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다약제내성 암세포에서 shMDR과 Sodium/Iodide Symporter 유전자의 이입에 의한 Doxorubicin 감수성과 방사성옥소 섭취의 증가
안손주 ( Sohn Joo Ahn ),이용진 ( Yong Jin Lee ),이유라 ( You La Lee ),최창익 ( Chang Ik Choi ),이상우 ( Sang Woo Lee ),유정수 ( Jeong Soo Yoo ),안병철 ( Byeong Cheol Ahn ),이인규 ( In Kyu Lee ),이재태 ( Jae Tae Lee ) 대한핵의학회 2007 핵의학 분자영상 Vol.41 No.3
안상봉 ( Sang Bong Ahn ),한동수 ( Dong Soo Han ),박혜선 ( Hye Sun Park ),김태엽 ( Tae Yeob Kim ),은창수 ( Chang Soo Eun ),전용철 ( Yong Cheol Jeon ),손주현 ( Joo Hyun Sohn ) 대한소화기학회 2010 대한소화기학회지 Vol.55 No.3
Segmental colitis associated with diverticular disease (SCAD) is a colonic inflammatory disorder with localized non-granulomatous inflammation at sigmoid colon, and associated with colonic diverticulosis. SCAD is an apparently uncommon disorder in Western. We experienced a rare case of SCAD in a 46-year-old woman who visited the hospital due to abdominal discomfort. Colonoscopic examination showed multiple sigmoid diverticula in association with a segment length colitis. Colonoscopic biopsies of the sigmoid colon demonstrated cryptitis and crypt abscess along with chronic inflammatory cells infiltration. The biopsies of the rectum was histologically normal. The patient was given the diagnosis of SCAD and treated with oral mesalamine. This is the first case of SCAD reported in Korea. (Korean J Gastroenterol 2010;55:189-193)
조직 특이 발현 Sodium Iodide Symporter 유전자 이입에 의한 방사성옥소 간암세포 치료와 광학영상을 이용한 치료효과 평가
장병국 ( Byoung Kuk Jang ),이유라 ( You La Lee ),이용진 ( Yong Jin Lee ),안손주 ( Sohn Joo Ahn ),류민정 ( Min Jung Ryu ),윤선미 ( Sun Mi Yoon ),이상우 ( Sang Woo Lee ),유정수 ( Jeong Soo Yoo ),조제열 ( Je Yeol Cho ),이재태 ( Jae T 대한핵의학회 2008 핵의학 분자영상 Vol.42 No.5
소화성 궤양 환자의 Helicobacter pylori 항생제 내성률 변화
방소영 ( So Young Bang ),한동수 ( Dong Soo Han ),은창수 ( Chang Soo Eun ),김지은 ( Ji Eun Kim ),안상봉 ( Sang Bong Ahn ),손주현 ( Joo Hyun Sohn ),전영철 ( Yong Cheol Jeon ),강정옥 ( Jung Oak Kang ) 대한소화기학회 2007 대한소화기학회지 Vol.50 No.6
목적: 항생제 내성은 Helicobacter pylori (H. pylori) 제균에 많은 영향을 미치므로 균주의 감수성 현황을 파악하는 것은 매우 중요하다. 국내에서는 proton pump inhibitor (PPI)를 포함한 amoxicillin, clarithromycin의 병합요법을 일차 약제로 추천, 사용하여 왔으나 사용 빈도가 늘어감에 따라 항생제 내성이 중요한 문제로 대두되었다. 이번 연구는 소화성 궤양 환자에서 분리한 H. pylori 균주를 대상으로 amoxicillin, clarithromycin, metronidazole에 대한 최소억제농도를 측정하고, 이전에 발표된 항생제 감수성 검사 성적과 비교하여 항생제 내성 변화와 항생제 내성 H. pylori 환자의 제균 성적을 알아보고자 하였다. 대상 및 방법: 2001년 1월부터 2005년 12월까지 한양대학교 구리병원에서 상부위장관 내시경검사를 받은 소화성 궤양 환자 466명을 대상으로 위생검 조직 배양을 시행하였다. H. pylori에 대한 최소억제 농도를 측정하기 위해 변형 액체배지희석법, E test 법, 디스크 확산법을 사용하였다. 결과: 466명의 소화성 궤양환자에서 H. pylori 감염이 확인된 환자는 265명이었고, 그 중 144명의 환자에서 H. pylori가 분리되어 배양률은 54.3%였다. H. pylori의 metronidazole, clarithromycin, amoxicillin에 대한 내성률은 각각 34.7%, 16.7%, 11.8%였으며, 다제 내성을 나타낸 균주는 16.7%였다. Amoxicillin 내성 균주는 PPI, amoxicillin, clarithromycin 3제요법으로 80%가 제균에 성공하였고, clarithromycin 내성 균주는 7.8%가 제균되었다. 일차치료에 실패한 metronidazole 내성 균주가 분리된 환자는 metronidazole을 포함한 4제 요법으로 모두 제균되었다. 결론: 최근 clarithromycin, amoxicillin에 대한 내성은 유의하게 증가 하였고, 상당수의 다제 내성 균주들이 분리되었다. Clarithromycin 내성 H. pylori 균주는 다른 항생제 내성 H. pylori 균주보다 제균 성적이 낮았다. H. pylori 내성 균주의 증가를 고려할 때 향후 제균 요법의 선택 시 clarithromycin을 포함 하는 일차약제의 선택에 신중을 기해야 한다. Background/Aims: Antibiotic resistance of Helicobacter pylori (H. pylori) is a significant clinical problem because it reduces the efficacy of eradication therapy. The aims of this study were to assess the changing patterns of antibiotic resistance of H. pylori in patients with peptic ulcer diseases and to evaluate the eradication rate in antibiotic resistant H. pylori strains. Methods: One hundred forty four H. pylori isolates obtained from 466 patients with peptic ulcer disease between June 2001 and December 2005 were examined for antimicrobial resistance. The minimum inhibitory concentration (MIC) of metronidazole