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- 저자 : Jin Hyoek Kim (검색결과 18 건)
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( Do Young Kim ),( In Hee Kim ),( Sook-Hyang Jeong ),( Yong Kyun Cho ),( Joon Hyoek Lee ),( Young-Joo Jin ),( Don Lee ),( Dong Jin Suh ),( Kwang-Hyub Han ),( Neung Hwa Park ),( Il Han Song ),( Young K 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Hepatitis C virus (HCV) infection leads to significant public health problem. The aim of this study is to reveal nationwide seroprevalence of HCV infection by a large-scale survey in South Korea. Methods: From January to December 2009, a total of 291,314 adults (≥20 years) underwent health check-up in 29 centers. The data of anti-HCV and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally obtained. Results: The overall seroprevalence of anti-HCV was 0.59% (1,718/291,314) in South Korea. Anti-HCV prevalence in females (0.60%, 729/112,506) was higher than that in males (0.55%, 989/178,808) (p=0.014). Gradual increase of anti-HCV positivity was observed, from 0.26% in twenties to 2.09% over seventies. The age-adjusted anti-HCV prevalence varied in different areas; higher in Busan, Jeonnam and Gyeongnam (1.34-1.86%), middle in Seoul and surrounding districts (0.42-0.77%), lower in Jeju (0.25%). Based on the Census 2009 of Korea, the age, sex, and area-adjusted anti-HCV positive rate in South Korea was estimated to be 0.78%. Among the 1,605 anti-HCV positive subjects, qualitative or quantitative serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among them, the residents in Gyeongsang, Seoul, Gyeonggi area showed higher frequency of positive HCV RNA than other areas, and 252 patients (94.0%) were diagnosed as chronic hepatitis, 11 patients (4.1%) as cirrhosis, and 5 patients (1.9%) as hepatocellular carcinoma in 5 (1.9%) patients. A total 61 patients received antiviral therapy after 2009 and overall sustained virologic response was achieved in 42 (84%) patients. Conclusions: Our data suggest that South Korea is one of the countries of relatively low overall HCV prevalence, which increase with age, especially over 5th decade. Further study on the risk factors and geographic difference of HCV epidemiology is warranted.
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( Do Young Kim ),( In Hee Kim ),( Sook Hyang Jeong ),( Yong Kyun Cho ),( Joon Hyoek Lee ),( Young Joo Jin ),( Don Lee ),( Dong Jin Suh ),( Kwang Hyub Han ),( Neung Hwa Park ),( Il Han Song ),( Young K 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Hepatitis C virus (HCV) infection leads to significant public health problem. The aim of this study is to reveal nationwide seroprevalence of HCV infection by a large-scale survey in South Korea. Methods: From January to December 2009, a total of 291,314 adults (≥20 years) underwent health check-up in 29 centers. The data of anti-HCV and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally obtained. Results: The overall seroprevalence of anti-HCV was 0.59% (1,718/291,314) in South Korea. Anti-HCV prevalence in females (0.60%, 729/112,506) was higher than that in males (0.55%, 989/178,808) (p=0.014). Gradual increase of anti-HCV positivity was observed, from 0.26% in twenties to 2.09% over seventies. The age-adjusted anti-HCV prevalence varied in different areas; higher in Busan, Jeonnam and Gyeongnam (1.34-1.86%), middle in Seoul and surrounding districts (0.42-0.77%), lower in Jeju (0.25%). Based on the Census 2009 of Korea, the age, sex, and area-adjusted anti-HCV positive rate in South Korea was estimated to be 0.78%. Among the 1,605 anti-HCV positive subjects, qualitative or quantitative serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among them, the residents in Gyeongsang, Seoul, Gyeonggi area showed higher frequency of positive HCV RNA than other areas, and 252 patients (94.0%) were diagnosed as chronic hepatitis, 11 patients (4.1%) as cirrhosis, and 5 patients (1.9%) as hepatocellular carcinoma in 5 (1.9%) patients. A total 61 patients received antiviral therapy after 2009 and overall sustained virologic response was achieved in 42 (84%) patients. Conclusions: Our data suggest that South Korea is one of the countries of relatively low overall HCV prevalence, which increase with age, especially over 5th decade. Further study on the risk factors and geographic difference of HCV epidemiology is warranted.
