Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database

조선욱,김정희,최한석,안화영,김미경,이은정 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.1

The Korean National Health Information Database (NHID) contains big data combining information obtained from the National Health Insurance Service and health examinations. Data are provided in the form of a cohort, and the NHID can be used to conductlongitudinal studies and research on rare diseases. Moreover, data on the cause and date of death are provided by Statistics Korea. Research and publications based on the NHID have increased explosively in the field of endocrine disorders. However, because the data were not collected for research purposes, studies using the NHID have limitations, particularly the need for the operational definition of diseases. In this review, we describe the characteristics of the Korean NHID, operational definitions of endocrine diseases used for research, and an overview of recent studies in endocrinology using the Korean NHID.

산화질소 분자 퍼텐셜에 적용한 Numerov-Cooley 방법

조선욱,Cho, Seon-Woog 대한화학회 2007 대한화학회지 Vol.51 No.2

Numerov-Cooley 방법을 적용할 때 양쪽에서 전파된 파동함수를 연결시키는 것이 관건인데, 잘 알려진 스프레드시트인 엑셀에서 해찾기 도구를 활용하여 Numerov 방법의 파동함수 연결을 해결하였다. 한쪽방향으로 전파하여 얻은 에너지 값과 반대쪽으로 전파하여 얻은 에너지 값들의 평균을 이용해 상태함수의 고유값을 정하는 방법도 같은 결과를 보임을 확인하였다. 산화질소 분자 퍼텐셜 위에서 이 방법을 적용하였고, 진동에너지에 따른 원자간 평균거리와 터널링 변화를 계산하였다. 진동에너지가 증가하면서 분자 결합 길이는 비례하여 늘어나지만, 터널 효과는 모든 진동 상태가 어느 정도의 확률을 가지며 에너지 증가에 둔감하다는 것을 확인하였다. In applying Numerov-Cooley method, Excel tool ‘Solver' is used to match those two wave functions propagated inward and outward, respectively. It is numerically confirmed that the same eigenvalue is obtained by using the average of two energy values of each inward and outward wave functions. This method is applied to a NO molecule potential, and we calculated the variations of the average bond distance and tunneling for a given vibrational energy. It is found that the average bond lengths increase proportionately to the vibrational energy, while the tunneling is not so sensitive to the energy changes. Rather substantial amount of tunnel effect is found for every vibrational state.

A High Frequency of Lobectomy Instead of Total Thyroidectomy to Treat Medullary Thyroid Cancer in Korea: Data from the Korean National Health Insurance Service

조선욱 대한내분비학회 2020 Endocrinology and metabolism Vol.35 No.4

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Sm^3+ 도핑된 GdVO4 형광체의 제조와 발광 특성

조선욱,조신호 한국진공학회 2012 Applied Science and Convergence Technology Vol.21 No.2

Gd1-xVO4:Smx^3+ phosphor powders were synthesized with changing the concentration of Sm^3+ ion by using a solid-state reaction method. The crystal structures of all the phosphors were found to be a tetragonal system, composed of (200) diffraction peak centered at 24.76°, and the morphology of grains approached the spherical form with homeogenous size distribution when the concentration of Sm^3+ ion was 0.05 mol. As for the photoluminescence properties, all of the phosphor powders, irrespective of Sm^3+ ion concentration, indicated the yellow, orange, and red emission peaked at 565, 603, and 645 nm respectively. As the concentration of Sm^3+ ion increases, the intensity of excitation spectrum showed a decreasing tendency on the increase of Sm3+ ion concentration. The maximum excitation and emission spectra were observed and the symmetry ratio was 1.19 at 0.05 mol of Sm^3+ ion. 고상 반응법을 사용하여 Sm^3+ 이온의 함량비를 변화시키면서 Gd1-xVO4:Eux^3+ 형광체 분말을 합성하였다. 모든 형광체 시료의 결정 구조는 24.76°에 중심을 갖는 (200) 주 회절 피크로 구성되는 정방정계이었으며, 결정 입자의 형상은 Sm^3+ 이온의 함량비가 0.05 mol일 때 구형에 근접하고 균일한 크기 분포를 나타내었다. 발광 특성의 경우에, Sm^3+ 이온의 함량비에 관계없이 모든 형광체 분말은 파장 565, 603, 645 nm에 피크를 갖는 각각 황색, 주황색, 적색 형광을 보였다. Sm^3+ 이온의 함량비가 증가함에 따라 흡수 스펙트럼의 세기는 감소하는 경향을 나타내었으며, Sm^3+ 이온의 함량비가 0.05 mol일 때 최대 흡수와 발광 스펙트럼이 관측되었고, 대칭비의 값은 1.19이었다.

