Poster Session : PS 0691 ; Rheumatology ; A Randomized, Double-Blind, Phase 3 Equivalence Trial Comparing the Etanercept Biosimilar, Hd203, to Reference Etanercept, in Combination with Methotrexate (MTX) in Korean Patients with Rheumatoid Arthritis (RA)

( Sang Cheol Bae ),( Jinseok Kim ),( Jung Yoon Choe ),( Won Park ),( So Ra Lee ),( Yong Ho Ahn ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Etanercept is a recombinant fusion protein that blocks TNF. HD203 is a biosimilar of etanercept with demonstrated comparability across pharmacokinetics, safety and tolerability. The objectives of this study were to evaluate equivalence in effi cacy and compare safety of HD203 with reference etanercept, in combination with MTX in patients with RA. (ClinicalTrials. gov NCT01270997). Methods: Korean patients (male or female aged =20 years) with active RA were randomized (1:1) to 25 mg HD203 or reference etanercept, administered subcutaneously twice weekly with MTX for 48 weeks. The primary endpoint was the proportion of patients achieving ACR20 at week 24. Secondary endpoints included ACRn, DAS28, andEULAR response at week 24 and 48, safety and immunogenicity. Results: In total, 294 patients were randomized: HD203, n=147; reference etanercept, n=147. The proportion of patients achieving ACR20 at week 24 was not signifi cantly different between HD203 and reference etanercept. Equivalent effi cacy was demonstrated within predefined margins. There were no significant differences between proportions achieving ACR20 at week 12 and 48. ACR50 and ACR70 displayed similar trends. There were no signifi cant differences between groups for ACRn, DAS28, and EULAR response. Safety set analysis (HD203, n=147; reference etanercept, n=146) revealed no signifi cant difference for treatment-emergent (all-causality) adverse events (AEs): HD203 76. 87% vs. reference etanercept 78. 08% (p=0. 8040). No significant differences between HD203 and reference etanercept were observed for adverse drug reactions, serious AEs, or discontinuations due to AEs. Few patients tested positive for anti-drug antibodies. Conclusions: The study met the primary endpoint of demonstrating equivalent effi cacy of HD203 compared to reference etanercept. HD203 was well tolerated, with a safety profi le comparable to reference etanercept in this population of patients with RA.

류마티스관절염과 만성 호산구성 폐렴에 동반된 호산구성 흉막삼출

지용관 ( Yong Gwan Jee ),라상호 ( Sang Ho Ra ),박유미 ( Yu Mi Park ),차재황 ( Jae Whang Cha ),강용석 ( Yong Seok Kang ),박정하 ( Jeong Ha Park ),강태영 ( Tae Young Kang ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.5

We describe a 48-year-old man with family history of rheumatoid arthritis (RA) affected by chronic eosinophilic pneumonia (CEP) with severe peripheral eosinophilia. CEP might develop as a complication of longstanding active RA. The patient with 5 months history of seropositive RA and chronic respiratory symptoms, alveolar and blood eosinophilia, peripheral pulmonary infiltrates and pleural effusion on chest imaging. The lung may be involved as an extraarticular manifestation of RA. However, CEP is not recognized as a typical lung manifestation of RA, and the two diseases rarely coexist. The effusion was an eosinophil predominant exudates and was characterized by low pH, and glucose level and high lactic dehydrogenase. The patient responded rapidly to combination of steroids and disease modifying anti-rheumatic drugs.

Network Analysis을 이용한 류마티스관절염 활액 대식세포에서 유전자 발현 연구

지종대 ( Jong Dae Ji ),김태환 ( Tae Hwan Kim ),이빛나라 ( Bit Na Ra Lee ),최성재 ( Sung Jae Choi ),이영호 ( Young Ho Lee ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.2

