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김찬규,신영록,김현정,배상병,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1
Purpose: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin's lymphoma (NHL), which is increasing in incidence, but there is no established optimal treatment modality. Thus, this study was investigated the clinicohistologic feature, the therapeutic modalities, and the prognosis for GI-NHL, as well as the factors affecting it. Methods: We retrospectively analyzed 45 patients who had been diagnosed as having GI-NHL and had been followed up from July 1994 to February 2005 at Soonchunhyang University Hospital. The patients were divided into groups according to the site of origin and to various other features, and the survivals of the various groups were compared. The modified Ann Arbor system and WHO classification were adopted for staging and histopathologic classification, respectively. Results: GI-NHL of the stomach, small bowel, ileocecal region, and colon occurred in 28 patients (62.2%), 5 patients (11.1%), 3 patients (6.7%), and 8 patients (17.8%), respectively, In one patient, the entire gastrointestinal tract was diffusely involved. The median age of patients was b5 years (25~78 years), and male-to-female ratio was 1:1.1. Fourteen patients were in stage Ⅰ, 24 in stage Ⅱ, 4 in stage Ⅲ, and 3 in stage Ⅳ. Surgical resection was performed in 19 patients, and combination chemotherapy was performed in 43 patients. Surgical resection only was performed in 4 patients, Chemotherapy only was performed in 26 patients. The expected overall 5 year survival of 45 patients was 39.6%, and there was a significant survival difference between the stages, but between sites of origin (p=0.842). The most important factors influencing the survival was the stage and other factors were not significant. Conclusion: The stomach was the most common site of GI-NHL. Most GI-NHL were localized Stage was the most important prognostic factor. However, Prospective randomized studies are needed to approve the therapeutic modality.
기니이픽 장관의 c-Kit 및 NK 1R 면역반응 세포구조에 대한 공초점 주사현미경적 연구
장인엽,김종중,문정석,김현곤,박찬국,전제열,전규배,조철희,유호진 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1
Background and Objectives: Immunolabelling of interstitial Cajal(IC) cells in the intestinal wall has recently been developed by using a specific marker, the anti-c-Kit antibody. Substance-P is a well-known neurotransmitter in the gastro-intestinal tract. Since the gastro-intestinal wall structures have already been well documented in the guinea pig, immunohistochemistry was done for the c-Kit-positive IC network and substance-P receptor(NK1R) in an attempt to provide a morphological basis for the mechanism regulating gastro-intestinal movement. Materials and Methods: Cryosection and whole-mount preparations of guinea pig small intestine and colon were single and double immunolabelled using the anti-c-Kit and NK1R antibodies. Immunolabelled specimens were observed under a confocal laser scanning microscope. Results : According to a three dimensional reconstruction study, it was found that (1) the c-Kit-positive celluar networks were widely distributed in the intestinal wall, (2) c-Kit-positive celluar networks encircled the ganlion, with strands in reticular configurations, and (3) the c-Kit-positive cells showed colocalization with NK1R in circular muscle(CM), not myenteric plexus(MY). Conclusion: The charateristic profiles of IC containing c-Kit-positive celluar networks and the relationship between c-Kit-positive and NK1R-positive structures provide a morphological basis upon the mechanism regulating gastro-intestinal motility.
