Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and Survival of Non-Small Cell Lung Cancer

이소연,( Mi Jeong Hong ),( Yi Young Choi ),( Hyo Sung Jeon ),( Seung Soo Yoo ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung Bae Lee ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Introduction: A number of genome-wide association studies (GWASs) have identified chromosomal regions containing genes associated with the risk of lung cancer. Genetic polymorphisms influence not only the development of cancer, but also cancer progression and prognosis. Therefore, we investigated the impacts of genetic variants associated with susceptibility to lung cancer in GWASs on the prognosis of NSCLC. Materials and Methods: This study included patients (n=363) with stage I, II, or IIIA (micro-invasive N2) NSCLC who under-went curative surgical resection at the Kyungpook National University Hospital, Daegu, Korea between September 1998 and December 2007. Eight single nucleotide polymorphisms (SNPs) in the six chromosomal regions (CRP rs2808630, FAM13A rs7671167, HHIP rs1489759, GYPA rs2202507, TERT rs2736100, CLPTM1L rs402710, BAT3 rs1052486, and CHRNA5 rs16969968) were genotype by a PCR-RFLP analysis. Results: None of the eight SNPs were significantly associated with overall survival and disease-free survival. In addition, when the patients were categorized according to age, gender, smoking status, tumor histology and pathologic stage, there were no significant associations between the eight SNPs and survival outcomes. Conclusions: These results suggest that the genetic variants identified by GWASs for lung cancer susceptibility are not sig-nificantly associated with the prognosis of patients with early stage NSCLC.

정신분열병과 기분장애 환자의 언어적 기억능력과 기억과정의 특성에 대한 연구

이소연,이분희,이정애,김계현,김용구,박선화,Lee, So-Youn,Lee, Bun-Hee,Lee, Jung-Ae,Kim, Kye-Hyun,Kim, Yong-Ku,Park, Sun-Wha 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2

Objectives:This study was to compare verbal memory ability among patients with schizophrenia, bipolar manic patients and unipolar depressive patients, and to understand their charicteristics of memory process. Methods:All subjects were hospitalized patients and had been interviewed by using the Structured Clinical Interview for DSM-IV(SCID). Schizophrenic patients(N=40), bipolar manic patients(N=17), and unipolar depressive patients(N=20) were assessed with K-AVLT for verbal memory and with K-WAIS for verbal IQ. Three groups were compared regarding total immediate recall, delayed recall, delayed recognition, learning curve, memory retention, and retrieval efficiency under controlled verbal IQ. Multiple regression analysis was performed to find which clinical factors have an influence on verbal memory ability. Results:In MANCOVA, differences of verbal memory test scores among the groups were statistically significant(F=1.800, p<.05). In post hoc analysis, Patients with schizophrenia and bipolar mania showed poorer performance in immediate recall, delayed recall, delayed recognition, retrieval efficiency than unipolar depres- sive patients. And schizophrenics performed poorly in delayed recall, delayed recognition, retrieval efficiency than nonpsychotic affective disorder group, but no difference in total immediate recall, delayed recall, delayed recognition, retrieval efficiency between the schizophrenic group and the psychotic affective group. Conclusions:These results partially confirm previous reports of verbal memory ability among major psychiatric disorders. Our results showed that psychotic symptoms were related with verbal memory, and longer duration of illness was related with poorer performance in schizophrenia and unipolar depression.

저회/석고 활용 긴급복구 유동성 채움재의 개발 및 현장적용 사례

이소연,정혁상,권순협,임대성,공진영,Lee, So-Yeon,Jung, Hyuk-Sang,Kwon, Soon-Hyeop,Lim, Dae-Sung,Kong, Jin-Young 한국건설순환자원학회 2018 한국건설순환자원학회지 Vol.13 No.3

