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Discovery of a Highly Specific and Potent Pan-RAF Inhibitor
홍성표,이윤호,최남송,남기엽,안순길 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.10
We describe the structure-based design and synthesis of N-(2,6-difluorophenyl)-3-(9H-purin-6-yl)pyridine-2-amine derivatives as a selective pan-RAF kinase inhibitor. The synthesized compounds showed highly potent and specific inhibition of the BRAFV600E mutant cell line. Among them, N-(3-((3-(9H-purin-6-yl)pyridine-2-yl)amino)-2,4-difluorophenyl)furan-3-sulfonamide (4b) exhibited the most potent inhibitory activities against protein kinase enzymes BRAFV600E, BRAFWT, and CRAF (IC50 of 2, 2, and 1 nM, respectively) and a mutant cell line bearing a BRAFV600E mutation, A375P (GI50 of 7 nM).
Synthesis and Anti-platelet Activity of Obovatol Derivatives
곽재환,정재경,이슬기,박은석,인진경,송지호,김영진,최남송,이희순,윤여표,홍진태,곽영신,민경훈 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7
Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatol in arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.
CoMFA and CoMSIA 3D QSAR Studies on Pimarane Cyclooxygenase-2 (COX-2) Inhibitors
이광옥,박현주,김영호,서승용,이용실,문성현,김남중,최남송,서영거 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.5
&RPSDUDWLYH PROHFXODU ILHOG DQDO\VLV DQG FRPSDUDWLYH PROHFXODU VLPLODULW\ LQGLFHV DQDO\VLV ZHUH SHUIRUPHG RQ WZHQW\ ILYH DQDORJXHV RI SLPDUDQH &2; LQKLELWRU WR RSWLPL]H WKHLU F\FORR[\JHQDVH&2;VHOHFWLYHDQWLLQIODPPDWRU\DFWLYLWLHVSLPDUDQH
금속촉매를 이용한 Carbocycle의 합성(II) -Cycloheptane의 합성-
서영거(Young Ger Suh),원숙란(Sug Lan Won),최남송(Nam Song Choi),조윤상(Youn Sang Cho) 대한약학회 1991 약학회지 Vol.35 No.4
An efficient synthetic route to carbocycle is described. 1,1,2-Trisubstituted cycloheptane has been synthesized from allylic carbonate by Pd(O) catalzyed cyclization.