어머니의 양육스트레스와 유아의 외현화 문제행동 및 학교준비도가 초등학교 1학년 학교적응에 미치는 영향

박정현 ( Park¸ Jeonghyeon ),이경님 ( Lee¸ Kyungnim ) 열린부모교육학회 2020 열린부모교육연구 Vol.12 No.4

본 연구는 어머니의 양육스트레스와 유아의 외현화 문제행동 및 학교준비도가 초등학교 1학년 학교적응에 어떠한 직·간접적 영향을 미치는지를 살펴보고자 하였다. 이를 위하여 한국아동패널 7차년도와 8차년도의 종단 자료 중 949명의 유아와 그들의 어머니를 대상으로 수집된 자료를 활용하여 Pearson의 적률상관분석과 구조방정식모형(SEM)분석을 실시하였다. 그 결과 첫째, 유아의 외현화 문제행동과 학교준비도는 초등학교 1학년 학교적응에 직접적 영향을 미치는 것으로 나타났다. 둘째, 유아의 외현화 문제행동은 학교준비도를 매개로 하여 초등학교 1학년 학교적응에 간접적 영향도 미치는 것으로 나타났다. 셋째, 어머니의 양육스트레스가 초등학교 1학년 학교적응에 영향을 미치는 경로에서 유아의 외현화 문제행동과 학교준비도의 순차적인 이중 매개효과 나타났다. 즉 어머니의 양육스트레스는 유아의 외현화 문제행동과 학교준비도를 순차적으로 매개하여 학교적응에 간접적 영향을 미치는 것으로 나타났다. 추가하여 초등학교 1학년 학교적응에 유아의 외현화 문제행동의 영향이 가장 큰 것으로 나타났다. 이러한 결과는 초등학교 1학년 학교적응을 위하여 유아의 외현화 문제행동에 대한 중재와 예방이 필수적임을 강조하고 학교준비도 증진을 위한 지도방안에 초점을 맞춘 교사교육 및 어머니의 양육스트레스 완화를 위한 부모교육이나 사회적 지원이 효과적임을 시사하고 있다. The purpose of this study was to examine the structural relationships among mother’s parenting stress, young children’s externalizing behavioral problems, school readiness and school adjustment in first grade. For this study, seventh(2014) and eighth(2015) data from the Panel Study on Korean Children (PSKC) were analysed by means of Pearson’s correlational relationships and structural equational modelling. The main results were as follows: first, young children’s externalizing behavioral problems and school readiness were found to have a direct effect on school adjustment in first grade. Second, young children’s externalizing behavioral problems was found to have an indirect effect on school adjustment in first grade through school readiness. Third, mother’s parenting stress was found to have an indirect effect on school adjustment in first grade through externalizing behavioral problems and school readiness. Additionally externalizing behavioral problems was found to be the most important variable predicting young children’s school adjustment in first grade. These results suggested that reducing externalizing behavioral problems and mother’s parenting stress, improving school readiness could help young children’s school adjustment in first grade.

The field application and test of insect pollinators in 5 fruit and vegetable crops

Kyeong Yong Lee,Hee Chul Lee,Somi Lee,Jeonghyeon Lim,Sun-young Lee,Young Uk Park,Young Bo Lee,Heeji Kim,Su-bae Kim,Bosun Park,Sujin Lee,Kyu-Won Kwak,Seong Hyun Min,Dong Hee Lee 한국응용곤충학회 2024 한국응용곤충학회 학술대회논문집 Vol.2024 No.04

국내 원예작물에서 화분매개곤충의 의존도는 해마다 증가하고 있다. 우리는 사과, 딸기 등 화분매개곤충의 의존도가 높은 주요 과수와 시설작물에 대하여 화분매개곤충의 사용기술을 개발하고 이를 현장에 적용하는 연구를 수행하고 있다. 2021년부터 2022년까지 딸기, 키위 등 5가지 주요 농작물에서 화분매개벌을 적용한 결과, 딸기에서 뒤영벌의 적용결과 기존 꿀벌과 통계적으로 같은 수준의 화분매개효과를 나타내었으며, 하우스에서 농약적용시 하우스 밖으로 벌통을 위치시키는 것이 방치보다 벌의 소실을 20% 더 감소시킬 수 있었다. 인공수분 에 의존하고 있는 씨없는 수박에서 수분수 식재와 꿀벌을 이용함으로 기존 벌 방사보다 16% 착과율을 향상시킬 수 있었다. 시설고추에서 꿀벌과 뒤영벌의 혼합사용시 기존 꿀벌 방사보다 고추 수량이 10% 향상되었고, 토마토 에서 660㎡당 뒤영벌의 봉군량을 1.5배 증가시 토마토 수량은 4.4% 향상되었다. 키위는 꿀벌로 기존의 인공수분 을 충분히 대체할 수 있었고, 인건비가 60%이상 절감되었다. 또한 현재 시판중인 30종의 살충제와 27종의 살균제 에 대하여 24시간내 반수치사를 보인 농약은 각각 살충제 6종와 살균제 4종 이었다. 이어서 2023년부터 참외, 멜론, 사과, 단감에 대한 현장적용연구가 진행되고 있다.

