Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

학교상담 수퍼비전 모평 구안

손현동,강진령 이화여자대학교 사범대학 교육과학연구소 2007 교육과학연구 Vol.38 No.2

전문상담교사의 전문성 신장과 효율적인 업무 수행을 돕기 위해 학교상담의 특성과 전문상담교사들의 독특한 역할을 고려한 학교상담 수퍼비전 모형이 구안되어야 할 필요가 있다. 이 연구의 목적은 전문상담교사를 위한 학교상담 수퍼비전 모형을 구안하는 것이다. 이러한 연구 목적을 달성하기 위해 수퍼비전 모형에 대한 문헌고찰을 통해 학교상담 수퍼비전 모형 구안의 방향을 설정하고 이를 바탕으로 모형을 구안하였다. 구안된 학교상담 수퍼비전 모형의 구성은 전문상담교사의 수퍼비전 목표, 수퍼비전 과정, 수퍼바이저의 역할·양식, 수퍼비전 방식을 포함하는 것이며 발달단계에 따라 개입방법이 선택되어지는 것으로 이루어져있다. 이 모형은 발달모형에 근거하고 있다는 점과 수퍼비전 목적과 목표, 수퍼비전 과정, 개입방법을 모두 포함하고 있는 통합적인 모형이라는 점이 특징이다. 구안된 학교상담 수퍼비전 모형은 학교상담의 특성과 전문상담교사들의 역할을 고려한 것으로, 전문상담교사들의 전문성 향상과 발달을 돕고, 효율적인 업무수행을 도울 수 있을 것으로 기대된다. To help school counselors enhance expertise and deliver a service effectivelyit is necessary to construct a school counseling supervision model reflecting the characteristics of school counseling and the peculiar roles of school counselors. The purpose of this study was to construct a school counseling supervisionmodel for school counselors. To achieve this purpose, the principles ofconstructing a model was established by reviewing literature about counselingand school counseling supervision model. And then based on these principles, aschool counseling supervision model was constructed. The school counseling supervision model presented in this study consists offour phases(entry, preparatory, implemental, terminal), and each phases hassubordinate stages. The constructed school counseling supervision model hascharacteristics that it is grounded on the developmental models and containssupervision purpose and objects, process, and intervention methods. Theconstructed supervision model is expected to help school counselors' professionalimprovement and their personal growth.

학교상담 수퍼비전 모형 구안

손현동,강진령 이화여자대학교 교육과학연구소 2007 교육과학연구 Vol.38 No.2

전문상담교사의 전문성 신장과 효율적인 업무 수행을 돕기 위해 학교상담의 특성과 전문상담교사들의 독특한 역할을 고려한 학교상담 수퍼비전 모형이 구안되어야 할 필요가 있다. 이 연구의 목적은 전문상담교사를 위한 학교상담 수퍼비전 모형을 구안하는 것이다. 이러한 연구 목적을 달성하기 위해 수퍼비전 모형에 대한 문헌고찰을 통해 학교상담 수퍼비전 모형 구안의 방향을 설정하고 이를 바탕으로 모형을 구안하였다. 구안된 학교상담 수퍼비전 모형의 구성은 전문상담교사의 수퍼비전 목표, 수퍼비전 과정, 수퍼바이저의 역할·양식, 수퍼비전 방식을 포함하는 것이며 발달단계에 따라 개입방법이 선택되어지는 것으로 이루어져있다. 이 모형은 발달모형에 근거하고 있다는 점과 수퍼비전 목적과 목표, 수퍼비전 과정, 개입방법을 모두 포함하고 있는 통합적인 모형이라는 점이 특징이다. 구안된 학교상담 수퍼비전 모형은 학교상담의 특성과 전문상담교사들의 역할을 고려한 것으로, 전문상담교사들의 전문성 향상과 발달을 돕고, 효율적인 업무수행을 도울 수 있을 것으로 기대된다. To help school counselors enhance expertise and deliver a service effectivelyit is necessary to construct a school counseling supervision model reflecting the characteristics of school counseling and the peculiar roles of school counselors. The purpose of this study was to construct a school counseling supervisionmodel for school counselors. To achieve this purpose, the principles ofconstructing a model was established by reviewing literature about counselingand school counseling supervision model. And then based on these principles, aschool counseling supervision model was constructed. The school counseling supervision model presented in this study consists offour phases(entry, preparatory, implemental, terminal), and each phases hassubordinate stages. The constructed school counseling supervision model hascharacteristics that it is grounded on the developmental models and containssupervision purpose and objects, process, and intervention methods. Theconstructed supervision model is expected to help school counselors' professionalimprovement and their personal growth.

미량 Ni 첨가 Fe-Ni 합금의 고온산화 거동에 관한 연구

孫根洙,尹在弘,金晋夏,金顯洙,成田敏夫,林重成 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.10

Oxidation behavior of Fe-Ni alloys added by small amount of Ni was studied, under the exposure to the temperatures up to 1100℃, 1150℃, and 1200℃, respectively. The slope of mass change curve representing an oxidation rate was 1 or 2 up to 20 seconds and decreased to 1/2 after 20 seconds in a parabolic shape. The temperature of the initial stage of oxidation increased more quickly at the furnace inside than at the surface of the specimen, and its behavior was reversed due to oxidation heat after 20 seconds later. Oxide layer was mainly composed of FeO. And particle of Fe_3O_4 and Fe_2O_3 was distributed in FeO layer. The order of the composition ratio for the oxide was Fe_2O_3,·Fe_3O_4,·FeO at the oxide surface, FeO,·Fe_3O_4,·Fe_2O_3 at the internal oxide, and FeO,·Fe_3O_4,·Fe_2O_3 at the surface of metal after stripping oxide layer.

