專門大學 齒衛生科의 敎育課程改善에 관한 硏究

鄭萬泰,吳世源,趙民貞,柳一光 광주보건대학 1984 論文集 Vol.9 No.-

This research was studied for the purpose of improving the curriculum of dental hygiene department injunior college and produced some results as follows; 1. The educational aim of dental hygiene department consists in improving students' talents with a view to cultivating dental hygienists necessary to the promotion of people's dental health as well as making a study of the technical Knowledge and theory about the prevention and hygiene of dental and oral diseases, Accordingly these five educational purposes as follows were re-established to achieve two goals. ⓐ Students should be able to do clinical Dental Assiting. ⓑ Students should be able to manage Preventive Dentistry. ⓒ Students should be able to do Dental Health Education. ⓓ Students should be able to guide and develop Public Health dentistry. ⓔ Making students have some qualities to accept the new knowledge and technique of Dental Health. 2. According to the improvement of curriculum, we make the distribution ratio of fundamental studies of developing qualities to technical studies of developing skills at the rate of 4 to 6, In addition we make the proprtion of the theory to the practice of technical subjects at the rate of 6 to 4. ◁표 원문 참조▷

오미자 열수추출물의 대장암세포 증식억제 효과

유민주;정하숙 덕성여자대학교 대학원 2011 덕성여자대학교 대학원 논문집 Vol.13 No.-

This study investigated anticancer activity of Schizandra chinensis Baillon for the evaluation as a functional food resources. Schizandra chinensis Baillon were extracted with water for 3 hr at 90 °C. In the present study, we investigated the antiproliferative activity of the water extract of Schizandra chinensis Baillon in human colon cancer cell line(HT-29) via cell viability assay, morphology study, cell cycle analysis and RT-PCR. The HT-29 cells were cultured in the presence of several concentrations(0, 1.0, 2.0, 4.0 mg/mL) of water extracts of Schizandra chinensis Baillon. As a result, Schizandra chinensis Baillon could inhibit the colon cell growth in a dose-dependent manners, which was associated with morphological changes and apoptotic cell death with cell shrinking, chromatin condensation and apoptotic bodies. In cell cycle analysis, treatment with Schizandra chinensis Baillon resulted in marked increases of colon cells in the GO(sub-Gl) and decrease in the G0/G1 phases. And p53 mRNA expression were increased. These results suggest that Schizandra chinensis Baillon inhibits the growth of human colon cancer cells by various apoptosis-aiding activities as well as apoptosis itself.

다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.

