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폴리메타크릴레이트를 이용한 케토로락 트로메타민 서방성 정제의 제조와 용출평가
전일순,윤재남,이은미,박용근,김동우,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-
To improve administration of ketolorac tromethamine, we prepared matrix tablets with Eudragit (RS 100 or 30D), diluents (avicel:lactose=l:l or Ca phosphate) and Mg stearate using wet-granulation method. Sustained release matrix tablets using Eudragit® RS 100 7 and 10% decreased dissolution rate at pH 1.2 and 68 Ca. phosphate as diluents showed more decreased dissolution rate than that of avicel:lactose (1:l). Sustained release matrix tablets using Eudragit® RS 30D also showed very effective sustained release of KT.
나노입자수송시스템을 이용한 파클리탁셀 정맥주사제의 제조 및 평가
전일순(Il Soon Jeon),김정수(Jeong Soo Kim),이계원(Gye Won Lee),지웅길(Ung Kil Jee) 대한약학회 2005 약학회지 Vol.49 No.4
Paclitaxel is an effective antineoplastic agent against ovarian, colon and breast tumors. But there have been many difficulties to formulate this drug due to the extremely low aqueous solubility. Paclitaxel is currently formulated in a vehicle composed of Cremophor EL and absolute ethanol mixture which is 5~20 fold diluted in normal saline or 5% dextrose solution before I.V. injection. However, this formulation has many problems such as allergic reactions and drug precipitation on aqueous dilution. To overcome these problems, we prepared the micelle and microemulsion systems for parenteral administration of paclitaxel by using glycofurol, Solutol?? HS 15 and oleic acid. Phase diagram, pH-rate stability, particle size distributions and pharmacokinetics of the systems were studied. Micelles and microemulsions formulated as nano-particle delivery system were physically and chemically stable. Therefore, these formulations might be the promising alternative candidate for the parenteral delivery of paclitaxel.
이은미,박종희,경기열,전일순,조혜정,지웅길 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-
The aim of this study was to improve the moisturizing and water retaining effects of a gel containing poloxamer 407, glycerin, sod hyaluronate, sorbo(sorbitol 70%). Topical preparations were formulated as a gel containing different concentration poloxamer 407, glycerin, sod. hyaluronate, sorbo(sorbito1 70%), lipid(ceramide. sphingosine ratio 1:l). We tested a various combination of different additives for the moisturizing effect The water holding capacity of the mixture was measured using a moisture analyzer. In vivo test was carried out on human skin using Skicon-200 and water retaining effect was increased by addition of lipid. Water evaporation test was performed by various concentration of additives and water evaporation characteristics of the preparations were determined using the moisture analyzer. Moisturizing and water retaining effects was increased by adequate combination of various additives with topical gel formulations.
분무건조법을 이용한 방출 제어형 케토로락 고형지질마이크로스피어의 제제설계
윤재남,이은미,김동우,박용근,전일순,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-
Ketorolac (KA) and ketorolac tromethamine (KT) is the nonsteroidal anti-inflammatory drugs (NSAIDs) and has been used widely. To improve its frequent administration by control of drug release. we prepared SLM of KA and KT using Mirj 45 and 52 as surfactants and tripalmitin and tristearin as lipids by spry drying method SLM, as a disperse system for injection, were evaluated by measurement of particle sizes. SEM and drug release pattern As a result. spherical SLM were prepared and their particle size were in the range of 25-125 μm, which were dependant on the types and contents of lipid and sururfactants. Their dissolution rate were decreased as increasing lipid contents.
고형지질마이크로스피어를 이용한 방출제어형 국소마취주사제의 제제설계 및 평가
박용근,이종화,김동우,윤재남,전일순,이은미,이계원,지웅길 대한약학회 2003 약학회지 Vol.47 No.2
Local anesthetics are used to reduce pain, but they are so frequently injected to patients. So, we prepared lidocaine solid lipid microspheres (SLM) as long acting abdominal injection using spray drying method and evaluated drug entrapment, particle size, SEM, zeta potential and in vitro and in vivo drug release pattern, The particle sizes of SLM were 30∼100$\mu$m and it is enough to inject into abdominal tissue. The entrapment efficiency of SLM was over 95% as spray drying method. Surfactant and PC decreased the burst effect by 20∼30%. In in vivo test, C-6 showed controlled release concentration profile in plasma for 8 days and C-5 sustained longer than we expected.