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Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12
Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.
데빅병 치료에 사용한 Interferon β-1b의 부작용 1예
김정미,조은경,조정선,최용석,한영수,한정호,김두응,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
A 63 year-old woman who had diagnosis of multiple sclerosis complaining left hemiparesis and fluctuating decreased visual acuity in her right eye and abnormal findings in pattern shift visual evoked potentials(PSVEPs) and on T2 weighted MR scanning. We treated her subcutaneously with 250μg interferon (3-lb(ITFß -lb) every other day. There were detected pancytopenia, skin rash, and abnormal liver function test seven days after the therapy. In spite of reducing the dose of interferon injection, abnormal laboratory findings were not returned to normal. Dose adjustment of interferon-I3 for body weight or race, may be helpful to reduce the side effects.
흔치않은 대상포진 치험 2예 : 비전형적 부위와 다른 부위로 재발한 예 Unusal Dermatome and Recurs Other Dermatome
김정미,조은경,조정선,최용석,한영수,한정호,김두응,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Herpes zoster is well known as an acute, self-limited disease of unilateral sensory dermatome caused by varicella-zoster virus and characterized by grouped vesicular skin eruption and pain over several dermatomes as well as single. This virus usually affects the thoracic dermatome and there are a few reports that this virus involves lower lumbar or sacral area, and recurrent cases. We experienced 2 cases that zoster virus involved L4 or S2 dermatome and left typical skin lesions, of which one was a recurrent case involving different dermatome at an interval of 8 years and the other was a rare case involving sacral dermatome.
해부학 실습에 의한 의과대학생들의 formaldehyde 폭로 정도와 formaldehyde 과민반응에 대한 조사연구
조수현,김헌,남윤정,김용대 충북대학교 의과대학 충북대학교 의학연구소 1993 忠北醫大學術誌 Vol.3 No.1
Formaldehyde induces not only irritation symptoms of eyes and respiratory tract but hypersensitivity reactions, such as contact dermatitis, allergic rhinitis, and asthma. To estimate the levels of exposure to formaldehyde during cadaver dissection in anatomy laboratory and to investigate the prevalence rates of irritation symptoms, allergic rhinitis and bronchial asthma, air concentrations of formaldehyde within cadaver dissection room were measured, and self-administrative questionnaire and enzyme linked immunosorbent assay(ELISA) were performed upon medical(n=182) and premedical students(n=69). For measurement of air formaldehyde level, chromotropic acid method(NIOSH method 3500) was used. Formaldehyde was conjugated to human serum albumin, and used as antigen in ELISA after identification of conjugation with immunoelectrophoresis. Prevailing symptoms during cadaver dissection were soreness of eyes or throat(92.9%), lacrimation(74.3%), rhinorrhea(49.7%), and sneezing(32.2%). Mean titers of IgE and IgG antibodies specific to formaldehyde-human serum albumin conjugate(F-HSA) of medical students were higher than those of premedical students. However, there was no case whose titers of anti-F-HSA antibody were higher than the twice of those of anti-HSA antibody or higher than the twice of the mean titers of premedical students. These results suggest that medical students were exposed to relatively high concentration of formaldehyde, but few asthma or allergic rhinitis were induced by formaldehyde exposure during cadaver dissection practice.
조용부,윤정배 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-
The experimental study from interior beam-column joint for RC frames is presented. Test parameters are concrete compressive strength, member flexural strength ratio and joint shear stress, which are the range of critical value for stable behavior. The results from cyclic loading tests show different behaviors with respect to parameters. Further investigations are need for higher concrete strength.
자색고구마가 사염화탄소 투여에 의한 흰쥐의 간손상 보호에 미치는 영향
조영자,김현아,방미애,오용비,정병춘,문윤호,정우진 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.3
The purpose of this study was to investigate the effects of dietary purple sweet potato(lpomoea batatas) powder on serum lipid levels and antioxidative enzymes in normal and pretective effect on hepatotoxicity rats induced by carbon tetrachlolide. Four groups of rats (3-week-old inbred Sprague-Dawley male rats) were normal rats fed control diet(C)_(1) induced hepatotoxicity rats fed control diet(EC)_(1) normal rats fed purple sweet potato diet(P), and induced hepatotoxicity rats fed purple potato sweet diet(EP). Rats were induced by single injection of 50% carbon tetrachloide(0.1 mL/100 g B.W., i.p.). The rats were fed ad libitum each of the experimental diet for 5 weeks. After 5 weeks the rats were sacrificed and activities of antioxidant enzymes and lipid peroxidation products were determined in their liver homogenates. But serum concentrations of lipid was not significant in all groups. Serum alanine aminotransferase(ALT/GPT) and aspartate aminotransferase(ALT/GPT)of the EC and EP groups were heigher than the C and P groups. The hepatic glucose 6-phosphatase(G9Pase) activity of the group fed purple potato diet(P) was lower than the other groups(p<0.05). However, The glutathione peroxidase(GPx) activities was not statistically different between the groups. Renal glutathione S-transferase(GST) activity of the EC and EP groups were lower than the C and P groups(p<0.05). In conclusion, these results suggest that purple sweet potato is believed to be possible protective effect on hepatotoxicity rats induced by carbon tetrachlolide.
BLDC 서보 모터용 One-chip DSP 컨트롤러 개발
조정목,김용재,조중선 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-
The Resolver usually used in industry is the absolute angle analog sensor that must be in order driving BLDC (brushless DC) motor, and it needs RDC(Resolver-to-Digital converter) for changing the output signal to digital to be applied to the SVPWM(Space Vector Pulse Width Modulation) algorithm. Commonly used S/W RDC needs trigonometric function. What it takes a lot of calculation time of processor is gotten at weak point. In this paper, S/W RDC is realized except trigonometric functions as a result of feedback resolver outputs after filtering using FIR filter. thus, processing time is reduced. So. One-chip DSP Controller operating the Vector Control, RDC, and SVPWM can be designed.