일부지역 대학생의 삶의 질에 영향을 미치는 제 요인

류미경,박경민,김정남 대한보건협회 1999 대한보건연구 Vol.25 No.1

본 연구는 일개 대학생을 대상으로 학교 환경 만족도, 학교내·외 안전에 대한 인식도, 학생활동참여도, 스트레스 관리, 건전한 건강실천행위 등 대학생의 삶의 질에 영향을 끼치는 환경요인과 건강관련 요인을 분석하여 대학생의 건강지향적 삶을 향상시키기 위한 프로그램 개발시 기초자료를 제시하고자 한다. 대구시에 소재하는 K대학교의 대학생 중입학 후 한학기 이상 학교생활을 경험한 대학생 500명을 대상으로 1998년 10윌 26일부터 11월 7일까지 2주동안 설문지를 배부하여 자료수집을 하였다. 연구도구로 조사대상 대학의 학교내 환경만족도 15문항(강의실만족도 6문항, 도서실 만족도 6문항, 교내 환경만족도3문항), 교·내외 안전에 대한 인식도 2문항, 교내 및 학교 주변 사고에 대한 직접경험 및 간접경험 4문항(도난사고, 폭력사고, 성폭력사고, 교통사고), 학생활동 참여도 3문항(동아리 활동, 총학생회 활동, 학생회 활동)을 조사하였으며 건강 실천 행위는 Breslow index를 이용하였다. 스트레스 관리는 Walker 등이(1987)이 개발한 건강증진생활양식(Health Promoting LifeStyle Profile)을 서(1995)가 수정보완한 것으로 대학생에게 적합한 스트레스 관리의 7문항을 신정하여 이용했으며, 삶의 질은 노(1988)가 개발한 도구를 이용하여, 서술통계방법, Pearson's correlation coefficient, stepwise multiple regression으로 분석한 결과 다음과 같은 결론을 얻었다. 학교환경에 대한 만족도는 평균점 2.72(SD=.54)로 낮은 수준이었다. 하위영역별 평균점은 강의실 만족도 2.36(SD=.55), 도서실 만족도 2.84(SD=.67), 교내 환경 만족도 2.96(SD=.54)이었다. 교내·외 안전에 대한 인식도는 교내안전인식도가 2.60으로 학교주변안전인식도 2.23보다 높게 나타났다. 교내 혹은 학교 주변에서 사고를 경험한 비율은 도난사고의 경험율이 가장 높게 나왔으며, 폭력사고와 성폭력사고도 자신이 경험한 경우보다 타인의 경험을 들었다는 경우가 비율이 높게 나왔다. 건강 실천 행위는 Breslow Index가 0∼3점인 군이 54.3%이며 4∼5인 군이 42.7%이며 6∼7인 군이 3.0%를 차지하여 97.0%가 나쁜 건강행위를 하는 것으로 나타났다. 스트레스 관리의 항목에서 전체적인 스트레스 관리의 평균점은 2.27이며, 하위영역으로 스트레스원이 무엇인가를 아는가는 평균점이 2.92이며, 스트레스를 해소하기 위해 특별한 방법(예: 이완요법)을 이용하는가는 평균점이 1.64로 가장 낮았다. 이는 자신들의 스트레스원에 대해 인지는 하고 있으나 올바른 스트레스 관리를 못하고 있음을 알 수 있다. 대학생의 영역별 삶의 질은 가족관계가 평균점3.49로 가장 높았으며 이웃관계, 자아존중감, 정서상태, 신체상태와 기능, 경제생활 순으로 나타났다. 삶의 질에 영향을 주는 요인을 단계적 중다회귀분석으로 분석한 결과, 스트레스 관리, 성별, 학교내 환경만족도, 보건학 수강유무, 건강실천행위가 삶의 질을 21.0% 설명하였다. 이상의 연구 결과를 기반으로 다음과 같은 제언을 한다. 1. 대학생의 특성, 환경, 복지에 적합한 구조화된 삶의 질 측정도구의 개발이 필요하다. 2. 대학생 올바른 건강실천행위와 스트레스 관리를 위해서 교내 보건교과목의 수강기회를 늘리고 건강증진프로그램과 스트레스 관리 프로그램의 도입과 강화가 필요하다. The purpose of this study, using a college student as the subject of study, are to analyse the satisfaction with the school circumstances, recognition about the security in the school and outside the campus, participation in school activites, managing the stress and practicing the sound health behavior, and to provide a basic material for programs which improve the health life quality of students. A Questionair test was done to K University students who have attended the school at leas! for a semester over two weeks (1998. 10.26-11.7). The Questionair includes 15 questions on the satisfaction with school surroundings (6 on classroom, 6 on library and 3 on circumstances in the school), 2 questions on the recognition about security on the campus and outside the school, 4 questions on direct and indirect experiences (thief, violences, sexual violence, traffic accident), 3 questions on participating in student activities(club activities, student's association). Breslow Index was used to check health practicing behavior. For the management of stress, out of Health Promoting Life style Profile, originally developed by Walk et al, and modified by Seo(1995), 7 items appropriate for student were chosen and Quality of life Scale developed by Noe(1988) was used to check Quality of life of college student. Next step, I used them to get Descriptive statistics, Pearson's correlation coefficient, stepwise multiple regression. The results are as follows: The satisfaction with school circumstances is low, whose average is 2.72 (SD=.54), And the satisfaction average on classroom is 2.36(SD=.55), on library is 2.84 (SD=.67), on circumstance in the school is 2.96 (SD=.54), The recognition about security on the campus is 2.60, higher than 2.23 outside the school. Theft experience is the highest. In the case of violence and sexual violence, indirect experience rate is higher than the direct one. For health practice behavior, Breslow index 0-3 group accounts for 54.3%, 4-5 group 42.7%, and 6-7 group 3.0%, which means 97.0% practices unhealthy behavior. For the management of stress, total stress managing average is 2.27; average on knowing the origin of stress is 2.92, and average on using the way of solving stress is the lowest 1.64. It can be inferred that they recognize the origin of stress but don't know how to deal with it. For the Quality of Life, the average on family relationship is the highest 3.49 and neighborhood relationship, self esteem, emotional conditions, physical conditions and function and economy life in order. When analysing the factors affecting life quality through 'stepwise multiple regression' method, stress management, sex, satisfaction with the circumstances in the school, taking health class or not, and practicing health behavior account for 21.0%. Accordingly, 1. Developing the organized tool to measure quality of life is needed, taking the characteristics of student, circumstances and welfare into consideration. 2. To establish the sound health practice behavior, there is urgent in need that the opportunity taking health subject should be increased, and health program and stress management program should be introduced and reinforced.

