Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-kB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1

( Jae Ho Choi ),( Sun Woo Jin ),( Eun Hee Han ),( Bong Hwan Park ),( Hyung Gyun Kim ),( Tilak Khanal ),( Yong Pil Hwang ),( Minh Truong Do ),( Hyun Sun Lee ),( Young Chul Chung ),( Hee Suk Kim ),( Tae 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

Purpose: The consequences of precipitously rising allergic skin inflammation rates worldwide have accelerated the risk of atopic dermatitis (AD). Natural product-based agents with good efficacy and low risk of side effects offer promising prevention and treatment strategies for inflammation-related diseases. We have already reported that Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) have many pharmacological effects, including anti-inflammatory and anti-allergic effects, but its influence on AD remains unclear. Therefore, we evaluated the inhibitory effect of CKS, mainly platycodin D, on AD-like skin symptoms in mice and the possible mechanisms in cells. Methods: Mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB). Four weeks after challenge, mice were treated with oral administration of CKS for 4 weeks. In addition, cells were used to evaluate the effect of CKS, mainly platycodin D, on the TARC expression regulated mechanism. Results: CKS attenuated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-α, IFN-γ, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells and mast cells in the ears. Moreover, CKS and platycodin D inhibited TNF-α/IFN-γ-induced TARC expression through the suppression of NF-κB and STAT1 and induction of Nrf2/ARE-mediated hemeoxygenase-1 (HO-1) expression in cells. Conclusion: We suggest that CKS and platycodin D inhibited the development of AD-like skin symptoms by regulating cytokine mediators and may be an effective alternative therapy for AD-like skin symptoms.ⓒ2014 Elsevler Gmbh. All rights reserved.

수중기지국 기반 수중통신망 구축 및 성능 시험

김도훈(Kim Do Hoon),채광영(Chae Kwang Young),고만재(Go Man Jae),정해지(Jeong Hae Ji),유호동(Liu Hao Dong),조용호(Cho Young Ho) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2

본 논문에서는 수중음향통신을 활용하여 CTD센서와 DO센서를 통해 수중환경데이터를 측정하고, 측정된 값을 육상에서 확인할 수 있도록 하는 실험을 진행하였다. 본 실험은 남해 실해역에서 20년 12월 12일부터 20일까지 진행되었으며, 구조물은 해수면에 해상부이 1대, 해저면에 수중기지국 2대, 센서노드 10대를 설치하였다. 모든 구조물에는 송신을 위한 트랜스듀서와 수신을 위한 하이드로폰이 장착된다. 해상부이는 해저면에 설치된 수중기지국과 센서노드에서 수중환경데이터를 수신한 후 육상 서버와 통신하여 패킷을 전송한다. 데이터는 1시간 단위로 전송되도록 설정하였으며 실험결과, 패킷 성공률은 약91.20%인 것을 확인하였다.

활막육종

김재도,윤영민,손정환,홍영기,손영찬,박정호,Kim, Jae-Do,Yoon, Young-Min,Son, Jeong-Whan,Hong, Young-Gi,Son, Young-Chan,Park, Jeong-Ho 대한근골격종양학회 1996 대한골관절종양학회지 Vol.2 No.1

Synovial sarcoma is an uncommon malignant soft tissue tumor which usually occurs in young-aged person, and frequently involves the lower extremities. Many authors recommended wide excision, adjuvant chemotherapy and radiation therapy. The proposed factors that affect the prognosis are age, size of tumor, site of tumor in the body, depth of tumor, histologic grade and method of treatment. The purpose of the study is to analyze the factors that affect the 5-year survival rate. We retrospectively evaluated 19 cases of synovial sarcoma treated in the Kosin University Medical Center from Jan. 1982 to Dec. 1994. The overall 5-year survival rate was 47.6% and the 5-year survival rates were significantly higher(P<0.05) in the group with smaller size of mass. The significantly lower 5-year survival rates were observed in the patient with deeply located lesion and with higher histologic grade. The 5-year survival rates were higher in the patients treated with wide excision than in the patients treated with amputation. But there was no significant difference between these groups. The adjuvant chemotherapy and radiotherapy were performed. In conclusion, we suggest that the better prognosis will be observed in the patients with smaller size of tumor mass, superficially located and lower histologic grade.

