의약분업 실시 전ㆍ후 영도지역 주민의 약국 및 의료기관 의료이용 양상 변화 분석

南銀祐,朴宰成,M. Nishigaki,T. Hamai 고신대학교 영도발전연구소 2000 영도연구 Vol.2 No.-

The purpose of this study is to assess the effects of the separation of prescribing and dispensing in Korea and to find how civilians' usage behaviors on medical institutes such as hospital, clinics, drugstore, and community health center are changed due to the policy. To examine the differences of usage behaviors, this study used a before-after design. Using self-administered questionnaires, this study performed survey from June 26 to August 1, 2000. Chi-square test and generalized logit model was utilized in each observation period. Based on the results of each observation period, this study evaluated the effects of the policy. On the basic finings, most civilians did not agree to the separation policy regardless of both observation periods. However, after the separation, civilians' behaviors seemed to be modified as the policy maker had intended. Most of civilians purchased their drugs from pharmacists after receiving physicians' prescriptions. Specifically, males and elder persons had the exactly same behaviors as the intended utilization behaviors. All study subjects agreed to the basic purpose of the policy for the purpose of the reduction of drug abuse and misuses. The implications of this study are two fold: First, how civilians' short-term inconvenience caused by the policy should be alleviated without interrupting well-established usage patterns. Second, a special attention to the elderly is needed.

부산지역 종합병원환자의 흡연실태 및 원내 흡연정책에 관한 인식도 조사

남은우,류황건,박재성,민체류 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.3

The purposes of this study were to identify patients' perceptions toward regulations of smoking in general hospitals and hazards caused by smoking. Moreover this study also identified smoking behaviors and punishment experience due to in-hospital smoking and education experiences of smoking in general hospitals. Around 88.0% of all respondents regardless of either smokers or non-smokers knew that hospitals are non-smoking area. However, 71.6% of smokers smoked during their hospital visits. For their smoking, only 51.0% of smokers utilized smoking rooms or areas for their smoking. Only 55.1% of smokers experienced punishments or notifications of warning due to their smoking. Around 93.0% of inpatients and outpatients acknowledged hazards toward their health caused by smoking. However, smokers did not realize the dangerous effects of passive smoking to other person. Only 38.1% of smokers said that passive smoking causes hazard of others' health. 63.8% of smokers hoped for secession of smoking but only 42.8% of them sustained their non-smoking periods over 5 moths. Based on these results, this study insists that a more enforced smoking policy in general hospitals be desperately needed for protecting patients' health and controlling smoking at unapproved areas. Moreover hospitals should take proactive actions to prevent smoking in hospitals. A health education program in hospitals should promote patients' self-efficacy to stop smoking and patients' understanding of the hazardous effects of passive smoking in hospitals.

영도구의 생식보건사업 성과분석 : 남자중학생을 대상으로 한 성교육 효과 분석을 중심으로 the Effects of Sex Education on Middle School Students

남은우,강혜숙,박성빈,최재임,민체류 고신대학교 영도발전연구소 2001 영도연구 Vol.3 No.-

The purpose of this study was to reduce the sexual problems of middle school students in Youngco-Gu, Busan. The survey was conducted by content analysis which was related with reproductive healty services such as budget, manpower, etc. This study was also conducted with sex education as the object and to measure the effects of sex education. Questionnaires from 203 students(7th-9th graders) in a male middle school were surveyed on Sept. 12-14, 2001. The statistical analysis used were t-test, paired t-test, one-way ANOVA and χ^2 test by using SPSS/PC+ WIN 8.0 program. The results of this study are summarized as follows: First, 66.2% of the students among the subjects had a religion, and of those 50% were buddhists, 34.4% christians, 9.5% catholic. Religion of sexual related matters showed no significant effect. Of these students 68.1% showed medium interest in sexual related matters, 18% little interest or none and 13.5% high interest. 8th graders seemed to show more interest in sexual related matters than other grades. 41.8% of Students seemed to get information on sexual matters from friends and 27.1% from the internet. 30.9% of the respondents talked about their boy/girl friends with their parents compared to 43.3% who chose to talk to their friends about their sexual related problems. Second, 56.7% logged into lascivious-sites on the internet. Of those who logged onto lascivious-sites 46.1% logged in once or twice a month, 31.9% once or twice a week, and 2.7% logged in daily, 69.2% Felt curiosity, 23.4% felt indecent and 7.5% felt like engaging in a sexual act after visiting one of these sites. Third, the effects of sex education on experimental groups of 7th graders showed a 2.1 point increase(p<0.1), 4 point increase for 8th graders(p<.001), and 9th graders increased by 3.3 points(p<.001). Therefore this showed that it was advantageous for students to have sex education. Fourth, the effects of sex education on the students attitude showed only a little more improvement than before in the controlled groups whereas the experimental groups showed a large increase in good attitude in a good direction. Therefore, the experimental groups showed better results in sexual attitude compared to the controlled groups(p<.01).

