의장출원의 동향분석

하문수 한국발명진흥회 1984 發明特許 Vol.9 No.9

신문기업의 현실성에 관한 소고

하문수 중앙대학교 정경대학 신문방송학회 1972 신문방송연구 Vol.2 No.-

적층형 세라믹 액츄에이터의 세라믹-전극간 계면이 전기적 특성에 미치는 영향에 대한 연구

하문수,정순종,송재성,이재신 한국전기전자재료학회 2002 전기전자재료학회논문지 Vol.15 No.10

The polarization and strain behavior of multilayer ceramic actuators fabricated by tape casting using a PNN-PZT ceramics were investigated in association with electrode size and internal layer number. Spontaneous polarization and strain decreased with increasing electrode size. In addition, the increase of internal layer number brought reduced spontaneous polarization and increased the field-induced strain. Because the actuators structure is designed to stack ceramic layer and electrode layer alternatively, the ceramic-electrode interfaces may act as a resistance to motion of domain wall. To analyze the effect of ceramic-electrode interface, the diffraction intensity ratio of (002) to (200) planes was calculated from X-ray diffraction patterns of samples subjected to a voltage of 200 V. The diffraction intensity ratio of (002) to (200) planes was decreased with increasing electrode size and internal layer number. The diffraction intensity ratio and straining behavior analyses indicate that the Polarization and strain were affected by the amount of 90°domain decreasing with increasing electrode size and internal layer number. Consequently, the change of polarization and displacement with respect to electrode size and layer number is likely to be caused by readiness of the domain wall movement around the interface.

복압성요실금 환자에서 TVT-O와 Monarc 술식의 단기 치료 성적 비교

이소연,하문수,김태흥,신형오,이신영,김태형 대한배뇨장애요실금학회 2008 International Neurourology Journal Vol.12 No.2

Puropose: Transobturator sling is a new minimally invasive treatment for female stress urinary incontinence. We compared the efficacy and safety of the two procedures, Monarc and TVT-O. Material and methods: We included 110 patients with stress urinary incontinence who underwent the Monarc (n=52) or TVT-O (n=58) procedure and followed up at least for 1 year. Preoperative evaluations, the indices of voiding and postoperative complication were investigated. They were analyzed by Student's t-test, Paired t-test and chi-square test. Results: There were no significant difference in the preoperative patients' characteristics, postoperative complication and success rate between the two groups. The preoperative and postoperative storage symptoms between two groups had no significant difference but the patients of both groups had significant improvement in storage symptoms such as frequency and urgency after surgery. Conclusions: The Monarc and TVT-O is equally effective and safe procedures as a treatment method of female stress urinary incontinence. (J Korean Continence Soc 2008;12:163-8)

Low-dose versus standard-dose bacille Calmette–Guérin for non-muscle-invasive bladder cancer: Systematic review and meta-analysis of randomized controlled trials

최세영,하문수,김정훈,지병훈,김진욱,장인호,김태형,명순철 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.2

Purpose: Intravesical BCG (bacille Calmette–Guérin) instillation in patients with non-muscle-invasive bladder cancer decreases the risk for tumor recurrence and progression. After one BCG product was discontinued, a chronic global BCG shortage occurred. We focused on identifying a reduced dose of BCG that could maintain efficacy and reduce adverse effects. Materials and Methods: We conducted a comprehensive literature search of PubMed, Embase, the Cochrane Library, CINAHL, Web of Science, and Scopus to identify randomized controlled trials through April 2021. The odds ratios (ORs) and 95% confidence intervals (CIs) for the low and standard doses in nine studies were compared. A low dose was defined as a low volume of BCG compared with the standard BCG dose (Armand Frappier, 120 mg; Connaught, 81 mg; Danish 1331, 120 mg; modified Danish 1331, 120 mg; Tokyo 172, 80 mg). Results: The low-dose group experienced aggravated recurrence (OR, 1.45; 95% CI, 1.09–1.94; p=0.01) but similar progression (OR, 1.11; 95% CI, 0.76–1.62; p=0.59), similar cancer-specific survival (OR, 1.02; 95% CI, 0.60–1.75; p=0.93), similar overall survival (OR, 1.09; 95% CI, 0.76–1.56; p=0.65), favorable adverse effects (OR, 0.41; 95% CI, 0.28–0.62; p<0.0001), and favorable withdrawal (OR, 0.42; 95% CI, 0.25–0.71; p=0.001). Conclusions: Low-dose BCG had more unfavorable outcomes than did standard-dose BCG in terms of recurrence. Tumor progression, cancer-specific survival, and overall survival were similar between the doses. Low-dose BCG improved adverse effects and withdrawal. In the setting of BCG shortage, low-dose BCG may have strong potential as an alternative.

Warfarin-Induced Penile Necrosis in a Patient with Heparin-Induced Thrombocytopenia

장인호,하문수,지병훈,권용욱,이상재 대한의학회 2010 Journal of Korean medical science Vol.25 No.9

A 56-yr-old man with lung adenocarcinoma presented with subsegmental pulmonary thrombosis. Platelet count on presentation was 531×109/L. The patient was anticoagulated with subcutaneous low molecular weight heparin (LMWH). Next day, oral anticoagulation was initiated with 5 mg of warfarin once daily with LMWH and LMWH was discontinued at third hospital day. On the third day of oral anticoagulation therapy, he complained of left leg swelling and prolonged painful penile erection of 24 hr-duration. His platelet count reached a nadir 164×109/L at that time, and the patient had a deficiency of protein C and S,with an activity level of 16% and 20% of normal value. Warfarin was stopped and he underwent penile aspiration. The next day, left leg edema and penile erection was disappeared, but penile and glans penis necrosis was started. This case illustrates that processes underlying heparin-induced thrombocytopenia (HIT) may also underlie warfarininduced skin necrosis.

