대한갑상선학회 갑상선분화암 진료권고안; Part I. 갑상선분화암의 초기치료 - 제3장 갑상선분화암의 수술 전후 합병증 평가 2024

유창환 대한갑상선학회 2024 International Journal of Thyroidology Vol.17 No.1

Thyroid surgery complications include voice change, vocal fold paralysis, and hypoparathyroidism. The voice status should be evaluated pre- and post-surgery. In patients with voice change, laryngeal visualization is needed. Intraoperative neuromonitoring helps reduce recurrent laryngeal nerve injury. The measurement of serum calcium, parathyroid hormone, and 25-hydroxyvitamin D levels is recommended to evaluate perioperative parathyroid function and prescribe supplementation preoperatively if necessary. For postoperative hypoparathyroidism, vitamin D and oral calcium supplementation are indicated based on serum parathyroid hormone and calcium levels and the severity of symptoms or signs of hypocalcemia. If long-term treatment is required, the appropriateness of treatment should be evaluated based on the disease itself and the consideration of potential benefits and harms from long-term replacement.

천식환자 허실변증별 혈액 싸이토카인 및 임상적 특성에 관한 단면적 연구

유창환,강성우,홍성은,김관일,이범준,정희재 대한한방내과학회 2020 大韓韓方內科學會誌 Vol.41 No.4

Objective: The aims of this study were to analyze deficiency-excess pattern identification and to compare the blood cytokines in patients with asthma. Methods: A total of 112 patients with asthma who met the inclusion and exclusion criteria were divided into deficiency syndrome and excess syndrome groups. Blood was examined for eotaxin, interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF)-α. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), a Visual Analogue Scale (VAS), and heart rate variability (HRV) tests were administered to both groups. Results: Pattern identification divided the 112 patients into two categories: a deficiency syndrome group (N=52) and an excess syndrome group (N=60). Analysis of blood cytokines showed higher levels of IL-4, IL-5, and IL-13 in the deficient pattern than in the excess pattern group, but the difference was not statistically significant. Analysis of the HRV revealed a significantly higher mean value for the very-low-frequency (VLF) and high-frequency (HF) bands in the deficiency than in the excess syndrome group. The morbidity duration was longer in the deficiency than in the excess syndrome group, but the difference was not statistically significant. Analysis of the QLQAKA and VAS scores showed a negative correlation, whereas BMI and VAS showed a positive correlation. Conclusions: Levels of blood cytokines, including eotaxin, IL-1β, IL-4, IL-5, IL-6, IL-13, and TNF-α, did not differ statistically between the deficiency and excess syndrome groups. The development of a more accurate asthma-specific pattern identification tool would be useful in asthma control.

소규모 철근콘크리트 건축물을 위한 비선형해석 프로그램 비교 II

유창환,김태완,박홍근 한국지진공학회 2015 한국지진공학회논문집 Vol.19 No.5

For small-size reinforce-concrete buildings, Midas Gen, OpenSees, and Perform-3D, which are structural analysis programs that are most popularly used at present, were applied for nonlinear static pushover analysis, and then difference between those programs was analyzed. Example buildings were limited to 2-story frames with irregular shaped walls. Analysis result showed that there were more differences than for frames only and frames with rectangular walls, but it was not so significant. Nevertheless, the capacity curve were different in some buildings, which is attributed to shape and location of walls, and feature of the analysis program. Especially, selection of automatic or manual input in Midas Gen, or nonlinear wall elements in Perform3D can affect the capacity curve and performance of the buildings. Therefore, the program users should understand the feature of the program well, and then conduct performance assessment. The result of this study is limited to low-story buildings so that it should be noted that it is possible to get different results for mid- to high-rise buildings.

소규모 철근콘크리트 건축물을 위한 비선형해석 프로그램 비교 I

유창환,김태완 한국지진공학회 2015 한국지진공학회논문집 Vol.19 No.5

For small-size reinforce-concrete buildings, Midas Gen, OpenSees, and Perform-3D, which are structural analysis programs that are most popularly used at present, were applied for nonlinear static pushover analysis, and then difference between those programs was analyzed. Example buildings were limited to 2-story frames only and frames with one or more rectangular walls. Analysis results showed that there was not much difference for frames only based on capacity curves. There were some differences for frames with rectangular walls, but it was not so significant. The global behaviors represented by the capacity curve were not so different, but the feature of each analysis program appeared when the results were analyzed in more detail. Therefore, the program users should understand the feature of the program well, and then conduct performance assessment. The result of this study is limited to low-story frames only and frames with rectangular walls so that it should be noted that it is possible to get different results for frames with non-rectangular walls or mid- to high-rise buildings.

