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의약분업 실시 전ㆍ후 영도지역 주민의 약국 및 의료기관 의료이용 양상 변화 분석
南銀祐,朴宰成,M. Nishigaki,T. Hamai 고신대학교 영도발전연구소 2000 영도연구 Vol.2 No.-
The purpose of this study is to assess the effects of the separation of prescribing and dispensing in Korea and to find how civilians' usage behaviors on medical institutes such as hospital, clinics, drugstore, and community health center are changed due to the policy. To examine the differences of usage behaviors, this study used a before-after design. Using self-administered questionnaires, this study performed survey from June 26 to August 1, 2000. Chi-square test and generalized logit model was utilized in each observation period. Based on the results of each observation period, this study evaluated the effects of the policy. On the basic finings, most civilians did not agree to the separation policy regardless of both observation periods. However, after the separation, civilians' behaviors seemed to be modified as the policy maker had intended. Most of civilians purchased their drugs from pharmacists after receiving physicians' prescriptions. Specifically, males and elder persons had the exactly same behaviors as the intended utilization behaviors. All study subjects agreed to the basic purpose of the policy for the purpose of the reduction of drug abuse and misuses. The implications of this study are two fold: First, how civilians' short-term inconvenience caused by the policy should be alleviated without interrupting well-established usage patterns. Second, a special attention to the elderly is needed.
Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations
Yamada, Y.,Nishida, T.,Ichihara, S.,Sawabe, M.,Fuku, N.,Nishigaki, Y.,Aoyagi, Y.,Tanaka, M.,Fujiwara, Y.,Yoshida, H.,Shinkai, S.,Satoh, K.,Kato, K.,Fujimaki, T.,Yokoi, K.,Oguri, M.,Yoshida, T.,Watanab Elsevier Scientific Publ. Co 2011 Atherosclerosis Vol.215 No.1
Objective: We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations. Methods: A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. Results: Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0x10<SUP>-7</SUP>) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. Conclusion: BTN2A1 may be a susceptibility gene for MI in Japanese individuals.