Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells

( Jae-sung Ryu ),( Kyu-tae Chang ),( Ju-taek Lee ),( Malg-um Lim ),( Hyun-ki Min ),( Yoon-ju Na ),( Su-bin Lee ),( Gislain Moussavou ),( Sun-uk Kim ),( Ji-su Kim ),( Kinarm Ko ),( Kisung Ko ),( Kyung- 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.6

The ACKNOWLEDGEMENTS should be corrected as follows, "This research was supported by a grant (Code# PJ0074922012) from the Korean Rural Development Administration, and has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2010-0022316 and KCG5401011), and the KRIBB/KRCF Research Initiative Program (NAP), Korea. The published article in this journal was a part of the 2013 Doctoral thesis of Jae-Sung Ryu submitted to Wonkwang University, Korea." and not "This research was supported by a grant (Code# PJ0074922012) from the Korean Rural Development Administration, and has been supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education Science and Technology (2010-0022316 and KCG5401011), and the KRIBB/KRCF Research Initiative Program (NAP), Korea."

남북경협의 활성화의 전제로써 개성공단 전면중단으로 인한 손해의 전보 가능성에 대한 연구

박신욱 ( Shin-uk Park ),조재욱 ( Jae-wook Cho ) 한국법정책학회 2020 법과 정책연구 Vol.20 No.4

본 논문에서는 남북경협을 재개하기 위한 토대로서 북한에 대한 인식을 비롯한 현재의 상황을 적시하였으며, 남북경협의 필요성과 의의에 대해 확인하였다. 이와 더불어 과거 남북경협이 갖는 한계도 함께 지적하였다. 제도가 갖는 한계로서 소위 3통 문제뿐만 아니라 외부적 여건에 취약한 구조가 그것이다. 그러나 이러한 문제들뿐만 아니라 내부적 문제도 존재하고 있음을 확인하였다. 대표적으로 통치행위로 인한 남북경협이 중단될 수도 있다는 사실이다. 특히 개성공단의 전면적 중단의 상황에서 그 누구도 일정한 안정성과 예측가능성을 가지지 못하였다는 점은 우리 법률이 갖는 한계를 명확하게 보여준다. 이와 관련하여 논문에서는 위법한 통치행위의 경우, 단순히 “통치행위는 불법행위가 되지 않는다”라는 결론을 이끌 수는 없다는 점을 통치행위를 입법행위와 동치시키는 논리구조를 통하여 위헌인 법률로 인하여 국민의 기본권인 재산권 침해하였다면, 그에 따른 책임도 부담하여야 한다는 결론을 도출하기 위하여 노력하였다. 추가적으로 지난 5·24조치와 관련된 우리 대법원 2013다205389 판결에서 확인할 수 있는 바와는 달리 개성공단 전면 중단의 경우에는 개성공단에 진출해있는 모든 기업들의 가동중단과 철수를 포함하고 있다는 점을 지적하였다. 그렇기에 개성공단의 중단과 관련한 국가배상책임이 긍정될 수 있는 가능성이 있다고 판단하였다. 긴급명령과 같은 수단은 최후적인 방법이 되어야 한다. 그렇기 때문에 3통의 문제를 해결하기 위한 입법적 방법과 함께 발생되어서는 안 되겠지만, 발생할 수도 있는 향후의 경협중단과 관련된 일련의 절차를 법률화하는 것 역시 향후 남북경협의 활성화의 전제가 될 것이다. All Koreans will have a consensus on peace on the Korean Peninsula. However, there is still a negative view on the inter-Korean economic cooperation. This view leads to the denial of the justification itself in promoting inter-Korean economic cooperation. However, the Moon Jae-in administration has declared that it will maintain its independent inter-Korean cooperation policy within the framework of international sanctions against North Korea. From the perspective of the theory of peace economy, it is clear that the promotion of economic cooperation provides an important engine for peace. This is because if the inter-Korean economic cooperation expands, the negative variables from “North Korea risk” will decrease and be suppressed to a minimum. In addition, through inter-Korean economic cooperation, North Koreans will learn directly or indirectly about capitalist economic logic, and can play a major role in correcting their distorted perceptions of South Korean society. However, it is time to discuss the effectiveness of these laws with the Kaesong Industrial Complex shutdown in 2016. In particular, the impact of the Kaesong Industrial Complex shutdown in 2016 was attributable to the decision of the Korean government. Based on this necessity, the thesis confirmed the necessity, significance, and limitations of the inter-Korean economic cooperation, and dealt with who should bear the responsibility for damages caused by the total suspension of the Kaesong Industrial Complex as a guarantee for the stability of the inter-Korean economic cooperation.

