A Tripartite Game Strategy to Promote the Commercialization of Research Results: A Synergistic Development Path Between Universities, Government, and Enterprises

Qi-Jia Liu,김영길 한국무역연구원 2024 무역연구 Vol.20 No.1

Purpose – The purpose of this paper is to explore the tripartite relationship between the government, universities, and enterprises in the process of improving China’s innovation index. We hope to gain an in-depth understanding of the dynamic game process among these three, and how various factors affect the way they cooperate in this process. Design/Methodology/Approach – Based on evolutionary game theory as a research tool, we constructed a tripartite evolutionary game model of universities, government, and commercial institutions, and analyzed the stability of each party's strategic choices and the relationship between the influence of each element. Findings – By simulating strategy combinations and the evolution process in different contexts, we derived the conditions for the occurrence of stable strategy combinations among universities, governments, and business organizations. Through the above study, we found that stable strategy combinations among government, universities, and enterprises are crucial in promoting the development of China’s innovation index. Research Implications – This study has important theoretical significance for understanding the dynamic relationship among government, universities, and firms, and also provides practical guidance for policy makers. Through this study, policy makers can have a clearer understanding of the needs and interests of each party, so that they can formulate more effective policies to promote the development of innovation activities.

Effect of Antrodia camphorata polysaccharides on letrozole-induced polycystic ovary syndrome (PCOS) model rats

Zhiqiang Liu,Chaojie Chong,Zhewen Dong,Yaqi Wu,Wanying Li,Haokun Chen,Shumei Zhong,Junyang Liu,Qi Qi Pang,Jia-Le Song,Yanyuan Zhou 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

To investigate the effect of ACP on letrozole-induced PCOS rats. All rats were divided into normal groups, PCOS group, metformin group and ACP group. The body weight (BW) was recorded every three days, and the final body weight as well as ovarian weight were recorded. Serum levels of TC, TG, HDL-C, LDL-C and E2, T, FSH and LH were measured by ELISA assay, and the LH/FSH ratio was calculated. The results showed that ACP decreased the BW and the ratio of ovarian to BW. Compared with the normal group, the serum levels of T, LH, LH/FSH, TG, TC, LDL-C increased, and the levels of FSH, E2, HDL-C decreased in PCOS group. ACP effectively improves the serum levels of FSH, LH/FSH, TG, TC, LDL-C and other related factors. The results of H&E staining of ovarian tissues showed that the ACP group showed different degrees of improvement in the reduced number of corpus luteum, thinning of granulosa cell layer, follicular capsular dilatation and follicular atresia. ACP not only reduces BW and the ratio of ovarian to BW, but also it can elevate the level of FSH and reduce LH/FSH, TG, TC and HDL-C levels. Furthermore, ACP can protect ovarian tissue to some extent.

Protective effect of centaureidin-3,5-O-biglucoside (C3G) on 5-fluorouracil(5-FU)-induced mucositis in BALB/c mice

Junyang Liu,Zixian Wang,Wanying Li,Zhewen Dong,Chaojie Chong,Yaqi Wu,Shumei Zhong,Haokun Chen,Zhiqiang Liu,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

To explore the effect of C3G on intestinal mucosal injury in 5-FU induced BALB/c mice. Mice were randomly divided into normal, model and C3G groups. After the last administration, mice were anesthetized, and calculated the thymus and spleen indexes. The ileum was used to stain with H&E observation. Serum levels of IL-1β, IL-6, IL-10 and TNF-α were determined by ELISA kits. Compared with the normal group, the model group had diarrhea, body weight and thymus and spleen index decreased significantly, intestinal villus epithelial cells fell off, crypt structure was destroyed, and inflammatory cell infiltration was observed. The body weight, thymus and spleen indexes of the treatment group and the prevention group decreased less, and the levels of TNF-α, IL-1β and IL-6 were significantly decreased, and the level of IL-10 was significantly increased relative to the model group. The intestinal villi structure was relatively complete, and a small amount of crypt structure was destroyed, with a small amount of inflammatory cell infiltration, which reduced the mucosal damage. The administration of C3G could protect intestinal mucosa from 5-FU-induced injury.

LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription

Luo Xiao-Jing,He Ming-Ming,Liu Jia,Zheng Jia-Bo,Wu Qi-Nian,Chen Yan-Xing,Meng Qi,Luo Kong-Jia,Chen Dong-Liang,Xu Rui-Hua,Zeng Zhao-Lei,Liu Ze-Xian,Luo Hui-Yan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Esophageal squamous cell carcinoma (ESCC) is one of the most life- and health-threatening malignant diseases worldwide, especially in China. Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and tumor progression. However, the roles and mechanisms of lncRNAs in ESCC require further exploration. Here, in combination with a small interfering RNA (siRNA) library targeting specific lncRNAs, we performed MTS and Transwell assays to screen functional lncRNAs that were overexpressed in ESCC. TMPO-AS1 expression was significantly upregulated in ESCC tumor samples, with higher TMPOAS1 expression positively correlated with shorter overall survival times. In vitro and in vivo functional experiments revealed that TMPO-AS1 promotes the proliferation and metastasis of ESCC cells. Mechanistically, TMPO-AS1 bound to fused in sarcoma (FUS) and recruited p300 to the TMPO promoter, forming biomolecular condensates in situ to activate TMPO transcription in cis by increasing the acetylation of histone H3 lysine 27 (H3K27ac). Targeting TMPO-AS1 led to impaired ESCC tumor growth in a patient-derived xenograft (PDX) model. We found that TMPO-AS1 is required for cell proliferation and metastasis in ESCC by promoting the expression of TMPO, and both TMPO-AS1 and TMPO might be potential biomarkers and therapeutic targets in ESCC.

Analysis of Subsynchronous Oscillation of Direct Drive PMSG Based Wind Farm Under Low Operating Condition

Qi Jia,Gangui Yan,Wenbo Hu,Kan Liu,Junxi Wang 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.1

Aiming at the sub-synchronous oscillation (SSO) problem that direct-drive permanent magnetic synchronous generator (PMSG) based wind farm under low operating conditions connects to the grid, based on the idea of graphical block modeing, the wind turbine generation (WTG), collector circuit and grid are regarded as discrete components. On the basis of establishing detailed models of each component, two linearized models of direct-drive PMSG based wind farm under different collector circuit topological structure is constructed. Wind farm impedance model is constructed based on state space equation of linearized model. The infl uences of current inner loop control parameters, grid strength, operating conditions on SSO characteristics are analysed. The diff erence between the two models in the study of SSO is compared. Finally, a time-domain simulation model of direct drive PMSG based wind farm connected to grid is built in EMTDC/PSCAD and the validity of the theoretical analysis is verifi ed.

Activated Protein C Protects Myocardium Via Activation of Anti-apoptotic Pathways of Survival in Ischemia-reperfused Rat Heart

Jia-Wang Ding,Xiao-Hong Tong,Jun Yang,Zhao-Qi Liu,Yan Zhang,Jian Yang,Song Li,Li Li 대한의학회 2010 Journal of Korean medical science Vol.25 No.11

Activated protein C (APC) is known to be beneficial on ischemia reperfusion injury in myocardium. However, the protection mechanism of APC is not fully understood. The purpose of this study was to investigate the effects and possible mechanisms of APC on myocardial ischemic damage. Artificially ventilated anaesthetized Sprague-Dawley rats were subjected to a 30 min of left anterior descending coronary artery occlusion followed by 2 hr of reperfusion. Rats were randomly divided into four groups; Sham, I/R, APC preconditioning and postconditioning group. Myocardial infarct size, apoptosis index, the phosphorylation of ERK1/2, Bcl-2, Bax and cytochrome c genes and proteins were assessed. In APC-administrated rat hearts, regardless of the timing of administration, infarct size was consistently reduced compared to ischemia/reperfusion (I/R) rats. APC improved the expression of ERK1/2 and anti-apoptotic protein Bcl-2 which were significantly reduced in the I/R rats. APC reduced the expression of pro-apoptotic genes, Bax and cytochrome c. These findings suggest that APC produces cardioprotective effect by preserving the expression of proteins and genes involved in anti-apoptotic pathways, regardless of the timing of administration.

Metrological performance investigation of swirl flowmeter affected by vortex inflow

Qi Liu,Jia-hui Ye,Guang Zhang,Zhe Lin,Hong-guang Xu,Zu-chao Zhu 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.6

In fluid transportation industries, long straight transition pipelines upstream of flowmeters are required to eliminate the influence of disturbed inflow on flow metering accuracy. To ensure an accurate flow measurement, the straight transition pipeline, which is often lengthy, can be shortened, particularly when the installation space is limited. However, the characteristics of disturbed flow (mainly characterized by vortex inflow) evolving along the straight transition pipeline to affect the metrological performance must be investigated for optimizing the pipeline length. The objective of this study was to investigate the metrological performance of a swirl flowmeter affected by the vortex inflow caused by flow regulation with a sleeve valve. The effect of a straight transition pipeline length upstream of a swirl flowmeter on the evolving characteristics of the vortex inflow was investigated experimentally and by conducting a numerical simulation under flow regulation parameters, including valve openings and flow velocities. The flow coefficients for different straight transition pipeline lengths were investigated to verify the flow simulation. The periodic pressure variation in the swirl flowmeter was monitored and its corresponding characteristic frequency was analyzed. It was found that the metrological characteristics of the swirl flowmeter were extremely affected by a smaller valve opening, which can be improved by lengthening the straight transition pipeline. By analyzing the velocity vector and vorticity in the internal flow field, the vortex inflow was found to be vulnerable to dissipation within a longer straight transition pipeline. The average vorticity at the cross-section of the entrance to the swirl flowmeter was adopted to evaluate the inflow vortex intensity. Additionally, a power curve model was established to assess the critical characteristic frequency determined by the maximum unaffected inflow vorticity for different straight transition pipeline lengths. This study can provide helpful insights to the metrological performance and pipeline arrangement in the field of fluid transportation engineering.