한방약물로부터 항고지혈증 치료약물개발(3) : In vitro에서 가미과루해백황금탕 및 구성약물의 항고지혈증 활성 Antihyperlipidemic Effects of Gamigwaruhaebaekwhanggum-Tang and Its Constituent Herbal Medicines in vitro

정은아,김남재,김윤경,김동현,이상인 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-

80% extract of Gamigwaruhaebaekbaekju-Tang (GGHBT), Gagamgwaruhaebaekbaekju-Tang (GGGHBT) and Gamigwaruhaebaekwhanggum-Tang (GGHWT) remarkably showed inhibitory effects on HMG-CoA reductase, lipid peroxidation of rat liver and LDL oxidation, and DPPH free radical scavenging effect in a dose-dependent manner. Especially, GGHWT which is formulated with Trichosanthis Fructus, Pinelliae Tuber, Aurantii Immaturus Fructus, Magnolia Cortex, Allii Macrostemi Bulbus, Cinnamomi Ramulus and Scutellariae Radix on the basis of Gwaruhaebaekbaekju-Tang listed on the traditional medicinal references showed more effective hypocholesterolemic activities in vitro bioassay than the other prescriptions.

종합병원 직원의 정보화교육을 위한 정보기술 이용행동의 전제요인의 변이에 관한 연구

박재성,남은우 한국보건정보교육학회 2000 보건정보교육학회지 Vol.2 No.1

Using the core constructs of the theory of reasoned action(TRA) and the technology acceptance model(TAM), this study tried to identify, based on demographic variables and IT adoption status, differences of hospital workers' behavioral pre-dispositions in using IT. Information derived from this study can contribute to desinging an effective IT training program that can fully take into account and persons with low education had Significantly lower scores of behavioral pre-dispositions than other sub-groups. Thus this study insists that focused training efforts for those groups result in a more effective solution to promote use of IT than an unfocused general IT training session. Moreover, the development of special IT training programs for the identified groups be an essential part for promoting their adoptions and use of IT.

분무건조법을 이용한 방출 제어형 케토로락 고형지질마이크로스피어의 제제설계

윤재남,이은미,김동우,박용근,전일순,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

Ketorolac (KA) and ketorolac tromethamine (KT) is the nonsteroidal anti-inflammatory drugs (NSAIDs) and has been used widely. To improve its frequent administration by control of drug release. we prepared SLM of KA and KT using Mirj 45 and 52 as surfactants and tripalmitin and tristearin as lipids by spry drying method SLM, as a disperse system for injection, were evaluated by measurement of particle sizes. SEM and drug release pattern As a result. spherical SLM were prepared and their particle size were in the range of 25-125 μm, which were dependant on the types and contents of lipid and sururfactants. Their dissolution rate were decreased as increasing lipid contents.

地黃의 품질평가

김남재,정은아,김희정,심상범,김종우 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

The dried roots of Rehmannia glutinosa(RG) have been used in the traditional medicine for treatment of diabetes, fever and dysuria, etc. In order to investigate the quality evaluation of the dried roots of RG, we conducted the physico-chemical and biological evaluation method. The amount of catalpol from commercial samples is very diverse about 0.00~3.89% by using HPLC method, because it is easily decomposed by processing of RG. So, we should try to identify the correlation with the contents of catalpol and biological activities of RG. We chose 3 samples which were a wide difference of catalpol contents between each sample(Sample-I; 3.4%, Sample-II; 2.8%, Sample-III; 0.05%). Sample-I and Sample-II were found to be more effective than Sample-III on the DPPH free radical scavenging effect and inhibitory effect on H₂O₂-catalyzed lipid peroxidation in rat liver in vitro. And, Sample-I and Sample-II exhibited more significant effects than Sample-III on accelerating actions of the small and large intestinal transport, and diuretic action in mice. So, it is suggested that the quantitative determination of catalpol should be required for the standardization of the dried roots of RG.