Development and Evaluation of a Korean Version of a Thyroid-Specific Quality-of-Life Questionnaire Scale in Thyroid Cancer Patients

유창환,박보람,류준선,조성애,이유진,이은경,황보율,주정남,정유석 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2

Purpose The purpose of this study was to develop a Korean version of the self-reported thyroid-specific quality of life (QoL) questionnaire for thyroid cancer patients (KT-QoL), and to evaluate its reliability and validity. Materials and Methods Two hundred seventy-two patients who underwent thyroidectomy from January to December 2010 were recruited in this study. The original version of the thyroid QoL was translated into Korean and evaluated for its reliability and validity. Using the developed KT-QoL, the postoperative QoL was evaluated until postoperative 1 year. Results At the preoperative baseline, the item internal consistency (IIC) ranged from 0.19 to 0.76, with low IIC values for items 2, 17, and 27. Item discriminant validity ranged from 86% to 97%. These values were similar at the postoperative periods. The internal consistency reliability (Cronbach’s ) was high for all dimensions, ranging from 0.90 to 0.95. The test-retest reliability (intraclass correlation coefficient) was acceptable (0.74-0.82). The external validity examined by the correlation between the item 1j (voice changes) of KT-QoL and the voice handicap index-30 ranged from 0.51 to 0.75. Patients’ QoL scores decreased after surgery, which demonstrated the sensitivity of the questionnaire. The QoL scores in patients with lobectomy showed best QoL scores postoperatively and those with receiving radioactive iodine still showed decreased QoL scores along the postoperative periods. Conclusion These results demonstrate that KT-QoL is a valid instrument for evaluating QoL of Korean patients with thyroid cancer.

Synovial Sarcoma of the Thyroid Gland

유창환,조경자,최승호 대한이비인후과학회 2011 Clinical and Experimental Otorhinolaryngology Vol.4 No.4

Primary synovial sarcoma of the thyroid is an extremely rare condition which has only been reported twice in the literature. We herein report a case of highly aggressive and rapidly lethal primary synovial sarcoma of the thyroid. A 72-year-old woman presented with extensive local invasion, rapid progression, and early distant metastasis secondary to primary thyroid synovial sarcoma. The tumor exhibited an atypical histologic and immunohistochemical staining pattern. Detection of SYT/SSX fusion transcript confirmed the diagnosis of synovial sarcoma. Due to the aggressive nature of primary synovial sarcoma of the thyroid gland, early diagnosis and comprehensive treatment including wide resection and postoperative chemoradiation is required.

등골 머리가 보존된 경우에서의 이소골 재건술의 술 후 성적

유창환,윤태현,김태수,안중호,김종양 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.3

Incus erosion with intact stapes head was most common ossicular impairment in chronic otitis media. Here, we aimed to investigate hearing and clinical results of the ossiculoplasties when the stapes head was intact. Subjects and Method:We analyzed 281 patients of ossiculoplasties over stapes head performed from 1990 to 2005. Patients were divided into 3 groups:Si group (n=121) included patients with interposition of prosthesis between malleus and stapes; Sc-PORP group (n=99) included patients with columellarization between tympanic membrane and stapes head with PORP; Sc-SC group (n=61) included patients with columellarization with the autologous materials between tympanic membrane and stapes head. Hearing improvement and extrusion rates of three groups were analyzed. Results:At 6 months after the surgery, the postoperative air-bone gap (ABG) level within 20 dB was 45%, 44%, 25% in Si, Sc-PORP, Sc-Sc, respectively. The closure of ABG was statistically better in Si and Sc-PORP compared with Sc-SC. In canal wall-up mastoidectomy, Sc-PORP showed better hearing results than Si, while Si was better than Sc-PORP in canal wall-down mastoidectomy. At 36 months after the surgery, extrusion-free survival according to the type of ossiculoplasty were 100%, 89.6%, 100% in Si, Sc-PORP, Sc-SC, respectively. Conclusion:Si and Sc-PORP provide good hearing results. However, Si has lower extrusion rates than Sc-PORP and remains stable over time. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:221-6)

한약 복용이 제 2형 당뇨 환자의 혈당 변화에 미치는 영향 : 후항적 차트 리뷰

유창환,강성우,홍성은,김관일,정희재,이범준 대한한방내과학회 2020 大韓韓方內科學會誌 Vol.41 No.6

Objective: This study was conducted to evaluate the effect of herbal medicine on blood glucose in diabetic patients. Methods: The subjects were patients with diabetes mellitus (DM) who had been admitted to Kyung Hee University Korean Medicine Hospital for more than 8 weeks for a primary diagnosis other than DM and who had taken herbal medicine for more than 8 weeks from January 2010 to February 2020. The medical records were analyzed retrospectively to confirm the characteristics of the subjects, and examination results included hemoglobin A1c (HbA1c), total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine. Changes in HbA1c before and after taking herbal medicine and changes according to subgroups were analyzed. Results: A total of 149 subjects with type 2 DM were selected as participants. After taking the herbal medicine, the HbA1c value was significantly decreased, and the statistical significance was maintained even when the effect of controlling antidiabetic agents was excluded. The decrease in HbA1c was higher in the poor glycemic control group. Liver and kidney functions did not show any significant changes after taking the herbal medicine. Conclusions: Administration of herbal medicine for a long period of 8 weeks or longer did not increase HbA1c in patients with DM complicated by other various diseases.

