정신분열병 환자의 도파민 $D_5$ 수용체 유전자형과 치료반응과의 연관

강성민,이민수,이충순,Kang, Sung Min,Lee, Min Soo,Rhee, Choong Soon 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2

Background : Dopamine receptors are strong candidates for involvement in schizophrenia and are target of a wide variety of antipsychotics. Dopamine $D_5$ receptor(DRD5) gene polymorphisms may be associated with various treatment response. The purpose of our study was define to what significance can be held as a predictor of treatment response in this polymorphism. Method : The total number of 116 Korean chronic schizophrenic patients was assessed after 48 weeks treatment. The Positive and Negative Syndrome Scale(PANSS) was rated for the clinical response to various antipsychotics. With the use of polymerase chain reaction amplification, we assessed this dopamine $D_5$ receptor polymorphism in schizophrenic patients who had been treated with antipsychotics, and related genotype with treatment response, to test the hypothesis that DRD5 polymorphism may lead to varying response to antipsychotics. Result : DRD5 polymorphism was not associated with treatment response to a variety of antipsychotics in chronic schizophrenic patients. Conclusion : Genetic variation of $D_5$ receptors do not predict treatment response to antispychotics.

정신분열병 환자의 도파민 $D_1$ 수용체 유전자형과 치료반응간의 연관

백종우,이민수,이충순,임동준,함원훈,Paik, Jong Woo,Lee, Min Soo,Rhee, Choong Soon,Lim, Dong Ju,Ham, Won Hun 대한생물정신의학회 2001 생물정신의학 Vol.8 No.1

Background : Dopamine receptors have been regarded as a strong candidate involved in etiology of schizophrenia and a target for various antipsychotic drugs. The purpose of our study was to investigate whether dopamine $D_1$ receptor(DRD1) gene polymorphisms would predict the treatment response to antipsychotics in schizophrenia. Method : One hundred thirty-four schizophrenic patients, who met DSM-IV criteria for schizophrenia were entered into a 48 -week study. The psychopathology of the patients was assessed at baseline, 12th, 24th 48th weeks of treatment by PANSS. Responders were defined by a 20% of the reduction in total PANSS score at end point. The genomic DNA fragment corresponding to nucleotides of dopamine $D_1$ receptor gene was amplified by polymerase chain reaction(PCR). Result: Neither allelic frequencies nor genotypes for dopamine $D_1$ receptor differed significantly between responders and non-responders. Also, there was no difference of changes of PANSS scores among three genotype groups of the dopamine $D_1$ receptor. Conclusion : Allelic variation in the dopamine $D_1$ gene is not associated with individual differences in antipsychotic response.

정신질환자를 위한 한국어판 작업행동 평가 척도의 신뢰도 및 타당도 연구

황태연(Tae-Yeon Hwang),이우경(Woo-Kyung Lee),한은선(Eun-Seun Han),이충순(Choong-Soon Rhee) 대한사회정신의학회 2004 사회정신의학 Vol.9 No.1

목 적: 최근 정신질환자의 작업기능에 관한 연구가 활발함에도 불구하고, 국내에서는 정신사회재활 프로그램에 참여하고 있는 만성 정신질환자들의 작업기능을 평가할 수 있는 도구가 부족하였다. 본 연구에서는 만성 정신질환자의 작업행동을 보다 정확하고 민감 하게 평가하기 위하여 비교적 간단하고 반복적인 실시가 가능한 작업행동평가척도(WBI)를 직업재활에 참여하고 있는 환자들에게 적용하여 그 신뢰도와 타당도을 검증하고자 한다. 방 법: 서울, 경기 지역에서 직업재활 프로그램에 참여하고 있는 정신분열병과 분열정동장애로 진단을 받은 158명을 대상으로 하였다. 평가에 사용한 작업행동평가척도(WBI)는 36문항으로 되어있고, 협동성, 작업습관, 작업의 질, 사회기술, 자기연출능력 등의 5개 하위 척도로 구성되어 있다. 평가는 작업자의 행동을 15분간 관찰하고 직속 감독자와의 면접 후에 하였다. 결 과: 한국어판 작업행동평가척도의 각 문항과 하위척도와의 상관은 .58~.94 범위였고, 문항-총점간 상관은 .45~.82의 분포를 나타내었다. 또한 각 하위척도 간의 상관계수 범위는 .29~.69로 나타났고, 모든 하위척도간의 상관은 정적으로 유의미하였다. 요인 분석 결과 작업의 질, 사회기술, 협조성, 작업습관 및 태도, 자기연출능력 등 5개의 요인이 추출되었으며, 5개 요인의 전체 설명변 량은 67.4%였다. 결 론: 한국어판 작업행동평가척도의 신뢰도와 타당도의 검증 결과, 신뢰도와 타당도는 매우 만족스러운 수준을 나타내었다. 다만 요인 분석 결과 5개의 요인을 구성하는 문항내용이 다소 상이하게 나타났다. 이러한 결과가 우리나라 정신질환자들의 독특한 증상군을 반영하는 것인지 혹은 정신보건센터 회원 간의 피험자 차이를 반영하는 것인지를 확인하기 위해서는 추가적인 연구가 필요할 것이다. Objectives:In spite of many studies regarding the occupational functioning of persons with mental illness, there are lack of tools to evaluate it properly. The Wok Behavior Inventory(WBI) is a standardized work performance assessment instrument specifically designed for persons with severe mental illness. The purpose of this study was to examine the reliability and validity of the Korean version of WBI. Methods:The subjects were 158 members in community mental health center around Seoul City and Kyonggi Province. KWBI consists of 26 items with subscale of cooperativeness, work habits, work quality, social skills, and personal presentation. Evaluation was done by the fifteen minutes observation of workers behavior in the job site and discussion with job supervisor. Results:Reliabilities of individual items, scales, and inventory total are in the good to excellent range. The internal consistency coefficients(Cronbach alpha) of each subscale ranged from .88 to .95. The validity of the KWBI was investigated by principal component analysis, yielding 5 factors of social skill, cooperativeness, work habit and attitude, work quality, and self presentation. Conclusion:Overall, the findings support the utility of KWBI as a tool to evaluate work related behavior in vocational rehabilitation for the chronic mentally ill patients.

