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고령층 근감소증 환자의 운동 서비스 제공을 위한 인터페이스 분석
김수림(Kim Soo Rim),김도윤(Kim Do Yun),오지수(Oh Ji Su),김정인(Kim Jeong In),김은진(Kim Eun Jin),하광수(Ha Kwang Soo) 한국HCI학회 2023 한국HCI학회 학술대회 Vol.2023 No.2
인구 고령화와 함께 다양한 노인 질환의 극복은 삶의 질 측면에서 중요한 관심 사항이 되고 있다. 다양한 노인 질환 중 근 감소증의 경우 근육량, 근력, 근육 기능 등이 감소하는 질환으로 일상생활이 어렵고 당뇨나 심혈관 질환에 영향을 미치게 되어 심각도가 높은 질병이다. 이에 본 연구에서는 근감소증 증상을 겪고 있는 노인을 위한 재활 운동용 웨어러블 디바이스를 제작하는 과정에서 이를 디지털적으로 제어하기 위한 재활 App. UX 전략방향을 제안하였다. 이를 통해 근 감소증 증상악화에 영향을 미치는 주요 원인 중 하나인 근력운동과 유산소 운동 부족을 극복하는 데 도움을 제공하고자 한다.
김수림 ( Soo Rim Kim ),권자영 ( Ja Young Kwon ),이은주 ( Eun Joo Lee ),박수연 ( Su Yeon Park ),허혜원 ( Hye Won Hur ),김영한 ( Young Han Kim ),박용원 ( Yong Won Park ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.8
We report on a newborn girl presenting with a 2.0×1.5 cm sized pinkish, doughy lump arising between right labia majora and anus. We performed antenatal sonogram at 33 and 36th weeks gestation. A polypoid mass of 0.8×1.0 cm sized in size was noted on ultrasonography. After birth, we observed a skin-covered protruding mass not to detect other anatomic anomalies-spinal anomalies, anorectal malformations, etc. After 3 months, excision of the perineal mass was done at the Department of Pediatric Surgery of our hospital. Mature fat cells were noted on histopathological exam. To our knowledge, there are few studies in the English literatures about congenital perineal lipoma without combined structural anomalies.
BARODON<sup>®</sup> 에 의한 Human Gastric Adenocarcinoma AGS 세포고사
조은혜,최수일,김수림,조성대,안남식,정지원,양세란,박준석,황재웅,박용호,이영순,강경선,Jo Eun-Hye,Choi Soo-Il,Kim Soo-Rim,Cho Sung-Dae,Ahn Nam-Shic,Jung Ji-Won,Yang Se-Ran,Park Joon-Suk,Hwang Jae-Woong,Park Yong-Ho,Lee Yong-Soon,Kang Kyung 한국독성학회 2005 Toxicological Research Vol.21 No.2
[ $BARODON^{(R)}$ ] is a multi-purpose, high functional alkali solution made by mixing and liquid-ionizing silicon, calcium, sodium, borax, organic carbon chemicals and silver. In this study, we have investigated the apoptotic potential and mechanistic insights of $BARODON^{(R)}$ in human gastric cancer cell line (AGS cells). In MTT assay, $BARODON^{(R)}$ reduced cell viability in AGS cells. Morphological features of apoptosis with marked cytoplasmic vacuolation and appearance of apoptotic peaks in flow cytometry were observed in AGS cells with$BARODON^{(R)}$ treatment. In addition, $BARODON^{(R)}$ induced apoptosis of stomach cancer cell is related to bax up-regulation, caspase 7 protease activation and subsequent cleavage of poly (ADP-ribose) polymerase (PARP). These results suggest that BARODON can induce the apoptosis of AGS cells through modulation of bcl-2 family and the activation of intrinsic caspase cascades, indicating that it is potentially useful as a anti-cancer agent.
심혈관질환 및 심혈관질환에 대한 위험요인이 과민성 방광 환자와 복압성 요실금 환자에게 미치는 영향에 대한 상관 분석
이효련 ( Hyo Ryun Lee ),김수림 ( Soo Rim Kim ),문여정 ( Yeo Jung Moon ),김세광 ( Sei Kwang Kim ),배상욱 ( Sang Wook Bai ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.10
Objective The purpose of this study was to investigate associations between overactive bladder/stress urinary incontinence and cardiovascular risk factors and disease. Methods We performed a retrospective review of 132 women with overactive bladder and 100 women with stress urinary incontinence, enrolled at Severance Hospital. Risk factors of cardiovascular disease included age, obesity, hypertension, diabetes, impaired fasting glucose, dyslipidemia, cardiovascular disease and familial history of cardiovascular disease. Results The two groups had no difference with cardiovascular disease, history of cardiovascular disease, age, obesity, smoking, alcohol, hypertension, dyslipidemia, excluding diabetes. In the univariate logistic regression analysis, diabetes was associated with prevalence of overactive bladder than stress urinary incontinence. In the multiple logistic regression analysis, there was no factor which had influence on the status of urinary incontinence. Conclusion While most risk factors of cardiovascular disease were not associated with overactive bladder, this study suggests that diabetes may have influence to overactive bladder than stress urinary incontinence.
