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신동미 한국막학회 2015 한국막학회 총회 및 학술발표회 Vol.2015 No.11
현대 산업사회의 발달에 따라 사회 경제적 수준은 크게 향상된 반면, 생활환경의 오염에 대한 염려는 날로 증폭되고 있다. 특히 건강에 대한 관심이 급증하면서 식품과 마시는 물에 대한 관심은 어느 때 보다 높다. 즉 수돗물 보다 각종 정수기를 사용한 깨끗한 물 또는 시판 생수의 선호도가 크게 증가하고 있으며, 동시에 이들의 영양적 가치에 대한 논란이 끊임없이 제기되고 있다. 그러나 일상적으로 미네랄의 급원은 전적으로 식품으로부터 제공되며, 정상적인 식생활에서 식수로부터 제공되는 미네랄 양은 무시할 정도로 매우 낮다. 인체가 섭취한 물은 체내에서 수많은 물질을 용해하여 소화, 흡수, 대사, 배설하는 모든 생리과정에 필수불가결한 역할을 하므로, 순수하고 안전함이 먹는 물의 주요 가치로 평가되어야 할 것이다
Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells
신동미,최경미,이윤선,김원균,신경오,오세관,정재철,이미경,이용문,홍진태,윤여표,유환수 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.6
Echinacea purpurea has been shown to haveanti-diabetic activities; for example, it activates peroxisomeproliferator-activated receptor c (PPARc) and increasesinsulin-stimulated glucose uptake. Adipogenesis has beenused to study the insulin signaling pathway and to screenanti-diabetic compounds. The present study was conductedto investigate the effects of an ethanol extract of E. purpurea(EEEP) and its constituents on the insulin-induced adipocytedifferentiation of 3T3-L1 preadipocytes. When adipocytedifferentiation was induced with insulin plus 3-isobutyl-1-methylxanthine and dexamethasone, the accumulation oflipid droplets and the cellular triglyceride content weresignificantly increased by EEEP. The expressions of PPARcand C/EBPa in adipocytes treated with EEEP were graduallyincreased as compared with control cells. Fat accumulationand triglyceride content of adipocytes treated with dodeca-2(E),4(E)-dienoic acid isobutylamide were significantlyincreased as compared with control cells. Theexpressions of PPARc and C/EBPa in adipocytes treatedwith dodeca-2(E),4(E)-dienoic acid isobutylamide weresignificantly higher than in control cells. These results suggestEEEP promotes the adipogenesis that is partiallyinduced by insulin and that dodeca-2(E),4(E)-dienoic acidisobutylamide appears to be responsible for EEEP-enhancedadipocyte differentiation.
신동미 한국막학회 2017 한국막학회 총회 및 학술발표회 Vol.2017 No.05
최근 건강에 대한 관심이 급증하면서 식품과 마시는 물에 대한 관심은 어느 때 보다 높다. 과거에는 수분공급이라는 본연의 목적으로만 물을 중요하게 생각했으나, 최근에는 다양한 기능성을 나타내는 기능성 물들이 등장하였다. 본 연구에서는 건강한 성인 남녀를 대상으로 하여, 4 주 동안 정수와 수소수 섭취가 체내 항산화 능에 미치는 영향과 그 작용 메카니즘을 알아보고자 하였다. 물의 종류에 관계없이, 충분한 양의 수분 섭취는 체지방 감소 및 항산화력 증진에 도움을 줄 것으로 사료된다. 특히 수소수는 연령, 성별, 흡연 유무에 따라 효과가 다르게 나타나기도 하였으나, 전반적으로 체내 항산화능을 개선시키고 활성산소를 억제하며, 면역세포 조절 및 유전자발현 조절을 통해 항산화제로서의 가능성을 지니고 있음을 확인하였다.
비타민 C 병용에 의한 흰쥐 혈중 루테인 함량 증가와 배양세포에서의 항산화 효과
이승현, 이윤선, 최경미, 신동미, 이용문, 윤여표, 유환수 충북대학교 약품자원개발연구소 2011 약학논문집 Vol.26 No.-
Lutein functions as an antioxdant that scavenges reactive oxygen species, and its consumption is inversely related to eye diseases such as age-related macular degeneration (AMD) and cataracts. This is supported by the finding that lutein and zeaxanthin (a stereo isomer) are concentrated in the lens and macula lutea, an area of the retina responsible for central and high acuity vision. The purpose of this study was to investigate whether lutein absorption may be modulated, and its antioxidant activity be improved by combining with vitamin C. Lutein content was determined by HPLC. The combination of lutein with vitamin C increased the serum levels of lutein in SD rats, and inhibited malondialdehyde (MDA) formation, indicating that antioxidant activity of lutein combined with vitamin C appears to be improved by increasing lutein content. These results suggest that the increased serum levels of lutein may be associated with improving AMD and cataracts in humans through the pathogenesis of antioxidant mechanism.
김진혁,신동미,이용성 생화학분자생물학회 2002 Experimental and molecular medicine Vol.34 No.3
Normalization of the data of cDNA microaray is anobligatory step during microarray experiments dueto the relatively frequent non-specific erors. Gener-ally, normalization of microaray data is based onthe null hypothesis and variance model. In theYangs model (Yang et al., 2001), at least two types ofnoises are included. The one is additive noise andthe other is multiplicative noise. Usually, backgroundis considered as one of additive noise to the signaland the variation between the signal pixels is therepresentative multiplicative noise. In this study, therelation between the signal (spot intensity minusbackground intensity) and background was observedand the influence of background on normalizationas a representative additive factor was investigated.Although the relation has not been considered as afactor affecting the normalization, it could improvethe accuracy of microaray data when the normaliza-tion was carried out considering signal/backgroundratio. The background dependent normalization de-creased the number of genes whose expression lev-els were changed significantly and it could maketheir distribution more consistent through the wholerange of signal intensities. In this study, printing pindependent normalization was also carried outregarding the printing pin as a representative multi-plicative noise. It improved the distribution of spotsin the Cy3-Cy5 scatter plot, but its effect was slight.These studies suggest that there are some influ-ences of the signals on the local backgrounds andthey must be considered for the normalization ofcDNA microarray data.
이영관,이훈복,신동미,강민정,이유진,노승주,이재우,이철범,민창기,최은영 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-
Indoleamine 2,3-dioxygenases (IDOs) are tryptophan-catabolizing enzymes with immunomodulatory functions. However, the biological role of IDO2 and its relationship with IDO1 are unknown. To assess the relationship between IDO2 and IDO1, we investigated the effects of co-expression of human (h) IDO2 on hIDO1 activity. Cells co-expressing hIDO1 and hIDO2 showed reduced tryptophan metabolic activity compared with those expressing hIDO1 only. In a proteomic analysis, hIDO1-expressing cells exhibited enhanced expression of proteins related to the cell cycle and amino acid metabolism, and decreased expression of proteins related to cell survival. However, cells co-expressing hIDO1 and hIDO2 showed enhanced expression of negative regulators of cell apoptosis compared with those expressing hIDO1 only. Co-expression of hIDO1 and hIDO2 rescued the cell death induced by tryptophan-depletion through hIDO1 activity. Cells expressing only hIDO2 exhibited no marked differences in proteome profiles or cell growth compared with mock-transfectants. Cellular tryptophan metabolic activity and cell death were restored by co-expressing the hIDO2 mutant substituting the histidine 360 residue for alanine. These results demonstrate thathIDO2 plays a novel role as a negative regulator of hIDO1 by competing for heme-binding with hIDO1, and provide information useful for development of therapeutic strategies to control cancer and immunological disorders that target IDO molecules.