심근경색 모델 흰쥐에서 스트레스가 B-type Natriuretic Peptide 발현 및 심박변이율 변화에 미치는 영향

이삼윤(Sam Youn Lee),이미경(Mi Kyoung Lee),김남호(Nam-ho Kim),주민철(Min Cheol Joo),조항정(Hyang Jeong Jo),강지숙(Ji Sook Kang),김병숙(Byung Sook Kim),윤선식(Sun Sik Yoon),최을식(Eul Sig Choi),이문영(Moon Young Lee) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

심박변이율의 감소는 심근 경색 환자에서 예후의 악화와 관련되어 있다. 심박변이율 중 very low frequency가 심부전환자의 예후를 판단할 수 있는 독립적 인자로서 사용이 가능하다고 보고된 바 있으며, 심실의 압력 증가에 반응해서 생성되는 B-type natriuretic peptide가 심근 경색의 예후 인자로서 사용할 수 있음 역시 보고된 바 있다. 본 연구에서는 심근경색 모델을 제작하여 일정의 회복 기간을 거친 다음 다시 일정 기간의 스트레스를 겪게 한 후 심박변이율의 변화 및 심실 조직에서의 BNP 발현 정도를 비교하여 스트레스에 의한 영향을 관찰하고자 하였다. Sprague-Dawley계 수컷 흰쥐 15마리를 대상으로 하였다. 실험동물은 인위적 스트레스 및 수술을 받지 않은 대조군(CON, n=5), 심근경색 수술을 받은 후 restraint stress를 받지 않은 군(MI+No Stress, n=5), 심근경색 수술을 받은 후 1주일 동안 restraint stress를 받은 군(MI+Stress, n=5)으로 분류하였다. 심근경색 모델 제작 직후 15분 이상 심전도의 변화를 기록하였으며, 2개월 정도 후 심근경색 수술을 받은 동물을 두 군으로 나누어 그 중 한 군에는 1주일 동안 restraint stress를 가한 후 restraint stress를 가하지 않은 동물과 심박변이율을 비교 분석하였다. 심실 조직은 좌심실 전벽 부위의 위축을 관찰할 수 있었고, 대식세포에 의하여 응고, 괴사된 심근세포의 탐식과 혈관이 풍부한 육아조직 및 섬유 변화를 볼 수 있었다. 심박변이율은 심근경색 수술을 받은 직후 심박수는 유의한 증가를 보였고, standard deviation of the normal to normal intervals (SDNN), very low frequency (VLF) 및 low frequency (LF)의 유의한 감소를 보였다. 심근경색 수술을 받았던 동물에서 두 달 정도의 회복 기간을 거친 후 스트레스를 받지 않은 군은 심박수 및 기타 심박변이율 분석에서 SDNN 값을 제외하고는 정상군과 유의한 차이를 관찰할 수 없었던 반면 1주일 동안 스트레스를 받은 군에서는 심박수가 다시 유의하게 증가했을 뿐만 아니라 SDNN, VLF 및 LF 역시 정상군과 유의한 차이를 보였다. 이상의 결과를 종합하면 심근경색 동물에 대해 1주일 동안 스트레스를 가한 결과 심박변이율이 감소하고 심실에서의 BNP 발현은 더욱 증가하여 악화함을 보여주고 있다. Diminished heart rate variability (HRV) is associated with less favorable prognosis after myocardial infarction (MI). It has been reported that very low frequency (VLF) power in HRV analysis is an independent risk predictor in patients with congestive heart failure and B-type natriuretic peptide (BNP) can be used as a prognostic factor of MI. The purpose of this study was to investigate whether stress has an effect to the changes of BNP expression and/or heart rate variability in MI model in rats. Male Sprague-Dawley rats were divided into 3 groups: control group (CON), MI group (MI+No Stress), and MI followed by stress group (MI+Stress). MI+Stress group rats were raised for a two month recovery period after the operation, followed by being exposed to restraint stress for 2 hours per day for 1 week. Electrocardiogram was recorded after the operation and the last day after 1 week of stress. The frequency components of HRV were calculated in the frequency domain such as VLF, low frequency (LF), high frequency (HF) and so on. In HRV analysis, standard deviation of the normal to normal intervals (SDNN) was significantly reduced in both groups compared to the control group. VLF and LF also were significantly reduced in MI+Stress group compared to the control groups. In addition, BNP expression in western blotting was shown the strongest bands in MI+ Stress group among experimental groups. These results suggest that BNP and HRV were aggravated by stress in MI rat model. (Korean J Str Res 2010;18:275∼285)

