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우혜인,주은연,홍승봉,이경화,강은숙 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.1
Background: Narcolepsy is a neurologic disorder characterized by excessive daytime sleepiness, symptoms of abnormal rapid eye movement (REM) sleep, and a strong association with HLA-DRB1*1501, -DQA1*0102, and -DQB1*0602. Here, we investigated the clinico-physical characteristics of Korean patients with narcolepsy, their HLA types, and the clinical utility of high-resolution PCR with sequence-specific primers (PCR-SSP) as a simple typing method for identifying DRB1*15/16, DQA1, and DQB1 alleles. Methods: The study population consisted of 67 consecutively enrolled patients having unexplained daytime sleepiness and diagnosed narcolepsy based on clinical and neurological findings. Clinical data and the results of the multiple sleep latency test and polysomnography were reviewed, and HLA typing was performed using both high-resolution PCRSSP and sequence-based typing (SBT). Results: The 44 narcolepsy patients with cataplexy displayed significantly higher frequencies of DRB1*1501 (Pc= 0.003), DQA1*0102 (Pc=0.001), and DQB1*0602 (Pc=0.014) than the patients without cataplexy. Among patients carrying DRB1*1501-DQB1*0602 or DQA1*0102, the frequencies of a mean REM sleep latency of less than 20 min in nocturnal polysomnography and clinical findings, including sleep paralysis and hypnagogic hallucination were significantly higher. SBT and PCR-SSP showed 100% concordance for high-resolution typing of DRB1*15/16 alleles and DQA1 and DQB1 loci. Conclusions: The clinical characteristics and somnographic findings of narcolepsy patients were associated with specific HLA alleles, including DRB1*1501, DQA1*0102, and DQB1*0602. Application of high-resolution PCR-SSP, a reliable and simple method, for both allele-and locus-specific HLA typing of DRB1*15/16, DQA1, and DQB1 would be useful for characterizing clinical status among subjects with narcolepsy.
우혜인,임신원,명우재,김도관,이수연 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Treatment response to antidepressants is limited and varies among patients with major depressive disorder (MDD). To discover genes and mechanisms related to the pathophysiology of MDD and antidepressant treatment response, we performed gene expression analyses using peripheral blood specimens from 38 MDD patients and 14 healthy individuals at baseline and at 6 weeks after the initiation of either selective serotonin reuptake inhibitor (SSRI) or mirtazapine treatment. The results were compared with results from public microarray data. Seven differentially expressed genes (DEGs) between MDD patients and controls were identified in our study and in the public microarray data: CD58, CXCL8, EGF, TARP, TNFSF4, ZNF583, and ZNF587. CXCL8 was among the top 10 downregulated genes in both studies. Eight genes related to SSRI responsiveness, including BTNL8, showed alterations in gene expression in MDD. The expression of the FCRL6 gene differed between SSRI responders and nonresponders and changed after SSRI treatment compared to baseline. In evaluating the response to mirtazapine, 21 DEGs were identified when comparing MDD patients and controls and responders and nonresponders. These findings suggest that the pathophysiology of MDD and treatment response to antidepressants are associated with a number of processes, including DNA damage and apoptosis, that can be induced by immune activation and inflammation.
