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      • 초임계 건조공정을 이용한 TiO2 에어로젤의 제조

        홍인권,이재동,김원일,Kim, Hyung Jin,이승문 한국공업화학회 2001 응용화학 Vol.5 No.2

        The commercial applications of the aerogel are such as catalysts, thermal insulation, particle detectors. In addition to growing commercial application of aerogel, there are also scientific and technical applications. In this study, wet gels were prepared by a sol-gel process using titanium(IV) chloride (TiCI₄) and the resulting aerogels were obtained by supercritical drying process of wet gels. The resulting gels were converted to xerogels, aerogel and sonogel by atmospheric drying, supercritical drying and ultrasonic extraction, respectively. The amount of solvent and propylene oxide were varied in the range of 67 to 1600 ㏖ and 16 to 239.7 ㏖ in the resulting gels. The gel time increased as amount of solvent but decreased as amount of propylene oxide.

      • KCI등재
      • SCOPUSKCI등재

        복부 도서형 피판을 이용한 음경재건술

        민대홍,김용운,백무현,김승홍 大韓成形外科學會 1995 Archives of Plastic Surgery Vol.22 No.3

        Total loss of the penis is frequently of traumatic origin. Other causes of loss or absence of the penis are cancer, infections, metabolic or vascular derangement, punitive ablation, or congenital abnormality. Phallic reconstruction techniques parallel the evolution of flap development and continue to evolve today. Many different techniques have been used in penile reconstruction. This article presents a new method of penile reconstruction in two patients. We designed an island flap on the upper abdomen to carry the deep inferior epigastric vessels and intercostal nerve. The dorsal penile nerve was coaped to the intercostal nerve in island flap. Urethra was made with full thickness skin graft from hairless groin or scrotal flap. Rib cartilage was used for stiffener. The donor site could be closed directly or covered with split-thickness skin graft.

      • KCI등재

        Differences in Clinical Outcomes Between Hydroxyurea-Resistant and -Intolerant Polycythemia Vera Patients

        Lee Sung-Eun,Hong Junshik,Bang Soo-Mee,Park Jinny,Choi Chul Won,Bae Sung Hwa,Kim Min Kyoung,Yoon Seug Yun,Kim Sung-Yong 대한의학회 2024 Journal of Korean medical science Vol.39 No.3

        Background: Previous studies have suggested that patients with polycythemia vera (PV) who exhibit hydroxyurea-resistance (HU-R) and -intolerance (HU-I) may have distinct characteristics and clinical outcomes. However, to date, no studies have reported a comparison between these two groups or assessed prognostic factors in these patients. Methods: The objective of this study was to evaluate clinical outcomes and identify prognostic factors among PV patients with HU-R or HU-I. We conducted a review of PV patients who received frontline treatment with HU from nine centers and identified 90 patients with HU-R or HU-I. Results: The cumulative incidence of thrombosis after 7 years of HU-R/I was 21.4%, and the incidence of disease progression was 22.5%. Comparing the HU-R and HU-I groups, the HU-R group had a significantly higher rate of disease progression (36.7% vs. 0.56%, P = 0.009), while there was no significant difference in thrombosis incidence (19.0% vs. 22.9%, P = 0.463). Multivariate analysis revealed that HU-R was an independent prognostic factor for progression-free survival (hazard ratio, 6.27, 95% confidence interval, 1.83–21.47, P = 0.003). Additionally, higher lactate dehydrogenase levels, multiple cardiovascular risk factors, and prior thrombosis were identified as unfavorable predictors of overall survival. Conclusion: These findings suggest that patients with HU-R face a higher risk of hematological transformation, but have a comparable risk of thrombosis to patients with HU intolerance. These distinctions should guide decisions on second-line treatment options and clinical trials involving these patients.

      • 黃기內托散의 소염 작용에 관한 실험적 연구

        홍성진,심성용,김경준,Hong, Sung-Jin,Sim, Seug-Yong,Kim, Kyung-Jun 대한한의진단학회 2004 大韓韓醫診斷學會誌 Vol.17 No.2

        Objective: Chronic otitis media is an inflammation and infection of the middle ear which is persistent. Chronic otitis media occurs when the eustachian tube becomes blocked repeatedly, multiple infections, ear trauma, or swelling of the adenoids. A chronic ear may be the result of an acute ear infection that does not clear completely, or the result of recurrent ear infections. A chronic ear infection may be more destructive than an acute ear infection because its effects are prolonged, and it may cause permanent damage to the ear. Methods : Experimental animals made use of 4-5 weeks age(weight 20-25g) ICR(male)mouse. In the breeding farm, the lighting time was controlled from 7:00 am until 7:00 pm, the temperature was controlled within $22{\pm}0.5{\circ}$ and water and food were not limited. The extracts which were extracted from Hwangginaetak-san devided low dose group( 1.0g/kg-HN) and high dose group(3.0g/kg-HN), they were intragastrically administered to the mouse of sample A and sample B prior to LPS I.P injection. Compared with inflammation induced group which were induced by LPS, we measured the WBC count, IL-6 level in plasma and TNF-${\alpha}$ level in plasma. Results: 1. Hwangginaetak-san decreased WBC count in inflammatory reaction induced by LPS 2. Hwangginaetak-san decreased IL-6 level in inflammatory reaction induced by LPS. 3. Hwangginaetak-san didn't decreased TNF-${\alpha}$ level in inflammatory reaction induced by LPS Conclusion: According to above results, Hwangginaetak-san was improved its suppression effect to the inflammatory reaction through WBC count and IL-6 level. So Hwangginaetak-san is considered to be used for treatment of chronic otitis media by controlling the WBC count and IL-6 level in plasma.