Objective. We wanted to investigate the mechanisms that could account for the pathogenesis of rheumatoid arthritis, so we examined the different expressions of the genes in rheumatoid arthritis (RA) synovial fluid macrophages as compared with that of normal peripheral blood (PB) monocyte-derived macrophages using microarray and bioinformatic analysis. Methods. We examined the expression of genes by using a gene expression oligonucleotide microarray. The differences of the gene expressions between the RA synovial macrophages and the normal PB monocytes-derived macrophages were analyzed using bioinformatic tools, including cytoscape and its plugin. Results. In this study, we found that 899 genes (464 genes up-regulated and 435 genes down-regulated) were differentially expressed between the two groups. Among the 899 genes, 552 genes were included for gene ontology analysis and network analysis. Based on biological process ontology, they were categorised mainly into immune response processes, responses to stimulus and signaling and regulation of biological processes. In addition to the genes related with STAT1 and AP-1 signaling, we found that the genes involved in the antigen processing and the cell cycle are abundantly expressed in RA synovial macrophages, suggesting that these genes may play an important role in the pathogenesis of RA. Conclusion. Our study suggest that this approach using integration of the gene expression profile with the protein interaction data may help to find several important pathogenic mechanisms in RA.

인터넷 통신에서 자바 바이트코드를 이용한 애플릿 보안

윤찬호,석경휴,나기창,배철수,나상동 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.1

Java applets are downloaded from web server through internet and executed in Java Virtual Machine of clients' browser. Before execution of java applets, JVM checks bytecode program with bytecode verifier and performs runtime tests with interpreter. However, these tests will not protect against undesirable runtime behavior of java applets, such as denial of service attack, email forging attack, URL spoofing attack, or annoying sound attack. In order to protect malicious applets, a technique used in this paper is java bytecode modification. This technique is used to restrict applet behavior or insert code appropriate to profiling or other monitoring efforts. Java byte modification is divided into two general forms, class-level modification involving subclassing non-final classes and method-level modification used when control over objects from final classes or interface. This paper showed that malicious applets are controlled by java bytecode modification using proxy server. This implementation does not require any changes in the web sever, JVM or web browser.

點郡 3㎖(H) 의 振動寫眞 및 Weissenberg寫眞에서의 特性

이진호,류보영,조소라,김문집,추금홍,서일환,임성수 순천향대학교 1993 논문집 Vol.16 No.3

Crtstallographic cell constants of point group ?? are a =b≠c, α=β=90。, and γ=120。. There are mirror plane symmetries in oscillation photography taken at a-axis and b-axis, but no plane symmetry at c-axis. Since Weissenberg zeroth layer taken at a- and b-axis obeys Friend's law, half of the photography shows non-symmetric unit of diffraction intensity. There are 6 mirror planes in the Weissenberg zeroth layer when the photography was taken at c-axis, therefore 1/12 of the unit cell is non-symmetric unit.

Weissenberg 寫眞 技法에 의한 酸化마그네슘(MgO)의 結晶構造

이진호,류보영,조소라,김문집,추금홍,서일환,임성수 순천향대학교 1993 논문집 Vol.16 No.3

The structure of MgO crystal is faced centered cubic(FCC) with cell parameters of a=b=c=4.21Å, α=β=γ=90。. The ionic bond length between Mg and O atoms is 2.1Å. This crystal belongs to m3m point group and to Fm3m space group.

合倂利得 推定에 關한 實證的 硏究 : 우리나라 企業合倂을 中心으로 An Empirical Test of The Bidding Firms

李聖淳,羅暎昊 홍익대학교 경영연구소 1993 경영연구 Vol.17 No.-

방사선 조사 마우스에서 소장움세포의 Apoptosis 발생에 미치는 생약의 효과

김성호,안미라,나승렬,이종환,김재하,조성기,장종식,신동호 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.1

