혈액관류 요법과 함께 L-카르니틴을 투여한 valproic acid 중독 환자 1례

정진희,김기범,안기옥,어은경,Jung Jin Hee,Kim Gi Beom,Ahn Ki Ok,Eo Eun Kyung 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2

Valproic acid (VPA) is used in the management of a variety of conditions including simple and complex absence seizure disorder. bipolar disorder, and migraine prophylaxis. Clinical manifestation of VPA overdose vary in severity from mild confusion and lethargy to severe coma and death. The treatment of VPA toxicity is mainly supportive. There is no specific antidote, nor are there specific guidelines for the management of VPA intoxication. Anecdotal reports describe the efficacy of naloxone and L-carnitine, but the data are insufficient to make strong conclusions. Various techniques of extracoporeal therapy for the management of VPA toxicity have been described, but none has prevailed as standard therapy. We report a patient with VPA overdose who was successfully treated with hemoperfusion with activated charcoal and L-carnitine. VPA levels of the patient was more than 1,000 ${\mu}g$/ml and was normalized after 3 times hemoperfusion. The patient was injected with L-carnitine by maximum 600 mg/kg/day for 5days without complications.

이질형 바이오 데이터베이스 통합을 위한 게이트웨이 시스템

정진희,정민아,Jung, Jin-Hee,Jung, Min-A 한국정보통신학회 2005 한국정보통신학회논문지 Vol.9 No.8

이질적인 생물 데이터베이스의 통합은 데이터간의 연계 분석의 필요성이 높아짐에 따라 중요한 문제로 대두되고 있다. 그러나 이러한 데이터베이스들은 초기에 이질적 환경에서 각기 다른 목적에 의해 생성되므로 포맷, 설계자가 불일치하는 등 여러 가지 문제점으로 인해 통합하는데 어려움이 따른다. 그러므로 이질적인 데이터베이스의 통합을 위해서는 초기단계의 설계가 무엇보다도 중요하다. 본 논문에서는 대표적인 핵산 데이터베이스인 Genbank와 단백질 데이터베이스인 Swiss-Prot을 통합하기 위해 ER 모델을 사용하여 개념적 모델을 보인 후, 이를 합병하여 통합모델을 제시한다. 또한, 핵산-단백질 자료로 연계되는 정보를 통합 서비스할 수 있는 시스템 구조를 제안한다. 제안된 바이오 게이트웨이 시스템은 개념적 설계 단계에서 가장 원자적인 단위로 분할하여 모델링 함으로써 정교한 질의 처리가 가능하고, 사용자가 상세 조건을 알고 있을 경우에 기존의 검색시스템과 달리 여러 번의 검색 과정을 거치지 않고, 단시간에 원하는 결과를 얻을 수 있다는 장점을 지닌다. The Integration of biological databases is critically important because of the interconnectedness of biological research. But it's not easy to integrate these databases for the different formats and designers in heterogeneous environments. So initial design is indispensable to integrate heterogeneous databases. In this paper, after we performed conceptual modeling on a popular nucleotide database, GenBank and a protein database, Swiss-Prot and integrated them by considering cross-reference. we also propose the integration system architecture called Bio-Gateway System, which can help users query closely linked information between two biological databases within one system differently from existing systems as well as query easily on condition that user knows fine condition for less effort.

의료보장 형태가 혈액투석 서비스 제공에 미치는 영향에 대한 다수준 분석

정진희,권순만,김경훈,이선경,김동숙,Jung, Jin-Hee,Kwon, Soon-Man,Kim, Kyoung-Hoon,Lee, Seon-Kyoung,Kim, Dong-Sook 대한예방의학회 2010 예방의학회지 Vol.43 No.3