김채원의 〈겨울의 환〉에 나타난 문학치료적 성격 분석

류미향(Ryu, Mi-Hyang) 한국어문학회 2017 語文學 Vol.0 No.137

This article redefines the significance of motherhood expressed in Kim Ch’ae-Wǒn’s novel entitled Kyǒul ǔi hwan , which represents motherhood as a force of vitality, transcendence, and spirituality. By employing the bibliotherapic approach toward literature, I observed that the literary representation of motherhood is connected to heal human wounds. The contemporary society prevails with the mental and psychological problems, as epitomized in the concept of “fatigue society” in Han Byǒng-Ch’ǒl’s writing. Han argues for the positive side of the “fatigue society” in which people focus on deliberation and contemplation. Such pursuit of the contemplative life is suggested in Illusion of winter. Specifically, this article focuses on the expression of motherhood as an instrument of healing, and I concentrate on the two particular scenes concerning the representation of motherhood: The mother who prepares a meal and sets the table, and the mother patiently waits for her family at the door. Specifically, the mother’s preparation of food symbolizes the vitality of life, while her waiting at the door captures the transcendental personality or spirituality of the mother character. Such portrayals serve to wrap and heal the wounds and scars, since motherhood occupies the inherent and sacred realm of humanity, where pain can never reach. The vitality and spiritual nature of life and nourishment in the Illusion of winter therefore suggests its significance in modern society. Conclusively, this study illuminates the literary representation of motherhood as a site of healing.

자궁경부 상피내 병변 환자에서 LEETZ 원추절제술 후 HPV DNA Test 추적 검사의 임상적 의의

김미향,이태화,오영림,이천준,김원규 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Objective: This study was performed to investigate the clinical significance and timing of HPV test for follow up of patients after LEETZ treatment in CIN lesion Methods: From January 2005 to December 2008, 105 patients with CIN were treated with LLETZ at Kosin university gospel hospital, Busan, Korea. After LEETZ, HPV test and Pap smear were done after 3months. Every HPV typing was done by HPV DNA chip. Results: A total of 105 cases were enrolled in this study. There were 25 patients with CINⅠ, 38 with CINⅡ, 42 with CINⅢ. Mean age was 41.95 years (range, 23-71 years) at the time of LEETZ. Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). During follow up after LEETZ, 65.6% had negative result after 3 month, 72.1% after 6 month, 73.9% after 9 month, 77.1% after 12 month, 79.2% after 15 month, 79.6% after 18 month, and 80.4% after 24 month. There were 2 cases of abnormal pap smear among persistent positive HPV DNA cases and no abnormal pap smear results in negative HPV DNA cases during follow up. Conclusion: Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). We suggest that HPV DNA test is recommended per 6 Months, and close observation is recommended in persistent positive HPV DNA test cases.

태반에 발생한 융모막혈관증 : 1예 보고

신향미,성노현 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.2

융모막혈관종은 태반에서 발생하는 가장 흔한 양성 종양으로 대개는 크기가 작고 태반체 속에 묻혀 있으며 증상이 없기 때문에 발견되지 않는 경우가 많다. 그러나 드물게 종양이 큰 경우에는 태반의 태아면 또는 모체면쪽으로 돌출하며 양수과다, 조산 등을 나타낼 수 있다 한편 이 종양은 비교적 흔한 종양임에도 불구하고 그 기원세포는 명확히 밝혀지지 않았다. 저자들은 27세 경산부의 태반에서 조산의 원인이 된 장경 8 cm의 융모막혈관종 1예를 경험하고 cytokeratin 18과 CD34에 대한 항체를 이용한 면역조직화학검사로써 융모막혈관종은 융모막반과 고정융모의 혈관에서 기원했을 가능성을 밝혔다. Chorangioma is the most common benign tumor of the placenta. A case of unusually large chorangioma associated with premature delivery is presented. At 26 weeks of gestation, a 27-year-old woman delivered a female infant. The placenta weighed 650 gm and a large, solid mass, measuring 8 cm in diameter, was seen on fetal surface of the placenta protruding into amniotic cavity. Microscopically, the tumor was composed of numerous capillary-sized vessels separated by inconspicuous stroma. Immunohistochemically, tumor cells showed staining for CD34, vimentin, alpha smooth muscle (α-SM) actin and cytokeratin 18. The blood vessels within the chorionic plate and anchoring villi stained for cytokeratin 18, but the vasculature of the terminal villi lacked cytokeratins. In these results, the chorangioma originate most likely from blood vessels of the chorionic plate and anchoring villi.