근로자의 화학물질 노출관련 기록 보존에 관한 연구

오상민 ( Sang Min Oh ),박동욱 ( Dong Uk Park ),유성재 ( Seoung Jae Yu ),정진우 ( Jin Woo Jung ),임경택 ( Kyung Taek Lim ),이재환 ( Jae Hwan Lee ),하권철 ( Kwon Chul Ha ) 한국산업위생학회 2013 한국산업보건학회지 Vol.23 No.4

Objectives: Employee exposure record refers to a record containing information about environmental(workplace) monitoring or measuring of a toxic substance or harmful physical agent. The aims of this study were to examine problems related to exposure records and provide some amendments to the Korean Industrial Safety & Health Act for the effective management of chemical substances under the law. Methods: This study performed a literature search and review on legal provisions related to exposure records of a number of different countries, including Korea, the USA, Japan, EU, Germany, and the UK. They were compared and investigated and the amendment of articles was suggested. Results: The results of this study were provided as suggested amendments to the related act. There were a variety of ways of improvement, including a 30-year retention period and the introduction of new access methods, contents, transfer, and maintenance methods. All exposure data elements have to be standardized, including reference to a similar exposure group(SEG), sampling strategy, and circumstances of exposure(e.g., date, shift length, use of personal protective equipment, etc.). The SEGs are described by process, job, task, and environmental agent. Conclusions: This study is expected to provide for the amendment of the related act in order to ensure effective management of exposure records and is helpful for solving the cause and result of occupational disease by keeping exposure records according to the Industrial Safety & Health Act.

상의성 낭종 4례

문재곤,김기욱,김한규 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.9

조기 대장암

이재범,박영진,박군주,김선회,박재갑,이건욱,박용현,최국진,김진복 대한대장항문학회 1998 Annals of Coloproctolgy Vol.14 No.3

아시아계 미국문학에 나타난 동물성과 유목적 주체에 대한 연구 : 킹스톤 소설을 들뢰즈적 관점에서 읽기 Deleuzian Reading of Kingston's Novels

추재욱 한국현대영미소설학회 2003 현대영미소설 Vol.10 No.1

Asian minorities had a little role in the huge multiplicity of American society. They were simply descendents of immigrants from minor nations who were considered as a labour force. However, the rise of literary works by minority descendants from Japan, China, and Korea started with the promotion of the minorities' status in America, which in return has prompted the minority writers to produce more literary works. Among other singularities in the works, the distinguishing feature appears as a metamorphosis from man to animal or to something like what is associated with a figure of the half man and half animal as in myths or paintings. Why do such human figures appear in the literary texts? This question leads us to think over the role of minorities and their works. Their positive role does rarely surface but their virtual capability functions to make the huge American multiplicity undergo a dynamic change. That is, the molecular movement made by the minorities is cracking-up the molar norms of the white-oriented American society so that the society cannot but receive the change of norms in the white dominant cultures. Eventually the movement has the momentum to build a new America. Monkey-becoming and stork-becoming show good examples of main characters in transformation who contribute to the building of new society.

