정보화시대를 대비한 화학공학 데이터베이스

최윤정,양대륙 ( Y . J . Choi,D . R . Yang ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.2

MR 댐퍼를 적용한 불안정판에서 하지 근력 훈련이 근 활성도에 미치는 영향 분석

최윤정,박용군,권대규,김동욱,김정자,김남균,Choi, Y.J.,Piao, Y.J.,Kwon, T.K.,Kim, D.W.,Kim, J.J.,Kim, N.G. 대한의용생체공학회 2007 의공학회지 Vol.28 No.5

Adequate postural control depends on the spatial and temporal integration of vestibular, visual, and somatosensory information. Especially, the musculoskeletal function is essential to maintain the postural control. The experimental studies was performed on the muscular activities in the lower extremities during maintaining and moving exercises on an unstable platform with Magneto Rheological(MR) dampers. The unstable platform of the developed system was controlled by electric currents to the MR dampers. A subject executed the maintaining and moving exercises which are presented through the display monitor. The electromyographies of the eight muscles in lower extremities were recorded and analyzed in the time and the frequency domain: the muscles of interest were rectus femoris(RF), biceps femoris(BF), tensor fasciae latae(TFL), vastus lateralis(VL), vastus medialis(VM), gastrocnemius(Ga), tibialis anterior(TA), Soleus(So). The experimental results showed that the muscular activities differed in the four moving exercises and the nine maintaining exercises. For the anterior-posterior pattern, the TA showed highest activities; for the left-right pattern, the TFL; for the 45, $-45^{\circ}$ pattern, the TFL and TA. Also, the rate of the increase in the muscular activities were affected by the condition of the unstable platform with MR dampers for the maintaining and moving exercises. The experimental results suggest that the choice of different maintaining and moving exercises could selectively train different muscles in various intensity. Futhermore, the findings suggested that the training using this system can improve the ability of postural control.

경계범주 자동탐색에 의한 확장된 학습체계 구성방법

최윤정,지정규,박승수,Choi, Yun-Jeong,Jee, Jeong-Gyu,Park, Seung-Soo 한국정보처리학회 2009 정보처리학회논문지B Vol.16 No.6

본 논문은 기존의 목표항목만을 위주로 한 학습체계에서 발생하는 오분류 문제의 해결을 위해 기존의 학습체계에 경계항목을 자동으로 탐 색하여 포함시켜 확대시키는 방법을 제안하고 있다. 여러 주제에 걸쳐 다양한 내용을 다루는 복잡한 문서들은 확실히 어느 범주로 분류해야 할 지 판가름하기 어려운 성질인 모호성이 강하다. 이러한 경우 모든 경우들을 정확히 구분할 수 있는 최적의 경계를 찾는 일은 더욱 어려운 일이 다. 복잡하고 불확실성이 높은 데이터들의 특징은 대부분 분류 경계영역에 위치하므로 이러한 분류경계의 데이터들을 새로운 학습 항목으로 인 식시키도록 하는 것이 필요하다. 본 연구에서는 주어진 목표항목 사이의 경계항목을 자동으로 탐색하여 학습체계에 추가하는 학습 체계 확장 알고리즘을 제시하고, 의도적인 학습오류를 발생시킨 후 기존방법과의 비교실험을 수행함으로써 제안방법의 정확성과 안정성을 비교하였다. 실 험결과 경계범주를 포함하여 학습 체계를 확장시켰을 때의 예측력은 기존 0.70에서 0.86으로 약 24% 향상 되었고, 오류를 포함시켰을 때의 예 측력은 기존 0.52에서 0.79로 약 49% 향상되었다. This paper shows a reinforced construction scheme of training data for improvement of text classification by automatic search of boundary category. The documents laid on boundary area are usually misclassified as they are including multiple topics and features. which is the main factor that we focus on. In this paper, we propose an automated exploring methodology of optimal boundary category based on previous research. We consider the boundary area among target categories to new category to be required training, which are then added to the target category sementically. In experiments, we applied our method to complex documents by intentionally making errors in training process. The experimental results show that our system has high accuracy and reliability in noisy environment.

논문편 : 소형아파트의 방위에 따른 실내온열환경 실태와 평가

최윤정,윤정숙 ( Yoon Jung Choi,Chung Sook Yoon ) 대한가정학회 1993 Human Ecology Research(HER) Vol.31 No.3

시료 희석 직접 주입 LC-MS/MS를 이용한 법화학 수용액 시료 중 카페인 신속 분석

최윤정,김희승,인문교,김진영,Choi, Yun Jeong,Kim, Hee Seung,In, Moon Kyo,Kim, Jin Young 대한약학회 2016 약학회지 Vol.60 No.3