Test-taking Strategies for the Cloze by Skilled and Less Skilled EFL Readers

한미향 새한영어영문학회 2007 새한영어영문학 Vol.49 No.1

This study investigated EFL Korean readers' test-taking strategies for the discourse cloze test and examined differences in strategy use in terms of their reading proficiency. The data collected from their retrospective verbal reports were analyzed according to a modified framework of Bachman (1985), Sasaki (2000) and Yamashita (2003). The findings revealed that overall, multiple strategy use was prevalent and text-level strategies were employed most frequently. The skilled students used more strategies, and were better at using information from a wider discourse context than the less skilled. Therefore, the discourse cloze reflected well global reading comprehension and discriminated well between the skilled and the less skilled groups, which supports the usefulness of the cloze as a measure of reading comprehension.

미국과 일본 미술교육과정의 동향 및 내용에 관한 비교연구

김향미 서울교육대학교 초등교육연구소 1997 한국초등교육 Vol.9 No.2

The purpose of this study is to obtain fundamental materials on the curricular reform measures of art education by comparatively examining the tendency of educational curriculums between the USA and Japan, especially based on the historical curricular changes of elementary art education. The subject that is conclusively suggested is to establish a curricular direction in order to set its general thought and concretely achieve its goal. Through its accumulated achievements of the goal following the establishment of the curricular direction, more concrete theory would be provided and its achievements could be newly expected. A curriculum, a phenomenon situated in a border side between an ideal educational policy and actual educational state, needs to more flexible educational structure, not only by a planned theory as far as it's for human beings having a self-contradiction.

일부 도시지역을 유배우여성들의 가족계획 실천정도에 관한 조사연구

김미향 순천청암대학 1989 論文集-順川看護專門大學 Vol.13 No.-

This survey aimed to grasp the actual practice of the family planning of married women in Urban areas. It was carried out through 400 numbers of random selected married women living in Jeonju City from July. 12, 1989 to August. 8, 1989. Questionnaire were used as the research means and the results were used as the research means and the results were analized by percentage and χ^2-test. The summarized results of this survey are as follows; 1. The average age at marriage of the group was 25.67years old, the average frequency of gravidity 4.16, and the number of their living chilgren 2.208. 2. The expieriences of Induced abortion were the average frequency of 1.157.(Age related to the Induced abortion p<.001^(***) level of significant difference) 3. 47.8% unwanted babies by reason of Induced abortion. 4. 68.5% of the group had the actual practice of contraception, and age, education level, religion and Occupation were not related to the significant difference) The most frequently used Contraceptive method was the Tubal Ligation 31.0%, Vasectomy 16.1%, Condoms 13.5%, Menstrual cycle method 13.5% and Oral Pill 6.6% were the next. 5. Regarding to the reasons for not using contraception "because of wanting to have more babies" commanded top ratio 42.1% and "worring about side reaction 19.O% were the next. 6. Most important route from which they knew about the Contraception was "Public health center. Hospital" commanded top ratio 43.3%. 7. 66.0% of the group knew about the correct meaning of family planning.

운동용 속옷의 착용효과 : 부위별 체지방의 변화를 중심으로 Focusing on the Change of Fat in Each Body

나미향,김미선,정복희 服飾文化學會 2002 服飾文化硏究 Vol.10 No.6

This study aimed at investigating the change of fat in each body part according to the wearing of sport underwear made of speciaily-processed materials. In this study. 6 females made up of three early twenties. and three later thirties took part in the exercises for 12 weeks to find out the change of fat amount in body. square of body part by CT and obesity after and before an exercise. The results are as follows: In the obesity condition after and before an exereise. Roller's index shows that in case of S1 and S4. one level was lowered concerning the basic physical strength and optimal index was not changed In the silhouette between body frames. there are differences between ages. The body fat rate decreased 35.95% on the average. and the amount of the body fat of females in twenties was more than that in thirties. The amount of body fat decrease with the lapse of exereising time, while the amount of body fat shows increased of 0 75%. which showed the minus correlation. The rate of averaged flat by CT went up after an exercise in every body part, and alsr the decreased value of subcutaneous fat was not proportioned to that of weight and girth. Inbody parts, the lower abdomen was shown 49.7%. navel part 47.7% and waist part 37.3% each in numerical value. In the thickness of subcutaneous fat concerning waist. the value of front-denter line was the lowest, and followed by rear-center line and lateral 1ine 120degree part in the navel showed the most fat layed, and the lowest fat layed was in the lateral part Concerning the 1ower part of abdomen, under-skin fat was the most layed in 120degree part like that of navel part .