Apoptosis의 유발을 억제하는 한약제를 파악하여 apoptosis와 관련된 정상적 또는 질병에 대한 연구에 자료를 제공하고자 방사선에 의해 유도된 apoptosis를 지표로 한의학적 처방에서 많이 사용되는 대표적 한약제(24종)의 효과를 검증하였다. 용안육, 산조인, 원지, 인삼, 복령, 목향, 천궁, 백작약, 승마, 시호 및 눈꽃동충하초 투여군에서 apoptosis는 감소되었으며, 이들 생약제는 apoptosis와 관련된 질병의 예방 및 치료에 적용할 수 있을 것이다. 추 후 이들 생약의 작용 기전에 대한 연구가 요구된다. This study was performed to determine the effect of several herbs on radiation-induced apoptosis in jejunal crypt cells. Longyanrou(Euphoris longana), Suanzaoren(Zizyphus vulgaris), Yuanzhi(Polygala tenuifolia), Rensan(Panax ginseng), Fuling(Poria cocos), Muxiang(Saussurea lappa), Chuanxiong(Cnidium officinale), Baishaoyao(Paeonia lactifolia), Shengma(Cimicifuga heracleifolia), Chaihu(Bupleurum falcatum) and Dongchongxiacao(Paecilomyces japonica) reduced the frequency of radiation-induced apoptosis(p<0.05). Although the mechanisms of this effect remain to be elucidated, these results indicated that Longyanrou, Suanzaoren, Yuanzhi, Rensan, Fuling, Muxiang, Chuanxiong, Baishaoyao, Shengma, Chaihu and Dongchongxiacao might be useful inhibitors of apoptosis, especially since these are relative nontoxic natural products.

신생아의 병적황달에 대한 임상혈액학적 고찰

박춘호,김성의,나창수 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1

A clinical and hematological observation was performed on 398 nowborn infants with hyperbilirubinemia who were admitted 10 the Department of Pediatrics, Chosun University Hospital from January, 1980 ro June, 1985. The following results were obtained 1) The incidence of hyperbilirubinemia was more frequent in male(63.8%) than in female(36.2%) 2) In the observation of the gestational period, its incidence was highest in full-term neonate(70%) and the next was pre-term neonate (25%) 3) In the observation of the delivery type, the incidence was highest in neonates with normal delivery(82.0%) and the next was c-section delivery (11.0%) 4) Idiopathic hyperbilirubinemia was the most common cause of pathological hyperbilirubinemia and the next wero breast-fed induced jaundice(10.4%), infection(9.3%), blood incompatibility(8.6%) in frequent of order. 5) The most common blood types of mother-baby in ABO blood incompatibility was 0-A (48.5%) and the next was O-B(42.5%) 6) The exchange transfusion were performed on 34 cases(8.5%). The mean serum bilirubin levels before exchange transfusion were 26.7±4.9㎎% in the cases of idiopathic hyperbilirubinemia(14 cases) and 25.9±6.5㎎% in the cases of blood incompatibility (17 cases). 7) The mean bilirubin levels before and after the exchange transfusion were 26.4㎎% and 11.9㎎% respectively and reducing rate of the bilirubin by exchange transfusion was 55%. Second exchange transfusion was performed in 2 cases(5.8%).

한국인 사춘기성 성장기에서의 수완부 골성숙도와 치아발육에 관한 연구

이상호,이미라 大韓小兒齒科學會 1992 大韓小兒齒科學會誌 Vol.19 No.1

The purpose of this study was to investigate the relationship of the development of teeth and the bone maturity of hand-wrist during pubertal growth period in Korean. The subjects used in this study were 295 children (male 147, female 148), ranging from 8 to 16 years of age, with good general health, none of whom had received orthodontic therapy. Panoramic radiographs and hand-wrist radiographs were used to evaluate to stage of teeth development and the bone marurity of hand-wrist and their relationship. The results were as follows; 1. In bone maturity of hand-wrist, a definite trend toward acceleration among females was evident, and in tooth maturation, a definite trend toward acceleration among females was evident in upper and lower canines. 2. In stage 3 of bone maturity of hand-wrist(onset of pubertal growth), the percentage distribution of developmental stage G in lower canine was the most most high(77%). The two es of the above were highly coincided with each other. 3. In spite of variety in correlation between teeth development and bone maturity of hand-wrist, there was the relatively close correlation in the lower first premolar in male(R=0.57) and the lower second premolar in female(R-0.73). 4. There was the highly close relationship between chronologic age and bone maturity of hand-wrist(R=0.82 in male, R=0.84 in female). However the correlation between chronologic age and teeth maturation was low, and different among various teeth(R=0.11-0.52).