Objectives: This study aims to compare quality indicators for the hemodialysis services between patients with health insurance and those with medical aid. Methods: This study used data from sampled hospitals that provided a hemodialysis service. A total of 2287 patients were selected, and the information for hemodialysis service has been granted from medical record reviews. A multi-level regression analysis was used to examine the differences in process and outcome indicators for hemodialysis between patients with health insurance and those with medical aid. Process indicators were defined as: frequency of hemodialysis, hemodialysis time, erythropoietin (EPO) use, measurement of hemodialysis dose at least once a month, measurement of phosphate at least once every three months, and measurement of albumin at least once every three months. Outcome indicators were defined as: hemodialysis adequacy, anemia management, blood pressure management, and calcium, phosphate and nutrition management. The total scores for outcome indicators ranged from 0 (worst) to 4 (best). Results: There was a significant difference in the measurement of hemodialysis dose at least once a month between patients with health insurance and those with medical aid (OR 0.66, 95% CI = 0.43 - 0.99). However, frequency of hemodialysis, hemodialysis time, EPO use, measurement of phosphate at least once every three months, measurement of albumin at least once every three months, hemodialysis adequacy management, Hb${\geq}$11 g/dL, blood pressure within the range of 100-140 /60-90 mmHg, calcium x phosphate${\leq}$55 $g^2/dL^2$ and albumin${\geq}$4 g/dL were not significantly different between the groups. Conclusions: There were no significant differences in outcome indicators for hemodialysis between the groups. Further studies are warranted into the mechanism that results in no differences in the outcome indicators for hemodialysis.

Pimozide와 Haloperidol 과량 복용 후 반복적으로 발생한 심실 빈맥 1례

정진희,장혜영,어은경,Jung, Jin-Hee,Jang, Hye-Young,Eo, Eun-Kyung 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.1

Pimozide and haloperidol are typical antipsychotics. They share a similarity in pharmacotherapeutic and adverse effect profiles. Cardiovascular effects may be seen as alterations in heart rate, blood pressure, and cardiac conduction. Conduction disturbances may occur ranging from asymptomatic prolongation of the QT interval to fatal ventricular arrhythmia. So in the case of anti psychotics overdose, the patient must be carefully monitored by continuous electrocardiography (ECG). We experienced a 34-year-old woman of schizophrenia with recurrent ventricular tachycardia after pimozide and haloperidol overdose. Initially she was slightly drowsy, however her ECG showed normal sinus rhythm. After 6 hours on emergency department entrance, her ECG monitoring showed ventricular tachycardia and we successfully defibrillated. There were five times events of ventricular arrhythmia during the in-hospital stay. She was discharged 5 days later without any other complications.

응집제 자동주입장치를 이용한 소화슬러지의 탈수효율 향상

정진희 ( Jin-hee Jung ),김진영 ( Jin-young Kim ),윤태경 ( Tae-kyung Yoon ),김정권 ( Jung-kwon Kim ),허승녕 ( Seung-nyung Huh ),정병길 ( Byung-gil Jung ) 한국환경기술학회 2013 한국환경기술학회지 Vol.14 No.6

본 연구는 하수처리장에서 발생되는 소화슬러지의 탈수성 향상을 위한 응집제 자동주입시스템과 기존 시스템의 탈수케이크 함수율 및 응집제 주입량에 미치는 영향을 비교·평가하는데 그 목적이 있다. 고분자 응집제 주입율은 기존 시스템에서 운영하고 있는 유입슬러지량 대비 고분자 응집제주입율인 14%를 기준으로 9%까지 점차적으로 낮추어 가면서 실험을 실시하였다. 실험결과 하수슬러지 탈수시 응집제 자동주입시스템이 기존시스템에 비해 함수율 및 약품주입량을 효과적으로 저감시킬 뿐만 아니라 중앙제어실을 통한 실시간 모니터링이 가능하므로 인력감축 유도 및 공정자동화에도 기여할 수 있을 것으로 판단된다. The purpose of this research was to evaluate the effects on enhanced sewage digested sludge dewatering and compare polymer dosage reduction between an automatic coagulant feeding system and a conventional system. The polymer dosage rate per sludge quantity was adjusted from 9% to 14% based on coagulant dosage of the conventional system. The results of this study indicate that the automatic coagulant feeding system not only could be effectively reduced the moisture contents and polymer dosage in the sewage sludge dewatering but also made the workforce reduction and automatic dewatering by real-time monitoring at central control room of sewage treatment plant more than a conventional system.

