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      • KCI등재

        Hypoglycemic effect of standardized Chrysanthemum zawadskii ethanol extract in high-fat diet/streptozotocin-induced diabetic mice and rats

        김양지,현규,이학성 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.6

        Chrysanthemum zawadskii (CZ) is a perennial herb belonging to the Asteraceae family. CZ is used medicinally to treat inflammatory and uterine diseases in Asia. CZ was extracted with 50% ethanol and CZ extract (CZE; at 125, 250, and 500 mg/kg body weight) was administered orally every day for 5 or 6 weeks to investigate the anti-diabetic effects in streptozotocin (STZ)-induced rats and STZ ? high-fat diet (HFD)-fed mice. CZE significantly decreased fasting blood glucose levels in STZ- and STZ ? HFD-induced diabetic models. In addition, glucose tolerance and insulin tolerance were improved in the STZ ? HFD ? CZE group by increasing insulin levels and decreasing hemoglobin A1c (HbA1c) levels in serum. Furthermore, CZE supplements decreased components of the serum lipid profile such as triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels. These results suggest that CZE may be a potential candidate for controlling hyperglycemia.

      • MCR에 의한 혐기성 소화에 대한 암모니아의 영향

        김양지,춘미,성일,종수 선문대학교 ·중소기업기술지원연구소 2002 선문공대 연구/기술 논문집 Vol.7 No.1

        혐기성 소화에서 미생물에 저해/독성 물질로 알려진 암모니아의 농도와 식종원에 따른 영향을 MCR(Master Culture Reactor)을 이용하여 회분식으로 분석하였다. 식종원은 축간농가 축산폐수 집수조의 침전슬러지 그리고 하수종말처리장 혐기성 소화조 잉여슬러지를 사용하였다. 식종원에 상관없이 암모니아는 1,500㎎NH_4-N/L에서 COD 제거율과 가스생성율로 측정된 혐기성 미생물의 활성에 저해영향을 주기 시작하여 2,500㎎NH_4-N/L에서 더욱 심하였다. 암모니아 저해 농도 범위에서 휘발성 유기산의 농도는 50㎎/L 범위로 유지되므로 메탄생성균 뿐만아니라 산생성균도 저해영향을 받는 것으로 나타났다. 축산폐수 집수조 침전슬러지로 식종된 경우 암모니아 2,500㎎NH_4-N/L 농도 범위 이상으로 운전하여도 COD 제거율과 가스생성율은 일정하게 나타났지만 하수종말처리장 혐기성 소화조 잉여슬러지로 식종된 경우 암모니아 농도가 증가할수록 COD 제거율과 가스생성율은 감소하였다. 결과적으로 암모니아에 장기간 순응된 축산폐수 집수조의 침전슬러지로 식종한 경우 암모니아의 저해 농도에 대하여 적응도 빨랐으며 저해영향도 적음을 알 수 있었다. The influence of ammonia and the sources of seeding on anaerobic digestion were investigated by batch operation of MCR(master culture reactor). The sources of seeding on anaerobic digestion were from swine wastewater collection pit and anaerobic digestion sludge of a municipal sewage treatment plant. The inhibition effects of ammonia on anaerobic microorganisms were initiated at ammonia concentration of 1,500 ㎎NH_4-N/L and the effects were increased by increasing ammonia concentration upto 2,500 ㎎NH_4-N/L regardless the sources of seeding as evidenced by decreases in COD removal efficiencies and biogas yields. The inhibition occurred to not only methanogens but also acidogens since the concentration of volatile fatty acids was maintained at 50 ㎎/L during the batch operations of MCR. The COD removal efficiency and biogas yield were maintained constantly while increasing ammonia concentration upto 2,500 ㎎NH_4-N/L when swine wastewater collection pit was used as seeding; however, those were decreased while increasing ammonia concentration when anaerobic digestion sludge was used as seeding. The results indicate that the seeding acclimated to high concentrations of ammonia for long time was easy in adaptation to high ammonia concentration and less subjective to ammonia inhibitory effects.

      • KCI등재

        Indications of an Adaptive Response to X-ray in Lymphocytes of Radiographers

        김양지,송주영,최수영,정해원 한국유전학회 2007 Genes & Genomics Vol.29 No.4

        Lymphocytes obtained from radiographers were iradiated with high-dose X-rays and analyzed for chromosome aberations and micronuclei to examine whether an adaptive response to ionizing radiation can be induced. The study subjects were seven male ome aberrations was lower in the lymphocytes of radiographers than in those of the controls when the lymphocytes were irradiated with 1 Gy of X-rays (7.93± 0.78 in radiographers, 8.31± 0.53 in controls), whereas the frequency was higher in the lymphocytes of radiographers before the irradiation (1.36±0.35 in radiographers, 0.13± 0.08 in controls). The same trend was observed for the frequency of micronuclei, but the diference was not statisticaly significant. The asociation with the frequencies of chromosome aberrations and micronuclei after 1 Gy of iradiation was significantly correlated in the radiographers and controls (Spearman’s correlation r=0.5, p=radiographers was correlated with the total cumulative dose (Spearman’s correlation, CA frequency, r=0.7, p<0.05; MN frequency, r=0.5, p=0.1). Thus, an adaptive response was observed in the radiographers, and therefore chronic occupational radiation exposure might act as an adapting dose.

