatry, otorhinolaryngology and gastrointestinal internal medicine. 9. CT showed 67.5% of contrast medium usage-rate followed by 60.4% of it in MRI. In contrast, ultrasonogrphy did not use any contrast medium. 10. For films used, 4 films(33.3%) were used most in CT, 2 films(28.6%), 3 films(16.2%) and 1 film(8.5%). For ultiasonography, 1 film(58.7%), 2 films(40.6%) and for MRI, 7 films(37.1%), 5 films(20.1%), 4 films(12.2%), 6 films(8.9%) in sequence.

유한 반사판을 갖는 Quadrifilar Helix 안테나의 해석 및 설계

이창희,성원모,최학근 단국대학교 신소재기술연구소 1996 신소재 Vol.6 No.-

유한 반사판을 갖는 Quadrifilar Helix 안테나의 복사특성을 해석하기 위하여 반사판을 WireGrid로 모델링하고 모멘트법을 적용하였다. 안테나의 구조피라미터를 변화시키면서 빔폭, 이득, 입력임피던스, 복사패턴을 계산하여 설계에 이용할 수 있는 데이터를 제시했다. 제시된 설계데이타를 이용하여 위성이동통신용 안테나를 제작하고 복사패턴과 이득, 축비등을 측정하였다. 복사특성 측정치는 이론적 계산치에 근접하는 것으로 나타났으며, 이득을 제외한 다른 복사특성들도 설계사양을 만족하는 것으로 나타났다. The wire-grid model and moment method were adopted to analyze radiation characteristics of quadrifilar helix antennas with finite plate. Radiation characteristics for various structure parameters of the antenna were calculated and presented. A mobile satellite communication antenna was designed and manufactured by use of the presented data. The measured radiation charicteristics, such as axial ratio, half power beamwidth, radiation pattern are in good agreement with the computed results and well satisfy the design specifications except gain.