흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

RFID 적용 원편파 패치 안테나의 설계

박규대,김환용 원광대학교 대학원 2009 論文集 Vol.42 No.-

In this paper, both circularly polarized patch antenna and modified loop antenna were investigated for ultra high frequency of 908.5MHz-914MHz radio frequency identification systems adopted to reader and transponder, respectively. The CP characteristics for reader antenna was realized by using truncation at the edge of patch and the bandwidth of resonance frequency was also enhanced with longer distance between ground plane and radiating patch. Futhermore, overall patch size was reduced to 1.73 times owing to narrow slit consist of inductance component at the radiating patch on RF-4 substrate with dielectric constant of 4.4 materials. The measurements results of fabricated prototype shows that antenna gain of 7.9dBi, 3dB beam width at radiation pattern of 87° and 105° for vertical and horizontal directions, respectively, with 15dB front-to-back ratio. The results shows that the proposed antenna features a compact size, wide impedance bandwidth, moderate gain, and excellent axial ratio. This antenna is well suitable for the applications in RFID readers.

표준 용매 벤젠의 Rayleigh 비의 온도 의존성

박일현,이종근,윤관한,조동환,민병길,방대석 金烏工科大學校 2000 論文集 Vol.21 No.-

The Rayleigh ratio of benzene is a very important physical constant with which the integrated scattered intensity of laser light scattering can be converted into the absolute value. In this study temperature dependence of Rayleigh ratio of this solvent has been investigated with two different methods in the temperature range of 25-75℃. It was found that in the direct measurement the non-linear behavior of its Rayleigh ratio were observed as increasing temperature even if the scattering volume correction was applied to the scattered intensity of benzene. However the result of indirect measurement based upon the invariance of molecular weight of standard polystyrene polymer for any polymer solution temperature showed us that its temperature dependence up to 75℃ could be expressed with the Benoit's linear equation rather than the non-linear one. It seems that the scattered intensity in direct method has more complicate contributions at the elevated temperature. Further research works are necessary in order to solve such discrepancy clearly.

내시경을 이용한 관골궁골절 정복술

박대환,이재욱,장경수,송철홍,한동길,안기영 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.1

Although the zygomatic arch can be employed as a key landmark to the accurate alignment of a displaced zygoma fracture, it has been traditionally avoided because of the need for a bicoronal incision. Exposure of the zygomatic arch by means of the conventional bicoronal incision has several possible disadvantages, including an increased risk of blood loss, alopecia, loss of sensation posterior to the incision, and traction palsy of the facial nerve. Endoscopic-assisted exposure of a zygomatic arch can largely obviate the disadvantages of a bicoronal incision and yield this site accessible to reduction and internal fixation in the routine treatment of displaced zygoma fractures. 9 cases of endoscope-assisted open reduction of zygomatic arch fracture and 3 cases of internal fixation of a moderately displaced zygoma fracture are presented. To accomplish this technique, a rigid 4 mm, 30 degree down-angled endoscope, trocar and cannula, endoscopic forehead lift instrument were used. The postoperative courses were satisfactory with few complications. The use of endoscope in the treatment of zygoma reduction provided an expanded field of vision, direct manipulation of lesions, minimal postoperative scar. In particular, exposure and fixation of the zygomatic arch were performed without the need for a bicoronal incision.

한랭작업 근로자들의 건강위해에 관한 연구

박호추,정설미,문덕환,이종태,김대환,김정호,최재일,황용식,이용희,이채언 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

In order to evaluate the status of cold exposure and its health hazards of workers at cold storage workplaces and to provide basic data for effective health care, the author measured core temperature and also observed clinical symptoms and signs, past and present history, and general health examination data on 99 cold exposed workers for exposure group and 96 non-exposed workers for control group working at 2 food refrigerating companies in Pusan area from January 6, 1998 to February 24, 1998. The results were as follows: 1. There was statistically significant difference in water intake between the exposure and control group and increased urine volume, urine frequency in exposure group without statistically significant difference. 2. Past and present illness in exposure group were hypertension (18.2%), hepatopathy (8.1%), gastro-intestinal disease(7.1%), arthritis (4.0%), intervertebral disc herniation(4.0%), and so on, and hypertension, arthritis was statistically significant difference compared to control group. 3. Symptoms in exposure group were fatigue(89.9%), headache (64.6%). drowsy(63.6%), neck stiffness(59.6%), excessive food intake(59.6%). general weakness(58.6%), hunger(58.6%), numbness(54.5%), and so on, and there was statistically significant difference between the exposure and control group except fatigue, drowsy. 4. As results of clinical test abnormality rate of the systolic, diastolic blood pressure and electrocardiogram were significantly higher in exposed group than control. 5. Core temperature in exposure group was statistically significantly lower than control group and the highest statistically significant inverse correlation with the working hours and working frequency of daily mean cold storage. As above results, the author suggested that the further studies should be conducted to evaluate the health status of workers about chronic health effects in cold workplaces and to establish effective health care methods for them.