      • Poster Session:PS 1154 ; Gastroenterology (Pancreatobilliary) : Biliary Ascariasis Infestation after Endoscopic Sphincterotomy

        ( Su Sie Rah ),( Seug Won Jung ),( Dong Chul Lee ),( Geum Soo Lee ),( Hyeung Chul Moon ),( Sang Wook Park ),( Gun Young Hong ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

        Ascarias lumbricoides is a common parasitic infestation in gastrointestinal tract. Migration of adult worm to biliary system implicates biliary complication. Interestingly, biliary ascariasis is known as one of the complication of EST in endemic area. But biliary ascariasis after endoscopic sphicterotomy is rarely reported in Korea. We report the case of biliary ascariasis caused after performing EST for treatment of common bile duct stones. 58- year-female Combodian from South East Asia visited our hospital for epigastric pain from 2 weeks ago. Laboratory fi nding revealed AST 122 IU/L, ALT 35 IU/L, ALP 122 IU/L, GGT 244 IU/L. CT scan showed multiple large stones in common bile duct. We extracted multiple brown stones by basket after endoscopic sphincterotomy and endoscopic papillary large balloon dilatation. Next day, we performed follow up ERCP for removal of remnant CBD stones. On cholangiogram, giant roundworm with remnant stone was noted in CBD, which wasn`t seen at prior ERCP. We caught the worm by snare and successfully pulled it out from common bile duct. The worm, 30cm long, round, whitish-pink colored, was identified as ascariasis lumbricoides. We detected round worm after performing endoscopic sphincterotomy which wasn`t noticed at fi rst ERCP. The worm seems to migrate to common bile duct easily because opening of major papilla was widened after EST. As the demand for organic food and immigration from endemic area increase in Korea, biliary ascariasis should be considered a diagnostic possibility especially in patient from the tropics.

      • KCI등재

        요추간판 탈출증에 수핵 용해술에 의한 치료결과

        김재도,홍영기,김석헌,손영찬,박정호,손정환 대한척추외과학회 1994 대한척추외과학회지 Vol.1 No.1

        We have experienced the 43 cases of HIVD patient treated with chemonucleolysis from July, 1987 to december, 1992. The evaluation Criteria for final outcome was Marked, Slight, and Un-improvement by Van Leeuwen et al. We analysed the data by symptom duration, and by number of criteria by McCulloch. Among the patients with symptom duration below 6 months, the symptom improvement was achived in 96%, and the patients who have 4 or 5 diagnosis crite- ria gained symptom improvement in 90%, Symptom improvement was observed in 81% of cases with follow up period more than one year. As compairied with conventional laminectomy, the chemonucleolysis is noninvasive, and has low morbidity & mortality rate than laminectomy, and nearly equal sucess rate, when the procedure is done by experienced surgeon, and by accurate mothod in proper candidate.

      • KCI등재

        단기교육으로 시행가능한 심실기능평가법

        김원,임경수,오병연,홍은석,김영식,김선만,이부수,현석천,김영득 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

        Background: The initial history, physical examination, and ECG assessment should focus on identification of potentially serious noncardiac or cardiac disorders, including coronary artery disease, congestive heart failure, and electrical instability at the emergency room. additionally, it is essential to define disease severity, stability and need for emergency therapy. echocardiography is a useful tool for this purpose. especially Doppler echocardiography may be more sensitive and time-saving diagnostic tool for the evaluation of patients presenting with cardiogenic symptoms. So we evaluate the feasibility of the echocardiographic measurement by emergency physicain after short-term course. Method and Results: Twenty volunteers(10 male, 38.8±9.3 years) were included in the study for measurement of myocardial performance index and established parameters of ventricular function using conventional echo-Doppler methods. Myocardial performance index: (ICT+IRT)/ET, was obtained by subtracting ejection time(ET) from the interval between cessation and onset of the mitral inflow velocity to give the sum of isovolumic contraction time(ICT) and isovolumic relaxation time(IRT). The most of mean values of echocardiogrphic parameters were not significantly different between those of cardiologist and those of emergency physicians(p<0.01). The duration for measuring myocardial performance index was shortest among echocardiographic parameters. the validity of echocardiographic parameters measured by emergency physicians was proved relatively good. Conclusion: It is proved to be feasible for emergency physician to perform echocardiographic evaluation of ventricular function after short-term course

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