류마티스관절염 환자에서 Methotrexate에 의해 유발된 것으로 추정되는 과색소침착 1예

이미소,이지현,이준영,박영민 대한피부과학회 2015 大韓皮膚科學會誌 Vol.53 No.3

3차원 피부 조직에서의 이온성 리포좀들 간의 약물 전달 효과와 색소침착 피부에서의 미백 효과 비교 연구

이미소,Wei Mao,이주원,박재근,Onah Vu Pham Nguyen,조완호,김수지,이준배,유혁상 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1

이 연구는 리포좀의 전하에 따라 3D skin에서의 약물 전달성을 확인하여 niacinamide(NA)를 탑재 시켰을 때 미백효과에 어떠한 차이가 나타날 수 있는지 확인하였다. DOTAP과 DOPS 등 각각 양전하와 음전하를 가지는 인지질을 포함하여 양이온성 리포좀(CL), 중성 리포좀(NL), 음이온성 리포좀(AL)을 만들어 리포좀의 특성, 리포좀의 전하에 따른 인공 막과 3D skin에서의 투과 정도, NA를 탑재하였을 때 색소침착된 피부에서의 미백 효과를 확인하였다. TEM을 통해 세 가지 리포좀 모두 100 ~ 125 nm 크기의 인지질 이중층 구조를 가지는 것이 확인되었고, 3D skin에 실제 적용한 실험들 에서는 전체적으로 CL이 NL과 AL에서보다 더 높은 피부 투과율을 보였고, 약물(NA) 또한 진피층까지 더 잘 전달하여 색소 침착 피부에서 멜라닌 생성이 더 많이 저해되는 것을 확인하였다. 이 외에도 세포 독성 실험을 통해 고농도로 리포좀들을 처리하였을 때에도 별 다른 세포 사멸 효과가 없다는 것을 입증해 피부에 사용해도 안전하다는 것을 확인하였다.

Association between Parenting Styles and Dental Caries in Preschool Children

이미소,탁민경,김재곤,양연미,이대우 대한소아치과학회 2020 大韓小兒齒科學會誌 Vol.47 No.1

This study aimed to evaluate the relationship between parenting styles and childhood dental caries using a sample of 3 to 6 years old children in Korea. The subjects were 158 children aged 3 to 6 years old and their parents in Korea. The parenting styles were divided into three groups (authoritative, authoritarian, and permissive) using a translated version of the Parenting Styles and Dimensions Questionnaire (PSDQ). Among the 353 parents/child dyads, 158 questionnaires were returned. Authoritative parenting style was the majority (95.6%), followed by authoritarian (3.8%), and permissive (0.6%). There were no statistically significant differences between dental caries and parenting styles. The mean of dft index in authoritative group was lower than others. In the authoritative domain, the higher the authoritative tendency, the lower the dft index. Overall, authoritative parenting styles resulted in low rates of dental caries for the children. The stronger the authoritative tendency of the parents, the lower the experience of dental caries in the children. Therefore, parenting styles were likely to affect the oral health of a child, but it seemed necessary to supplement the evaluation tool to evaluate the parenting styles.

성문하압 증진 훈련을 통한 연인두폐쇄부전 아동의 언어치료 효과

이미소,김화수 대한구순구개열학회 2018 대한구순구개열학회지 Vol.21 No.1

Introduction: Cleft palate child are born with a naturally broken palate, and this anatomical structure has a significant effect on the development of speech and ability of expressive language. The velopharyngeal inadequacy (VPI) may still be in after the surgery, and therefore have speech characteristics such as hypernasality and compensatory articulation. Materials and Methods: In this study, subglottal pressure enhancement tools have been developed to encourage VPI child to improve speech production ability. Results: As a result of performing sub-glottal pressure improvement training on VPI child with this tool, the degree of nasalance and the articulation accuracy was improved. Conclusions: The tool improves the sub-glottal pressure and mouth cavity pressure in VPI child, effective for reducing hypernasality and articulation errors.

구개열 아동의 의사소통 관련 삶의 질에 대한 연구

이미소,김화수 국제다문화의사소통학회 2018 국제다문화의사소통학회 학술대회 Vol.2018 No.11

구개열 환자는 출생 시부터 여러 가지의 복합적인 어려움을 겪게 되는데, 의사소통에 있어서는 언어의 발달 지 연, 조음 및 공명의 결함이 나타날 수 있다. 최근 환자의 심리적인 측면을 평가하는 삶의 질에 대한 평가가 관심 을 받고 있는데, 본 연구에서는 구개열 환자의 의사소통 관련 삶의 질을(QCL)에 대해 연구하고자 한다. 연구 대상은 구개열 아동 30명과 일반 아동 30명을 포함하였다. 집단 별 QCL을 평가한 후, 독립표본 t-검정을 실시 하였다. 연구 결과 구개열 아동의 QCL 점수가 일반 아동의 QCL 점수보다 현저하게 낮게 나타났다. 본 연구는 QCL을 우리말로 타당하게 번안하여 국내에서 사용할 수 있는 도구로 제시하였다는데 의의가 있고, 구개열 아동 의 QCL을 측정해봄으로써, 구순구개열 집단의 의사소통 관련 삶의 질을 증진하기를 기대한다.