텍스트마이닝을 활용한 전통 장류 언론자료 분석

유창환,이병서 한국산학기술학회 2022 한국산학기술학회논문지 Vol.23 No.12

In this study, we examined 1,130 newspaper reports related to traditional pastes among traditional foods during a 68 months duration (Jan 2017 to Aug 2022) to analyze keywords and extract core words from the articles. The top 10 keywords referring to traditional sauces were extracted, depending on their frequency of appearance and weightage in these articles. The keywords were analyzed to examine the characteristics of the newspaper articles reporting traditional sauces. The association between the 10 keywords was subsequently quantified and graphically visualized using the association analysis. Results revealed that the largest group formed contained the keyword 'traditional pastes', with Sunchang-gun, Cheonggukjang, and excellence as the major sub-hubs. This indicates that amongst the various factors discussed, articles on traditional sauces focus more on Sunchang-gun, Cheonggukjang, and excellence. The next analysis extracted keywords from 628 newspaper articles, excluding duplicated ones. Primary keywords were selected based on the region, item, and adjective of traditional sauces. The major keywords determined were Sunchang-gun, Gangjin-gun, and middle school. Thus, we inferred that regional keywords are well-associated with the supporting policy of local governments, and there are differences in keyword trends when considering all articles and excluding duplicated articles. This study is significant in that text mining is used to analyze the press data instead of applying direct analysis prevalently used. Contrary to conventional research, this is an experimental study wherein text mining is applied to calculate text statistics, followed by combining with association analysis to identify the article contents in the form of keywords and uncover characteristic messages. In summary, we determined that the articles related to traditional pastes focus on region-specific support and promotion projects rather than on the sauce industry or cultural values. Although newspaper articles tend to concentrate on social issues with the property of the newspaper considered, it is necessary to continuously share and publicize the cultural values, historicity, and development plan of the sauces. 본 연구에서는 2017년부터 2022년 8월까지 5년 8개월간 보도된 전통 장류 관련 신문기사 1,130건을 수집하고해당 기사들에서 핵심 키워드를 추출하여 분석하였다. 우선 1,130건의 기사에서 출현 빈도 및 가중치가 높은 전통 장류 관련 상위 10개 핵심 키워드를 도출하였다. 도출된키워드를 분석하여 현재까지 전통 장류 관련 신문 기사의 특징을 살펴보고 도출된 10개 키워드 간 관계를 연관분석기법으로 수치화 및 시각화하였다. 분석 결과 ‘전통 장류’ 키워드를 가장 큰 허브로, ‘순창군’, ‘청국장’과 ‘우수성’을 하위허브로 키워드 그룹이 형성되는 구조였다. 이는 전통 장류 관련 기사는 다양한 주제 중에서 ‘순창군’, ‘청국장’ 및 ‘우수성’이 중심임을 보여준다. 다음으로 중복 기사를 제외한 628건 신문 기사 내 핵심 키워드를 추출하는 분석을 하였다. 주요 키워드는 전통 장류의지역, 품목, 형용사에 관련된 키워드들이 추출되었다. 중복 기사를 제외한 주요 키워드는 순창군, 강진군, 중학교가 상위에 있었다. 지역 키워드는 주로 지자체의 정책 지원과 연관되었음을 유추할 수 있으며, 전통 장류의 전체 기사와 중복기사를 제외한 키워드의 우선순위는 차이점이 있는 것으로 나타났다. 본 연구는 신문 기사를 직접 분석하는 기존의 방법에서 벗어나 텍스트마이닝 기법을 활용하여 텍스트 데이터를 분석하였다는 데 의의가 있다. 기존 내용분석 방법과 달리 텍스트마이닝을 사용하여 텍스트 통계량을 계산하고 이를 연관분석기법과 연계함으로써 기사의 내용을 키워드 형태로 파악하고 특징적인 메시지를 도출한 실험적인 연구이다. 분석을 통해나타난 결과를 요약하면, 전통 장류 관련 기사는 특정 지역 중심의 추진사업에 주목하고 있어 전통 장류의 문화적 가치와 역사성, 산업발전 방안 등을 대중과 공유하려는 노력이 필요하다고 판단된다.

한약 치료를 통해 비용종(Nasal polyp)이 소실된 부비동염 환자 치험 증례 1례

유창환,도하윤,강성우,노지애,김관일,이범준,정희재 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.5

Objective: The purpose of this case study was to report the effect of Korean medicine treatment on a patient diagnosed with a nasal polyp. Methods: A 62-year-old female patient with a nasal polyp visited the clinic sixteen times from September 11th, 2018 to December 18th, 2018. The patient was treated with Eunhwayeongyo-tang, Haeyeol-tang, Hongsamkyungok-go extract, and acupuncture during the treatment period. We evaluated the improvement of symptoms by nasoendoscopy. Results: After the Korean medicine treatment, the nasal polyp was completely eradicated. Hyperemia of the nasal mucous membrane and rhinorrhea were also relieved. Conclusion: The study findings suggested that Korean medicine treatment (Eunhwayeongyo-tang, Haeyeol-tang, and Hongsamkyungok-go extract, and acupuncture) might be effective for treatment of patients diagnosed with nasal polyps.