에너지 활용 고도화를 위한 실내 식물 CO₂ 흡·방출량 딥러닝 모델 개발

이승훈(Seung Hun Lee),김보라(Bo Ra Kim),신봉규(Bong Kyu Shin),정민흥(Min Heung Jeong),남영효(Young Hyo Nam),이승욱(Seunguk Lee),이정현(Jeonghyeon Lee),이재원(Jae Won Lee) 대한기계학회 2024 대한기계학회 춘추학술대회 Vol.2024 No.4

Normobaric Oxygen Exposure Promote the Sensitivity of Paclitaxel in Paclitaxel Resistant Lung Cancer Cells by CHOP Activation and Disregulation of Autophagy

( Jeonghyeon Im ),( Hee Young Kwon ),( In Kyoung Kim ),( Chang Dong Yeo ),( Sei Won Kim ),( Heayon Lee ),( Jung Won Heo ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Purpose Hyperbaric oxygen therapy (HBO) to increase anticancer effect, despite several positive Results, has been suggested to have a toxicity problem in other tissues, so further studies on the conditions and application of oxygen therapy are needed. The purpose of this study is to evaluate the anticancer effect of paclitaxel (PTX) in lung cancer cells under normobaric oxygen exposure. Methods Non-small cell lung cancer (NSCLC) cell line A549 and the paclitaxel resistant cell line A549/PR were used. Cell viability, ability of migration and proliferation were evaluated in room air (RA) or normobaric oxygen (NBO) air condition for 48hs. The expression apoptosis related proteins was detected. For elucidation of the cell death in PTX treated A549/PR cells by NBO, the expression level of the C/EBP homologous protein (CHOP) and autophagy related proteins were analyzed. Results NBO exposure attenuated cell viability, ability of migration and proliferation ability in A549 cells and A549/PR cells therby increased apoptotic cell death by PTX. CHOP expression of A549/PR cells was increased by NBO exposure compare to RA condition. And conversion of LC3B-I to LC3B-II by PTX was reduced in A549 and A549/PR cells in NBO exposure (Figure 1-3). Conclusions Our Results show that NBO exposure synergistically increased the apoptotic cell death of A549 and A549/PR cells by paclitaxel. Also, cell death of A549/PR cells under NBO condition was induced by CHOP-mediated disregulation of autophagy. These findings suggest that the NBO exposure can promote the sensitivity of paclitaxel in lung cancer cells by CHOP activation and disregulation of autophagy.

GRIM-19 Ameliorates Multiple Sclerosis in a Mouse Model of Experimental Autoimmune Encephalomyelitis with Reciprocal Regulation of IFNγ/Th1 and IL-17A/Th17 Cells

Jeonghyeon Moon,Seung Hoon Lee,Seon-yeong Lee,Jaeyoon Ryu,Jooyeon Jhun,JeongWon Choi,Gyoung Nyun Kim,노상호,박성환,조미라 대한면역학회 2020 Immune Network Vol.20 No.5

