http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The National Health Plan 2030: Its Purpose and Directions of Development
Oh Yumi 대한예방의학회 2021 예방의학회지 Vol.54 No.3
The National Health Plan 2030 (HP2030) started to be prepared in 2017 and was completed and announced in December 2020. This study presents an overview of how it was established, the major changes in policies, its purpose, and future directions. This study analyzed the steps taken in the past 4 years to establish HP2030 and reviewed major issues at the international and governmental levels based on an evaluation of HP2020 and its content. HP2030 establishes 6 divisions and 28 topic areas, and it will continue to expand investments in health with a total budget of 2.5 trillion Korean won. It also established goals to enhance health equity for the first time, with the goal of calculating healthy life expectancy in a way that reflects the circumstances of Korea and reducing the gap in income and healthy life expectancy between regions. The establishment of HP2030 is significant in that it constitutes a sustainable long-term plan with sufficient preparation, contains policy measures that everyone participates in and makes together, and works towards improvements in universal health standards and health equity. With the announcement of HP2030, which includes goals and directions of the national health policy for the next 10 years, it will be necessary to further strengthen collaboration with relevant ministries, local governments, and agencies in various fields to concretize support for prevention-centered health management as a national task and to develop a health-friendly environment that considers health in all policy areas.
Oh Jaeik,Hwa Chanwoong,Jang Dongjun,Shin Seungjae,Lee Soojin,Kim Jiwon,Lee Sang Eun,Jung Hae Rim,Oh Yumi,Jang Giyong,Kwon Obin,An Joon-Yong,Cho Sung-Yup 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
N6-Methyladenosine (m6A) RNA modification plays a critical role in the posttranscriptional regulation of gene expression. Alterations in cellular m6A levels and m6A-related genes have been reported in many cancers, but whether they play oncogenic or tumor-suppressive roles is inconsistent across cancer types. We investigated common features of alterations in m6A modification and m6A-related genes during carcinogenesis by analyzing transcriptome data of 11 solid tumors from The Cancer Genome Atlas database and our in-house gastric cancer cohort. We calculated m6A writer (W), eraser (E), and reader (R) signatures based on corresponding gene expression. Alterations in the W and E signatures varied according to the cancer type, with a strong positive correlation between the W and E signatures in all types. When the patients were divided according to m6A levels estimated by the ratio of the W and E signatures, the prognostic effect of m6A was inconsistent according to the cancer type. The R and especially the R2 signatures (based on the expression of IGF2BPs) were upregulated in all cancers. Patients with a high R2 signature exhibited poor prognosis across types, which was attributed to enrichment of cell cycle- and epithelial–mesenchymal transition-related pathways. Our study demonstrates common features of m6A alterations across cancer types and suggests that targeting m6A R proteins is a promising strategy for cancer treatment.
아동ㆍ청소년기 복합외상경험과 성인기 대인외상의 관계: 해리경험, 관계중독, 내면화된 수치심의 매개효과
오유미(Yumi Oh),이민규(Min Kyu Rhee) 대한스트레스학회 2021 스트레스硏究 Vol.29 No.1
본 연구에서는 아동ㆍ청소년기 복합외상경험과 성인기 대인외상과의 관계에서 해리경험, 관계중독, 내면화된 수치심의 매개효과를 검증하였다. 성인 238명을 대상으로 외상경험 척도, 한국판 사건충격척도 수정판, 해리 경험 척도, 관계중독질문지, 내면화된 수치심 척도로 설문을 실시했고 자료 분석은 기술 통계분석, 상관 분석, 신뢰도 분석, 구조방정식 모델이 사용되었다. 연구 결과, 아동ㆍ청소년기 복합외상경험에서 해리경험, 관계중독, 내면화된 수치심을 매개로 하여 성인기 대인외상에 영향을 미치는 삼중 매개효과가 유의한 것으로 확인되었다. 본 연구의 의의와 제한점을 논의하였고, 추후 연구에 필요한 시사점을 제안하였다. Background: The purpose of this study is to verify the mediating effects of dissociation experience, relationship addiction, and internalized shame in the relationship between complex trauma experience in childhood-adolescence and interpersonal trauma in adulthood. Methods: Two hundred and thirty-eight adults participated in this study. They were administered the Korean versions of the Trauma Antecedents Questionnaire, Impact of Event Scale-Revised, Dissociative Experiences Scale, Relationship Addiction Questionnaire, and Internalized Shame Scale. The data were analyzed with descriptive statistics, correlation analysis, reliability analysis, and structural equation modeling. Results: First, dissociation and internalized shame had a double mediating effect in the relationship between complex trauma experience in childhood-adolescence and interpersonal trauma in adulthood. Second, relationship addiction and internalized shame had a double mediating effect in the relationship between complex trauma experience in childhood-adolescence and interpersonal trauma in adulthood. Third, dissociation, relationship addiction, and internalized shame had a triple mediating effect in the relationship between complex trauma experience in childhood-adolescence and interpersonal trauma in adulthood. Conclusions: Therapeutic intervention for revictimization should address symptoms such as dissociation, relationship addiction, and internalized shame. In addition, people with complex trauma experiences in childhood-adolescence require preventive intervention to avoid further exposure to interpersonal trauma.