Park, Seong-Kyu,Won, Jong-Ho,Kim, Hyun-Jung,Bae, Sang-Byung,Kim, Chan-Kyu,Lee, Kyu-Taeg,Lee, Nam-Su,Lee, You Kyoung,Jeong, Dae-Chul,Chung, Nak-Gyun,Kim, Hyun-Soo,Hong, Dae-Sik,Park, Hee-Sook The Korean Academy of Medical Sciences 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22 No.3
<P>Mesenchymal stem cells (MSCs) have recently been identified and characterized in humans. Moreover, MSC secrete cytokines that can support hematopoietic progenitor growth. In the present study, we evaluated whether the efficacy of hematopoietic stem cell transplantation is improved by their co-transplantation with MSC, and whether this is positively correlated with the dose of infused MSCs. Accordingly, irradiated NOD/SCID mice were transplanted with 1×10<SUP>5</SUP> human CD34+ cells in the presence or absence of culture expanded MSCs (1×10<SUP>6</SUP> or 5×10<SUP>6</SUP>). We evaluated human hematopoietic cell engraftment by flow cytometry and assessed MSC tissue distributions by fluorescence in situ hybridization. We found that CD45+ and CD34+ cell levels were significantly elevated in a dose-dependent manner in cotransplanted mice 4 weeks after transplantation. The engraftments of CD33+ and CD19+ cells also increased dose-dependently. However, the engraftment of CD3+ cells did not increase after co-transplantation with MSCs. Human Y chromosome+ cells were observed in multiple tissues and were more frequently observed in mice co-transplanted with 5×10<SUP>6</SUP> rather than 1×10<SUP>6</SUP> MSCs. These results suggest that MSCs are capable of enhancing hematopoietic cell engraftment and distribution in multiple organs in a dose-dependent fashion.</P>
Systematic analysis of cDNA microarray-based CGH.
Park, Chan Hee,Jeong, Ha Jin,Choi, Yeon Ho,Kim, Sang Cheol,Jeong, Hei Chul,Park, Kyu Hyun,Lee, Gui Yeon,Kim, Tae Soo,Yang, Sang Wha,Ahn, Sung Whan,Kim, Yang Seok,Rha, Sun Young,Chung, Hyun Cheol UNKNOWN 2006 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.17 No.2
<P>cDNA microarray-based CGH (Microarray-CGH) is a useful technique for detecting genomic aberrations with a high resolution. However, the criteria for determining a genomic alteration have not been determined. We evaluated the genome-wide measurement of copy number of each gene in normal gastric and placenta tissues with both sex-matched, direct and sex-mismatched, indirect designs using 17K cDNA microarray. The results revealed the range of genomic copy number of normal tissues to be +/-0.3 of the log(2) ratio (gain >0.3, loss <-0.3) in the autosomal genes with direct and indirect designs. The copy number at a gene level from the X chromosomal genes using the direct and indirect sex-mismatched designs was +/-0.68 of the log(2) ratio (amplification >0.68, deletion <-0.68). In summary, the suggested method can be used as a guideline for analysis of genomic aberration using a Microarray-CGH in both direct and indirect designs.</P>
Traumatic Neuroma of Remnant Cystic Duct Mimicking Duodenal Subepithelial Tumor: Case Report
Dong-Hwan Kim,Ji-Ho Park,Jin-Kyu Cho,Jung-Wook Yang,Tae-han Kim,Sang-ho Jeong,Young-Hye Kim,Young-Joon Lee,Soon-Chan Hong,Eun-Jung Jung,Young-Tae Ju,Chi-Young Jeong,Ju-Yeon Kim 대한외과학회 2020 대한외과학회 학술대회 초록집 Vol.2020 No.11
동종 조혈모세포이식 후 발생한 이차성 담즙성 간경변과 다발성 근염
양재훈,김성한,김현정,김희경,김찬규,정진태,이남수,노학재,이규택,박성규,원종호,진소영,홍대식,박희숙 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1
조혈모세포이식을 받은 환자에서 만성 이식편대 숙주질환의 증상으로 발생할 수 있는 다발성근염과 담즙성 간경변은 각각 드물게 보고되나 다발성근염과 담즙성간경변이 동시에 발생한 경우는 극히 드물다. 이에 저자들은 동종조혈모세포이식 14개월 후 상하지 근무력감과 전신쇠약감을 주소로 내원한 환자에서 근전도, 근조직검사, 항미토콘드리아 항체, 간 조직검사를 통하여 다발성 근염과 이차성 담즙성 간경변이 동시에 발생한 경우를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Polymyositis and biliary cirrhosis have been described as a rare complications in patients who develop chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The concomittant occurrence of polymyositis and biliary cirrhosis developing after allogeneic HSCT might be extremely rare. Fourteen months after HSCT, a 25-year-old man developed polymyositis with biliary cirrhosis as manifestations of chronic GVHD. Polymyositis was diagnosed by the serum muscle enzymes, electromyographic, and histopathologic findings, and biliary cirrhosis was confirmed by the antimitochondrial antibody and histopathologic findings. His clinical condition was improved with cyclosporin and low dose prednisolone therapy. We report herein a case of polymyositis and secondary biliary cirrhosis that occurred concomittantly after allogeneic HSCT.