      • KCI등재

        재생 문화공간 체험이 심리적 치유에 미치는 영향

        김양지,윤갑근 한국문화공간건축학회 2021 한국문화공간건축학회논문집 Vol.- No.73

        All human actions are done in space, and the impact of space on us cannot be ignored. These spaces are also given meaning and value through human experience and become factors that can be determined by human psychological standards. From the perspective that space is the main body of human beings and should be a comfortable environment, we would like to analyze the impact of the experience of regenerative cultural space, which has recently revived the place and historical nature of the past and preserves eco-friendly spatial resilience. Verifying the hypothesis of the study showed that both the independent variables sensory experience and Pine & Gilmore's experience had a definitive effect on psychological healing, while the escape, playful and aesthetic experiences of Pine & Gilmore had a definitive effect on psychological healing, but no educational experience. Looking at the results comprehensively, the experience of regenerative cultural spaces affects human psychological healing, and in particular, escape experiences that feel out of everyday life and other spaces affect psychological healing the most. This can be said to be a psychological immersion given by the uniqueness and freshness created by the fusion of the sphere and God in a regenerative cultural space that is not felt in a uniform and formal urban space. As a result of this study, the regenerative cultural space is important as a space where people can feel psychological recovery and emotional stability, and the physical aspect of the space is important, but emotional space design for human experience will be necessary.

      • KCI우수등재

        Bleomycin, Mitomycin C 및 Cadmium에 의한 CHO 세포의 적응반응

        김양지,한정호,정해원 한국환경보건학회 1992 한국환경보건학회지 Vol.18 No.2

        Pretreatment with low concentration of Bleomycin and Cadmium rendered Chinese Hamster Ovary Cells more resistant to the induction of chromosome aberration by subsequent high concentration of same agent, however Mitomycin C did not function in that way. The cells pre-exposed to low dose of Cadmitim did not show cross-resistance to challenge dose of Mitomycin C for the induction of chromosome aberration, but cells pre-exposed to Bleomycin showed cross resistance. And the cells pre-exposed to low dose of Mitomycin C showed cross resistance to challenge of Bleomycin, but Cadmium did not.

      • KCI등재

        도라지 종자의 영양학적 특성 평가

        김양지,우혜련,임지영,석중 한국응용과학기술학회 2018 한국응용과학기술학회지 Vol.35 No.2

        In this study, proximate composition, crude fiber, reducing sugar, free sugars, organic acids, minerals and amino acids of Platycodon grandiflorum seeds were analyzed to evaluate its nutritional value. Moisture, crude protein, crude fat, crude ash and carbohydrate contents of seeds were 6.97, 26.05, 27.46, 3.78 and 35.74%, respectively. Crude fiber of 6.31% and reducing sugars of 1.54% were also determined. Sucrose(1,661 mg/100 g) and lactic acid(1,224 mg/100 g) were most abundant free sugar and organic acid, respectively. Both phosphorus and potassium were main minerals that contained more than 700 mg in 100 g seeds. Amino acids analysis of 100 g seeds showed that glutamic acid(3.45 g), arginine(2.51 g), aspartic acid(1.66 g), leucine(1.29 g), lysine(1.10 g), alanine(1.05 g) and glycine(1.04 g) were abundantly contained in order, while others were less than 1 g. 본 연구에서는 도라지(Platycodon grandiflorum A. DC) 종자의 영양학적 특성을 평가하기 위해 일반성분, 조섬유, 환원당, 유리당, 유기산, 무기질 및 아미노산 함량을 분석하였다. 종자의 수분, 조단백질, 조지방, 조회분, 탄수화물 함량은 각각 6.97, 26.05, 27.46, 3.78, 35.74%였으며 조섬유 함량은 6.31%, 환원당 함량은 1.54%이었다. 종자에 존재하는 유리당으로는 sucrose가 1,661 mg/100 g, 유기산으로는 lactic acid가 1,224 mg/100 g 으로 가장 풍부하였으며, 인과 칼륨이 주요 무기질로서 700 mg/100 g 이상 존재하였다. 종자 100 g에서의 아미노산 조성을 분석한 결과, 글루탐산(3.45 g), 아르기 닌(2.51 g), 아스파르트산(1.66 g), 루신(1.29 g), 라이신(1.10 g), 알라닌(1.05 g), 글리신(1.04 g) 순이었 으며 그 외의 아미노산은 1 g 이하로 존재하였다.

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