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2차 및 3차 위상 항을 가지는 정현파 음성-오디오 모델의 빠른 하모닉 합성 방법
김종학(Jong-Hark Kim),김규진(Kyu-Jin Kim),정규혁(Gyu-Hyoek Jung),김영준(Young-Jun Kim),이인성(In-Sung Lee) 대한전자공학회 2006 대한전자공학회 학술대회 Vol.2006 No.11
In this paper, we propose a harmonic synthesis method that consumes a small complexity in sinusoidal audio models using a quadratic and a cubic phase. The quadratic phase ret can be separated into a over-sampling function and a inverse Fourier transform(IFFT) function. By applying the boundary condition of frequency and phase between frames, we at first derive the harmonic synthesis function with the quadratic phase. The harmonic synthesis ret is composed of the IFFT function and the overlap-add function with a reduced complexity. Also, we at second derive the fast harmonic synthesis function with cubic phase term; the 3<SUP>rd</SUP> parameter of the cubic phase term is constrained to be independent apart from harmonic index. Experimental results show that the proposed method significantly reduce the complexity of conventional cosine synthesis method while maintaining the performance.
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Age as a clinical predictor of relapse after induction therapy in ulcerative colitis.
Jang, Eun Sun,Lee, Dong Ho,Kim, Jaihwan,Yang, Hyo-Joon,Lee, Sang Hyub,Park, Young Soo,Hwang, Jin Hyoek,Kim, Jin-Wook,Jeong, Sook-Hyang,Kim, Nayoung,Jung, Hyun Chae,Song, In Sung G. Thieme 2009 Hepato-gastroenterology Vol.56 No.94
<P>BACKGROUND/AIMS: Whether older patients with ulcerative colitis (UC) have a better clinical course than younger patients is unclear. We compared the clinical characteristics between older and younger age groups in South Korea to elucidate the impact of age on relapse in UC. METHODOLOGY: Patients between 18 and 85 years old who were diagnosed with UC at Seoul National University Bundang Hospital between 1 May 2003 and 31 Oct 2007 were enrolled. It was reviewed their symptoms, endoscopic and pathologic findings, and drugs used in induction treatment. RESULTS: Of the 73 patients with UC who achieved remission after induction treatment, 38 relapsed. The patients aged 18-44 and 45-85 years had similar clinical features, but the relapse rate was significantly higher in the younger group (69.2 vs. 32.4%; p = 0.002). In a multivariable analysis, age 45-85 years old was an independent protective factor against relapse (OR, 0.146; 95% CI, 0.035-0.508; p = 0.003) after adjusting for sex, frequency of diarrhea, hematochezia grade, disease extent, and systemic steroid used in induction treatment. CONCLUSION: An age of 45 years or older is an independent predictor of less relapse in UC.</P>
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간세포암종에서 간절제술 후 이환율과 사망률에 영향을 미치는 위험 인자
김완욱,이광웅,최성호,허진석,김용일,김성주,이대성,이환효,백승운,고광철,이준혁,최문석,유병철,조재원 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.1