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of caffeine in forensic aqueous sample. The centrifuged sample ($100{\mu}l$) was diluted 50-fold with distilled water. The diluted sample ($400{\mu}l$) was then diluted further with $200{\mu}l$ of 0.1% formic acid solution and $400{\mu}l$ of acetonitrile containing 500 ng of caffeine-(3-methyl-$^{13}C_3$) prior to LC-MS/MS analysis. The mobile phase was composed of 0.1% formic acid in distilled water (A) and acetonitrile (B). Chromatographic separation was performed by using a Zorbax SB-C18 ($100mm{\times}2.1mm$ i.d., $3.5{\mu}m$) column and caffeine was eluted within 1.1 min. Linear least-squares regression with a 1/x weighting factor was used to generate a calibration curve with the coefficients of determination ($r^2=0.9983$). The lower limit of quantification was $25ng/ml$ for the analyte. The process efficiency was 98.6~100.1%. Intra- and inter-day precisions were not more than 2.1% and 1.7%, while intra- and inter-day accuracies were ranged from -6.8 to 4.5%, respectively. The suitability of the method was examined by analyzing unknown forensic aqueous samples.

사군자탕(四君子湯) 및 사물탕(四物湯)이 methotrexate로 유도(誘導)된 흰쥐의 면역기능저하(免疫機能低下)에 미치는 영향(影響)

최윤정,김장현,Choi Yun-Jung,Kim Jang-Hyun 대한한방소아과학회 1999 대한한방소아과학회지 Vol.13 No.1

The effects of Sagunjatang and Samultang on the immunosuppression induced by methotrexate(MTX) in rats were investigated in this study. The multiple parameters of immunity assessed in each rats included leukocyte count, lymphocyte rate, the number of lymphocyte in tibial bone marrow, contact hypersensitivity to DNFB, morphological change of thymocyte and IgG antibody on SDS-PAGE. Sprague-Dawley male rats were used and divided into five groups at random. Group A was normal control. Group B, the MTX treatment control, was injected i.v. with 2mg/kg of on days 9, 11 after sensitization with SRBC on 5th day. Group C, the experimental control, was treated Sagunjatang for 18days and MTX. Group D was treated Samultang for 18days and MTX. Group E was treated Sagunjatang-Samultang for 18days and MTX. The dosage of Sagunjatang and Samultang was $1m{\ell}/day$ respectively. In the case of Group E, rats Were fed Sagunjatang $1m{\ell}$ in the morning and Samultang $1m{\ell}$ in the afternoon. The results are summarized as follows: 1. Leukocyte count in rats induced by intravenous sensitization with SRBC was decreased significantly in Group E. 2. Leukocyte counts of 2weeks later after being treated MTX were increased significantly in Groups C and D. 3. Lymphocyte rate in rats induced by intravenous sensitization with SRBC wasn't changed significantly in all the experimental groups. 4. Lymphocyte rate of 2weeks. later after being treated MTX was increased significantly in Group D. 5. The number of lymphocyte in tibial bone marrow was incereased significantly in Group C. 6. Contact hypersensitivity wasn't changed significantly in all the experimental groups. 7. Morphological finding of thymocyte in group C was similar to normal group as compared with control group. 8. Purified IgG of all the experimental groups showed two bands of 50,000 and 25,000 on SDS-PAGE. But there was no difference among experimental groups.

학습방법개선과 후처리 분석을 이용한 자동문서분류의 성능향상 방법

최윤정,박승수,Choi, Yun-Jeong,Park, Seung-Soo 한국정보처리학회 2005 정보처리학회논문지B Vol.12 No.7

자동문서분류는 문서의 내용에 기반하여 미리 정의된 항목에 자동으로 할당하는 작업으로서 효율적인 정보관리 및 검색등에 필수적인 작업이다. 기존의 문서분류성능 향상을 위한 연구들은 대부분 분류모델 자체를 개선시키는 데 주력해왔으며 통계적인 방법으로 그 범위가 제한되어왔다. 본 연구에서는 자동문서분류의 성능향상을 위해 데이터마이닝 기법과 결함허용방법을 이용하는 개선된 학습알고리즘과 후처 리 방법에 의한 RTPost 시스템을 제안한다. RTPost 시스템은 학습문서 선택작업 이전에 분류항목 설정의 문제를 다루며, 분류함수의 성능보다는 지정방식의 문제점을 감안하여 학습과 분류 후처리 프로세스를 개선하려는 것이다. 이를 통해 분류결과에 중요한 영향을 미쳐왔던 학습문서의 수와 선택방법, 분류모델의 성능등에 의존하지 않는 안정적인 분류가 가능하였고, 이를 분류오류율이 높은 경계선 인접영역에 위치한 문서들에 적용한 결과 높은 정확율을 얻을 수 있었다. 뿐만 아니라, RTPost 프로세스를 진행하는 동안 능동학습방법의 장점을 수용하여 학습효과는 높이며 비용을 감소시킬 수 있는 자가학습방법(self learning)방법의 효과를 기대할 수 있다. Automated text categorization is to classify free text documents into predefined categories automatically and whose main goals is to reduce considerable manual process required to the task. The researches to improving the text categorization performance(efficiency) in recent years, focused on enhancing existing classification models and algorithms itself, but, whose range had been limited by feature based statistical methodology. In this paper, we propose RTPost system of different style from i.ny traditional method, which takes fault tolerant system approach and data mining strategy. The 2 important parts of RTPost system are reinforcement training and post-processing part. First, the main point of training method deals with the problem of defining category to be classified before selecting training sample documents. And post-processing method deals with the problem of assigning category, not performance of classification algorithms. In experiments, we applied our system to documents getting low classification accuracy which were laid on a decision boundary nearby. Through the experiments, we shows that our system has high accuracy and stability in actual conditions. It wholly did not depend on some variables which are important influence to classification power such as number of training documents, selection problem and performance of classification algorithms. In addition, we can expect self learning effect which decrease the training cost and increase the training power with employing active learning advantage.