골반장기탈출증 수술 전 시행하는 요역동학 검사에서 수술 후 결과에 영향을 미치는 유용한 지표와 동시수술의 타당성: 후향적 코호트 연구
조주현 ( Ju Hyun Cho ),김수림 ( Soo Rim Kim ),문여정 ( Yeo Jung Moon ),김세광 ( Sei Kwang Kim ),배상욱 ( Sang Wook Bai ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.4
Objective To evaluate effective parameters of preoperative urodynamic study (UDS) before performing surgery for pelvic organ prolapse (POP) and to validate effectiveness of concomitant surgery on urinary outcomes. Methods This was a retrospective cohort study of 308 patients who had UDS before POP surgery from January 2006 through December 2010 at Yonsei University Severance Hospital, Seoul, Korea. The patients who were diagnosed with stress urinary incontinence (SUI) by positive result of UDS (group 1) had a concomitant sling operation with POP surgery. And the patients were not diagnosed with SUI by negative result of UDS (group 2) did not. Results The prevalence rate of de novo SUI in group 2 (3.1%, n = 4) higher than group 1 (1.7%, n = 3), but there was no statistically signifi cant difference between the two groups. We checked 5 parameters of UDS (valsalva leak point pressure, maximal urethral closing pressure [MUCP], maximal fl ow rates, detrusor pressure at maximal fl ow [PdetMax], maximal cystometric capacity confi dence). PdetMax and MUCP was statistically signifi cant parameter in postoperative de novo SUI (odds ratio [OR], 1.020; 95% confi dence intervals [CI], 1.001-1.038) and postoperative de novo urgency urinary incontinence (UUI; OR 0.969; 95% CI, 0.942-0.996). Conclusion This study suggests that results of preoperative UDS and concomitant surgery can be associated with prevalence rate of postoperative de novo SUI. Focused on prevalence of postoperative urinary complications, concomitant surgery was better than only prolapse surgery. PdetMax in SUI and MUCP in UUI were statistically signifi cant parameters of UDS related on urinary outcome.
BARODON^®에 의한 Human Gastric Adenocarcinoma AGS 세포고사
조은혜(Eun-Hye Jo),최수일(Soo-Il Choi),김수림(Soo-Rim Kim),조성대(Sung-Dae Cho),안남식(Nam-Shic Ahn),정지원(Ji-Won Jung),양세란(Se-Ran Yang),박준석(Joon-Suk Park),황재웅(Jae-Woong Hwang),박용호(Yong-Ho Park),이영순(Yong-Soon Lee),강경선 한국독성학회 2005 Toxicological Research Vol.21 No.2
BARODON^® is a multi-purpose, high functional alkali solution made by mixing and liquid-ionizing silicon, calcium, sodium, borax, organic carbon chemicals and silver. In this study, we have investigated the apoptotic potential and mechanistic insights of BARODON^® in human gastric cancer cell line (AGS cells). In MTT assay, BARODON^® reduced cell viability in AGS cells. Morphological features of apoptosis with marked cytoplasmic vacuolation and appearance of apoptotic peaks in flow cytometry were observed in AGS cells with BARODON^® treatment. In addition, BARODON^®-induced apoptosis of stomach cancer cell is related to bax up-regulation, caspase 7 protease activation and subsequent cleavage of poly (ADP-ribose) polymerase (PARP). These results suggest that BARODON^® can induce the apoptosis of AGS cells through modulation of bcl-2 family and the activation of intrinsic caspase cascades, indicating that it is potentially useful as a anti-cancer agent.
마우스 유방암 모델에서 5-Aza-2'-deoxycytidine의 암줄기세포 유지 억제 효과
노경진(Kyoung-Jin Nho),양인숙(In-Sook Yang),김란주(Ran-Ju Kim),김수림(Soo-Rim Kim),박정란(Jeong-Ran Park),정지윤(Ji-Youn Jung),조성대(Sung-Dae Cho),남정석(Jeong-Seok Nam) 한국생명과학회 2009 생명과학회지 Vol.19 No.8
비정상적 DNA메칠화는 암 발생에 있어 중요한 역할을 한다. 최근 연구에 의하면 암줄기세포 유지에 있어 DNA과메칠화가 연관되어 있다고 보고하고 있다. 따라서 본 연구는 4T1 유방암 실험모델에서 demethylating agent인 AZA 처리에 따른 후성유전적 변화가 암줄기세포의 유지 및 증식에 있어 어떠한 영향을 미치는지 조사 하였다. 4T1 세포에서 AZA 처리에 따른 tumorsphere 형성이 감소 하는 것을 in vitro 실험을 통해 관찰 하였고, in vivo 실험에서는 줄기세포 조절 유전자들(Oct-4, Nanog. Sox2)의 발현이 감소 되는 것을 확인 하였다. 본 연구 결과로 볼 때 4T1 유방암 실험모델에서 AZA에 의한 후성유전적 변화는 줄기세포 조절 유전자(SRG)들의 발현을 조절하면서 암줄기세포 특성을 변화시켜 암줄기세포의 증식 및 유지를 억제 할 것으로 사료된다. 향후 이러한 DNA 메칠화억제를 항암치료에 응용하면, 암줄기세포를 파괴함으로써 암의 재발 및 악성화를 효과적으로 제어 할 수 있을 것으로 사료된다. Aberrant DNA methylation plays an important role in the development of cancer. It has been reported recently that DNA hypermethylation is involved in the maintenance of cancer stem cells. The present study was designed to test the hypothesis that the demethylating agent, 5-aza-2‘-deoxycytidine (AZA), can inhibit the potential for maintenance of cancer stem cells. To validate this hypothesis, we used 4T1 syngeneic mouse models of breast cancer. The AZA pre-treated 4T1 cells showed a dramatic inhibition of tumorsphere formation, compared to their counterparts in vitro. In addition, the AZA treatment significantly suppressed the expression of stem regulator genes, such as oct-4, nanog and sox2, compared to counterparts in vivo. Therefore, selective inhibition of DNA methylation may be useful for stem-specific cancer therapy.