기록관리를 위한 업무분석 방법론 연구: 호주표준 AS 5090을 중심으로

이소연,오명진,Lee, Soo Yeon,Oh, Myung-Jin 한국기록학회 2005 기록학연구 Vol.0 No.12

There have been growing interests in work process analysis methodology, ever since ISO 15489 and DIRKS were introduced to the Korean archival and records management community. It is because the methodology has been expected to provide with much needed information, with which records management programs could be designed. The information encompass from those needed in developing macro-organizational framework such as business classification schemes, to those essential to identify exact points of time, at which records management systems should capture records during each phase of business process. The Korean community, however, currently possesses a surprisingly scanty understanding of the methodology. The present paper aims to promote its understanding among Korean archivists and records managers, by reviewing an Australian standard of Work Process Analysis for Recordkeeping(AS 5090). It begins with drawing attention to the fact that the work process analysis is utilized in diverse areas, encompassing systems development, organizational re-engineering, and human resources management in business settings. When the methodology is implemented in records management settings, therefore, focus should be lied in finding out ways of creating and capturing records from the routine business activities. The paper then reviews the relationship among the three standards, AS 5090, DIRKS, and ISO 15489. Most parts of the paper are dedicated to review AS 5090 in detail, with examples. The paper also provides with output forms to be used to organize and represent results from the analysis.

환아 어머니 교육이 육아지식 정도 및 외래간호 만족도에 미치는 영향

이소연,최미혜,권혜진,Lee So Yeon,Choi Mi Hye,Kwon Hye Jin 한국아동간호학회 1997 Child Health Nursing Research Vol.3 No.1

The purpose of this study were to find out the practical way to enlarged child-raising knowledge and to enhance their satisfaction with out-patient care by evaluating how effectively the education is done by nurses for mothers with ill-child and how their satisfaction with out-patient care changed. This study was designed as a Nonequivalent Control Group study. The subjects studied were consisted of the experimental and control group. Each consisted of 50 mothers with ill-child in pediatric department at one university hospital in Seoul. The period of this study is from May 20, 1996 to J one 28, 1996. The first data were collected from both of experimental and control groups in which mothers with ill-child come to the hospital for the first time. After this being done, the experimental group had been educated by the planned program and then the second data were collected from them. On the contrary, as for the control group, there had been no education and the second data were col looted on the same method. The data analysis was done by SPSS program. The results of this study are as follow, 1 The child-raising knowledge level of mothers with education was higher than that of with no education. (t=18.84, df=49, p=0.000) 2. The satisfaction with out-patient care level of mothers with education was higher than that of no education. (t=10.51, df=49, p=0.000) Based on these results, I suggest as follow, 1. The research on the patients and their family should be made not only in pediatric department, but in every out-patient department. 2. For more effective education, it is required for all out-patient nurses to research the education demand of patients and their family. 3. To increase the effect of education, there must be the consultation room in out-patient department. 4. The meetings with the mothers with ill-child of the same illness have to be established and periodical education must be executed. 5. Audio-visual education programs like video tapes are needed to make use of waiting time for the medical treatment. 6. On-line consulting programs are needed.

생각하는 힘을 키우는 독서논술

이소연,Lee, So-Yeon 대한출판문화협회 2006 출판저널 Vol.364 No.-

디지털 아카이빙의 표준화와 OAIS 참조모형

이소연,Lee, So-Yeon 한국과학기술정보연구원 과학기술정보센터 2002 Journal of Information Science Theory and Practice Vol.33 No.3

OAIS Reference Model has become a basis for exchanging ideas and cooperating among institutions and various sectors concerned with digital archiving. It has been also recently approved as a new ISO standard. This paper reviews major concepts and issues that the reference addresses. It also introduces current activities of institutions and projects that have contributed to the development process of the model. Conclusion is devoted to address the importance of cooperation among cultural institutions. These institutions are taking the responsibility of preserving digital information for the long-term as authentic as possible and delivering it to the next generation. 디지털 정보보존 관련 분야와 기관간 의견교환과 협력의 기반이 되는 OAIS 참조모형이 최근 ISO 표준으로 인증 발표되었다. 이 논문은 OAIS 참조모형이 정의하고 있는 주요 모형들과 디지털 아카이빙에 관련된 문제들을 논의하고 이 모형의 개발에 참여한 주요 기관 및 프로젝트의 활동을 소개하였다. 귀중한 문화유산인 디지털정보를 진본 상태로 유지하면서 장기적으로 보존하여 현재와 후대의 인류에게 전승하는 책무를 맡고 있는 문화기관들의 협력 필요성에 대해서도 논의하였다.