공업지역 하수처리장 하수방류수 재이용을 위한 (Birm + UF막) 공정 적용 시 금속물질 및 유기물질 제거에 관한 연구

정진희 ( Jin-hee Jung ),최영익 ( Young-ik Choi ) 한국환경기술학회 2016 한국환경기술학회지 Vol.17 No.5

본 연구에서는 고탁도시 막차압 상승을 방지하기 위해 (Birm Filter + UF막)을 적용해 금속이온 (Mn 및 Fe) 및 유기물질의 제거특성을 파악하고자 하였으며, 막오염의 주원인 물질인 금속이온 제거 (Mn 및 Fe)를 통해 막오염을 저감하고자 하였다. Birm filter + UF막의 연계처리 공정 적용 시 48.4% 및 49.7%로 역세 시간에 따른 제거효율 변화는 UF막 제거효율에 큰 영향을 미치지 않는 것으로 나타났으며 (Birm filter + UF막) 전처리 공정으로서 우수한 편은 아니지만 긍정적인 역할을 할 것으로 판단된다. 유기물질인 BOD₅의 경우 평균 58.9% 제거효율을 나타내었으며, COD_Mn의 경우 평균 60.6% 제거되었다. TOC의 경우 평균 21.2%의 제거효율을 나타내었다. (Birm filter + UF막)의 연계처리 공정으로는 TOC를 효과적으로 제거하기 어려운 것으로 나타나 추가공정으로 RO막 등 기타 추가 공정이 필요할 것으로 판단되며, 본 연구에 사용되어진 원수는 분해성 유기물 보다는 난분해성 유기물의 직접적인 유입이 많고 그 밖에 상당량 미생물에 의한 생물학적 분해가 낮다는 것을 알 수 있었으며 그밖에 산화성 무기물이 상당량 포함되어 있다는 것을 알 수 있었다. The purpose of this research was to identify the removal characteristics of metal ions (Mn and Fe) and organic matters by applying a combined Birm filter and UF membrane process. Additionally, the objective of using the particular media was to prevent an increase in transmembrane pressure under high turbidity conditions and to reduce the membrane fouling by removing the primary cause of membrane fouling, namely, the metals Mn and Fe ions. After applying the treatment processes Birm filter and UF membrane, the changes in the removal efficiency for Mn and Fe ions according to the backwash time was 48% and 49.7%, indicating there was little efficiency of the membrane. Therefore, the linked process was considered to play a positive role, although it was found not superior to the Birm filter - UF membrane pre- treatment process. As regards the organic matter BOD₅, As regards the organic matter BOD₅, showing the an average removal efficiency of 58.9%. Concerning COD_Mn showing the an average removal efficiency of 60.6%. As to TOC, showing an average removal efficiency of 21.2%. The results have indicated that the linked treatment process of the Birm filter-UF membrane could not effectively remove TOC; therefore, an additional process would be necessary, such as employing an RO membrane. The results have indicated that the linked treatment process of the Birm filter-UF membrane could not effectively remove TOC; therefore, an additional process would be necessary, such as employing an RO membrane. In addition, it was found that the raw water used for the present research showed a number of direct influxes containing more non-biodegradable than biodegradable organic matters. Moreover, this water showed low biodegradation by a substantial amount of microorganisms and contained a large amount of oxidative inorganic matters.

하수처리수 재이용을 위한 막분리 공정시 응집조건에 따른 투과효율 변화에 관한 연구

정진희 ( Jin Hee Jung ),장성호 ( Sung Ho Jang ),최영익 ( Young Ik Choi ) 한국환경과학회 2011 한국환경과학회지 Vol.20 No.6

The objectives of this research are to investigate the proper coagulation conditions which are a type and doses of coagulants, mixing conditions (velocity gradients and mixing times), pH and so on through Jar-test, to evaluate the flux variations, permeate, backwashing according to characteristics of pretreatment of the wastewater by means of MF membranes for river maintenance water reuse. The effluent water from B-city K-sewage treatment plant are used for this research. Turbidity and suspended solids(SS) are 14.2 NTU and 10.4 mg/L respectively. This condition causes fouling for membrane process. The flux decline could be reduced when coagulation pretreatment was carried out. Optimal coagulations PAC which are commonly used in the sewage treatment plant was observed in this research. The results indicate that an optimal coagulation dose and pH are 80 ppm and pH of 7 respectively, but coagulation efficiency was lower at strong acid or strong base. Results showed that continuous and steady operations in membrane separation process by means of the effective removal of organic matter and turbidity with coagulation pretreatment of sewage secondary effluent were achieved.