보건관리대행 기관의 사업장내 진료에 대한 근로자 요구 및 실시 의향

원종욱,송재석,정선아,박화미,노재훈 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.1

목적 : 본 연구에서는 보건관리대행 사업에 있어 사업장내 진료에 대한 수요와 보건관리대행기관의 방문진료 제공에 대한 의향을 조사하여 사업장내 진료에 대한 욕구를 파악하고, 이를 토대로 사업장내 진료에 대한 기초적인 자료를 제공하는데 목적이 있다. 방법 : 근로자들의 의료이용 행태와 방문진료에 대한 요구도를 파악하기 위해 167개 보건관리대행 사업장의 사업주와 보건담당자, 그리고 1,350명의 근로자에게 설문 조사를 실시하였고, 사업주 121명(72.5%), 보건담당자 145명(86.8%), 근로자 816명(60.5%)이 응답하였다. 일차진료의 제공 가능성을 파악하기 위해서 전국의 66개 보건관리대행기관의 의사와 간호사 및 행정책임자에게 우편 설문조사를 실시하여 의사 31명 (47.0%), 간호사 38명(57.6%) 및 행정책임자 34명(51.5%)이 응답하였다. 결과 : 보건관리대행 사업을 수행하고 있는 의사의 87%와 간호사의 94%가 보건관리대행 업무를 담당하면서 많은 근로자들로부터 투약 등 진료를 요구받고 있었고, 100 %의 간호사와 행정책임자 94%, 의사의 76 %가 보건관리대행 사업에서 진료를 수행하는 것이 필요하다고 생각하고 있었다. 한편사업주의 85 %, 보건관리 담당자 86 %와 근로자81 %가 보건관리대행기관에서 사업장내 진료를 시행 할 때 이를 수용하겠다고 응답하였다.결론 대다수의 근로자와 사업주가 보건관리대행기관의 진료를 요구하고 있었고, 보건관리대행 기관의 의사와 간호사가 사업장에서의 진료를 수용할 의향이 있고, 직업성 뇌심혈 관계질환의 예방 등 필요성이 인정된다면 보건관리대행 의사의 사업장내 진료를 인정해야 한다고 생각된다. Objectives : This study was performed to survey worker's demands for worksite medical care and agency's intention for offering worksite medical care in Group Health Service Agency. Methods : One study subjects were employers, workers and office personnels in 167 factories. They were asked for medical care utilization behavior and worksite medical care demand. 121 employers(72.5%), 145 office personnels(86.8%) and 816 workers(60.5%) answered the questionnaire. The other subjects were doctors, nurses and administrators in 66 Group Health Service Agencies nationwide. They were asked for intention of offering worksite medical care in Group Health Service Agency through the mail survey. 31 doctors (47.0%), 38 nurses (57.6%) and 34 administrators answered the questionnaire. Results : 87 percentage of doctors and 94 percentage of nurses had experiences of being requested to prescribe and laboratory examination. All nurses, 94 percentage of administrators and 76 percentage of doctors thought that it was necessary to give medical treatment at worksite. Also in worksite 85 percentage of employers, 86 percentage of office personnels and 81 percentage of workers answered that they accepted the worksite medical care when it would be given. Conclusions : Worksite medical care should be permitted because almost of all workers and employers requested worksite medical care, and doctors and nurses in Group Health Service Agency were willing to give worksite medical care and there was necessity to prevent occupational cerebrovascular disease.

소음성 난청 선별검사용 문진표의 유용성

송재석,최병수,원종욱,노재훈 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4

목적 : 소음 특수건강진단시 문진표의 유용성을 알기 위하여 실시되었다. 방법 : 자료로는 전국을 5대 권역으로 나눈 후 연구에 협조적인 산업보건기관을 대상으로 하여, 소음성 난청이 발생한 사업장과 그 부서에 대하여 정상인 근로자의 검진기록과 작업환경측정 기록 및 문진표를 수집하여 분석하였다. 결 과 : 각각의 문진 항목과 청력이상 여부에 대한 분석결과, 귀에서 소리가 난다고 하는 항목과 최근 작은 소리가 잘 안들린다고 하는 만성 특이적 항목만 청력이상 여부와 관계가 있었고, 급성 항목들은 청력 이상 여부와 통계적 연관성이 없었다. 또한 7개의 설문 항목과 연령 및 근무경력만을 이용하여 청력이상을 판정한다고 하였을 때, 실제 건강진단 결과와 비교하게 되면 민감도, 59 %, 특이도, 88 %로 계산 되었으며, 평균 23 %정도가 잘못 분류되었다. 결 론 : 만성적이고 특이적인 항목을 위주로 한 단순하고도 판별력있는 항목의 개발이 필요하며, 이러한 항목들을 전산화하였을 때, 효과적인 소음성 난청의 선별검사 체계를 구축할 수 있을 것이다. Objectives : This study was performed to investigate the effectiveness of the questionnaire. Methods : Workers'health examination records, work environment record, and questionnaires of selected industries as samples were analysed using logistic regression analysis and discrimination analysis Results'Cases of bearing impairment (Dl+C) as dependent variables, and age, work duration and level of environmental noise as independent variables were selected for multiple unconditional logistic regression analysis. Odds ratio was 4.04 in hearing difficulty, 2.78 in tlnnitus and 1.08 in age. In the second analysis Noise induced hearing loss is selected as dependent variable. The OR in hearing difficulty was 3.67(95 % C.1. : 1.61 8.61), and was 1.09(95 % C.1. : 1.05-1.14) in age. Conditionnal multlple logistic regression analysis was performed. In hearing impairment as dependent variable, the OR of age was 1.02(95 % C.1. : 1.00-1.04) and other variables were not significant. However, NIHL as dependent, the OR of hearing difficulty was 4.57(95 % C.1. : 1.43-14.67). According to multiple logistic regression adopting each items of questionnaire as dependent variable, the only item of hearing difficulty showed significant difference with hearing ability. The discrimination analysis was performed with the class variable of hearing impairment, and discrimination variables of age, work duration, and environment noise level. The sensitivity of 59 %, and specificity of 88 %, and average error count of 23 % were obtained. When the numbers of items answered in questionnaire were assumed as the parameter of judgement for noise induced hearing loss (NIHL), the highest sensitivity and specificity were 33.5% and 49.0% in cases of more than two items answered. Conclusions : The development of items that is simple and discriminative mainly consisted of chronic and specific diseases related items is needed. Computerization for newly developed items might be needed to establish effective surveillance system for NIHL in the future.