새로운 학술커뮤니케이션 환경과 미래형 전자저널 컨소시엄 운영모형 : KESLI를 중심으로

이소연,Lee, So-Yeon 한국과학기술정보연구원 2008 Journal of Information Science Theory and Practice Vol.39 No.1

학술정보 커뮤니케이션 환경이 급변함에 따라 전자저널 컨소시엄이 그 본연의 기능을 다하기 위해서는 참여기관이 만족할 수 있는 서비스를 제공하기 위한 즉각적 전략과 함께, 전 세계적으로 벌어지고 있는 근본적 변화주도 움직임에 대처하기 위한 전략이 필요하게 되었다. 이 연구는 우리나라의 대표적인 전자저널 컨소시엄인 KESLI를 중심으로 한 미래형 컨소시엄 운용모형을 제안한다. 여기서 제안하는 미래형 컨소시엄 운영모형은 단기적 대응기능 강화 전략, 장기적 변화주도 전략, 그리고 추진체계를 세 축으로 하고 있다. As scholarly information environment rapidly changes, library consortia for electronic journal licensing come to require strategies to better address service needs of member institutions as well as to take parts in more progressive initiatives. This study aims to develop a more future-oriented and progressive business model for electronic journal licensing consortia. The model is based on three pillars: strategies for responding to immediate needs; long-term strategies for leading change; and organizational infrastructure.

A Functional Polymorphism in CSF1R Gene Is Associated with Risk of Lung Cancer among Never-smoking Females

이소연,( Hyo Gyoung Kang ),( Hyo Sung Jeon ),( Seung Soo Yoo ),( Shin Yup Lee ),( Myung Hoon Lee ),( Young Tae Kim ),( Yeul Hong Kim ),( Yeun Jun Chung ),( Yun Chul Hong ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.0

Purpose: It has been estimated that the proportion of never-smokers among females with lung cancer is 53% worldwide and 75% in Korea. We conducted a two-stage study to identify genetic factors responsible for lung cancer susceptibility in female never-smokers. Material and Methods: In a discovery set, 2,228 potentially functional single nucleotide polymorphisms (SNPs) of 1,994 genes using the Affymetrix custom-made GeneChip, which were related to lung carcinogenesis in 181 female never-smokers with lung cancer and 179 controls. A replication study was performed on an independent cohort of 235 cases and 465 healthy controls. The functional effect of the rs10079250 was predicted through a three dimensional models of the CSF1R protein. Results: Among the 2,228 SNPs, 38 SNPs that were associated with lung cancer risk with P values lower than 0.05 in the discovery set were selected for validation. Among the 38 SNPs, the CSF1R rs10079250 was most significantly associated with lung cancer risk (in combined analysis, odds ratio=1.49, 95% confidence interval=1.16-1.92, p=0.002; under a dominant model for the variant allele). Homology-based model for CSF1R indicates that the rs10079250 lead to increase positive charge of CSF binding region of CS1FR, thereby increasing chance for binding of CSF to CSF1R. In addition, this SNP was found to increase phosphorylation of mitogen-activated protein kinase, JNK. Conclusions: Our results suggest that the CSF1R rs10079250 is functional and contribute to lung cancer susceptibility in never-smoking females.

전기차 ICT 융합기술 및 표준화 동향

이소연,박상준,Lee, S.Y.,Park, S.J. 한국전자통신연구원 2011 전자통신동향분석 Vol.26 No.6

자동차 분야 최대의 행사인 SAE World Congress 2011의 주제는 'Charging Forward Together'로, 주제연설과 기술세션 그리고 전시회 전체적으로 플러그인 전기차를 대대적으로 다루었다. 130여년 전 유럽에서 처음 등장하여 그 동안 상용화와는 멀게만 느껴졌던 전기차 기술이 배터리의 기술발전과 충전 인프라의 한계를 서서히 극복하며 기존의 내연기관차에 당당히 맞서게 된 것이다. 전문가들은 전기차와 ICT 기술의 접목이 유기적으로 이루어지면, 지금의 내연기관차에서 볼 수 없는 새로운 서비스들을 많이 경험할 수 있을 것으로 예상하고 있다. 본 고에서는 전기차 ICT 융합과 관련한 기술 중 특히 충전 통신 기술과 최신 표준화 현황에 대해 자세히 다루고 향후 나아가야 할 방향에 대해 살펴보고자 한다.