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김희연,홍진환,박혜경,한상배,박종석,이은주,이정성,송경희,최은희,최영준,소경아,성영제,이주엽 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
본 연구는 분말상 원료(전분, 대두분)의 저장유통시 품질변화를 건전성과 안전성 측면에서 검토하여 식품의 기준 ·규격 설정f.」 합지적으로 반영하고자 하였다. 전분과 패두분의 이물을 검사하고, 2종 대두분(중국산, 미국산)을 ?0일간 IS'c와 30t에 저장하면서 성상, 수분, 산가, 과산화물가, 지방산 조성,아플라톡신 BB의 생성여부를 분석하였다. 중국산 대두분 30'』 저장군에서 50일 이후 곰팡이가 발생한 것 이외에 모든 시료에서 양호한 성상을 나타내었고, 전분과 대두닥 모든 시료에서 이물은 검출되지 않았다. 산가는 중국산과 미국산 시료간에 편차를 보여 증국산 30"C, 50일 저장시료에서 약 10배끙도 증가하였고, 과산화물가는 저장 90일후 15'E 저장군은 약 2.3배, 30'c 저장군은 3배정도 증가하였다. 대두분의 주요 지방산은 linoleic acidf18. 2), oleic acid(18 : 1), palmitic acid(16 : 0)이었으며, 3개월 저장에 따른 지방산 함량의 변화는 미미하였다. 아플라톡신 B₁은 모든 시료에서 검출되지 않았다. The objective of this study was to investigate auality changes of type raw materials(starch, soy flour) during various storage conditions. Starchflour(source of China, U.S.A) were slfred under two temperature(15'C, 30'c) forSensory evaluation, (o.reign material test, moisture content, acid value, peroxide ualue,composition, aflatorin Bi were analyzed. China soy flour(stor·ed 30'f) was contaminated by fungj on 50 days. Except for soy flour contardnated by fungi, sensory characteristics were not changed and foreign mater;als were notdetected. Acid value of China soy flour(stored at 30'C, 90 days) was about 10 times higherlevel before storage and acid value was more influenced by source(China, USA). Peroxide valuewas in proportion with the storage period slightly. The major fatty acid of soy flour waslinoleic acid(18 . 2), an(3 the change of fatty acid composition was not observed. Aflatoxlrl Blwas not detected.
Role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps
Kim, Jong-Yeup,Kim, Dong-Kyu,Yu, Myeong Sang,Cha, Min-Ji,Yu, Seong-Lan,Kang, Jaeku D.A. Spandidos 2018 MOLECULAR MEDICINE REPORTS Vol.17 No.1
<P>Chronic rhinosinusitis (CRS) is a highly prevalent disease characterized by mucosal inflammation of the nose and paranasal sinuses. CRS can be divided into two main categories, CRS with nasal polyps (NPs; CRSwNP) and CRS without NPs (CRSsNP). Although the pathophysiology of CRS remains unclear, DNA methylation has been implicated in the etiology of CRSwNP. The aim of the present study was to elucidate whether DNA methylation of specific genes is involved in the development of NPs. In total, 18 individuals were included in the present study, and were divided into three groups: CRSwNP (n=7), CRSsNP (n=7) and healthy controls (n=4). NP tissues were obtained from the seven patients with CRSwNP and biopsies of the inferior turbinate mucosa from all three groups were used as controls. Methylated genes detected by methyl-CpG-binding domain sequencing were validated by methylation-specific polymerase chain reaction (PCR), bisulfite sequencing, and reverse transcription-quantitative PCR (RT-qPCR). Methyl-CpG-binding domain sequencing identified 43,674 CpG islands in 518 genes. The promotor regions of 10 and 30 genes were hypermethylated and hypomethylated, respectively, in NP samples compared with controls. The top four genes with altered hypomethylation in NP tissues were, Keratin 19 (<I>KRT19</I>), nuclear receptor subfamily 2 group F member 2 (<I>NR2F2</I>), A Disintegrin-like And Metallopeptidase (Reprolysin Type) with Thrombospondin type 1 motif 1 (<I>ADAMTS1</I>) and zinc finger protein 222 (<I>ZNF222</I>). RT-qPCR demonstrated that the expression levels of <I>KRT19</I>, <I>NR2F2</I> and <I>ADAMTS1</I> were significantly increased in NP tissues; however, there was no difference in the levels of <I>ZNF222</I> between NP and control tissues. Further studies are required to confirm the relevance of these epigenetic modifications in the mechanisms underlying NP formation.</P>
Kim, Jong-Yeup,Cha, Min-Ji,Kwon, Soon-Sung,Kim, Dong-Kyu SAGE Publications 2017 American journal of rhinology & allergy Vol.31 No.6
<P>Conclusion: Our findings indicated that highly educated patients who underwent corrective septorhinoplasty required more detailed preoperative guidance, including more complete information on the limitations of the surgery.</P>