The protein encoded by the Gene Associated with Retinoid-Interferon-Induced Mortality-19 (GRIM-19) is located in the mitochondrial inner membrane and is homologous to the NADH dehydrogenase 1-alpha subcomplex subunit 13 of the electron transport chain. Multiple sclerosis (MS) is a demyelinating disease that damages the brain and spinal cord. Although both the cause and mechanism of MS progression remain unclear, it is accepted that an immune disorder is involved. We explored whether GRIM-19 ameliorated MS by increasing the levels of inflammatory cytokines and immune cells; we used a mouse model of experimental autoimmune encephalomyelitis (EAE) to this end. Six-to-eight-week-old male C57BL/6, IFNγ-knockout (KO), and GRIM-19 transgenic mice were used; EAE was induced in all strains. A GRIM-19 overexpression vector (GRIM19 OVN) was electrophoretically injected intravenously. The levels of Th1 and Th17 cells were measured via flow cytometry, immunofluorescence, and immunohistochemical analysis. IL-17A and IFNγ expression levels were assessed via ELISA and quantitative PCR. IL-17A expression decreased and IFNγ expression increased in EAE mice that received injections of the GRIM19 OVN. GRIM-19 transgenic mice expressed more IFNγ than did wild-type mice; this inhibited EAE development. However, the effect of GRIM-19 overexpression on the EAE of IFNγ-KO mice did not differ from that of the empty vector. GRIM-19 expression was therapeutic for EAE mice, elevating the IFNγ level. GRIM-19 regulated the Th17/Treg cell balance.

A Phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers

Lee, Hae Won,Lim, Mi-sun,Seong, Sook Jin,Lee, Joomi,Park, Jeonghyeon,Seo, Jeong Ju,Yun, Hwi-yeol,Baek, In-hwan,Kwon, Kwang-il,Yoon, Young-Ran Informa UK, Ltd. 2011 Expert opinion on drug metabolism & toxicology Vol.7 No.12

<P><B><I>Objectives:</I></B> An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compare the pharmacokinetics, pharmacodynamics and safety of triflusal EC with triflusal in healthy Korean male subjects to determine bioequivalence and non-inferiority for the purposes of marketing approval.</P><P><B><I>Methods:</I></B> A randomized, open-label, two-period, crossover study was conducted in 38 subjects. Either triflusal EC or triflusal was administered orally as a single 900 mg loading dose (day 1) followed by eight 600 mg/day maintenance doses on days 2 - 9, with a 13-day washout period. The plasma concentrations of 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), the predominant active metabolite of triflusal, were assessed after administration of the loading dose, using HPLC/MS/MS. The platelet aggregation response to arachidonic acid was determined using turbidimetric aggregometry. </P><P><B><I>Results:</I></B> The 90% CIs, for the geometric mean ratios of the log-transformed AUC<SUB>τ</SUB> and C<SUB>max</SUB> of HTB were seen to be within the predetermined range of 0.8 - 1.25. Triflusal EC was also shown to be non-inferior in its anti-aggregatory effect. No serious AEs were reported during this study.</P><P><B><I>Conclusions:</I></B> The pharmacokinetic and pharmacodynamic profiles of the two triflusal formulations met the requirements for bioequivalence and non-inferiority, respectively. Both formulations were well tolerated.</P>

Accelerate the Shift to Green Energy with PVDF Based Piezoelectric Nanogenerator

Jeonghyeon Lee,Sugato Hajra,Swati Panda,Wonjeong Oh,Yumi Oh,Hyoju Shin,Yogendra Kumar Mishra,Hoe Joon Kim 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.11 No.1

The two greatest difficulties humanity faces are environmental catastrophe and air degradation, and renewable energy from the ocean, solar, and wind offers a possible answer. This research describes a piezoelectric energy harvester (PENG) for harvesting low-frequency water wave energy. The poled PENG device based on a ferroelectric polymer polyvinylidene fluoride (PVDF) delivers a voltage of 32 V and a current of 130 nA. The PENG achieves a power of 1.38 µW at 500 MΩ. The low-frequency vibrations generated from the laboratory equipment were effectively converted into usable electrical energy. Furthermore, the output performance of four PVDF-based PENG units connected in parallel was placed inside a 3D printed housing after being exposed to water waves delivered a voltage of 1.1 V and current of 170 nA. This work presents an efficient approach for gathering low-frequency wave energy and realizing the blue-energy dream. This study offers a cost-effective approach for gathering low-frequency water wave energy and realizing the blue-energy vision.