교정용 선재의 직경 증가를 위한 전기도금법과 무전해도금법의 비교연구

김재남,이기헌,황현식,성영은 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.3

The purpose of this study was to evaluate electroless plating as a method to increase diameter of an orthodontic wire through comparison with eletroplating. After pretreatment for plating to the stainless steel orthodontic wire of 0.016 inch. the electoless plating was done under the condition of 90'c until the diameter of the wire was increased to 0.018 inch using Hessonic-Gr® which was sold by Shin-Pung metal. On the process of electroless plating the diameter of wire was measured every 5 minute to examine the increasing ratio of the wire's diameter per time unit. And to examine the uniformity, the diameter of each 3 points of the electroless-plated orthodontic wire was measured. An X-ray diffraction test was performed to analyze the nature of the plated metal and physical property test was made. Through the comparison with electroplating, following results were obtained. 1. In stiffness. yield strength, and ultimate strength of electroless plating wire group showed higher tendency than those of electroplated wire group, and in stiffness and ultimate strength there was statistically significant difference between two groups. 2. In the electroless plating wire group. the increasing ratio of the diameter was 0.O0461±0.00003 mm/5min (0.O0092 mm/min). In the electroplated wire group, that was 0.O0821±0.O0015 mm/min. 3. The results of uniformity test to measure the diameter of each 3 points showed a tendency of uniformity in all the two plating method. The results of this study suggest that the electroless plating wire is more close to the ready-made wire than electroplating wire in terams of the physical property. On the other hand. the length of plating time should be solved for the clinical application of electroless plating.

정신분열병과 기분장애의 Cavum Septi Pellucidi에 관한 자기공명영상 연구

신상은,강민희,김철응,이정섭,배재남 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

연구목적: 뇌자기공명촬영술을 이용하여 정신분열병 환자와 기분장애 환자, 대조군의 Cavum Septi Pellucidi를 측정하여 정신분열병과 기분장애에서 생물학적인 원인 중 하나인 신경 발달학적 가설을 알아보는데 있다. 방법: 34명의 정신분열병 환자와 18명의 기분장애 환자, 22명의 대조군에게 자기공명촬영술을 시행하여 CSP의 출현 빈도 및 CSP의 크기에 따른 출현빈도를 비교분석하여 다음과 같은 결과를 얻었다. 결과: CSP의 출현 빈도는 정신분열병 환자에서 61%, 기분 장애환자에서 61%, 대조군에서 41%로 나타났다. T1 강조 축상 영상에서 가장 크게 보이는 단면에서 가로로 가장 긴 부분의 길이가 3mm 이상으로 정의한 큰 CSP의 출현빈도는 정신분혈병환자에서 24%, 기분 장애 환자에서 11%, 대조군에서 5%였고 정신분열병, 기분장애, 대조군의 순으로 높은 빈도를 보였으나 통계적인 유의성은 없었다. 결론: 정신분열병, 기분장애, 대조군의 순으로 큰 CSP의 빈도가 높은 경향성은 확인할수 있었으나 통계적으로 유의한 차이는 아니었다. 그러나 본 연구는 여러 가지 제한점이 있었기 때문에 신경발달학적 가설을 알아보기 위해서는 향후 환자수를 확대하고 보다 정교하게 고안된 연구가 필요하다. Objectives: This study was designed to verify neuro-developmental hypothesis of schizo-phrenia and mood disorder. Methods: We performed Brain Magnetic Resonance Imaging study in 34 schizophrenic patients, 18 mood disorder patients and 22 controls and compared the incidence and the size of carum septi pellucidi(CSP). Results: The incidences of CSP in schizophrenia, mood disorder and controls were 61%,61%, and 41%, respectively. The incidences of large CSP, defined as largest diameter larger than 3mm in T1-weighted image, were 24% in schizophrenic patients, 11% in mood disorder patients, and 5% in controls. But they didn't show statistically significant differences. Conclusion:We could find the tendency that the incidence of CSP was high as following order ; schizophrenia, mood disorder, controls. But it was not statistically significant difference. To verify neuro-developmental hypothesis, we need larger pool of patients and better study design.

한방약물로부터 항고지혈증 치료약물개발(2) : 수종 한약재의 항고지혈증 효과

김남재,정은아,김동현,이상인 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

In the previous reports, we selected 80% MeOH extract of 7 herbs including Scutellariae Radix(SR), Paeoniae Radix Rubra(PRR), Moutan Cortex(MC), Angelicae Gigantis Radix(AGR), Crataegi Fructus(CF), Bambusae Caulis in Taeniam(BCT) and Cinnamomi Ramulus(CR), which exhibited the inhibitory effect on HMG-CoA reductase and DPPH free radical scavenging effect in vitro, and antihyperlipidemic effects on antihyperlipidemic rats induced by Triton WR 1339 in vivo. Among them, SR, MC, AGR and BCT showed significant suppression of elevated serum LDL-cholesterol level, and AGR and CF showed significant liver weight increase on high cholesterol diet induced hyperlipidemic mice. And, SR, PRR, AGR, BCT and CR significantly supressed the elevated serum total cholesterol and triglyceride levels on corn oil induced hyper lipidemic rats. Then, in order to research new antihyperlipidemic agents from the oriental medicinal herbs, we chose SR, AGR, CR and BCT which have the antihyperlipidemic effect in vitro and in vivo, and those herbs were systematically frationated with organic solvent. EtOAc fraction of SR, hexane fraction of BCT, AGR and chloroform fraction of CR exhibited remarkably inhibitory effect on HMG-CoA reductase activity.