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건강한 폐경기 여성에서 호르몬 대체요법이 경동맥 내중막두께에 미치는 영
신장열,차봉수,정춘희,심원흠,이현철 대한내분비학회 2006 Endocrinology and metabolism Vol.21 No.1
Background: Cardiovascular disease is the leading cause of death in postmenopausal women. The use of hormone replacement therapy (HRT) preventing for cardiovascular disease in postmenopausal women remains controversial. We investigated the effect of HRT on carotid intima-media thickness (IMT) according to the HRT duration in healthy postmenopausal women. Methods: One hundred and twenty postmenopausal women (mean age: 55.4 ± 3.3 years) were classified into never users, short-term, and long-term users according to the HRT duration. Carotid IMT was measured, and the clinical and biochemical cardiovascular risk factors were examined.Results: The mean IMT was significantly thinner in the long-term users than that in the never users (0.62 ± 0.11 vs. 0.71 ± 0.14 mm, P < 0.01). Also, the maximal IMT was significantly thinner in the short-term and the long-term users. However, there is no significant difference in the mean and maximal IMTs between the estrogen alone and estrogen plus progestins used group. The period exposed to menopause was significantly shorter in the long-term users than that in the never users (1.8 ± 2.3 vs. 4.3 ± 3.3 years, P < 0.001). Conclusion: Our findings suggest that if HRT is initiated during early postmenopausal period before the onset of atherosclerosis, HRT may have a beneficial effect on the prevention of carotid atherosclerosis (J Kor Soc Endocrinol 21:14~21, 2006). 연구배경: 관상동맥질환은 폐경기 여성의 주된 사망 원인으로 알려져 있다. 현재 폐경기 여성에서 심혈관질환 예방을 위한 호르몬 대체요법의 사용은 논란의 여지가 많다. 이에 저자 등은 건강한 폐경기 여성에서 초음파를 이용하여 경동맥 내중막두께를 측정하여 투여기간에 따라 호르몬 대체요법이 경동맥 죽상경화증에 미치는 영향을 고찰하였다.방법: 심혈관질환의 과거력이 없는 50세에서 60세까지의 폐경기 여성 120명을 호르몬 대체요법 투여기간에 따라 투여 받지 않은 대조군 (52명), 3년 미만 투여군 (40명), 및 3년 이상 투여군 (28명)으로 분류하였다. 심혈관질환의 위험인자로 알려진 임상적 특성과 생화학적 인자를 측정하였으며, 경동맥 죽상경화증의 정도를 평가하기 위해 초음파를 이용하여 경동맥 내중막두께를 측정하였다.결과: 경동맥 내중막두께의 평균값은 대조군에 비해 3년 이상 투여군에서 유의하게 낮았다 (0.62 ± 0.11 vs. 0.71 ± 0.14 mm, P < 0.01). 또한, 경동맥 내중막두께의 최대값도 대조군에 비해 3년 미만 투여군 및 3년 이상 투여군에서 각각 유의하게 낮았다. 그러나 에스트로겐 단독투여군과 프로게스테론 병용투여군 간에 경동맥 내중막두께의 평균값 및 최대값은 유의한 차이를 보이지 않았다. 폐경에 노출된 기간은 3년 이상 투여군에서 대조군에 비해 유의하게 짧았다 (1.8 ± 2.3 vs. 4.3 ± 3.3 years, P < 0.001).
호산구증다증을 동반한 P-ANCA 양성 괴사성 사구체신염
신장열 ( Jang Yel Shin ),강이화 ( Ea Wha Kang ),류동렬 ( Dong Ryeol Ryu ),송정식 ( Jung Sik Song ),이원기 ( Won Ki Lee ),박용범 ( Yong Beom Park ),김루시아 ( Lucia Kim ),정현주 ( Heun Ju Jung ),이수곤 ( Soo Kon Lee ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.1
Antineutrophil cytoplasmic antibodies (ANCAs) are now regarded as a serologic marker for pauci-immune crescentic necrotizing glomerulonephritis either in renal-limited form or in association with systemic vasculitis, such as Wegener`s granulomatosis, microscopic polyarteritis, and Churg-Strauss syndrome. Two major ANCA antigens have been indentified: proteinase3, which produces a cytoplasmic staining pattern termed C-ANCA, and myeloperoxidase, which produces a perinuclear pattern termed P-ANCA on ethanol-fixed neutrophils by indirect immunofluorescence. In ANCA- associated diseases, eosinphilia in excess of 1.5×10(9)/L has been proposed to be characteristic of Churg-Strauss syndrome and is rare in other forms of ANCA-associated systemic vasculitis and crescentic necrotizing glomerulonephritis. Recently, there were two cases of P-ANCA positive crescentic necrotizing glomerulonephritis with peripheral blood eosinophilia and extrarenal microscopic vasculitis without asthma or granulomas. We experienced a patient with P-ANCA positive pauci-immune necrotizing glomerulonephritis with few eosinophilic infiltration and eosinophilia. He improved with oral prednisolone along with combination of intravenous cyclophosphamide. So we report this case with the review of literature.