치은부에 이중인공진피(Terudermis^(�) 이식 후 조직학적 평가

김민정,정현주,류승희,박병주 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.4

The autogenous free gingival graft is the most predictable procedure currently used to increase the width of the attached gingiva in periodontal therapy. But the major disadvantage of the procedure is to create the 2ndary multiple surgical wounds at both a donor site and a recipient site. The other problem is the limited amount of available graft material. Therefore, recent researches have been focused on the development of the biomaterial to substitute gingival tissue. The purpose of this study was to compare the histologic healing after grafting of bilayer artificial dermis and free gingival graft. Four non-smoking subjects (mean age, 32.5 years) in systemically healthy state and good oral hygiene were selected according to their particular needs for correction of mucogingival deformities as suggested by Nabers : 1) zones of minimal attached gingiva, 2) areas of thin gingiva, 3) areas of inadequate vestibular formation, and 4) frenum problems. The recipient sites were prepared through the conventional free gingival graft procedure and were grouped according to the graft materials : Experimental group-bilayer artificial dermis (Terudermis ; Terumo Co. Japan)(n=5) ; Control group-free gingival graft with autogenous palatal mucosa(n=6). Biopsies were harvested from 11 sites (containing adjacent attached gingiva and graft) at 1, 2, 3 and 6 weeks postsurgery to evaluate histologic healing. At the third week in the experimental group and at the second week of in the control group, the grafts has been stabilized on the recipient bed and the graft border has been blended into the surrounding tissue. In the experimental group, the epitheial migration from the adjacent tissue to graft was observed after 1 week of grafting and the distribution of the inflammatory cells were reduced, collagen layer of the artificial dermis was lost and the basement membrane was formed after 3 weeks of grafting. At 6 weeks of grafting, both groups demonstrated orthokeratinized epithelium and increased thickness of epithelial tissue, similar to the adjacent tissue and the rete peg formation. It was difficult to distinguish the graft from adjacent normal tissue. Histologic evaluation revealed a biologic acceptance and incorporation of the collagen layers of the graft tissue to the host tissue, without severe inflammatory response. In conclusion, a bilayer artificial dermis is essentially similar to autogeneous free gingival graft in the correction of mucogingival problems, and has the advantages of decreased patient morbidity(no donor site) and availability of abundant amounts of graft material when needed.

전류제어형 PWM컨버터를 이용한 동기발전기용 여자시스템에 관한 연구

장수진,류동균,서민성,김준호,원충연,이진국 성균관대학교 2003 학술회의지원논문목록집 Vol.2003 No.-

동기발전기 출력전압은 여자시스템의 계자전류 제어에 의해 일정하게 유지된다. 고주파 PWM 컨버터(전류제어모드 buck컨버더)형태의 여자시스템은 부하변동이 발생하였을 때 동기발전기의 계자전류를 제어하게 된다. 이 논문은 정상상태 및 과도상태에서의 안정화를 개선하기 위하여 여자시스템의 설계 및 실험에 대해 다루었다. 시뮬레이션 및 실험 결과는 제안된 여자시스템이 50kW 동기발전기의 DVR에 의해 응답시간이 개선되었음을 보여주었다. The output voltage of synchronous generator is regulated constantly by field current control in excitation system. High frequency PWM converter (current control mode buck conveter) type excitation system for synchronous generator is able to control exciter current when the load change happened. This paper deals with the design and evaluation of the excitation system for a synchronous generator to improve the steady state and transient stability. The simulation and experimental results show that the proposed excitation system is able to improve the response time by the DVR(digital voltage regulator) of 5O[kW] synchronous generator.

류마티스 관절염과 전신경화증의 중복증후군 1예

이은지,서광원,유충헌,박봉수,허민영,김지현,김혜란,김동욱 인제대학교 2008 仁濟醫學 Vol.29 No.-

Overlap syndrome is a disease that combines major features of more than one rheumatic disease in the same patient. A 58 year-old female who was diagnosed as rheumatoid arthritis (RA) developed skin thickening and dyspnea. Clinical and laboratory findings revealed that she was affected by systemic sclerosis (SSc) and interstitial lung disease. Finally, she was diagnosed as overlap syndrome consistent with RA combined with SSc. The authors report a case of RA-SSc overlap syndrome with relevant literatures.

Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPARγ agonist-induced adipogenesis

Ryu, Min Jeong,Kim, Soung Jung,Choi, Min Jeong,Kim, Yong Kyung,Lee, Min Hee,Lee, Seong Eun,Chung, Hyo Kyun,Jung, Saet Byel,Kim, Hyun-Jin,Kim, Koon Soon,Jo, Young Suk,Kweon, Gi Ryang,Lee, Chul-Ho,Shong Springer-Verlag 2013 Molecules and cells Vol.35 No.2

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Chung, Hyo Kyun,Ryu, Dongryeol,Kim, Koon Soon,Chang, Joon Young,Kim, Yong Kyung,Yi, Hyon-Seung,Kang, Seul Gi,Choi, Min Jeong,Lee, Seong Eun,Jung, Saet-Byel,Ryu, Min Jeong,Kim, Soung Jung,Kweon, Gi Rya The Rockefeller University Press 2017 The Journal of cell biology Vol.216 No.1

<P>Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and –non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPR<SUP>mt</SUP>), an adaptive stress-response pathway activated by mitochondrial proteotoxic stress. Using mice with skeletal muscle–specific deficiency of <I>Crif1</I> (muscle-specific knockout [MKO]), an integral protein of the large mitoribosomal subunit (39S), we identified growth differentiation factor 15 (GDF15) as a UPR<SUP>mt</SUP>-associated cell–non-autonomous myomitokine that regulates systemic energy homeostasis. MKO mice were protected against obesity and sensitized to insulin, an effect associated with elevated GDF15 secretion after UPR<SUP>mt</SUP> activation. In <I>ob</I>/<I>ob</I> mice, administration of recombinant GDF15 decreased body weight and improved insulin sensitivity, which was attributed to elevated oxidative metabolism and lipid mobilization in the liver, muscle, and adipose tissue. Thus, GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin resistance.</P>

<i>Crif1</i> Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice

Ryu, Min Jeong,Kim, Soung Jung,Kim, Yong Kyung,Choi, Min Jeong,Tadi, Surendar,Lee, Min Hee,Lee, Seong Eun,Chung, Hyo Kyun,Jung, Saet Byel,Kim, Hyun-Jin,Jo, Young Suk,Kim, Koon Soon,Lee, Sang-Hee,Kim, Public Library of Science 2013 PLoS genetics Vol.9 No.3

<▼1><P>Impaired mitochondrial oxidative phosphorylation (OXPHOS) has been proposed as an etiological mechanism underlying insulin resistance. However, the initiating organ of OXPHOS dysfunction during the development of systemic insulin resistance has yet to be identified. To determine whether adipose OXPHOS deficiency plays an etiological role in systemic insulin resistance, the metabolic phenotype of mice with OXPHOS–deficient adipose tissue was examined. Crif1 is a protein required for the intramitochondrial production of mtDNA–encoded OXPHOS subunits; therefore, <I>Crif1</I> haploinsufficient deficiency in mice results in a mild, but specific, failure of OXPHOS capacity <I>in vivo</I>. Although adipose-specific <I>Crif1</I>-haploinsufficient mice showed normal growth and development, they became insulin-resistant. <I>Crif1</I>-silenced adipocytes showed higher expression of chemokines, the expression of which is dependent upon stress kinases and antioxidant. Accordingly, examination of adipose tissue from <I>Crif1</I>-haploinsufficient mice revealed increased secretion of MCP1 and TNFα, as well as marked infiltration by macrophages. These findings indicate that the OXPHOS status of adipose tissue determines its metabolic and inflammatory responses, and may cause systemic inflammation and insulin resistance.</P></▼1><▼2><P><B>Author Summary</B></P><P>Type 2 diabetes is one of the most challenging health problems in the 21<SUP>st</SUP> century. Although insulin resistance is regarded as a fundamental defect that precedes the development of type 2 diabetes, the nature and cause of insulin resistance remain unknown. Adipose tissue is an important organ that determines whole-body energy metabolism, and its dysfunction is a critical element in the development of systemic insulin resistance. Adipose mitochondrial function is suppressed in the insulin-resistant state, and increased adipose mitochondrial biogenesis is associated with the reversal of insulin resistance by a PPARγ agonist. However, despite these important observations, little is known about how mitochondrial respiratory dysfunction in white adipose tissue (WAT) causes insulin resistance. To determine whether adipose deficiency of mitochondrial respiratory capacity plays an etiological role in systemic insulin resistance, the metabolic phenotype of mice with mitochondrial OXPHOS (oxidative phosphorylation)–deficient adipose tissue was examined. Crif1 is a protein required for the translation of mtDNA–encoded OXPHOS subunits. Interestingly, mice haploinsufficient for <I>Crif1</I> in adipose tissue showed reduced OXPHOS capacity and developed marked insulin resistance.</P></▼2>