김세형 ( Se Hyung Kim ),박성규 ( Seong Kyu Park ),김현정 ( Hyun Jung Kim ),김찬규 ( Chan Kyu Kim ),이남수 ( Nam Su Lee ),원종호 ( Jong Ho Won ),박희숙 ( Hee Sook Park ),김용익 ( Yong Ik Kim ),이정석 ( Jeong Seok Lee ),윤미화 ( Mi 대한내과학회 2007 대한내과학회지 Vol.72 No.3
Background: There has been growing evidence of the importance of the N-methyl-D- aspartate (NMDA) receptor in intractable pain. There is good evidence from experimental animal models and clinical trials that ketamine as a NMDA receptor antagonist relieves neuropathic pain. We evaluated whether ketamine in low doses as an adjuvant to opioid treatment improves analgesia with tolerable adverse effects. Methods: 58 patients with intractable cancer pain received ketamine for 3 days. Each pain type was classified as a somatic, visceral, or neuropathic pain. We assessed pain at 6 hourly intervals with vital signs using a numeric rating scale. Data on opioid doses, ketamine dose, and adverse effects were recorded daily on an assessment chart. To be designated as a responder, a patient had to show a 50% or greater reduction in the mean pain scale. Results: The overall response rate was 34.5%. The results according to the type of pain mechanism showed that 47% (15/32) patients with neuropathic and 25% (5/20) patients with somatic pain responded. In 24 cases (41.4%), the requirement for an opioid dose was reduced after infusion of ketamine. The most common adverse effects were nausea and vomiting. Eleven patients complained of drowsiness or transient hallucination. However, most adverse effects were mild to moderate and were easily relieved by treatment. Conclusions: This study demonstrates that the infusion of ketamine in low doses may have an effect on intractable cancer pain and in reducing opioid requirements, especially neuropathic pain with acceptable toxicities. Therefore, ketamine may be useful as an adjuvant to opioid treatment in cancer patients who are receiving palliative care. (Korean J Med 72:298-305, 2007)
Jeong, Yong Jin,An, Tae Kyu,Yun, Dong-Jin,Kim, Lae Ho,Park, Seonuk,Kim, Yebyeol,Nam, Sooji,Lee, Keun Hyung,Kim, Se Hyun,Jang, Jaeyoung,Park, Chan Eon American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.8
<P>Complementary inverters consisting of p-type organic and n-type metal oxide semiconductors have received considerable attention as key elements for realizing low-cost and large-area future electronics. Solution-processed ZnO thin-film transistors (TFTs) have great potential for use in hybrid complementary inverters as n-type load transistors because of the low cost of their fabrication process and natural abundance of active materials. The integration of a single ZnO TFT into an inverter requires the development of a simple patterning method as an alternative to conventional time-consuming and complicated photolithography techniques. In this study, we used a photocurable polymer precursor, zinc acrylate (or zinc diacrylate, ZDA), to conveniently fabricate photopatternable ZnO thin films for use as the active layers of n-type ZnO TFTs. UV-irradiated ZDA thin films became insoluble in developing solvent as the acrylate moiety photo-cross-linked; therefore, we were able to successfully photopattern solution-processed ZDA thin films using UV light. We studied the effects of addition of a tiny amount of indium dopant on the transistor characteristics of the photopatterned ZnO thin films and demonstrated low voltage operation of the ZnO TFTs within +/- 3 V by utilizing Al2O3/TiO2 laminate thin films or ion-gels as gate dielectrics. By combining the ZnO TFTs with p-type pentacene TFTs, we successfully fabricated organic/inorganic hybrid complementary inverters using solution -processed and photopatterned ZnO TFTs.</P>