목적: 간세포암종은 우리나라에서 간절제의 가장 흔한 적응증이다. 그러나 간경변을 동반한 경우가 많아 수술 후 이환율과 사망률이 높아 수술 전후 처치에 주의를 요한다. 최근에는 외과적 술기의 발전과 수술 전 및 수술 후 처치의 향상으로 이환율과 사망률이 감소하고 있으나 다른 수술에 비해 여전히 높다. 이에 본 연구에서는 간세포암종의 수술 중 위험 인자를 알아보고 수술 후 이환율과 사망률을 줄일 수 있는 방법을 찾아보고자 하였다. 대상과 방법: 1994년 11월부터 2001년 12월까지 간세포암종으로 진단받고, 간절제술을 시행받은 환자 510명을 대상으로 하였다. 대상 환자의 평균 연령은 51.6세였고, 남녀 비는 4.01 : 1이었다. 수술 전 HBsAg (+)는 76.0%, 수술 전, anti-HCV (+)는 8.2%였으며 종양의 크기는 평균 5.19 ㎝이었다. 환자 중 26.2%에서 수술 전 경도자 동맥색전술의 병력이 있었으며 8.7%에서 수술 전 경피적 간문맥색전술을 시행받았다. 시행받은 수술은 종양절제술 55예, 분절절제술 127예, 구역절제술 77예, 반간절제술 214예, 동반 혹은 확대 반간절제술 37예였다. 위험 인자로 나이, 성별과 각종 임상 지표(간기능 수치, 프로트롬빈시간, 혈청 알부민, 혈당, 알파태아단백, ICG 검사, 수술 전 경도자 동맥색전술, 경피적 간문맥색전술 시행 여부) 등의 수술 전 인자, 수술의 종류, 수술 시간, 수혈량 등의 수술 인자, 그리고 종양의 크기, 종양의 수, 간경변 여부 등의 병리조직학적 인자 등을 분석하였다. 분석자료는 대상 환자들의 의무기록을 통해 후향적 방법으로 조사하였다. 수술 사망은 수술 후 30일 이내에 사망한 경우로 정의하였고, 입원 사망은 수술 후 합병증으로 퇴원하지 못하고 사망한 경우로 정의하였다. 단변량 분석은 student t test와 x² test를 이용하였으며, 다변량 분석은 logistic regression을 이용하였다. 결과: 수술 후 합병증은 총 56예(10.5%)에서 나타났으며, 조절되지 않는 복수 19예, 호흡기 합병증 10예, 상처 합병증 8예, 간기능 이상으로 인한 고빌리루빈혈증 6예, 출혈 5예, 고질소혈증 4예 등이었다. 수술 사망은 5예(0.98%), 입원 사망은 수술 사망을 포함하여 6예(1.1%)였다. 이중 간부전과 연관된 사망이 5예였고, 간부전과 동반된 흡인성 폐렴으로 사망한 예가 1예 있었다. 이환율에 영향을 미치는 인자를 다변량 분석을 통해 알아본 결과, 수술 중 수혈량(P=0.002), 프로트롬빈시간(P=0.038), 혈당 수치(P=0.002)가 통계학적으로 의미가 있었고, 다변량 분석 상 수술 후 사망률과 관련된 인자로는 나이(P=0.028), 혈당 수치(P=0.011), 수술 전 경도자 동맥색전술 시행 여부(P=0.046) 등이 의미 있는 것으로 나타났다. 결론: 위의 위험 인자 분석을 통해 간세포암종에서 간절제시에 수술 후 이환율을 중이기 위해 가능한한 수술 중 출혈을 최소화하면서 불필요한 수혈을 피하고, 당뇨 환자에서는 수술 후 이환율과 사망률이 상대적으로 높고, 고령 환자에서는 사망률이 상대적으로 높으므로 수술 전후 처치에 세심한 주의가 필요함을 알 수 있었다. 수술전 경도자 동맥색전술 시행 여부가 수술 후 사망률과 유의한 상관성이 있었고 이에 대한 지속적인 연구가 필요하리라 생각된다. Background/Aims: Recently, mortality following surgical resection for hepatocelluar carcinoma has been reduced significantly. Morbidity, however, is still significant. This study evaluated the risk factors leading to morbidity and mortality. Methods: 510 patients who had a hepatic resection form Nov. 1994 to Dec. 2001 were included. The patient demographics showed a mean age of 51.6 years with a male to female ratio of 4:1. The HBsAg was positive in 76.0% and the anti-HCV was positive in 8.2%. The mean tumor size was 5.2 cm, 26.2% of patients had preoperative transcatheter arterial embolization (TAE), and 8.7% had preoperative percutaneous transhepatic portal embolization (PTPE). Limited resection was performed in 259 cases (50.7%), and major resection was conducted in 251 cases (49.1%). Risk factors included age, sex, laboratory findings (liver function test, prothrombin time, albumin, glucose, α-fetoprotein, ICG test), preoperative TAE, PTPE, operation type, operation time, intraoperative transfusion, tumor size, and cirrhosis. Results: The morbidity was 10.5% (54 cases). Operative death occurred in 5 cases (1.0%). Hospital death, including operative death, occurred in 6 cases (1.2%). Five cases were associated with hepatic failure and 1 case was associated with aspiration pneumonia accompanying hepatic failure. Transfusion (P=0.002), glucose (P=0.002), and prothrombin time (P=0.038) were significantly related to morbidity. Age (P=0.028), glucose (P=0.011), and TAE (P=0.046) were significantly related to mortality. Conclusions: Intraoperative transfusion, which is mainly related to intraoperative bleeding, should be reduced if possible to decrease morbidity. Diabetes mellitus patients and the elderly need careful perioperative management.(Korean J Hepatol 2004;10:51-61)