공분산분석에서 선형위치통계량을 이용한 비모수 검정법

최윤정,김동재,Choi, Yoonjung,Kim, Dongjae 한국통계학회 2017 응용통계연구 Vol.30 No.3

공변량(covariate)이 존재하는 경우, 각 처리군 간 효과의 차이를 검정하기 위한 대표적인 비모수적 방법에는 Quade (1967)가 제안한 검정법이 있다. 또한 반응변수에 대해 공변량으로 단순선형회귀분석을 실시하여 얻은 잔차에 대해 일원배치분산분석과 Kruskal Wallis가 제안한 방법을 적용하는 방법, 그리고 Hwang과 Kim (2012)이 제안한 비모수적 도구인 위치(placement)를 이용한 방법이 있다. 본 논문에서는 공분산분석 모형에서 Hwang과 Kim (2012)이 제안한 방법을 확장하여 공분산분석에서의 새로운 방법을 제안하였다. 또한 모의실험(Monte Carlo simulation study)을 통하여 기존의 검정법들과 제안한 방법의 검정력을 비교하였다. Quade (1967) proposed RANK ANCOVA, which is a nonparametric method to test differences between treatments when there are covariates. Hwang and Kim (2012) also proposed a joint placement test on covariate-adjusted residuals. In this paper, we proposed a new nonparametric method to control the effect of covariate on a response variable that uses linear statistics on covariate adjusted-residuals. The score function used in the linear statistics was proposed by Jeon and Kim (2016). Monte Carlo simulation is also conducted to compare the empirical powers of the proposed method with previous methods.

증식성 근막염의 세침흡인 세포학적 소견

최윤정,이상엽,양우익,정순희,이광길,Choi, Yoon-Jung,Yi, Sang-Yeop,Yang, Woo-Ick,Jung, Soon-Hee,Lee, Kwang-Gil 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.1

Proliferative fasciitis is a benign pseudosarcomatous mesenchymal lesion occurring in the subcutis. The lesion occurs clinically as a tumorous mass that develops within a rather short time in elderly patients. We recently experiecened a case of fine needle aspiration cytology of proliferative fasciitis in the left anterior chest wall of a 72 year-old male patient. The smear revealed two types of cells. One was the large and mostly oval cell with one or two nuclei lying at the periphery of the cell body and abundant basophilic cytoplasm like the ganglion cell. The nuclei were round to oval, had vesicular chromatin and contained prominent nucleoli. The other was the spindle shaped fibroblast with an oval nucleus. The differential diagnosis includes a true tumor such as ganglioneuroma, rhabdomyosarcoma, and liposarcoma and therefore fine needle aspiration cytology is very much indicated in order to exclude these possibilities.

고압동결고정을 이용한 애기장대 줄기의 cryo-SEM 분석법

최윤정,이경환,제아름,채희수,장지훈,이은지,권희석,Choi, Yun-Joung,Lee, Kyung-Hwan,Je, A-Reum,Chae, Hee-Su,Jang, Ji-Hoon,Lee, Eun-Ji,Kweon, Hee-Seok 한국현미경학회 2012 Applied microscopy Vol.42 No.2

The scanning electron microscopy is an ideal technique for examining plant surface at high resolution. Most hydrate samples, however, must be fix and dehydrate for observation in the scanning electron microscope. Because the microscopes operate under high vacuum, most specimens, especially biological samples, cannot withstand water removal by the vacuum system without morphological distortion. Cryo-techniques can observe in their original morphology and structure without various artifacts from conventional sample preparation. Rapid cooling is the method of choice for preparing plant samples for scanning electron microscopy in a defined physiological state. As one of cryo-technique, high-pressure freezing allows for fixation of native non-pretreated samples up to $200{\mu}M$ thick and 2 mm wide with minimal or no ice crystal damage for the freezing procedure. In this study, we could design to optimize structural preservation and imaging by comparing cryo-SEM and convention SEM preparation, and observe a fine, well preserved Arabidopsis stem's inner ultrastructure using HPF and cryo-SEM. These results would suggest a useful method of cryo-preparation and cryo-SEM for plant tissues, especially intratubule and vacuole rich structure.