Postoperative Thyroid-Stimulating Hormone Levels Did Not Affect Recurrence after Thyroid Lobectomy in Patients with Papillary Thyroid Cancer

이명철,김민주,최훈성,조선욱,이국행,박영주,박도준 대한내분비학회 2019 Endocrinology and metabolism Vol.34 No.2

Background: Thyroid-stimulating hormone (TSH) suppression is recommended for patients who undergo thyroidectomy for differentiated thyroid cancer (DTC). However, the impact of TSH suppression on clinical outcomes in low-risk DTC remains uncertain. Therefore, we investigated the effects of postoperative TSH levels on recurrence in patients with low-risk DTC after thyroid lobectomy. Methods: Patients (n=1,528) who underwent thyroid lobectomy for papillary thyroid carcinoma between 2000 and 2012 were included in this study. According to the mean and dominant TSH values during the entire follow-up period or 5 years, patients were divided into four groups (<0.5, 0.5 to 1.9, 2.0 to 4.4, and ≥4.5 mIU/L). Recurrence-free survival was compared among the groups. Results: During the 5.6 years of follow-up, 21 patients (1.4%) experienced recurrence. Mean TSH levels were within the recommended low-normal range (0.5 to 1.9 mIU/L) during the total follow-up period or 5 years in 38.1% or 36.0% of patients. The meanand dominant TSH values did not affect recurrence-free survival. Adjustment for other risk factors did not alter the results. Conclusion: Serum TSH levels did not affect short-term recurrence in patients with low-risk DTC after thyroid lobectomy. TSHsuppression should be conducted more selectively

PET의 기본개념

李明哲 대한의학협회 1995 대한의학협회지 Vol.38 No.3

Photocatalytic Degradation of Soot on TiO₂: The Role of OH Radicals in a Solid-Phase Reaction

이명철,최원용 한국공업화학회 2002 한국공업화학회 연구논문 초록집 Vol.2002 No.0

최근 TiO₂ 표면에서 발생하는 활성산소종의 거동에 대한 연구가 활발히 이루어지고 있다. OH 라디칼이 TiO₂ 표면에서 발생한 후 탈착하여 용액 및 기체상으로 확산한다는 연구이다. 본 연구에서는 Soot/TiO₂ 표면에서의 광촉매 반응을 통해서 Soot의 분해 거동과 TiO₂ 표면에서 발생한 OH 라디칼의 확산에 따른 결과를 제시하였다. 흡착되어 있는 Soot는 광촉매 표면에서 광분해 반응으로 분해가 일어나며 soot의 두께, 자외선 조사방향, 습도 및 반응기체에 따라 분해 거동이 다르게 나타났다. 특히, UV가 조사된 TiO₂ 표면에서 발생한 OH 라디칼이 일정한 거리로 떨어진 Soot 물질을 분해할 수 있음을 확인 할 수 있었다. 액상이나 기상 중의 분해물질이 광촉매 표면으로 확산해와서 흡착한 다음 반응이 진행되는 경우와는 달리 TiO₂ 표면 위에 고정화된 soot의 분해반응은 OH 라디칼의 확산에 의하여 진행됨을 알 수 있었다. OH 라디칼의 확산 반응에 대한 이해는 고상 광촉매 반응을 이해하는데 중요한 정보를 제공한다.

폐로 전이된 악성 Schwannoma

이명철,김상규 한국의학사 1991 診斷과治療 Vol.11 No.10

방사성동위원소 배뇨방광촬영술의 신장예후 예측성능

이명철,김석기,이동수,정준기,김광명,최황 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.2

Purpose: As vesicoureteral reflux (VUR) could lead to renal functional deterioration when combined with urinary tract infection, we need to decide whether operative anti-reflux treatment should be performed at the time of diagnosis of VUR. Predictive value of radioisotope voiding cystography (RIVCG) for renal outcome was tested. Materials and Methods: In 35 children (18 males, 17 females), radiologic voiding cystourethrography (VCU), RIVCG and DMSA scan were performed. Change in renal function was evaluated using the follow-up DMSA scan, ultrasonography, and clinical information. Discriminant analysis was performed using individual or integrated variables such as reflux amount and extent at each phase of voiding on RIVCG, in addition to age, gender and cortical defect on DMSA scan at the time of diagnosis. Discriminant function was composed and its performance was examined. Results: Reflux extent at the filling phase and reflux amount and extent at postvoiding phase had a significant prognostic value. Total reflux amount was a composite variable to predict prognosis. Discriminant function composed of reflux extent at the filling phase and reflux amount and extent at postvoiding phase showed better positive predictive value and specificity than conventional reflux grading. Conclusion: RIVCG could predict renal outcome by disclosing characteristic reflux pattern during various voiding phases. (Korean J Nucl Med 2000;34:135-143)