뇌졸중 환자에서 연하장애와 신체기능장애의 연관성

김도성,심영주,김기찬,정호중 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Backgrounds : In almost stroke patients, dysphagia is improved with rehabilitation therapy. But, it is not identified the relationship between dysphagia and physical function recovery in stroke patients. Methods : A total of 21 patients with stroke-caused swallowing disorders based on a videofluoroscopic swallowing study (VFSS) were examined swallowing function and physical function at admission and after treatment for 4 weeks (including Vitalstim). Swallowing function was evaluated by the functional dysphagia scale (FDS) using VFSS before treatment and after treatment. Physical function was evaluated by the motricity index (MI) and modified barthel index (MBI) at admission and after 4 weeks. And the relationship between dysphagia and physical function recovery was evaluated. Results : After treatment for 4 weeks, total score, residue in oral cavity, oral transit time, laryngeal elevation and epiglottic closure, residue in valleculae, residue in piriform sinus, coating of pharyngeal wall after swallow were significantly decreased in FDS (p<0.05). There were a significant improvement in MBI (p<0.05) and the correlation between FDS and MBI. But, MI was not showed correlation with FDS. Conclusions : There was relationships between swallowing function improvement and recovery of physical function in almost FDS factors.

응급센터 입원환자의 통증처치에 대한 응급의학적 고찰

도병수,김현정,정준영,도호석,이창현,이삼범 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2

Study objective: To recognize importance of pain management in ED and properly manage the ED patients complaining pain by analyzing the intervals between arrival time in ED and pain medicine starting time, the types and the administered routes of pain medicine. Design: Retrospective review of ED charts Setting: University teaching hospital Participants: The patients had admitted in ED of Yeungnam University Hospital with a chief complaint of acute abdominal pain or pain due to bone fracture between June 1, 1995 and December 31, 1995. Results: The study group consisted 256 patients, 161 of them female. ED administrations of analgesics were 103 cases, 17 of them administered more than two times. The average time interval between arrival time and medication time was 169.02±120.25 minutes. Each types of perceived analgesics were antispasmodics 55 cases(53.40%), NSAID 26 cases(25.24%) and opioid 19 cases(18.45%). Every analgesics were administered through intramuscular routes, except only 3 cases. Violences of patients or relatives due to delayed pain control were occured 32 cases, 5 cases of them self-discharged and looked for other hospitals. Conclusion: Emergency physicians including interns and residents delayed management so long and ordered inappropriate administration routes and types of analgesics. So we thought proper protocols about pain management in ED were established.

High Density Plasma 발생 장치의 구성 및 특성

황도원,손영호,김인수 경운대학교 산업기술연구소 1999 産業技術硏究論文誌 Vol.1 No.1(B)

High density plasma deposition system was organized using electron cyclotron resonance source, and its plasma properties were measured by using the Langmuir probe method. The ECR microwave plasma conditions could be controlled by means of mass flow controller and ECR microwave power according to the vacuum pressure of 2.3×10^-5 Torr to 5.2×10^-2 Torr. The ion density was increased with an increase of gas flow rate, and a decrease of the distance between ECR source and substrates. The electron temperatures were decreased with an increase of gas flow rate, and a decrease of the distance between ECR source and substrates. The estimated plasma potential was from 27.0V to 31.5V

만성두통환자에게 적용한 비약물적 치료가 통증행동에 미치는 영향

최도영,임사비나,차남현,김건식,이재동,김수영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : This study is a random-controlled post-design for confirmation of headache degree, quality of life, and satisfaction to therapeutical effect on chronic headache adults after management of non-medicinal treatment (acupuncture therapy and stellate ganglion block therapy). Methods : 51 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as chronic headache patients. The qualified patients were classified in to two groups, acupuncture group (AT group, n=28) and stellate ganglion block group (SGB group, n=23). Treatment was applied 2 times a weeks for 4 weeks. The effects of both groups were analyzed using VAS scores, BPI (Brief Pain Inventory) and the satisfaction degree to the therapy. Results : 1. The recognized score of the headache of AT group and SGB group was reduced indicating the degree of the headache was released. 2. The recognition at damage to the quality of life was reduced post therapy of AT group and SGB group, in which general activity, mood, enjoyment of life, personal relationship, and sleeping showed significant improvement of life quality. 3. The satisfaction degree to the therapy showed lower score than expectation to it in AT group and SGB group, however, it was not significant. Conclusions : The results showed that the four-week non-medicinal treatment (AT and SGB) in chronic headache patients was effective for reducing headache and releasing its damage in daily life, however, no difference in superiority was found. Therefore, non-medicinal treatment (AT therapy and SGB) could be utilized in chronic headache patients.

