Prediction of Alzheimer's Pathological Changes in Subjective Cognitive Decline Using the Selfreport Questionnaire and Neuroimaging Biomarkers

홍윤정,박경원,Do-Young Kang,Jae-Hong Lee 대한치매학회 2019 Dementia and Neurocognitive Disorders Vol.18 No.1

Background and Purpose: Subjective cognitive decline (SCD) may be the first symptomaticstage of Alzheimer's disease (AD). Hence, a screening tool to characterize the patients'complaints and assess the risk of AD is required. We investigated the SCD neuroimagingbiomarker distributions and the relevance between the self-report questionnaire andAlzheimer's pathologic changes. Methods: Individuals aged 50 and above with consistent cognitive complaints withoutany objective cognitive impairments were eligible for the study. The newly developedquestionnaire consisted of 2 parts; 10 questions translated from the ‘SCD-plus criteria’and a Korean version of the cognitive failure questionnaire by Broadbent. All the subjectsunderwent physical examinations such as blood work, detailed neuropsychological tests,the self-report questionnaire, brain magnetic resonance imagings, and florbetaben positronemission tomography (PET) scans. Amyloid PET findings were interpreted using both visualrating and quantitative analysis. Group comparisons and association analysis were performedusing SPSS (version 18.0). Results: A total of 31 participants with SCD completed the study and 25.8% showedpositive amyloid depositions. The degree of periventricular white matter hyperintensities(WMH) and hippocampal atrophy were more severe in amyloid-positive SCDs compared tothe amyloid-negative group. In the self-reported questionnaire, the ‘informant's report adecline’ and ‘symptom's onset after 65 years of age’ were associated with more Alzheimer'spathologic changes. Conclusions: Amyloid-positive SCDs differed from amyloid-negative SCDs on WMH,hippocampal atrophy, and a few self-reported clinical features, which gave clues on theprediction of AD pathology.

원자력이용시설 방사성폐기물(목재류) 자체처분 사례 연구

홍윤정,장원혁,김종진,이진우 대한방사선방어학회 2021 대한방사선방어학회 학술발표회 논문요약집 Vol.2021 No.11

Efficacies of Cognitive Interventions in the Elderly with Subjective Cognitive Decline: A Prospective, Three-Arm, Controlled Trial

홍윤정,이재홍,최은지,한노을,김지은,박소희,김형지,강동화 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.2

Background and Purpose A cognitive intervention (CI) is thought to improve cognition and delay cognitive decline via neuronal plasticity and cognitive resilience. Subjective cognitive decline (SCD) might be the first symptomatic stage of Alzheimer’s disease, but few studies have examined the beneficial effect of CIs in SCD. We aimed to determine the efficacy of a 12-week, small-group-based, multidomain CI in elderly patients with SCD. Methods Participants diagnosed with SCD (aged 55–75 years) were consecutively allocated to three groups: group 1, which received group-based CI implementation with lifestyle modifications; group 2, which received home-based lifestyle modifications without CI; and group 3, in which no action was taken. The primary outcome variables were the scores on computerized tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB). The secondary outcomes included scores on tests evaluating general cognition, memory, visuospatial, and executive functions, as well as scores for the quality of life (QoL), anxiety, depression, and degree of subjective complaints. Changes in scores during the study period were compared between groups. Results The study was completed by 56 SCD participants. The baseline characteristics did not differ among the groups. The primary outcomes (CANTAB scores) did not differ among the groups. However, the outcomes for phonemic word fluency, verbal memory, QoL, and mood were better for group 1 than for the other two groups. Improvements in verbal memory function and executive function were related to the baseline cognitive scores and group differences. Conclusions CI in SCD seems to be partially beneficial for executive function, memory, QoL, and mood, suggesting that CI is a useful nonpharmacological treatment option in this population.

동의보감(東醫寶鑑) 외용고(外用膏)에 대한 고찰(考察)

홍윤정,송지청,심현아,금경수,이시형,Hong, Yun-Jung,Song, Ji-Chung,Shim, Hyun-Ah,Keum, Kyung-Soo,Lee, Si-Hyeoung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.3

Objective : The study was performed to investigate prescriptions, herbal drugs, how to make of external ointment treatment in "Dongeuibogam". Method : I will try to find out external ointment treatment in "Dongeuibogam" using a word, Go(膏). Result : 1. The external ointment has been widely used medical diseases as well as sugical diseases. 2. The same prescription name to have different information was written by other people. 3. Various kinds of medicinal herbs, minerals, anlmals were used and type of oil or juice was used to dissolve these. 4. Methods to make the external ointment were to grind medicines or melt medicine. 5. The external ointment was used to put in eyes or to push into wound and rubed the skin. Conclusion : Go(膏) In "Dongeuibogam" are external ointment treatment when they are used at skin. However, they are used as internal medicine in other side so we might be careful to use Go(膏) for medicine.

