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안토시아닌의 항산화 활성 증진을 위한 후코이단 기반의 나노이온복합체
민대홍,나건 한국생체재료학회 2012 생체재료학회지 Vol.16 No.2
To improve the antioxidant efficiency of anthocyanin, fucoidan-anthocyanin nanocomplex has been investigated. The nanocomplex was fabricated by simple process in water phase to minimize loss of anthocyanin. In the nanocomplex,structure of anthocyanin was changed from flavylium cation to quinoidal base structure. Between 200 to 300 nm of spherical nanocomplex was observed by dynamic light scattering (DLS) and field emission scanning electron microscopy (FE-SEM). The nanocomplex has 10 fold lower critical assemble concentration (CAC) value (0.025 mg/ml) than free anthocyanin (0.25 mg/ml). The radical scavenging rate of anthocyanin against DPPH radicals and hydrogen peroxide were improved from 76% to 79% and from 20% to 60%, respectively. Finally, anticancer activity of anthocyanin was measured to estimate the in vitro radical scavenging activity. In the lipopolysaccharide (LPS) mediated reactive oxygen species (ROS) rich condition, the nanocomplex effectively reduced cancer cells viability (77%) to compared with free anthocyanin (121%). Therefore, we conclude that fucoidan-anthocyanin nanocomplex has a potential for use as a carrier for anthocyanin delivery. These nanocomplexes would prove useful application in the food, beverage and pharmaceutical industries.
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생분해성 고분자 조성에 따른 스텐트 코팅용 필름의 약물 방출 특성 및 평활근세포 증식 억제 효율 분석
민대홍,박태현,이동기,나건 한국생체재료학회 2013 생체재료학회지 Vol.17 No.1
The drug-eluting stent coating film (PTX-Eluting PTFE film) was investigated by using poly(lactic-co-glycolic acid) (PLGA) and poly L-lactic acid (PLLA) via dip coating technique and characterized by thickness, drug eluting test, contact angle, proliferation of smooth muscle cell (SMC). The thickness of the films in ranged from 0.039 μm to 0.045 μm according to the composition of PLGA and PLLA. The sustained release behavior of paclitaxel (PTX) was observed for 65 days at PLGA:PLLA (3:7) film. The surface degradation behavior of the film exposed for 65 days in PBS buffer depends on the ration of PLLA. For monitoring of restenosis, the attachment and proliferation of SMC on the film was observed by fluorescence microscopy. The attachment and proliferation of SMC increase with increasing of PLLA content. It means that the hydrophilic property of the film surface leads to suppress the attachment and proliferation of SMC.
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