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일차병소의 재발없이 두개강외 전이한 천막상부 수강상피종 : 1예 보고
김한규,김순철,조경기,김광명,설대위,지제근 대한신경외과학회 1981 Journal of Korean neurosurgical society Vol.10 No.2
A case of supratentorial ependymoma in a 48-year-old man. After operation and radiological treatment, metastasis to scalp and cervical lymph node occurred, without recurrence of primary focus. 11cases of intracranial ependymoma with extracranial metastasis were reviewed. Metastasizing intracranial ependymomas are 3 times as frequent in males and originate above tentorium. The most effective transmission of metastasis of ependymoma is through the blood stream and the frequent sites of metastasis are lungs, pulmonary hilus, mediastinum, Iiver, scalp, vertebra, femoral bone and cervical lymph nodes. Our case is the oldest among reported cases and metastasized to relatively rare site.
흰쥐에서 Iodine-131-Iododeoxyadenosine 의 생체분포 및 유방암 영상화에 관한 연구
김혜원,원종진,최시성,이현철,김창근,김선구,Yang, David J,이강무,민병철,이종덕,Kim, E Edmund 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.4
Purpose: I-131 labeled (2'-deoxy-2-iodo-β-D-arabinofuranosyl) adenine (IAD) may be involved in DNA synthesis during active proliferation of tumor cells. We conducted this study to find out the biodistribution of IAD and its feasibility for scintigraphic tumor imaging. Materisls and Methods: Tosyl acetyl-adenosine was dissolved in acetonitrile, and I-131-NaI was added and heated to synthesize IAD. Female Fisher 344 rats innoculated with breast tumor cells were injected witb 0.27 MBq of IAD. Rats were sacrificed at 0.5, 1, 2, 4, 24h and the % of injected dose per gram of tissue (%ID/g) was determined. For scintigraphy, rats bearing breast cancer were administered with 1.11 MBq of IAD and imaging was perforrned after 2 and 24h. Then, rat body was fixed and rnicrotomized slice was placed on radiographic film for autoradiography, Results: %ID/g of tumor wa.' 0.74 (0.5h), 0.73 (1h), 0.55 (2h), 0.38 (4h), and 0.05 (24h), respectively. At 1h after injection, %ID/g of tumor was higher than that of heart (0.34), liver (0.42), spleen (0.47), kidney (0,69), muscle (0.14), bone (0.33) and intestine (0.51). However, %1D/g of tumor was lower than blood (1.06), lung (0.77), and thyroid (177.71). At 4h, %ID/g of tumor in comparison with other tissue did not change. Tumor contrast expressed by tumor to blood ratio was 0.69 and tumor to muscle ratio was 5.11 at 1h. However, these ratios did not improve through 24h. On autoradiogram and scintigraphy at 2 and 24 hour, the tumor was well visualized. Conclusion: This results suggest that Ial) may have a potential for tumor scintigraphy. However, further work is needed to improve localization in tumor tissue. (Korean J Nucl Med 1998;32:374-81)
J. E. Kim(김주언),Y. H. Kim(김용현),B. S. Kim(김병수),H. I. Kim(김홍일),S. H. Park(박수호),S. J. Lee(이석준),David Paredes,N. Kim(김남훈) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월
Additive manufacturing (AM) enables the fabrication of complex designs which are typically unobtainable from conventional manufacturing methods. Thanks to the advantage of design flexibility, AM has recently gained attentions from diverse industries with its developments. In energy generation fields, large-size wind turbine blades require complex features to improve efficiency which can highly benefit from utilization of AM technology. In this research, a design for additive manufacturing (DFAM) of fabricating wind turbine blade is investigated, which is conventionally produced by assembling panels with shear webs. Through DFAM process considering design requirements, a generative design is adopted in the inner portion of the wind turbine blade, which replace shear webs, and the assembling process between panels and webs is removed. Finite element analysis is conducted to examine the natural frequency and mechanical performance of the resulting blade. By designing suitable structure, the natural frequency of the wind turbine blade is optimized efficiently to the using environment, and the desirable mechanical performance is obtained with lower weight.