Effects of Pilger Rolling and Heat Treatment on Microstructure and Corrosion Resistance of Ag-electroplated 304 Stainless Steel Tubes

Hyun Park,Woo‑Jin Lee,Jae‑Han Son,Han‑Kyun Shin,Sung‑Kyu Hong,Hyo‑Jong Lee 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8

We introduce a cost-effective method that combines electroplating with metal cold working processes to manufacture compositetubes with robust corrosion resistance. First, a 3-step electroplating process was developed to form an adhesive anduniform Ag coating on the outer wall of a 304 stainless steel tube. The process consisted of a Ni-strike step for removing thepassivation layer of the initial 304 tube, Cu deposition for smoothing the surface by adding a buffer layer, and Ag deposition. To reinforce the interfacial adhesion between the electroplated layers and the 304 tube and increase the area of the Ag coating,a pilger rolling or pilger rolling + heat-treatment process was performed after the Ag electroplating process. Scanningelectron microscopy of the composite tubes after each process indicated that the as-deposited Ag coating changed fromhaving a rough to smooth surface after only pilger rolling and with additional heat treatment. Electron backscatter diffractionanalysis of the microstructures and textures of the tubes revealed that dynamic recrystallization occurred extensively duringpilger rolling, resulting in the formation of a relatively defect-free grain structure without heat treatment. Furthermore,electrochemical polarization curves determined that the Ag-coated composite tubes are superior to the uncoated 304 tubein terms of corrosion resistance under Cl−atmosphere, owing to the formation of a AgCl passivation layer during testing. Surface analysis of the composite tubes suggests that the properties of the AgCl passivation layer are related to the grainsize of the Ag coating and the density of plastic-deformation-induced defects.

Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofi bers

Jin‑Kyung Jeon,Hyunseon Seo,Jimin Park,Soo Ji Son,Yeong Rim Kim,Eun Shil Kim,Jong Woong Park,Woong‑Gyo Jung,Hojeong Jeon,Yu‑Chan Kim,Hyun‑Kwang Seok,Jae Ho Shin,Myoung‑Ryul Ok 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation.

뇌동맥류파열에 의한 뇌지주막하출혈 환자의 수술시기에 따른 예후 분석

손진열,박인성,황수현,백선하,김은상,정진명,김재형,한종우 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.3

靑少年體操의 運動强度 및 에너지 消費量에 관한 硏究

孫泰烈,趙顯喆,鄭正眞 成均館大學校 科學技術硏究所 1988 論文集 Vol.39 No.1

The purpose of this study is to analysis energy expenditure and exercise intensity in adolesent gymnastics. The regression equation obtained from the results of HR and VO_2 was used to calculate Energy consumption for 7males and 5females. As a result of this study it was gained the conclusion as following 1. The energy expenditure in adolesent gymnastics appeared 36.26±7.80cal/4.5min, 19.17±3.85ca1/4.5min male and female students for each. 2. From the view of %HR_max, the exercise intensity of the adolesent gym. appeared 74.2±9.6%, 85.0±13% male and female students for each. 3. It was concluded that the adolesent gym. would be an adequate exercise in problem having training and warm-up effect to male student, training effect to female student.

일개대학병원에서 수막알균 백신 사용의 경험

손동욱,이찬우,정영국,조래정,이혜경,김은실,이진수,정문현 대한감염학회 2007 감염과 화학요법 Vol.39 No.6

Meningococcal infection is a life threatening disease that leaves serious sequelae in spite of appropriate treatment, thus vaccination for high risk groups are Important for the prevention of meningococcal diseases. However, the vaccine for Neisseria meningitidis has not been available in Korea until we introduced bivalent (serogroup A and C) polysaccharide vaccine for the first time for relief works in our university hospital. The vaccine was administered from January 2005 to March 2007 to 317 persons. of the groups administered, the largest group among them were 133 (133/317, 42%) students who planned to study abroad and needed the vaccination for secure entrance to school dormitories. This group was followed by health care workers, travellers to the regions of the world with high risks of meningococcal diseases, and splenectomised patients. To ratioalize the domestic use of meningococcal vaccine, the availability of vaccines first needs to be simplified by introducing them to the domestic market; for this to be possible, the approval system for vaccines should be reformed and epidemiogical studies need to be carried out.

열선 유속계를 이용한 노즐유동의 난류 분사류 초기영역에 관한 연구

김선진,손현철 서강정보대학 1998 論文集 Vol.17 No.-

In this present study, the flow characteristics of axial symmetric jet flow in an initial region are investigated experimentally. The contraction was made by the Morel's Method and the experimental data was analyzed by statistical technique. In this study, mean velocity and other turbulent quantities were measured by Hot-Wire Anemometer units and half velocity radius, potential core length, and jet spreading radius were calculated. Assumed by Gaussian distribution pattern, The divided two region's flow characters Were matched by asymptotic approach equation and were modelled with exponential pattern in the initial region.