토끼에서 알파 환원효소억제제 (5-alpha Reductase Inhibitor)의 단기투여가 음경해면체 및 정낭조직의 수축이완과 정액성상에 미치는 영향: 예비연구

이신영,김세철,하문수,응웬 하이박,이주형,이장희,명순철 대한남성과학회 2011 The World Journal of Men's Health Vol.29 No.1

Purpose: Adverse sexual experiences such as erectile dysfunction (ED), loss of libido, and ejaculation disorders have been consistent side effects of 5-alpha reductase inhibitors (5ARI). The aim of this study was to evaluate the effects of 5ARI (finasteride) treatment on semen parameters and contraction of the corpus cavernosum and seminal vesicles in male rabbits. Materials and Methods: Adult male New Zealand White rabbits (n=10) were randomized into 2 groups: finasteride-treatment (5ARI) group and vehicle-treatment (control) group. The 5ARI group received daily oral finasteride (10 mg/day) by gavage for 4∼6 weeks, and the control group received the same concentration of the vehicle. The semen volume and semen parameters between the 2 groups were compared; thereafter, contraction or relaxation responses of smooth muscle strips of the corpus cavernosum and seminal vesicles were observed in an organ bath. Results: Semen magnesium (14.2 vs 5.1 mg/dl) and protein (2.2 vs 1.6 g/dl) concentrations were significantly lower in the 5ARI group than in the control group. The concentrations of other parameters such as electrolytes (Na/K/Cl), fructose, and citrate did not differ between the 2 groups. The contractile responses to norepinephrine (NE) significantly increased in the 5ARI group compared to the control group and the relaxation responses to acetylcholine (ACh) or sodium nitroprusside (SNP) also increased in the 5ARI group. The contractile responses of the seminal vesicular strips to NE significantly decreased in the 5ARI group compared with the control group. Conclusions: The results suggest that finasteride may decrease contraction of seminal vesicle tissue and alter semen parameters. The effect of finasteride on erectile tissue was double-faced; enhancing both contraction and relaxation. Further study is needed in this respect.

저온소성 마이크로파 유전체 세라믹스 복합체의 Tape Casting특성

이우석,김창환,하문수,정순종,송재성,류봉기,Lee, Woo-Suk,Kim, Chang-Hwan,Ha, Mun-Su,Jeong, Soon-Jong,Song, Jae-Sung,Ryu, Bong-Ki 한국세라믹학회 2005 한국세라믹학회지 Vol.42 No.2

마이크로파 유전체 세라믹스 $BaO-Nd_{2}O_3-TiO_{2}(BNT)$계 상용분말과 PbO-base의 결정화 유리프릿 복합체를 출발원료로 하여 테입 케스팅법으로 그린시트를 제초하기 위해 첨가유기물의 조성 변화에 따른 슬러리의 분산특성 및 유동특성 그리고 최종그린시트의 그린/소결밀도 변화를 연구하였다. 분산제량의 증가는 분산에 유효하였으나, 일정량 이상이 첨가되면 분산을 저해하는 요인으로 작용하였으며 복합체 분말에 1.75 wt$\%$의 fish oil을 첨가하였을 때 분산특성이 가장 우수하였다 준비된 모든 조성의 슬러리에서 의가소성거동(shear thinning)이 나타났고 파우더, 바인더 그리고 유기물의 전체 함량이 증가할수록 상대점도는 증가하는 경향을 나타내었다. 복합체 분말과 용매의 비율 65 : 35, 결합제는 6 wt$\%$, 가소제는 3 wt$\%$에서 테이프의 특성이 가장 우수하였다. 이때 슬러리의 점도는 677cps, 그린/소결밀도는 $3.3g/cm^3,\;5.56g/cm^3$로 각각 나타났다. Sintering behavior of $BaO-Nd_{2}O_3-TiO_2$ with a Pb-based glassceramics frit were investigated in order to understand an effect of glassceramics as a low temperature sintering agent on dielectric ceramics. A green sheet form was fabricated through tape casting method with the glassceramic fut added $BaO-Nd_{2}O_3-TiO_2$. The dispersion properties, rheological properties and final density of dielectric composit slurry as a function of amount and composition of organic additives was examined. The dispersants' addition was effective in controlling dispersion of the ceramics in solution. The addition of excessive dispersant showed adverse effect on dispersion. The prepared slurries, containing ceramic : powders, glass-ceramics and various kinds of organic viechles, exhibited typical shear thinning behavior. The best properties of tape casting appeared powder to solvent ratio 65 : 35 and amount of the binder 6 wt$\%$ and plasticizer 3 wt$\%$. The viscosity of the slurry was 677 cps and green/sintered density in the tape was $3.3 g/cm^3,\;5.56 g/cm^3$ respectively.

촉매를 이용한 반도체가스의 처리용량 측정연구 ( The Treatment Capacity of a Catalytic Scrubber for Semiconductor Gas )

한상욱,이진홍,김진석,오상협,하문수 한국대기환경학회 2000 한국대기환경학회 학술대회논문집 Vol.- No.-

무연 압전 액츄에이터의 신뢰성 평가 연구

문상호,함용수,고중혁,하문수,정순종 한국세라믹학회 2009 세라미스트 Vol.12 No.5