골다공증의 치료와 예방

이명철 한국만성질환관리협회 1996 월간성인병 Vol.186 No.-

효율적 구조 질의를 지원하는 바다-Ⅳ/XML 질의처리기의 설계 및 구현

이명철,김상균,손덕주,김명준,이규철 한국데이타베이스학회 2000 Journal of information technology applications & m Vol.7 No.2

갑상선기능항진증에서 좌심실용적 및 기능변화에 관한 연구

이명철,고창순 대한핵의학회 1983 핵의학 분자영상 Vol.17 No.2

The purpose of this study is to investigate the effects of thyroid hormone on the left ventricular(LV) volume and function in man with untreated hyperthyroidism and to determine the effects of successful therapy for thyrotoxicosis on the ventricular pathophysiology. In the precent study, equilibrium ralhianuclide cardiac angiography was performed and LV volume index, ejection phase indexes of LV performance, serum thyroid hormone levels and other hemodynamic parameters were measured in 28 normal subjects and 39 patients with hyperthyroidism before treatment and again every 4 weeks for the first 2 months after the initiation of effective therapy. The result obtained were as follows; 1) In the untreated hyperthyroid state heart rate, blood volume, cardiac index and stroke volume index(97±14 beats/min, 73.5±11.8 ml/kg, 6.9±1.4 l/min/m2 and 77.6±13.8 ml/m2, respectively) were increased significantly compared to those in normal control(74±12beats/min, 65.6±14.8 ml/kg, 3.8±1.2 l/min/m2 and 56.6±13.2 ml/m2 rely). (Mean±SD). 2) There was a significant increase in LV end-diastolic volume index in patients with hyperthyroidism(30.5±7.5 for hyperthyroid group compared to a normal control of 22.2±6.5;P〈0.001), whereas end-systolic volume index remained unchanged 9.6±3.6 and 8.8±3.3 respectively). 3) In patients with hyperthyroidism, LV ejection fraction was 70.0±5.6%, fractional shortening 32.9±5.1%, mean velocity of circumferential fiber shortening(mean Vcf) 1.34±0.31 circ/sec and maximum ejection rate 3.47±0.80. All the ejection phase indexes were significantly greater than those in normal control(65.2±5.7%, 28.8±3.2%, 0.88±0.37 circ/sec and 2.27±0.50, respectively; p〈0.001). 4) Effective therapy produced significant decrease in all the values of serum thyroid hormone concenrations(p〈0.001), hemodynamic parameters(p〈0.001), end-diastolic volume index(p〈0.01) and ejection phase indexes of LV contractility in patients with hyperthyroidism and after one to two months, when the patients were euthyroid, these measurements were in the rangeof normal. 5) A significant linear correlation between mean Vcf and serum thyroxine level(r=0.63. p$lt;0.001) as well as between mean Vcf and serum triiodothyronine level(r=0.62, p$lt;0.001) was found. The lesser degree of correlation was also noted between other ejection phase indexes and serum thyroid hormone concentrations. The resilts indicate that the major effects of excess thyroid hormone on the LV in human beings with hyperthyroidism are an enhancement of LV function and an increase in LV endsiastolic volume and that these effects cause predictable reversible cardiac alteration which are changed dramatically and immedately after effective therapy.

이식신 거부반응에서 99mTc-tin colloid 스캔의 의의

이명철,이정상,조보연,고창순,김승택,김성권,오하영,박선양 대한핵의학회 1982 핵의학 분자영상 Vol.16 No.2

$quot;Renal transplant uptake of Tc-99m-tin colloid was evaluated in 26 patients. Seventy-seven examinations were performed comparing transplant with bone marrow activity, clinical and/or pathological diagnosis. There were 13 instances of acute rejection; 7 of these exhibited slight uptake of radiocolloid in the renal transplant, 1 had marked uptake, and 5 had no evidence of uptake. There were 7 instances of chronic rejection; 5 of which demonstrated marked transplant uptake of radiocolloid, 1 had slight uptake, and 1 had no evidence of uptake. There were 2 instances of acute tubular necrosis and 55 instances of normal transplant function, but none of these exhibited transplant uptake of radiocolloid. From the result, the uptake of Tc-99m-tin colloid by renal transplant appears to signal rejection as long as the vascular supply is not severely compromised. Acute rejection may be represented by slight radiocolloid uptake, and chronic rejection by marked uptake when compared to bone marrow activity.$quot;

원전 종사자 및 주변주민에 대한 역학조사와 중장기 추진의 의의

이명철,Lee, Myeong-Cheol 한국동위원소협회 2000 동위원소회보 Vol.15 No.2