David J. Kim 서강대학교 종교연구소 2019 Journal of Korean Religions Vol.10 No.2
Four Pillars and Four Diviners: Fate, Fluidity, and Invention in Horoscopic Saju Divination in Contemporary South Korea
Kim, Y.,Han, S.,Yeom, M.,Kim, H.,Lim, J.,Cha, J.Y.,Kim, W.Y.,Somers, David E.,Putterill, J.,Nam, H.,Hwang, D. Cell Press 2013 Developmental cell Vol.26 No.1
Biological networks consist of a defined set of regulatory motifs. Subcellular compartmentalization of regulatory molecules can provide a further dimension in implementing regulatory motifs. However, spatial regulatory motifs and their roles in biological networks have rarely been explored. Here we show, using experimentation and mathematical modeling, that spatial segregation of GIGANTEA (GI), a critical component of plant circadian systems, into nuclear and cytosolic compartments leads to differential functions as positive and negative regulators of the circadian core gene, LHY, forming an incoherent feedforward loop to regulate LHY. This regulatory motif formed by nucleocytoplasmic partitioning of GI confers, through the balanced operation of the nuclear and cytosolic GI, strong rhythmicity and robustness to external and internal noises to the circadian system. Our results show that spatial and functional segregation of a single molecule species into different cellular compartments provides a means for extending the regulatory capabilities of biological networks.
Kim, Yun-Gon,Gil, Geun-Cheol,Jang, Kyung-Soon,Lee, Sukmook,Kim, Hyoung-Il,Kim, Jung-Sik,Chung, Junho,Park, Chung-Gyu,Harvey, David J.,Kim, Byung-Gee John Wiley Sons, Ltd. 2009 Journal of mass spectrometry Vol.44 No.7
<P>N-glycan structures released from miniature pig endothelial and islet cells were determined by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF), negative ion electrospray ionization (ESI) MS/MS and normal-phase high performance liquid chromatography (NP-HPLC) combined with exoglycosidase digestion. Totally, the identified structures were 181 N-glycans including 129 sialylated and 18 α-galactosylated glycans from pig endothelial cells and 80 N-glycans including 41 sialylated and one α-galactosylated glycans from pig islet cells. The quantity of the α-galactosylated glycans from pig islet cells was certainly neglectable compared to pig endothelial cells. A number of NeuGc-terminated N-glycans (80 from pig endothelial cells and 13 from pig islet cells) are newly detected by our mass spectrometric strategies. The detailed structural information will be a matter of great interest in organ or cell xenotransplantation using α 1,3-galactosyltransferase gene-knockout (GalT-KO) pig. Copyright © 2009 John Wiley & Sons, Ltd.</P>
Kim, Yun-Gon,Kim, Sun-Young,Hur, Young-Mi,Joo, Hwang-Soo,Chung, Junho,Lee, Dong-Sup,Royle, Louise,Rudd, Pauline M.,Dwek, Raymond A.,Harvey, David J.,Kim, Byung-Gee WILEY-VCH 2006 Proteomics Vol. No.
<P>The immunogenic nonhuman carbohydrate sequences in membrane proteins from porcine kidney were identified and characterized using MALDI-TOF MS and ESI-QTOF-MS. The MALDI profile, investigated by incubation with exoglycosidases, showed a series of about 40 carbohydrates that were identified as high mannose glycans (Man<SUB>3–9</SUB>GlcNAc<SUB>2</SUB>) and complex bi-, tri-, and tetra-antennary glycans with and without core fucose. The antennae of many of the complex glycans were terminated with α-galactose residues, with the numbers of these residues ranging from one up to the number of antennae. Negative ion ESI-MS/MS spectra confirmed the location of the α-galactose residues on the ends of the antennae. This total glycan profile of the membrane proteins from porcine kidney will thus provide important information for the study of molecular interactions between antigenic carbohydrates and proteins in xenotransplantation.</P>