Eu³⁺ 함량비가 Y_1-xPO₄:Eu_x³⁺ 적색 형광체의 발광 특성에 미치는 영향

조선욱,조신호,Cho, Seon-Woog,Cho, Shin-Ho 한국진공학회 2011 Applied Science and Convergence Technology Vol.20 No.6

고상 반응법을 사용하여 $Eu^{3+}$ 이온의 함량비를 변화시키면서 $Y_{1-x}PO_4:{Eu_x}^{3+}$ 적색 형광체를 합성하였다. 모든 적색 형광체의 결정 구조는 $25.88^{\circ}$에 중심을 갖는 (200) 주 회절 피크로 구성되는 정방정계이었으며, 결정 입자의 형상은 $Eu^{3+}$ 이온의 함량비가 증가함에 따라 구형에 근접하고 균일한 크기 분포를 나타내었다. 형광 특성의 경우에, $Eu^{3+}$ 이온의 함량비에 관계없이 모든 세라믹은 파장 593.0과 619.2 nm에 피크를 갖는 각각 적주황색과 적색 형광을 나타내었다. $Eu^{3+}$ 이온의 함량비가 증가함에 따라 여기 스펙트럼의 파장은 약간씩 장파장 쪽으로 이동하면서 흡수 세기는 증가하는 경향을 보였으며, $Eu^{3+}$ 이온의 함량비가 0.15 mol일 때 최대 흡수 및 발광 스펙트럼이 관측되었다. $Y_{1-x}PO_4:{Eu_x}^{3+}$ red phosphors were synthesized with changing the concentration of $Eu^{3+}$ ion by using a solid-state reaction method. The crystal structures of all the red phosphors were found to be a tetragonal system composed of (200) diffraction peak centered at $25.88^{\circ}$, and the morphology of grains approached the spherical form with homeogenous size distribution as the concentration of $Eu^{3+}$ ion increased. As for the photoluminescence properties, all of the ceramic phosphors, irrespective of $Eu^{3+}$ ion concentration, showed the red-orange and the red emission peaked at 593.0 and 619.2 nm respectively. As the concentration of $Eu^{3+}$ ion increased, the excitation spectrum moved into a longer wavelength with the increase of emission intensity. The maximum excitation and the emission spectrum were observed at 0.15 mol of $Eu^{3+}$ ion.

Characteristics of Body Composition and Muscle Strength of North Korean Refugees during South Korean Stay

조선욱,이소희,고은실,김시은,김석중 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.4

Background: The aim of this study was to investigate the changes of body composition and muscle strength of North Korean refugees (NKRs) according to their duration of stay in South Korea. Methods: NKRs who volunteered and were living in South Korea, aged 20 to 75 years were recruited. Body compositions were analyzed by bioelectrical impedance analysis. Muscle strength was measured with the hand grip test. Demographic and migration information was obtained with a questionnaire. Results: A total of 158 volunteers were recruited at a mean age of 48.3±11.4 years. The mean time from when they escaped from North Korea and arrived in South Korea was 5.8±4.3 years. Height, weight, and body surface area were significantly smaller in all NKRs compared to South Korean controls, except for women aged over 50 years. In females of younger ages (<50 years), NKRs with more than a 4-year stay in South Korea had a higher weight and fat mass than that of those who had a shorter stay (less than 4 years) in South Korea. All NKRs had a weaker grip strength than that of the age-matched controls from South Korea. Conclusion: The NKRs showed relatively smaller physiques and weaker muscle strength than that of the South Korean controls. In younger female NKRs, shorter South Korean stay group showed small body weight and fat mass than that of longer South Korean stay group. Specific health support programs might be needed.

