운동신경원성 질환을 동반한 전측두엽 치매 1례

최성혜,나덕렬,김병준,이정일,서연림,김상은 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

치매환자들의 운전실태: 노인성치매임상연구센터 연구

최성혜,이지욱,김수정,최준용,권지원,윤병남,김종헌,윤보라,양영순,김상윤,정지향 대한치매학회 2014 Dementia and Neurocognitive Disorders Vol.13 No.4

Background: There are few studies about driving and dementia in Korea. The purpose of this study is to investigate the real condition of automobile driving in patients with dementia and the characteristics of those who continue to drive after diagnosis of dementia. Methods: A total of 4,377 patients including 3,792 with Alzheimer’s disease and 585 with vascular dementia were recruited from multiple nationwide hospitals. Clinical evaluations and neuropsychological tests were done in them according to the protocol of the Clinical Research Center for Dementia of South Korea study. Caregivers replied which patients drove an automobile, gave up driving, or has never driven. The same evaluations of them were followed after one year. Results: There were 272 (6.2%) drivers, 321 (7.3%) ex-drivers, and 3,784 (86.5%) non-drivers with dementia. Drivers with dementia were younger and had higher Korean Mini-Mental State Examination (K-MMSE) (21.5±4.3 vs 19.8±5.1 vs 17.4±5.2, p<0.001) and lower Clinical Dementia Rating scale-Sum of Boxes (CDR-SB) scores (4.08±2.15 vs 5.80±3.41 vs 5.83±3.39, p<0.001) compared with ex-drivers and non-drivers with dementia. The drivers and ex-drivers with dementia had higher educational level and a higher proportion of male compared with non-drivers with dementia (77.6% vs 80.1% vs 23.3%, p<0.001). About 54.6% of the drivers with dementia continued to drive at one year after diagnosis of dementia. They had higher K-MMSE (23.2±3.6 vs 20.8±4.5, p=0.003) and lower CDR-SB scores (3.30±1.47 vs 4.40±1.85, p=0.001) at baseline compared with those who quitted driving after baseline. Conclusions: Male patients who were relatively young and had high educational level and mild dementia had a tendency to drive an automobile at that time of diagnosis of dementia. About half of them continued to drive after diagnosis of dementia.

소형무장헬기 탑재 표적획득추적장비의 표적좌표 성능개선

최성혜,윤시영,김미정,김병훈 한국항공우주학회 2013 한국항공우주학회 학술발표회 논문집 Vol.2013 No.4

소형무장헬기와 같은 공격형헬기의 표적획득 추적장비는 공대공 또는 공대지 공격을 위해 목표물의 정밀한 좌표를 제공하는 것이 중요하다. 본 논문에서는 기존의 전자광학장비가 적용했던 체계 GPS/INS로 헬기자세를 보상하여 표적시선을 측정하는 방법과 최신장비에 적용되고 있는 내부김발에 IMU를 장착하여 표적시선을 직접 측정하는 방법의 오차모델을 비교하여 표적좌표 정확도의 개선정도를 확인하였다. The TADS(Target Aquisition and Designation System) mounted on the Light Armed Helicopter have to provide precise target locations to the Command & Control System. The existing EO/IR system calculated the target location using the target LOS(line of sight) that is obtained by gimbal angles for body axis and helicopter attitudes received from the platform GPS/INS. In the latest system, the target LOS directly is measured by on-gimbal IMU. In this paper, we analysis the target location error models of these systems and compare their performances.

혈관성 치매에서의 간단한 인지기능 평가 방법

최성혜 대한뇌졸중학회 2000 Journal of stroke Vol.2 No.2

혈관성치매에는 여러 아유형(subtype)이 있다. 그 중의 하나로서 Multi-infarct dementia는 territory infarction이 반복되어 발생하는 혈관성 치매이다[1]. 따라서 territory infarction의 위치에 따라 다양하게 나타나고‘patch’한 임상 양상을 보인다[2]. 연구자들은 단일 뇌경색으로도 치매가 발생할 수 있음을 보고하였고 이를 Single strategic infarct dementia라 명명하였다[3]. Single strategic infarct dementia도 뇌손상 부위에 따른 각기 독특한 임상 양상을 보인다[2]. 이에 비해 subcortical vascular dementia (VaD)는 기전, 뇌손상의 부위, 그리고 임상양상에 비교적 동질성을 보인다. Small vessel disease로 인하여 lacunar infarcts (lacunar state)과 ischemic white matter lesions (Binswanger type)이 발생하여 신경심리학적으로 집행기능(executive function)의 이상과 기억력 저하를 가져온다[4]. 일본에서 연구된 자료를 보면 혈관 성치매 환자 중 subcortical VaD가 5 2 %로 가장 흔한 아유형이었다[5]. 우리 나라에서 혈관성치매의 아유형별로 분포가 조사된 역학 자료는 없지만 일본과 유사하리라 판단된다. 따라서 본 글에서는 혈관성 치매의 한 아유형인 subcortical VaD에 초점을 맞추려 한다. Korean Journal of Stroke 2000;2(2): 126~130

단축형 Samsung Dementia Questionnaire (S-SDQ)의 개발과 타당도 평가

최성혜,나덕렬,오경미,박병주 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

효율적인 Fuzzy 규칙 선택 메카니즘에 관한 연구

최성혜,정환묵 대구효성가톨릭대학교 응용과학연구소 1993 응용과학연구논문집 Vol.2 No.-

In this paper, we study the fuzzy logic function that are represent a infinite multi-valued logic function. The infinite multi-valued logic function takes a truth value of proposition in fuzzy set of close interval[0,1]. Assuming that the Boolean function is the number system of modulus-2, the infinite multi-valued logic fouction is expanded the number system of modulus-M. Using the concept off the differential of extended Boolean function, we study of the properties and differentiations of fuzzy logic function, the structure of the function is analyzed. Finally, it shown that the proposed fuzzy logic function is an efficient rule selection method for fuzzy reasoning.