치성광여래도(熾盛光如來圖)에 그려진 신선문자도상(神仙文字圖像) 고찰 -서울 안양암 금륜전 치성광여래도를 중심으로-

정진희(Jung jin hee) 한국민화학회 2020 한국민화 Vol.- No.13

서울 종로구 창신동에 자리한 안양암은 1889년 거사 이창진에 의해 만들어진 도심지에 설치된 포교소와 같은 성격을 보이는 사찰이었다. 안양암이 창건될 때 지었던 칠성각은 이후 금륜전으로 전각명이 바뀌게 되는데 그 내부에는 七元星君像들과 2점의 〈熾盛光如來降臨圖〉가 소장되어 있다. 금륜전 상단 후불도로 현괘된 〈치성광여래강림도〉는 20세기 전반 최고의 화승으로 이름이 높았던 고산당 축연이 1924년 그린 작품이고 그 옆 봉안된 〈치성광여래강림도〉 역시 비슷한 시기에 조성된 것으로 추정된다. 불교 칠성신앙을 도해한 이들 불화의 화면에는 도화원 화가와 민화 화가들이 歲畫의 주제로 다루었던 〈신선문자도〉 도상을 차용하여 화면을 구성하는 특징이 나타난다. 19세기 후반 이후 조성된 치성광여래도에서 壽星老人은 화면에 빠지지 않고 그려지는 구성요소 가운데 하나로 노자를 신격화한 태상노군을 그린 것이다. 안양암 치성광여래도 제작에 참여하였던 화승 축연은 불화의 도상이 공유되고 화풍이 전승되던 시대적 양상을 따르는 과정에서 壽星老人과 仙童獻壽圖가 합쳐진 神仙文字圖像을 적극적으로 활용하여 독창적인 구성으로 수성노인을 재해석하였다. 안양암 금륜전 〈치성광여래강림도〉에 〈신선문자도〉 도상을 차용하여 그려진 수성노인은 19세기 치성광여래도에서 태상노군을 나타내던 의미가 아니 아닌 연수와 복록을 부여하는 남극수성노인이라는 본연적 의미로 변용되어 표현한 것이다.이와 같은 시도는 이 작품 이전에도 이후에도 볼 수 없는 특징적인 사례로 불화와 민화의 관련성을 보여주는 사실이라 할 수 있다. 그의 새로운 시도가 이후 화승들에 의해 공유되지 않았던 사실에서 불화라는 장르에서 노골적으로 표현된 도교적 색채는 당시 화승들에게 호응을 얻지 못하였음을 말해준다. 하지만 고산이 그린 이 작품들을 통해 당시 민화와 불화의 도상이 공유되었고, 화승이 불교회화뿐만 아니라 일반 민화도 그렸을 가능성을 보여주고 있다는 점에서 그 의미는 적지 않다. Located in Changshin-dong, Jongno-gu, Seoul, Anyang-am was a temple with the same characteristics as a missionary center built in the city center created by Lee Chang-jin in 1889. Chilseonggak, which was built when Anyangam was founded, was later renamed Geumryunjeon Hall, which has 〈七元星君像〉 and two pieces of and 〈熾盛光如來降臨 圖〉 inside it. 〈Chiseonggwangnyeollaegangnimdo〉 inside the Geumryunjeon Hall was painted in 1924 and created by the most famous Hwaseung in the first half of the 20th century, and it is estimated that another 〈Chiseonggwangnaegangnimdo〉, which was enshrined next to it, was also created at the similar time. The Shinsunmunjado drawn on Sehwa also features a painting borrowed from Chilseongdo, a Buddhist painting, to form a painting. In Chisung Gwangnyeondo, which was created after the late 19th century, has the main charactersitic that depicts Taesang-no-gun, a deified elder. The monk called Hwaseung , who participated in the production of Anyangam Chisung Gwangnyeondo, reinterpreted Suseong Noin in its original composition by actively utilizing 神仙文字圖像 which is the combination of 壽星老人 and 仙童獻壽圖 and strictly followed tradition. The Suseong Noin, who was copied from the painting Shinseonjajajado and drawn in the 〈Chiseonggwangbearimdo〉, was transformed into an Antarctic Suseong Noin who gave training and retrogression, not a representative of Taesang-do in the 19th century. Such an attempt, which shows the connection between buddhist painting and folk painting, is an exotic example that cannot be seen in any paintings. The explicit use of Taoist color in the Buddhist painting, which was his new attempt, did not appeal to the monks as his new attempts were not shared and admitted by the monks at that time. However, the paintings by Gosan showed that the paintings of folk paintings and Buddhist paintings at that time were shared, and that Hwaseung may have painted not only Buddhist paintings but also ordinary folk paintings.