was determined by modified broth microdilution method (mBMD) and E test. MICs of clarithromycin and amoxicillin were determined by mBMD, E test, and disc diffusion test. The breakpoints for metronidazole, clarithromycin, and amoxicillin resistance were defined as >8μg/mL, >1μg/mL, and ≥1μg/mL, respectively. Results: Resistance to metronidazole and clarithromycin was detected in 34.7% and 16.7% of H. pylori isolates, respectively. During the recent 5-year study period, amoxicillin-resistant rate of H. pylori was 11.8%, and multi-drug resistance rate of H. pylori was 16.7%. The eradication rate of clarithromycin containing triple therapies was low (7.8%) in clarithromycin-resistant H. pylori strains. Conclusions: The proportions of clarithromycin-resistant H. pylori strains have increased significantly over the last 5-years. There is an increasing tendency for the emergence of strains with multi-drug resistance. The increase in clarithromycin-resistant strains results in a decrease in eradication rate for H. pylori. In areas with high clarithromycin resistance, new alternative first-line treatment combination should be considered. (Korean J Gastroenterol 2007;50:356-362)
근치적 위절제술을 시행한 위암 환자에서 보조요법으로서 5-Fluorouracil, Epirubicin과 5-Epirubicil,Cisplatin의 복합화학요법의 효과 비교
최정혜,안명주,한동수,손주현,전용철,박훤겸,백홍규,이홍기,남영수 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.2
To compare 5-fluorouracil plus epirubicin (FE) to 5-fluorouracil plus cisplatin (FP) chemotherapy as adjuvant therapy for patients with resected gastric cancer. Between August 1995 and March 2000, 46 patients with completely resected gastric cancer received six courses of FE (5-fluorouracil 1000mg/m2/day, D2-D5, epirubicin 70mg/m2, D1) or FP (5-fluorouracil 1000mg/m2/day, D2-D5, cisplatin 70mg/m2, D1) chemotherapy. The 23 patients were assigned to each treatment group. A total of 127 courses of treatment were given both FE and FP group. The FP group tended to show more risk of overall death rate. But there were no differences between FE and FP groups in terms of overall survival or disease-free survival. Both treatment arms were generally well tolerated to chemotherapy. We concluded to be no significant differences between FE and FP groups in terms of overall survival or disease-free survival. To define the efficacy of adjuvant chemotherapy for gastric adenocarcinoma, further prospective randomized trials with large number of patients should be warranted.
궤양성 대장염과 동반된 상장간막정맥 및 간문맥 혈전증 1예
전용철,박경남,한동수,김병훈,손주현,안명주,조윤주,송승찬 대한소화기학회 1998 대한소화기학회지 Vol.32 No.3
Thromboembolism is a infrequent extraintestinal complication of inflammatory bowel disease. Especially, portal vein and superier mesenteric vein thrombosis are rare complications of ulcerative colitis and its mortality is invariably fatal. The mechanism of thrombolic complications in inflammatory bowel disease remains enigmatic. Moreover, the clarification of the hypercoagulable state remains elusive. This report describes the case of 27-year-old-female with active ulcerative colitis. The patient revealed portal vein and superior mesenteric vein thrombosis with ascites detected by abdominal ultrasound exammation and computed tomography and successfully treated with combined anticoaulation therapy.
소장에 다발성 장중첩증을 유발한 전이성 악성 피부 흑색종 1예
박경남,한동수,이민호,장세진,최호순,이오영,남승우,함준수,임현철,이성희,기춘석,안명주,손주현,윤병철 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.6
We present herein the case of 31-year-old man with disseminated malignant melanoma in whom a multiple metastasis into jejunum causing multiple intussusceptian. At laparotomy, multiple variable sized metastatic melanoma were noted on proximal and distal jejunum. To our knowledge, there was no report about multiple intussusceptions by malignant melanoma in Korea.