매몰이의 교정

박대환,김태모,한동길,안기영 대구효성가톨릭대학교 1998 연구논문집 Vol.57 No.2

Cryptotia is deformity of the antihelix, especially its superior crus. There are various available methods that can be used for the surgical correction of cryptotia, but their main purposed is the provision of skin for the upper part of the skin and correction of deformed cartilage. We have repaired 13 cryptotia deformities in 9 patients with aesthetically satisfactory results using Z-plasty for auriclocephalic sulcus correction and vertical incision at superior crus of antihelix and then mattress suture or cartilage graft from cavum of concha for cartilage correction.

수지말단부 손상의 분류와 재건

박대환,한동길,안기영 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3

Finger tip injuries are in increasing tendency and the treatment must be focused toward preserving length and providing normal sensitivity. The 61 injured digits distal to DIT joint in 49 patients were managed in various procedures from May, 1990 to June, 1991. The authors classified the injured digits into 6 groups and selected the best surgical procedures according to the extent of the injuries. The 6 groups were : A. Volar skin and pulp loss without exposed bone B. Large volar skin and pulp loss with exposed distal phalanx C. Straight-transecton involving nail bed injury. D. Dorsally directed injury with little remaining nail bed E. Germinal matrix injury F. Injury at DIT joint level Tentatively recomonended surgical procedures by the extent of injury were : 1. Secondary intention or skin graft for level A 2. Local flap coverage for level B 3. Composite graft or Local advancement flap for level C 4. Local flap coverage or primary closure after bone shortening and residual nail ablation for group D 5. Micro-replantation or distant flap or local flap according to the state of the injury for group E and F

원위부를 기초로 한 도서형 정맥 피판의 임상적 응용

박대환,황동하,안기영 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.6

Skin flaps are characterised by arterial inflow and venous outflow. Since Baek et al(1985) demonstrated experimentally the possibility of raising a flap based only on a single vein surviving without arterial inflow, experimental and clinical attempts in using the 'flow through' venous flap, proximally pedicled venous flap, and distally pedicled venous flap have been performed and developed. In our study, five flaps with only a distal venous pedicle were carried out; two saphenous venous flap, one cephalic venous flap, one external jugular venous flap, and one dorsal venous flap of hand. Four of these five survived completely without complication but only the external jugular venous flap showed partial necrosis. These flaps are useful because of almost infinite donor site, quicker and simpler technique than free flap, and little donor site morbidity. Further studies are required for improved survival rate of venous flap.

무증상 당뇨환자의 T 반사 변화

안규환,조용진,김상화,사은희,임용빈,김대성,정대수,박규현 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

매몰이의 연골 변형의 교정

박대환,김태모,한동길,안기영 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.5

The key points of treatment of cryptotia are the elevation of invaginated ear helix and the correction of deformed cartilage. Prevention of stabilized cartilage contouring from returning to the previous state is also important. The authors carried cartilage plasty by modified Fukuda's method that several incisions are made along the crus, and then the crus is flattened using mattress suture in cases of mild cartilage deformity. In cases of severe cartilage deformity, the cartilage plasty by Onizuka method was carried. The cartilage graft from cavum on concha served as a splint for prevention of recurrence of cartilage deformities. We have repaired 13 cryptotic deformities in 9 patients with aesthetically satisfactory results using vertical incision at the superior crus of antihelix with mattress suture or cartilage graft from cavum of concha for cartilage correction. The correction of deformed cartilage by modified Fukida or Onizuka method is a good option for the treatment of cryptotia.