김도영,신장열,허갑범,이현철,임승길,김경래,송영득,남재현,안철우,박석원,강신명 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.4
Although calcification of such endocrine gland as adrenal or pineal gland is common, extensive calcification of the pituitary gland is unusual. Calcification is a well recognized but uncommon feature of prolactin-secreting, growth hormone-secreting and non-functioning pituitary tumours. The calcification varies in extent, but rarely exceeds a tiny amount histologically or radiologically. Recently, we had the opportunity to investigate two patients with radiologically demonstrated "pituitary stone" (severely calcified pituitary adenoma). The first Patient, a 51 year-old female, initially presented with general weakness, dizziness, visual disturbance, and loss of hair for 2 months. She was suspected to have a pituitary lesion. Decreased secretion of GH, TSH, LH, and FSH was demonstrated by dynamic tests. On CT scan, she was found to have multilobulated calcified sella mass. She was successfully managed by medical treatment. The second patient, a 65 year-old male, presented with general weakness, nausea, vomiting and polyuria for 2 months. Combined pituitary stimulation test showed subnormal response of GH and prolactine. Radiologic studies revealed pituitary stone which was managed with medical treatment of hormone replacement. We suggest that calcific changes in the pituitary adenoma might be common and occur to the extent of pituitary stone formation with the possible alteration of hormonal secretion (J Kor Soc Endocrinol 14:739-744, 1999).
김도영,신장열,허갑범,이현철,임승길,김경래,송영득,남재현,안철우,최규헌,조정래,이준규,남수연,한재호,정현주 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.1
Banter's syndrome is characterized by hypokalemia, metabolic alkalosis, hyperreninemia and secondary hyperaldosteronism without hypertension and edema. Histologically, existing hyperplasia of the juxtaglomerular cell occurs mostly in childhood or adolescence, and initial presentation in patients over 40 years old of age is very rare. It has been recorded that Bartter's syndrome is associated with glucose intolerance, but not with overt diabetes mellitus. Whether this association is coincidental or causal is uncertain, although hypokalemia can cause glucose intolerance. We experienced a case of Banter's syndrome in 44 years old non-insulin dependent diabetic woman. She improved with potassium supplements along with combination of prostaglandin synthetase inhibitor and aldosterone antagonist. We report present case with the review of literature.
최수인,정다은,임정수,이미영,신장열,정춘희,허지혜 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.1
Background The aim of this study was to investigate the association between regional body fat distribution, especially leg fat mass, and the prevalence of diabetes mellitus (DM) in adult populations. Methods A total of 3,181 men and 3,827 postmenopausal women aged 50 years or older were analyzed based on Korea National Health and Nutrition Examination Surveys (2008 to 2010). Body compositions including muscle mass and regional fat mass were measured using dual-energy X-ray absorptiometry. Results The odds ratios (ORs) for DM was higher with increasing truncal fat mass and arm fat mass, while it was lower with increasing leg fat mass. In a partial correlation analysis adjusted for age, leg fat mass was negatively associated with glycosylated hemoglobin in both sexes and fasting glucose in women. Leg fat mass was positively correlated with appendicular skeletal muscle mass and homeostasis model assessment of β cell. In addition, after adjusting for confounding factors, the OR for DM decreased gradually with increasing leg fat mass quartiles in both genders. When we subdivided the participants into four groups based on the median values of leg fat mass and leg muscle mass, higher leg fat mass significantly lowered the risk of DM even though they have smaller leg muscle mass in both genders (P<0.001). Conclusion The relationship between fat mass and the prevalence of DM is different according to regional body fat distribution. Higher leg fat mass was associated with a lower risk of DM in Korean populations. Maintaining leg fat mass may be important in preventing impaired glucose tolerance.