최적화 응용을 위한 개선된 Hopfield 신경망 모델에 관한 연구

정영호,임영도 동아대학교 공과대학 부설 한국자원개발연구소 1993 硏究報告 Vol.17 No.1

Due to the rugged energy function of the original Hopfield networks, the output is usually one local minimum in the energy function. This paper presents and analysis on the location of local minima in Hopfield networks and discribes modified network architecture to eliminate local minima. This modified Hopfield networks has been successfully applied to the construction of analog-to-digital converter with optimal solutions. Experimental results on the voltage transfer chracteristics of data converter is presented.

마이크로 프로세서에 의한 自己制御형 永久磁石 同期 電動機의 驅動 및 運轉 特性의 改善

윤병도,김윤호,김일환,이용석 중앙대학교 기술과학연구소 1989 기술과학연구소 논문집 Vol.19 No.-

전력 전자 공학의 발달에 의해 영구자석 동기전동기의 운전 분야가 대단히 진보되고 있음이 최근 논문을 통해서 보고 되고 있다. 영구자석 동기전동기는 크기와 중량의 감소로 인한 장점, 회전자의 동손이 없으므로 효율이 높다는 장점이 있어 각종 분야의 응용에 유리하다. 본 연구는 마이크로프로세서와 전압원 인버터를 사용한 자기제어형 영구자석 동기전동기의 구동장치를 제안한다. 영구자석 동기전동기의 운전은 고정자 전류와 역기전력을 동기화 시킴으로서 가능하게 한다. 고 분해능의 인크리멘탈 엔코더를 사용하여 영구자석 동기전동기에 적합한 자기제어형 PWM. 인버터 설계를 가능하게 하였다. 저속 영역에서 토오크 리플을 감소 시키기 위해 펄스 수를 제어하였으며 운전중 최적 부하각의 제어는 토오크-속도 특성을 개선시킴을 검토 하였다. Recent research has indicated that the permanent magnet synchronous motor(PMSM) drives are considerably improved by the development of power electronics. The PMSMs are favoured in many applications as there are advantages in size and weight reduction, and in efficiency due to elimination of the field copper losses. This paper presents a Self-Controlled PMSM, fed by voltage suource inverter based on the microprocessor. The proper operation of the PMSM can be ensured only if the stator current is always synchronized with is Back-EMF. The use of incremantal encoder with high resolution makes it possible to design a Self-Controlled PWM inverter for a PMSM. The pulse ratios are controlled to reduce the torque ripple in the low-speed drive region. In addition, torque-speed characteristics are improved by the control of optimal load angle.

만성 견비통에 대한 동씨침 치료의 무작위 대조군의 임상 연구

김찬영,권나현,신예지,남동우,김건형,김종인,최도영,이윤호,이재동 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Objectives : To observe the effect of acupuncture treatment in chronic shoulder pain patients. Methods : 36 voluntary patients were randomly assigned to an acupuncture treatment group(E GrouP, n=18) and a control group(C GrouP, n=18). The E Group patients received acupuncture treatment on LI_(15), TE_(14), GB_(21) and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for four weeks. The C Group patients received no treatment. All patients in both groups were instructed to practise self exercise in their daily lives. Evaluations were made at baseline and after four weeks of study. The Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's subjective pain was measured by Visual Analogue Scale(VAS). The obtained data was analyzed. Results '. The E Group showed significant(p<0.05) improvement in CSA, SPADI and VAS after four weeks of treatment. The C Group showed significant(p<0.05) improvement in CSA, but the change of SPADI and VAS was insignificant(P>0.05). CSA and SPADI of E Group significantly(p<0.05) improved compared to the C GrouP, but the difference of VAS change in the two groups was insignificant(p>0.05). Conclusions : Four weeks of acupuncture treatment significantly improved CSA, SPADI and VAS. The improvement of CSA and SPADI was significant(p<0.05) compared to untreated patients.