우혜인,박형두,이용화,이동환,기창석,이수연,김종원 대한진단검사의학회 2011 Annals of Laboratory Medicine Vol.31 No.1
Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is an autosomal recessive hereditary metabolic disorder of mitochondrial fatty acid β-oxidation. It is characterized by hypoketotic hypoglycemia, hyperammonemia, seizure, coma, and sudden infant death syndrome-like illness. The most frequently isolated mutation in the acyl-CoA dehydrogenase, medium-chain (ACADM) gene of Caucasian patients with MCADD is c.985A>G, but ethnic variations exist in the frequency of this mutation. Here, we describe 2 Korean pediatric cases of MCADD, which was detected during newborn screening by tandem mass spectrometry and confirmed by molecular analysis. The levels of medium-chain acylcarnitines, including octanoylcarnitine (C8), hexanoylcarnitine (C6), and decanoylcarnitine (C10), were typically elevated. Molecular studies revealed that Patient 1 was a compound heterozygote for c.449_452delCTGA (p.Thr150ArgfsX4) and c.461T>G (p.L154W) mutations, and Patient 2 was a compound heterozygote for c.449_452delCTGA (p.Thr150ArgfsX4) and c.1189T>A (p.Y397N) mutations. We also detected asymptomatic MCADD in some patients by using a newborn screening test and confirmed it by ACADM mutation analysis. This report presents evidence of the biochemical and molecular features of MCADD in Korean patients and, to the best of our knowledge, this is the first report of the c.461T>G mutation in the ACADM gene.
우혜인 한국유통과학회 2022 The Journal of Industrial Distribution & Business( Vol.13 No.8
Purpose: CEOs develop policies through their effective decision-making while employees implement the policies so that a business realizes the expected returns. This research focuses on the importance of the CEO's sustainable leadership to distribute environmental education culture to improve employees' environmental performance. Research design, data and methodology: The PRISMA that is selected by the present research is an evidence-based minimum group of entities for reporting in systematic reviews and meta-analyses. The core focus of the concept is to note studies that evaluate the impacts of intervention and can also be utilized as a basis for writing systematic reviews rather than intervention evaluations. Results: The current investigation indicates that there are four kinds of suggestions (a. Increased organizational learning, b. Open communication, c. Participative decision making, d. Psychological empowerment) how the management should develop sustainable leadership for distributing green culture and improving employee green performance. Conclusions: Based on four solutions, the present research concludes that sustainable leadership for CEOs is not only of advantage in terms of protecting the environment and the people, but it fosters increased organizational learning. Increased organizational learning leads to better employee sustainable performance, which includes financial performance and the social and environmental initiatives the organization implements.
취업주부와 전업주부의 생활만족도 요인분석-요가수련정도와 정신건강을 중심으로-
우혜인 ( Hye In Woo ) 한국무용교육학회 2014 韓國舞踊敎育學會誌 Vol.25 No.2
This study aims to analysis of the effect on life satisfaction by degree of yoga practice and mental health of employed and nonemployed mothers. The subjects of this study were a total of 322 married mothers(190 employed and 132 nonemployed mothers) of participation of yoga practice. The method of the statistical analysis used in this study, were multiple regression analysis. As a result of this data analysis, the conclusions of this study are as follows. First, employed and nonemployed mothers of degree of yoga practice is shown a significant effect on their mental health. Second, employed and nonemployed mothers of degree of yoga practice and mental health is shown a significant effect on their life satisfaction.
16S rRNA 염기서열분석과 생화학적 검사로 동정한 Microbacterium oxydans 에 의한 중심정맥관 연관 균혈증 1예
이남용,우혜인,이장호,이승태,기창석 대한임상미생물학회 2010 Annals of clinical microbiology Vol.13 No.4
Microbacterium oxydans는 환경에 널리 분포하는 coryneform의 그람 양성 막대균으로 과거에는 오염균으로 생각되었으나최근 몇 년간 사람에서의 감염보고가 증가하고 있다. Microbacterium 균종은 60여종 이상이 알려져 있으며 균종 간에16S rRNA의 염기서열의 일치도가 높고 생화학적 성상의 차이가 명확하지 않은 경우가 있어 대부분의 임상미생물 검사실에서는 균종까지 정확히 동정하기 어려운 균으로 알려져 있다. 본 증례에서 저자들은 미만성 대세포 림프종 환자에서중심정맥관 연관 균혈증을 일으킨 M. oxydans 1예를 생화학적 성상과 16S rRNA 염기서열분석을 통해 동정하였기에 문헌고찰과 함께 보고하는 바이다. [대한임상미생물학회지 2010;13:173-177]