Distinct Pro-Apoptotic Properties of Zhejiang Saffron against Human Lung Cancer Via a Caspase-8-9-3 Cascade

Liu, Dan-Dan,Ye, Yi-Lu,Zhang, Jing,Xu, Jia-Ni,Qian, Xiao-Dong,Zhang, Qi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Lung cancer is the leading cause of cancer-related death worldwide. Here we investigated the antitumor effect and mechanism of Zhejiang (Huzhou and Jiande) saffron against lung cancer cell lines, A549 and H446. Using high performance liquid chromatography (HPLC), the contents of crocin I and II were determined. In vitro, MTT assay and annexin-V FITC/PI staining showed cell proliferation activity and apoptosis to be changed in a dose- and time-dependent manner. The inhibition effect of Jiande saffron was the strongest. In vivo, when mice were orally administered saffron extracts at dose of 100mg/kg/d for 28 days, xenograft tumor size was reduced, and ELISA and Western blotting analysis of caspase-3, -8 and -9 exhibited stronger expression and activity than in the control. In summary, saffron from Zhejiang has significant antitumor effects in vitro and in vivo through caspase-8-caspase-9-caspase-3 mediated cell apoptosis. It thus appears to have more potential as a therapeutic agent.

A Mutation in <i>PGM2</i> Causing Inefficient Galactose Metabolism in the Probiotic Yeast <i>Saccharomyces boulardii</i>

Liu, Jing-Jing,Zhang, Guo-Chang,Kong, In Iok,Yun, Eun Ju,Zheng, Jia-Qi,Kweon, Dae-Hyuk,Jin, Yong-Su American Society for Microbiology 2018 Applied and environmental microbiology Vol.84 No.10

<P>IMPORTANCE Saccharomyces boulardii is a probiotic yeast strain capable of preventing and treating diarrheal diseases. However, the genetics and metabolism of this yeast are largely unexplored. In particular, molecular mechanisms underlying the inefficient galactose metabolism of S. boulardii remain unknown. Our study reports that a point mutation in PGM2, which codes for phosphoglucomutase, is responsible for inferior galactose utilization by S. boulardii. After correction of the mutated PGM2 via genome editing, the resulting strain was able to use galactose faster than a parental strain. While the PGM2 mutation made the yeast use galactose slowly, investigation of the genomic sequencing data of other S. boulardii strains revealed that the PGM2 mutation is evolutionarily conserved. Interestingly, the PGM2 mutation was beneficial for growth at a higher temperature on glucose. We speculate that the PGM2 mutation was enriched due to selection of S. boulardii in the natural habitat (sugar-rich fruits in tropical areas).</P>

Lignin Based Flexible Electromagnetic Shielding PU Synergized with Graphite

Jia Zhang,Yunxia Qi,Yumei Zhang,Jinchi Duan,Bairun Liu,Baijun Liu,Zhaoyan Sun,Yiquan Xu,Wei Hu,Niaona Zhang 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1

In this paper, lignin (L)-based polyurethane (FeGLPU) with excellent electromagnetic shielding properties wasprepared and studied. The modified reduced iron powder was modified with KH550, and then the obtained modified reducediron powder (Fe) was mixed with lignin, polyethylene glycol 200 (PEG200), hexamethylene diisocyanate (HDI) and graphite(G) to in-situ synthesize the FeGLPU. The thermal stability, mechanical properties, electronic conductivity, and morphologyof the composite FeGLPU were characterized in detail. The electromagnetic interference shielding effectiveness (EMI SE) ofFeGLPU was tested in the frequency range of 8.2-26.5 GHz. When the content of Fe and G was fixed at 10 % and the lignincontent was 5 %, the maximum EMI SE was 21.6 dB, and the frequency width of EMI SE greater than 10 dB was 18.3 GHz. The conductivity was 4.27×10-4 S/m, and the tensile strength of Fe10G10L5PU reached 11.7 MPa. When the lignin contentincreased to be 20 %, the maximum EMI SE was 22.5 dB, and the frequency width of EMI SE greater than 10 dB was18.3 GHz. The conductivity was 1.06×10-2 S/m, and the thermal decomposition temperature T5 (5 % weight loss) reached234 °C. The obtained excellent EMI SE should be due to the synergistic effect of Fe, G and lignin. It can be observed fromthe SEM observation that the G and Fe are uniformly dispersed in PU matrix with strong interfacial interaction. It wasillustrated that the prepared FeGLPU was with efficient electromagnetic shielding properties, good mechanical properties,and high thermal stability. This lignin based electromagnetic shielding PU was proposed to have broad application prospectsdue to its low expenses and ecology friendliness.