2015개정 교육과정 중학교 기술교과 로봇 체험활동과제 개발

이미소,이경택 한국교원대학교 뇌기반교육연구소 2020 Brain, Digital, & Learning Vol.10 No.3

The purpose of this study is to develop a robot hands-on activity task for the ‘manufacturing technology’ section of the middle school technology subject of the 2015 revised curriculum. The study procedure proceeded to the preparation-development-improvement phases. In the preparation stage, the textbook of the 2015 revised curriculum was analyzed to suggest the necessity of robot education, and commercial education robots were analyzed to supplement the weak points. In the development stage, a robot education kit that differentiates it from the existing robots was developed, and teaching and learning materials that can be used together were developed to construct a robot hands-on activity task. in the improvement phase, expert verification was first conducted, and the robot hands-on activity task including the robot education kit and teaching and learning materials were preliminary tested to correct and supplement them. The results obtained in this study are as follows. First, a robot education kit was developed that can learn the components, operation principles, etc. of the robot, including all of the components of them, the driving unit, the control unit, the sensor unit, and the power unit. Second, some parts of the robot education kit were designed and manufactured by the students themselves, so that students can show their creativity in the assembly process of the robot education kit. Third, in order to construct the robot hands-on activity task with the robot education kit, teaching and learning materials on the robot’s operation principle, robot type, and robot components were developed.

Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells

이미소,이경훈,민아름,김정은,김성영,장혜민,임지민,김소현,하동현,정원재,서경진,양예원,김태용,오도연,방영주,임석아 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2

Purpose Pim kinases are highly conserved serine/threonine kinases, and different expression patterns of each isoform (Pim-1, Pim-2, and Pim-3) have been observed in various types of human cancers, including gastric cancer. AZD1208 is a potent and selective inhibitor that affects all three isoforms of Pim. We investigated the effects of AZD1208 as a single agent and in combination with an Akt inhibitor in gastric cancer cells. Materials and Methods The antitumor activity of AZD1208 with/without an Akt inhibitor was evaluated in a large panel of gastric cancer cell lines through growth inhibition assays. The underlying mechanism was also examined by western blotting, immunofluorescence assay, and cell cycle analysis. Results AZD1208 treatment decreased gastric cancer cell proliferation rates and induced autophagy only in long-term culture systems. Light chain 3B (LC3B), a marker of autophagy, was increased in sensitive cells in a dose-dependent manner with AZD1208 treatment, which suggested that the growth inhibition effect of AZD1208 was achieved through autophagy, not apoptosis. Moreover, we found that cells damaged by Pim inhibition were repaired by activation of the DNA damage repair pathway, which promoted cell survival and led the cells to become resistant to AZD1208. We also confirmed that the combination of an Akt inhibitor with AZD1208 produced a highly synergistic effect in gastric cancer cell lines. Conclusion Treatment with AZD1208 alone induced considerable cell death through autophagy in gastric cancer cells. Moreover, the combination of AZD1208 with an Akt inhibitor showed synergistic antitumor effects through regulation of the DNA damage repair pathway.

Ag NPs anchored M13 Bacteriophage for Photovoltaic Enhancement in Organic Solar Cells

이미소,강재욱 한국고분자학회 2018 한국고분자학회 학술대회 연구논문 초록집 Vol.43 No.2

해양생물 소재 STS 수업이 중학교 학생들의 해양 인식에 미치는 효과

이미소,박국태,권용주,정진수 한국환경교육학회 2006 環境 敎育 Vol.19 No.1

The purpose of this study was to test effect of STS instruction using the subject matter of marine life on middle school students' perception of ocean. The objects of 156 students were sampled from the 1st grade of a middle school and were divided into an experimental group and a control group. 79 students of the control group were treated with traditional instruction, while 77 students of the experimental group were treated with STS instruction materials. All of the students took test of perception of ocean before and after the instructions. The perception of ocean was divided into four categories; value of sea, development of marine resources, research and conservation of sea, and perception of sea-related vocation. The results of the pretest and the posttest indicated that the perception of ocean of the experimental group was statistically significantly higher than that of the control group. Specially in categories of the value of sea and the research and conservation of sea, the scores of the experimental group were significantly higher than those of the control group.

Chlorin-e6 Conjugated Polydopamine Capped Gold Nanoparticles for Synergy Effect by Combining Photothermal and Photodynamic Therapy

이미소,유혁상,Mao Wei,박재근,조완호,Oanh-Vu Pham-Nguyen 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2

Photothermal therapy 와 polydynamic therapy 를 결합시켜 시너지 효과를 내는 방법이 최근 항암 치료에 많이 사용되고 있는 것처럼 본 연구에서도 두 가지 파장의 근적외선 빛(650 nm, 808 nm)을 이용해 시너지 효과가 발생함을 보았다. 여기에 쓰이는 입자를 만들기 위해 polydopamine (PDA)와 감광제인 Chlorin-e6 을 금 나노 입자(AuNP)에 차례로 코팅하였다(Ce6@PDA@AuNP). AuNP 는 808 nm 의 빛을 흡수하여 SPR 효과에 의해 열을 발생시키게 되고, Ce6 은 650 nm 의 빛을 흡수하여 ROS 를 발생시켜 표적 세포의 사망을 유발할 수 있다. 여러 분석들을 통해 이 입자의 특성들을 확인하였고, 한 파장의 근적외선 빛을 조사할 때 보다 두개 파장의 빛을 사용할 때 더 높은 온도 상승과 더 많은 Ce6 이 방출됨을 확인하였다. 이와 같은 행동 양상들이 세포 및 동물 실험에도 동일하게 적용되는지 확인해본 결과 pH 가 낮아질수록 조사된 파장의 종류에 따라 암세포에 더 큰 악영향을 줄 수 있음이 확인되어 결과적으로 이 나노 입자가 항암 치료에 사용이 가능하다고 말할 수 있다.