원자력이용시설 방사성폐기물(목재류) 자체처분 사례 연구

홍윤정,장원혁,김종진,이진우 대한방사선방어학회 2021 대한방사선방어학회 학술발표회 논문요약집 Vol.2021 No.11

카보닐 계열의 배출 특성과 그에 따른 악취 발생 기여도비교 연구: 반월공단내 주요 산업시설물들을 중심으로

홍윤정,전의찬,김기현 한국대기환경학회 2006 한국대기환경학회지 Vol.22 No.5

The carbonyl compounds in the atmosphere belong to one of the regulatory pollutants for the malodor controldesignated by the Korean Ministry of Environment (KMOE). In the present study, the emission concentrationlevels of carbonyl compounds were measured along with a number of criteria odor pollutants from a total of 47individual companies (June 2004 to January 2005). The results of our study showed that a number of carbonylcompounds(such as formaldehyde, acetaldehyde, acetone, and butyraldehyde) maintained signicantly high meanconcentrations of 298 to 372ppb. In contrast, other carbonyl compounds were low enough with the mean valves of0.54 to 19.1 ppb. It was found that except for such industries as metal production or leather processing, theiremissions were generally quite significant. If the measured values were evaluated in terms of malodor intensity,butyraldehyde appeared to be the most significant contributor to the malodor release. According to themeasurements made in strong source areas, it can be concluded that several carbonyl compounds (acetaldehyde,propionaldehyde, butyraldehyde, isovaleraldehyde, and valeraldehyde) are useful enough to diagnose malodorrelease from those source areas. It should also be addressed that a number of carbonyl compounds added newly asthe result of malodor control legislation were not sensitive enough to diagnose malodor release from such sources.

국내 남성 패션 유튜버 및 패션 콘텐츠 특성 연구

홍윤정 한국패션비즈니스학회 2022 패션 비즈니스 Vol.26 No.1

This study analyzed characteristics of domestic male fashion YouTubers and fashion contents in accordance with the need to analyze various content demands and testes of male consumers in the fashion industry. Using literature research and fashion expert evaluation, characteristic factors of fashion YouTubers were derived and the popular content of fashion YouTubers was classified by subject to analyze contents according to characteristics of YouTubers. Based on literature research, ten representative male fashion YouTubers were evaluated by fashion experts. Characteristics of male fashion contents in Korea were derived from attractiveness-friendliness, friendliness, professionalism-friendliness, and expertise. Contents of male fashion YouTubers were mainly composed of styling contents that could feed back daily looks, fashion-related information contents, and Vlogs. They mainly dealt with daily fashion coordination evaluation made by YouTubers. Based on the proportion of fashion information easily accessed by ordinary men through single fashion item’s recommendations, shopping know-how or styling tip was mainly dealt with. This study was significant in that it analyzed characteristics and contents of male fashion YouTubers according to the need to analyze various content demands and tastes of male consumers who have recently emerged as an important consumer group in the fashion industry.

榴亭 趙東祐 硏究

洪閏晶 동선사학회 1992 성신사학 Vol.10 No.-

CERREX 소프트웨어를 이용한 KRR-1의 해체비용평가

홍윤정,박승국,박희성,박국남,최윤동,박장진 한국방사성폐기물학회 2016 한국방사성폐기물학회 학술논문요약집 Vol.2016 No.10

영리병원을 둘러싼 쟁점에 대한 연구 : 옹호연합모형(ACF: Advocacy Coalition Framework)을 적용하여

홍윤정 이화여자대학교 법정대학 행정학과 2013 梨花行政 Vol.- No.18

본 연구는 국내 영리병원 도입을 둘러싼 쟁점의 경과를 옹호연합모형 (ACF: Advocacy Coalition Framework)를 적용하여 살펴보고자 한다. 다소 안정적인 외적 변수로 문제영역의 속성은 보건의료에 대한 정부 지원의 낮은 수준, 행위별 수가제 등 병원의 영리추구를 유도하는 한국 보건의료계의 실태, 사회문화적 가치는 의료공공성과 민영화의 가치를, 기본적 법적 구조는 경제자유구역의 지정 및 운영에 관한 특별법 및 제주특별자치도 설치 및 국제자유도시 조성을 위한 특별법을 제시하고 있다. 역동적 외부 사건으로 사회경제적 조건의 변화는 한국에서 지속적으로 있어 왔던 병원 시장의 고급화・대형화 경쟁의 최근 드러난 한계를, 지배집단의 변화는 신정부 집권과 정책 집행주력 부처의 변화를, 그리고 다른 하위체제로부터의 정책결정 및 영향은 소자본 의료계 중심의 영리병원 추진 움직임 등을 들고 있다. 그런데, ‘여론의 변화’에 있어서 여론 자체는 사실상 변화한 적은 없지만, 여론을 수렴하는 과정에서 정부의 개입이 있었고 그래서 명확하게 합의된 국민의 의견이 공식적으로 발표된 역사가 길지 않기 때문에 이에 대해 단정적으로 다루지 않고 불가피하게 혼란이 있는 영역으로 남겨 두었다. 다음으로 외적 변수와 정책 하위체제를 연결시키는 연합기회구조에 대해 설명하고, 이어서 큰 정부 옹호연합과 작은 정부 옹호연합의 형성과 신념체계를 설명하고 있다. 양 연합의 활동과 정책중개자의 역할을 알아 본 뒤, 정책학습에서는 양 영합의 극단적인 의견대립으로 인해 내부지향적 정책학습이 행해지고 상대방 진영을 포함하는 정책학습이 일어나지 않음을 파악할 수 있었다. 정책산출은 협상에 의한 합의 중 교착상태(a hurting stalemate)에 의한 정책산출과 외부충격에 의한 정책산출로 나누어 보고 있다. 결론적으로, 신념이 이해관계에 못지 않은 중요한 단위로 이해되어야 함을 시사해주고 있는 ACF 모형 에 의한 영리의료법인 도입을 둘러싼 쟁점의 분석은 그 나름대로의 유용성을 발견할 수 있었으나 다른 기법과의 병행 실시에도 관심을 기울여야 한다는 것과 더 나아가 한국적 특성에 맞는 모델 수정이 필요함을 나타내고 있다.