국내 중소기업의 연구개발 활동과 기술 혁신 현황

이정현(Lee, Jeonghyeon),김상균(Kim, Sang Kyun) 한국경영학회 2021 한국경영학회 통합학술발표논문집 Vol.2021 No.8

4차 산업혁명을 견인할 혁신 주체로서 중소기업의 역할이 증가함에 따라, 기술경쟁우위를 창출하기 위한 중소기업의 연구개발 투자가 강조되고 있다. 본 연구에서는 이러한 시대적 요구에 적합하게 국내 중소기업의 기술 혁신이 이루어지고 있는지 확인하고자, 2011년부터 2018년의 국내 중소기업의 년도 별, 산업별 연구개발 활동을 분석하였다. ’18년 기준 총 1,247,013개의 기업데이터를 보유하고 있는 중소기업 지원사업 통합관리시스템 (SIMS) 데이터를 사용하여 연구를 진행하였다. 2011년부터 2018년까지의 국내 중소기업의 년도 별 연구개발비용을 분석해본 결과, 2014년까지 점차 증가하던 연구개발비용은 2015년을 기점으로 소폭 감소하다 2017년부터 다시 증가하였다. 같은 기간의 연구개발 성과로 국내 중소기업의 특허출원 건수를 분석한 결과, 꾸준히 증가하던 특허출원 건수는 2016년을 기점으로 2018년까지 점진적으로 감소하였다. 연구개발 투입 및 성과는 년도 별로 일관되지 않고 증감이 존재하였는데, 이는 매몰 비용성격의 연구개발이 국내 경기 및 기업의 재무 상황의 영향을 받아 일정하게 이루어지지 못했기 때문으로 보인다. R&D의 일반적 특징으로 볼 수 있으나, 보다 일관적, 전략적으로 연구개발을 수행해 신기술을 안정적으로 확보하는 것이 필요한 것으로 보인다. 또 산업별 연구개발 성과에 대해 알아보기 위해, 2018년 국내 중소기업의 산업별 특허출원 건수에 대해서도 분석하였다. 융복합화로 제조업을 넘어 전 산업에서의 기술 혁신 노력이 진행되는 상황 속에서, 산업별 연구개발 현황을 통해 4차 산업혁명의 중소기업 영향 정도를 파악하려는데 그 목적이 있다. 분석 결과, 제조업(53%)을 이어 도매 및 소매업(17%), 정보통신업(13%), 전문, 과학 및 기술 서비스업 (7%) 순으로 특허출원이 이루어지고 있었다. 전 산업에서의 특허출원 건수 중 제조업이 차지하는 비중은 52.5%, 서비스업 비중은 29.7%로 나타났다. 제조업뿐 아니라 서비스업에서도 활발하게 특허출원이 이루어지고 있었다. 4차 산업 혁명의 영향으로 기술 혁신 양상이 변화 중인 것으로 파악된다.

한의학과 문학의 교섭 양상 연구 : 藥名詩를 중심으로

이정현(Jeonghyeon Lee) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.3

In this study, YakMyeongSi were considered to define relations of Tradional Korean Medicine(TKM) and literature. In the introduction, present related studies were searched to clarify YakMyeongSi are completely different from medical property songs( YakSeongGa). Related data about YakMyeongSi and YakSeongGa were extracted for the initial findings. In chapter 2, medical name verse was defined as 'a type of free verses with one or more medical names in each verse to be interpreted ordinarily' based on records and examples of YakMyeongSi. In China, it originated from " Book of Odes" and " Songs of Chu", and it was most popular in the Song-China. Medical names actually referred to medical names in the early forms of the Warring States Period, but the complete form of YakMyeongSi started to appear in the Tang-China. In chapter 3, 34 YakMyeongSi and 5 related data were suggested in tables as the present conditions of Korean YakMyeongSi. With actual examples, better comprehension of YakMyeongSi were intended. Also, the fact that Korean YakMyeongSi were completed in forms at the end of Goryeo and beginning of Joseon dynasty. The motivations of writing YakMyeongSi were also studied. Medical names were put into verses because they well expressed landscapes and emotions. Propagation of medical knowledge was the basis of YakMyeongSi. There are limits in defining the relations of TKM and literature with some YakMyeongSi. More studies must be carried out on YakMyeongSin various records with details and interests. Also, study to define general relations of TKM and literature must be carried out together by examining TKM in literary forms such as medical introductions or medical property songs and literature pieces that expressed principles and materials of TKM.

고효율 CIGS 태양전지를 위한 CdS 박막의 Cd 소스에 따른 효과에 관한 연구

이정현(Jeonghyeon Lee),김동욱(Donguk Kim),김민하(Minha Kim),이재형(Jaehyeong Lee) 대한전기학회 2015 대한전기학회 학술대회 논문집 Vol.2015 No.11