Kim, Jong-Yeup,Cha, Min-Ji,Park, Young-Seon,Kang, Jaeku,Choi, Jong-Joong,In, Seung Min,Kim, Dong-Kyu Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.4
Eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most challenging problems in clinical rhinology. FZD5 is a receptor for Wnt5A, and its complex with Wnt5A contributes to activating inflammation and tissue modification. Nasal polyps and eosinophil/non-eosinophil counts are reported to be directly correlated. This study investigated the expression and distribution of FZD5, and the role of eosinophil infiltration and FZD5 in eosinophilic CRSwNP pathogenesis. The prognostic role of eosinophil levels was evaluated in seven patients with CRSwNP. Fifteen patients with CRS were classified based on the percentage of eosinophils in nasal polyp tissue. Methylated genes were detected using methylCpG-binding domain sequencing, and qRT-PCR and immunohistochemistry were used to detect FZD5 expression in nasal polyp tissue samples. The results showed that mRNA expression of FZD5 was upregulated in nasal polyps. FZD5 expression was significantly higher in nasal polyp samples from patients with eosinophilic CRSwNP than in those from patients with non-eosinophilic CRSwNP, as indicated by immunohistochemistry. Furthermore, inflammatory cytokine levels were higher in eosinophilic CRSwNP-derived epithelial cells than in normal tissues. In conclusion, FZD5 expression in nasal mucosal epithelial cells is correlated with inflammatory cells and might play a role in the pathogenesis of eosinophilic CRSwNP.
김종엽 ( Kim Jong Yeup ),조경수 ( Kyung Soo Cho ),김응모 ( Ung-mo Kim ) 한국정보처리학회 2010 한국정보처리학회 학술대회논문집 Vol.17 No.2
2007년 Amazon.com이 미국에서 e-Book 전용 단말기 ‘Kindle’을 출시한 이래, Sony와 대형 서점 Barnes&Noble등 메이저 업체는 물론 다수의 중소업체들이 e-Book 시장에 진출하고 있다. 최근에는 Apple이 iPad를 출시하고 e-Book 시장에 진출한 가운데, Google 역시 6월 이후 e-Book 시장에 진출할 것을 발표함으로써 e-Book 시장의 경쟁이 더욱 치열해지고 있다. e-Book의 급속한 보급증가와 함께 이런 방대한 도서를 관리하는 곳에서 자동 도서 분류의 필요성도 증가하고 있다. 기존의 문서분류 방법들은 대게 수작업, 텍스트(단어)의 집합으로 간주하여 기계 학습방법을 그대로 적용하거나 약간의 변형을 가한 방법들이 대부분 이었다. 본 제안서에서는 데이터 마이닝 분야에서 사용되는 DRFP-Tree 구조를 이용하여 e-Book 내의 문장들의 패턴을 저장하고 이를 사용하여 e-Book을 분류하는 방법을 제안한다.
Lee Ki-Il,Han Younghwan,Ryu Jae-Sung,In Seung Min,Kim Jong-Yeup,Park Joong Su,Kim Jong-Seok,Kim Juhye,Youn Jubin,박석래 대한면역학회 2022 Immune Network Vol.22 No.4
Tobacco smoking (TS) has been known as one of the most potent risk factors for airway inflammatory diseases. However, there has been a paucity of information regarding the immunologic alteration mediated by TS in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). To identify the effect of TS, we harvested human tissue samples (never smoker: n=41, current smoker: n=22, quitter: n=23) and analyzed the expression of epithelial-derived cytokines (EDCs) such as IL-25, IL-33, and thymic stromal lymphopoietin. The expressions of Th2 cytokines and total serum IgE showed a type-2 inflammatory alteration by TS. In addition, the epithelial marker E-cadherin and epithelial-mesenchymal transition (EMT)-associated markers (N-cadherin, α-SMA, and vimentin) were evaluated. Histological analysis showed that EDC expressions were upregulated in the current smoker group and downregulated in the quitter group. These expression patterns were consistent with mRNA and protein expression levels. We also found that the local Th2 cytokine expression and IgE class switching, as well as serum IgE levels, were elevated in the current smoker group and showed normal levels in the quitter group. Furthermore, the expressions of E-cadherin decreased while those of N-cadherin, α-SMA, and vimentin increased in the current smoker group compared those in the never smoker group. Taken together, these results indicate that TS contributes to the deterioration of pathogenesis by releasing local EDCs and Th2 cytokines, resulting in EMT in patients with CRSwNP. We verified that alterations of immunological response by TS in sinonasal epithelium can play a vital role in leading to CRSwNP.