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( Sue Jin Kim ),( Moon Seok Choi ),( Ja Young Kang ),( Dong Il Choi ),( Cheol Keun Park ),( Geum Youn Gwak ),( Joon Hyoek Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ),( Byung Chul Yoo ) 대한소화기기능성질환·운동학회 2009 Gut and Liver Vol.3 No.4
Background/Aims: Compact lipiodol uptake without enhancement on multiphasic helical computed tomography (CT) has been suggested as a radiologic response criterion in hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE) and subsequent partial hepatectomy. However, its usefulness has not been fully investigated in the explanted liver. Methods: Between 1998 and 2007, 81 patients with HCC underwent 1-9 sessions of TACE followed by liver transplantation (LT). Thirty-nine tumors in 29 patients showed a radiologic response on CT performed prior to LT. The radiologic response criteria and the duration of the response were evaluated to predict total necrosis in the explanted liver. Results: Among the 39 tumors, 34 nodules (87.2%) exhibited total pathological necrosis. While 13 out of 16 tumors (81.3%) with a radiologic response for 6 months or less were completely necrotic, 21 out of 23 tumors (91.3%) with a radiologic response of longer than 6 months showed total necrosis. Conclusions: Our results suggested that the radiologic response criteria based on serial CT images might be useful for predicting total necrosis of TACE-pretreated HCC in LT. (Gut and Liver 2009;3:285-291)
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Jun Young Kim,Kyu Hyoek Yoen,Ji Hoon Kyhm,Woon Jo Cho,김태중,김영동,Jin Dong Song 한국진공학회 2015 Applied Science and Convergence Technology Vol.24 No.6
High contrast grating (HCG) is the structure made up of the sub-wavelength grating of high-index and the surrounding layer of low-index, which reveals high contrast between two materials. Its advantages include high reflectivity over a broad bandwidth, polarization and wavelength selectivity, optical high-Q resonator, and phase modulation. In this work, the HCG structure comprising of indium tin oxide (ITO) and Silicon (Si), for the surrounding layer and the grating layer respectively, was studied. Its theoretical model was established, and transmittance, phase and optical behavior were calculated by rigorous coupled-wave analysis and finite element method. Furthermore, the established structure was fabricated to validate its feasibility. The fabricated structure shows the focusing capability whose length is about 10 μm, and the feasibility of the structure was demonstrated. It is also meaningful that ITO layer can contribute to the fabrication of the HCG structure, leading to enable the structure to be electrical-driven.
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