Samsung Dementia Questionnaire의 타당도와 신뢰도 평가

최성혜,나덕렬,강연욱,이원용,박병주 대한신경과학회 1998 대한신경과학회지 Vol.16 No.3

한국판 Global Deterioration Scale의 타당도

최성혜,나덕렬,이병화,함동석,정지향,정용,구은정,하충건,안성신 대한신경과학회 2002 대한신경과학회지 Vol.20 No.6

치매 환자들의 행동심리적 증상의 평가 도구

최성혜 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1

The behavioral and psychological symptoms of dementia (BPSD) are often treatable. BPSD changes as the dementias progresses, requiring reevaluation and implementation of new interventions in the course of the illness. The principal instruments for assessment of BPSD currently in use include Neuropsychiatric Inventory (NPI), BEHAVE-AD, and Behavior Rating Scale for Dementia (BRSD) of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). They are scored on the basis of information provided by the caregiver who is familiar with the subject. The NPI addresses delusions, hallucinations, agitation/aggression, depression/dysphoria, anxiety, euphoria/elation, apathy/indifference, disinhibition, irritability/lability, aberrant motor behavior, night-time behavior, and appetite/eating change. The severity, frequency and caregiver distress of the behavior are rated. To reduce clinician's time taken to administer the NPI, the Brief Questionnaire form of the NPI and Caregiver-Administered NPI were developed. To measure behavioral disturbances in nursing home residents, NPI-Nursing Home version was developed. The BEHAVE-AD addresses delusions, hallucinations, activity disturbances, aggressiveness, diurnal rhythm disturbances, affective disturbances, and anxiety and phobias. The severity of the behavior is rated. The BRSD has eight factors that mapped onto clinically relevant domains:depressive features, psychotic features, defective self-regulation, irritability/agitation, vegetative features, apathy, aggression, affective lability. Item of BRSD are scaled according to frequency of psychopathology.

아동, 청소년기 심리적 경직성의 측정 : 한국형 아동 및 청소년용 회피-융합척도(K-AFQ-Y)의 타당화

최성혜,김은정 한국인지행동치료학회 2015 인지행동치료 Vol.15 No.3

본 연구는 Greco, Lambert와 Baer(2008)가 아동과 청소년의 심리적 경직성(psychological inflexibility)을 측정하기 위해 개발한 아동 및 청소년용 회피-융합척도(Avoidance and Fusion Questionnaire for Youth: AFQ-Y)를 우리나라 아동, 청소년에게 적용하여 신뢰도와 타당도를 검증하고자 했다. 이를 위해 초등학생 261명(남 130, 여 131)과 중학생 460명(남 235, 여 225)에게 한국형 아동 및 청소년용 회피-융합척도(Korean Version of the Avoidance and Fusion Questionnaire for Youth: K-AFQ-Y)와 사고억제 질문지, 수용-행동 질문지, 아동발현 불안척도, 청소년 행동평가척도 자기보고용, 단축형 행복척도를 실시하였다. K-AFQ-Y는 양호한 내적 합치도(Cronbach’s α=.87)와 좋은 검사-재검사 신뢰도(r=.83)를 보였고, 확인적 요인분석 결과, 원 척도와 동일한 일요인 구조가 적합한 것으로 나타났다. 상관분석 결과, K-AFQ-Y는 인지회피의 일종인 사고억제척도와는 높은 정적상관을, 수용척도와는 유의미한 부적상관을 보였다. 또한, 우울, 불안, 신체증상, 규칙위반, 공격성 같은 증상척도와는 정적상관을, 행복척도와는 부적상관을 보였다. 특히, 수용전념치료 모델의 주요 심리과정인 사고억제와 수용의 영향을 제거한 후에도 K-AFQ-Y는 증상 및 행복척도와 유의미한 상관이 유지되었다. 이 결과들은 K-AFQ-Y가 아동, 청소년의 심리적 경직성을 측정하는 데에 있어 신뢰롭고 타당한 도구이며, 심리적 경직성이 아동과 청소년의 다양한 정신병리 증상과 삶의 질에 기여하는 독특한 구성개념임을 시사한다. 마지막으로 연구의 의의와 제한점을 논의하였다. This study aimed to examine the reliability and validity of the Korean version of the Avoidance and Fusion Questionnaire for Youth(AFQ-Y; Greco, Lambert, & Baer, 2008), a child-report measure of psychological inflexibility. Elementary and middle school students(n=721) completed Korean version of AFQ-Y(K-AFQ-Y), White Bear Suppression Inventory(WBSI), Acceptance and Action Questionnaire(AAQ), Revised Children’s Manifest Anxiety Scale(RCMAS), Youth Self-Report(YSR), and Concise Measure of Subjective Well-Being (COMOSWB). The K-AFQ-Y showed adequate internal consistency reliability (Cronbach’s α=.87) and good test-retest reliability(r=.83). In addition, confirmatory factor analysis showed that K-AFQ-Y fitted a one-factor measurement model. The K-AFQ-Y correlated positively with anxiety, depression, somatic complaint and problem behavior, and negatively with subjective well-being. Also, The K-AFQ-Y correlated as expected with conceptually overlapping process, thought suppression and acceptance. Even after removing the effects of related constructs(thought suppression and acceptance), the K-AFQ-Y correlated significantly in the expected directions with all measures. These results support the convergent and construct validity of K-AFQ-Y. Overall, the results suggest that the K-AFQ-Y may be an useful child-report measure of core acceptance and commitment therapy process, psychological inflexibility. Finally, the implication and limitation of this study were discussed.