퍼지 제어기를 이용한 브러시리스 직류전동기의 속도 제어에 관한 연구

김선욱,김재문,김연충,이상석,원충연 成均館大學校 科學技術硏究所 1997 論文集 Vol.48 No.2

This paper deals with the speed control of a BLDCM with rectangular back electromotive force using fuzzy logic controller. The fuzzy PI controllers make the many degrees of freedom in proportion to the number of the rule for input and its ability of adjustment for control input is excellent. Thus, the proper adjustment of the fuzzy rules can provide the good performance for the system. Above all, the advantage of the fuzzy controller has the characteristic of robustness for parameter variation, load change, noises. As a current controller, a hysterisis current controller is implemented, and in order to reduce torque ripple in low speed range, current controller detects the uncommutating mode current for every 60 electrical degree. The fuzzy speed controller is implemented by MCS80C196KC, a 16 bit one-chip microprocessor. The experimental results show that the performance of the fuzzy speed controller is superior to that of the conventional PI controller in terms of robustness for the change of load torque.

만성정신분열증의 정량화 뇌파검사 소견

지재현,설현욱,조경형 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.1

본 연구는 만성 정신분열증 환자 30명과 정상대조군 21명의 뇌파 중 델타파와 쎄타파를 분석해 봄으로써 만성 정신분열증 환자의 국소뇌파 소견과 유병기간, 약물투여량 및 투여기간, 양성증상과 음성증상에 따른 뇌파소견을 보고자하였다. 연구결과는 다음과 같다. 첫째, 만성 정신분열증 환자와 정상대조군간에 델타파와 쎄타파의 국소뇌파량을 t 검증한 결과 델타파에는 유의한 차이가 없으나, 쎄타파는 전 부위에서 유의한 차이를 보였다. 둘째, 만성정신분열증 환자의 델타파 및 쎄타파는 유병기간에 따른 유의한 차이가 없고, 투약기간이 길어질수록 F7, T3, C3, C4의 델타가 감소하는 경향을 보이고, 항정신병약물 투여량이 많을수록 P3, P4, C4, T5, T6, O1, O2의 쎄타가 증가하는 경향을 보였다. 셋째, 양성증상의 유무에 따라 Fp2의 델타에 유의한 차이를 보이고, 음성증상의 유무에 따라서는 Fp2, T3, C3, P3, O1의 델타에 유의한 차이를 보였다. 넷째, 판별분석을 시행한 결과 qEEG의 델타파와 쎄타파의 국소 뇌파량만으로 만성정신분열증 환자 30명중 29명을 (96.7%) 만성 정신분열증으로 판별할 수 있었다. 이상에서 만성정신분열병 환자의 서파가 정상대조군과는 유의한 차이를 보이며 유병기간에 따른 차이는 없으나 투약기간과 투여량에 따른 차이를 보이고 음성 증상을 가진 환자에서 좌측 대뇌반구의 기능저하를 추측케한다. Electroencephalographic recordings in 30 medicated patients fulfilling the DSM-Ⅲ-R criteria for chronic schizophrenia and 21 normal healthy controls was studied, using computerized electroencephalography. The delta activity and theta activity were compared between the patients and the normal healthy controls, then the differences in delta activity and theta activity of the patients were analyzed according to duration of illness, duration of medication, dosage of medication, and the presence of positive and negative symptoms. In the comparison study of chronic schizophrenic patients and the normal healthy controls, the theta activity showed a significant difference in all regions, and a significant difference in abnormal electroencephalographic activity appearance rate. In the analysis of the delta and theta activities of the chronic schizophrenic patients, duration of illness had no significant influence, the delta activity in F7, T4, C3, and C4 regions showed a tendency to decrease as duration of medication increased, the theta activity in P3, P4, C4, T5, T6, O1, O2 regions showed a tendency to increased with the increment of dosage of neuroleptics. The delta activity in Fp2, T3, C3, P3, O1 regions showed a significant difference between those patients with and without negative symptoms. In summary, the theta activity of the chronic schizophrenic patients showed a significant difference in comparison with that of the normal controls. In chronic schizophrenic patients, no difference in electroencephalograph was apparent regarding the duration of illness, but significant differences were shown when analyzed regarding the duration and dosage of medication. According to the results of this study, dysfunction of left cerebral hemisphere could be presumed to be present in patients with negative symptoms.