Eu³⁺ 농도가 적주황색 형광체 Gd_1-xPO₄:Eu_x³⁺의 발광 특성에 미치는 영향

조선욱,Cho, Seon-Woog 한국재료학회 2011 한국재료학회지 Vol.21 No.11

Red-orange phosphors $Gd_{1-x}PO_4:{Eu_x}^{3+}$ (x = 0, 0.05, 0.10, 0.15, 0.20) were synthesized with changing the concentration of $Eu^{3+}$ ions using a solid-state reaction method. The crystal structures, surface morphology, and optical properties of the ceramic phosphors were investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM), and photoluminescence (PL) spectrophotometry. The XRD results were in accordance with JCPDS (32-0386), and the crystal structures of all the red-orange phosphors were found to be a monoclinic system. The SEM results showed that the size of grains increases and then decreases as the concentration of $Eu^{3+}$ ionincreases. As for the PL properties, all of the ceramic phosphors, irrespective of $Eu^{3+}$ ion concentration, had orange and red emissions peaks at 594 nm and 613 nm, respectively. The maximum excitation and emission spectra were observed at 0.10 mol of $Eu^{3+}$ ion concentration, just like the grain size. An orange color stronger than the red means that $^5D_0{\rightarrow}^7F_1$ (magnetic dipole transition) is dominant over the $^5D_0{\rightarrow}^7F_2$ (electric dipole transition), and $Eu^{3+}$ is located at the center of the inversion symmetry. These properties contrasted with those of a red phosphor $Y_{1-x}PO_4:{Eu_x}^{3+}$, which has a tetragonal system. Therefore, we confirm that the crystal structure of the host material has a major effect on the resulting color.

Best Achievements in Translational and Basic Thyroidology in 2020

조선욱,박영주 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.1

This review discusses articles published in 2020 that presented noteworthy achievements in translational and basic thyroidology. Previously unresolved questions about thyroid hormone receptor actions and signaling mechanisms were answered using various novel in vitro and in vivo models. Using high resolution cryo-electron microscopy, the fine functional structure of thyroglobulin was demonstrated, and new insights into the pathogenesis of thyroid disease were achieved, with a focus on research into thyroid-disrupting chemicals and the gut microbiome. Novel therapeutic approaches were tried in the field of advanced thyroid cancer treatments.

췌장 낭성 종괴로 발현한 인슐린종 1예

조선욱,이은정,곽수헌,조영민,신찬수,박경수,김성연,조보연,이홍규 대한내분비학회 2006 Endocrinology and metabolism Vol.21 No.6

Cystic islet cell neoplasms are among the rarest entities in the differential diagnosis of cystic tumor of the pancreas, and this malady raises difficult clinical problems. The diagnosis of insulinoma could be difficult if the functional activity is incomplete, which possibly leads to blunted symptoms of hypoglycemia and failure in the laboratory to provide evidence of hyperinsulinemia. Furthermore, if the imaging shows a smaller tumor than usual or an unusual morphology like cyctic tumor, then physicians can become somewhat confused. We report here on a clinical case of cystic insulinoma with the typical neuroglycopenic symptoms and laboratory- confirmed hyperinsulinemia. At resection, a 2-cm cavitary mass without central necrosis was excised and this was confirmed histologically as a purely cystic insulioma. This is the first report of a functional cystic insulinoma of the pancreas in Korea. We suggest that the differential diagnosis of endocrine tumor must be considered for any pancreatic cyst, and especially when it is discovered in a patient who is clinically suggestive of having the associated syndrome. (J Kor Endocrinol Soc 21:552~555, 2006) 췌장의 낭성 내분비 종양은 임상적으로 매운 드문 질환으로, 모든 췌장 내분비 종양의 2~3%에 불과하다. 저자들은 췌장의 낭성 인슐린 종양으로 진단 받고 수술로써 완치된 우리나라 첫 증례를 보고하며, 췌장의 낭성 종양의 한 감별 진단으로 췌장 내분비 질환, 특히 인슐린종이 포함되어야 함을 강조하고자 한다.

면역세포와 암세포의 상호작용

조선욱 대한갑상선학회 2013 International Journal of Thyroidology Vol.6 No.2

Tumor microenvironment is defined as a heterogeneous complex composed of cancer cells, vascular endothelial cells, fibroblasts, and diverse immune cells. Cancer immunology is the study of interactions between the immune system and cancer cells which is applied to develop therapeutic strategies for human cancers. This review focused on tumor promoting myeloid derived cells such as tumor associated macrophages (TAM) and myeloid derived suppressor cells (MDSC) and their therapeutic applications.