초등학생과 부모의 삶의 질 지각에 대한 토착심리 분석

임미향,박영신,김의철 한국아동교육학회 2005 아동교육 Vol.14 No.1

이 연구에서는 한국의 초등학생과 부모를 대상으로 삶의 질 지각과 관련된 토착심리를 분석하였다. 초등학교 6학년 233명과 그들의 부모 466명이 표집되었다. 분석 결과, 가정생활 삶의 질을 결정하는 요소로서, '화목한 가족관계' '경제적 여유' '여가생활' '자기조절' '교육문제'와 같은 요소들이 확인되었다 초등학생의 학교생활 삶의 질은 '친구관계'와 '학업성취'에 의해 영향을 받았다. 부모집단의 직장생활에서 삶의 질은 '경제적 요인' '인간관계' '성취감' 등에 주로 결정되었다. 직장에서 성취수준이 낮은 집단일수록 '경제적 요인'을, 성취수준이 높은 집단일수록 업무에서의 '성취감'이 중요하였다. 여가생활에서 삶의 질을 높이는 요소로, '다양한 취미생활' '경제적 여유' '시간적 여유' '자기조절' '원만한 인간관계'가 지적되었다. 종합적인 삶의 질을 높이는 요소로, 초등학생은 '화목한 가정' '여가생활' '학업성취' '자기조절' '원만한 인간관계'를 부모는 '경제적 요인' '자기조절' '여가생활' '화목한 가정'을 주로 지적하였다. This study examines the indigenous psychology of quality of life among Korean primary students and their parents. Sample were composed of 6 grade 233 primary students and their 466 parents. The factors that influence quality of life are 'harmonious family life' 'financial security' 'various hobbies' 'self-regulation' and 'education'. Within the school setting, the factors that influence quality of life are 'relationship with friends' and 'academic achievement'. For the quality of life at work, parents responded that the important factors that enhance or reduce the quality of life are 'financial factor' 'harmonious relations' and 'occupational achievement'. With the adult sample, those respondents with low levels of achievement report 'financial factor' as the most important factor. Those respondents with high levels of achievement report 'occupational achievement' as the most important factor. As for the leisure setting, the factors that raise quality of life are 'various hobbies' 'financial security' 'time to spare' and 'harmonious interpersonal relations' For the overall quality of life, factors that raise quality of life for students are 'harmonious family life' 'leisure activity' 'academic achievement' 'self-regulatio?and 'harmonious interpersonal relations'. For parents, they are 'financial security' 'self-regulation' 'leisure activity' and 'harmonious family life'.

Bacillus subtilis BK-17이 난소를 절제한 흰쥐의 혈 중 지질 함량 변화에 미치는 영향

박미화,김미향 신라대학교 자연과학연구소 2006 自然科學論文集 Vol.15 No.-

여성은 폐경 시 estrogen에 의해 정상여성보다 심혈관련 질환의 발병률이 높아진다. 따라서 본 연구에서는 혈관관련 질환의 예방에 사용되는 혈전용해제 개발의 목적의 일환으로 갱년기 장애 시 유발되는 체내의 지질 함량 증가에 있어서 Bacillus subtilis BK-17이 미치는 영향을 조사하기 위해 흰쥐에 인위적 폐경을 유도하여 Bacillus subtilis BK-17를 투여함으로써 그에 따른 혈 중 지질 함량에 미치는 영향을 검토하였다. 그 결과 난소절제 후 Bacillus subtilis BK-17추출물 투여는 난소 절제에 의해 야기되는 total-cholesterol 의 증가를 감소시키고, 중성지질을 감소시키며, HDL-cholesterol의 감소를 증가시키는결과, Bacillus subtilis BK-17이 갱년기 장애 시 발생찰 수 있는 지질변화에 효과가 있는 것으로 나타나 혈전 용해제로서의 기능이 있는 것으로 사료되어 진다. Bacillus subtilis BK-17, which was isolated from a decaying rice plant, known as fibrinolytic enzyme. The ovariectomized rat is proposed as an experimental model for the rapid development of menopausal symptoms. Following loss of ovarian function, postmenopausal women display an increased incidence of hypertension and coronary heart disease, which is at least partially attributable to an increase in the total cholesterol, LDL-cholesterol and triglyceride levels, as well as a reduction in the HDL-cholesterol levels. Two groups were surgically ovariectomized (OVX). The third group was sham operated. Sprague- Dawley female rats were randomly assigned to the following groups : sham-operated rats (Sham), ovariectomized control rats (OVX-Control), ovariectomized rats supplemented with Bacillus subtilis BK-17 (OVX-BK17). The aim of this study was to evaluate the effects of the purified fibrinolytic enzyme from Bacillus subtilis BK-17 on the lipid on serum in ovariectomized rats.