경기도 지역 정신보건 사업의 추진배경과 정책결정과정

이충순,윤배중,이주훈,이종국,고영,이영문,최향순,김혜숙 용인정신의학연구소 1997 용인정신의학보 Vol.4 No.2

정신보건 정책에 대한 제안 : 민간정신병원의 견해를 중심으로

이충순 용인정신의학연구소 1995 용인정신의학보 Vol.2 No.1

정신병원과 의료법

이충순 용인정신의학연구소 1994 용인정신의학보 Vol.1 No.1

정신감성 59례에 대한 정신의학적 고찰

이충순,이인표,이주호,성경희 용인정신의학연구소 1994 용인정신의학보 Vol.1 No.1

이식증이 있는 정신박육지연 환자들과 연폭로 근로자들에 대한 연폭로 지표와 혈액학적 소견에 관한 연구

이충순,이성수,안규동,이병국 순천향대학교 1994 논문집 Vol.17 No.2

In order 1) to invesgate the possible relationship between lead exposure indices, hematologic findings and pica, and to compare the frequency of anemia or iron deficiency in mentally-retarded patients who have the symptom of pica with other study subjects, and 2) to find out the most reliable and feasible test method for the biological monitoring of lead in lead-exposed workers, PbB, ZPP, urine σ-LAL, RBC, Hgb, Hct, MCV, iron, TIBC, sex, age, and duration of work of admission were measured and checked in 50 lead-exposed workers, 118 lead-unexposed subjects and 32 mentally-retarded patients with pica. The results observed were as follows : 1. The means of Hgb, Hct, MCV and calcium of mentally-retarded patients with pica were lower than other two groups and the means of PbB, urine σ-ALA and ZPP of lead-exposed workers were higher than other two groups. 2. The means of PbB and ZPP of mentally-retarded patients with pica were higher, but the means of Hgb, Hct, MCV and calcium of mentally-retarded patients with pica were lower than mentally-retarded patients without pica. 3. While PbB had close correlation with ZPP,the ZPP had negative correlation with Hgb, Hct, MCV and iron in mentally-retarded patients with pica. 4. While PbB had close correlation with ZPP, urine δ-ALA and Hct, the ZPP had negative correlation with Hct, MCV and duration of work in lead-exposed workers. 5. While the means of PbB and urine δ-ALA were higher in male than female, there was no difference of ZPP in lead-exposed workers whose PbB was higher than 40 ㎍/dl. 6. The mean of urine δ-ALA level was higher in the group of highest blood lead level group(>60 ㎍/dl), and in the group of highest ZPP level group(>150 ㎍/dl). 7. Stepwise multiple regression of mentally-retarded patients indicated that pica was very significantly contributed to the dependent variables(PbB, ZPP, Hgb, Hct, MCV, anemia). 8. Stepwise multiple regression of mentally-retarded patients with pica indicated that iron was significantly contributed to the dependent variables(PbB, ZPP, RBC). 9. Stepwise multiple regression of lead-exposed workers indicated that sex was significantly contributed to the dependent variables(PbB, urine δ-ALA, Hgb, Hct ), and duration of work significantly contributed to the dependent variables (ZPP, urine δ-ALA, MCV).

실행기능(Exceutive Function)과 범법행위 : 소년범집단과 청소년통제집단의 실행기능 비교

조선미,이충순,오은영,김지현,박근영 용인정신의학연구소 1997 용인정신의학보 Vol.4 No.2

임상양상 및 인지적 특성에 따른 소년범들의 분류

오은영,이충순,조선미,김지현 용인정신의학연구소 1997 용인정신의학보 Vol.4 No.1