默照禪과 看話禪의 悟門에 대한 見解

정진희(Jung, Jin-Hie) 보조사상연구원 2009 보조사상 Vol.31 No.-

선종은 실천수행을 매우 중시한다. 깨달음을 설하지 않는 선수행문은 생명력이 없는 껍데기에 불과하다고 말할 수 있다. 대혜종고선사는 묵조선은 깨달음의 문을 설하지 않는 선법이라 비판한다. 과연 대혜의 말처럼 묵조선은 깨달음을 설하지 않는 것인가? 묵조선은 깨달음을 ‘고향집으로 되돌아가는 것(向本家歸鄕).’이라 표현한다. 묵조좌선이 바로 본래 구족한 불성을 현현한 것이므로 특별히 도달해야 할 곳이 없다는 것이다. 즉 새삼 깨달음을 강조할 필요가 없다는 입장이다. 간화선 역시 ‘本具佛性’의 입장에 근거한다. 그러나 수행자에게 화두참구수행이라는 새로운 수행법이 제시되고 간화선법이 확립되면서 이를 통해 본래 구족한 자성청정불성을 증득할 것을 강조한다. 그래서 간화선수행법은 먼저 반드시 깨달음의 문이 있다는 것을 믿어야 하며, ‘以悟爲則’해야 한다는 입장이다. 묵조수행문은 묵조좌선이 바로 깨달음의 현현이라는 견해이므로 따로 깨달음의 목표설정과 이에 이르는 수행과정을 강조하지 않는다. 간화선은 화두참구수행법으로 본래 구족한 불성을 증득한다는 입장이므로 깨달음이라는 목표설정이 반드시 필요하며 이에 이르는 과정 역시 매우 중시한다. 묵조선, 간화선 모두 본각의 입장이지만, 두 선법의 오문(悟門)에 대한 견해 차이는 후학지도과정에서 수행과정과 도달처의 중시여부로 직결된다. Practicing Buddhist meditation is said to be very important in Seon Buddhism. Seon Buddhist practice which does not include the teaching of Enlightenment has been regarded as the useless one. Da Hui Zhong Gao(大慧宗?), the Seon master, criticised that Mukjo Seon practice does not include the teaching of enlightenment. Is is true that Mukjo Seon practice does not teach only Buddhist Enlightenment? Mukjo Seon regards enlightenment as 'returning to its hometown'(向本家歸鄕). Mukjo meditation practice was thought to manifest the inner Buddha-nature within all beings. This could be the reason why Mukjo meditation no longer emphasize the importance of Enlightenment. Ganhwa Seon also has its foundation in the innate Buddha-nature(本具佛性). Step by step, there introduced Hwa-du, pondering over a doubtful question in this meditation practice. When this method was established, realizing one's pure inner Buddha-nature was emphasized. Thus, one who practice Ganhwa Seon first believe the path of Enlightenment and this point was summarized as 'regarding Enlightenment as a goal'. Both Mukjo and Ganhwa Seon practice basically insisted that beings are already enlightened. Although there are differences in the detail meditation technique and method between them, these differences relay only on their emphasize either on the method of practice or on the aim of practice.

하수방류수 재이용을 위한 Birm filter + UF 적용시 용도별 사용 가능성 및 막오염 특성

정진희 ( Jin-hee Jung ),이승철 ( Seung-chul Lee ),성낙창 ( Nak-chang Sung ),최영익 ( Young-ik Choi ) 한국환경과학회 2016 한국환경과학회지 Vol.25 No.11

In response to the water shortage problem, continued attempts are being made to secure consistent and reliable water sources. Among various solutions to this problem, wastewater effluent is an easy way to secure the necessary supply, since its annual output is consistent. Furthermore, wastewater effluent has the advantage of being able to serve various purposes, such as cleaning, sprinkling, landscaping, river management, irrigation, and industrial applications. Therefore, this study presents the possible use of reclaimed industrial wastewater treated with Birm filters and a UF membrane, along with an analysis on membrane fouling. The preprocessing stage, part of the reclamation process, used Birm filters to minimize membrane fouling. Since this study did not consider heavy metal levels in the treated water, the analyses did not include the criterion for irrigation water quality. However, the wastewater reclaimed by using Birm filters and a UF membrane met every other requirement for reclaimed water quality standards. This indicated that the treated water could be used for cleaning, channel flow for maintenance, recreational purposes, and industrial applications. The analysis on the fouling of the Birm filter and UF membrane required the study of the composition and recovery rate of the membrane. According to SEM and EDX analyses of the UF membrane, carbon and oxygen ion composition amounted to approximately 57%, whereas inorganic matter was not detected. Furthermore, the difference in the recovery rates of the distressed membrane between acidic and alkaline cleaning was more than ~78%, which indicated that organic rather than inorganic matter contributed to membrane fouling.