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Antiemetic Effect of Dexamethasone in Dogs Sedated with Medetomidine
강한샘,장환수,권영삼,장광호 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.6
Antiemetic effect of dexamethasone in dogs sedated with medetomidine was evaluated. On the day of experiment, five minutes prior to medetomidine (40 μg/kg, IM) injection, dexamethasone was administered intravenously at the doses of 0.25, 0.5 and 1.0 mg/kg. Control group was received at 0.1 ml/kg of saline instead of dexamethasone. The dose of 0.5 and 1.0 mg/kg of dexamethasone significantly reduced emetic episode. The degree of sedation determined by visual sedation scoring was not influenced by dexamethasone pretreatments. In addition, the values of complete blood counts and blood chemistry did not show significant changes and were within normal ranges before and the day after experiment. These results show that the doses of 0.5 and 1.0 mg/kg of dexamethasone are useful and safe method to prevent emetic episode inducing by medetomidine in dogs, without evidence of any clinically relevant influences.
투석접근로의 기능실조 개선을 위한 구난술로서의 수술적 혈전제거술과 하이브리드치료 간 비교분석
강한샘,한규담,최은혜,박영삼,서연호,김철승 대한혈관외과학회 2012 Vascular Specialist International Vol.28 No.4
Purpose: Salvage operation is performed to improve the functional deficit of vascular access. This study is planned to evaluate the utility of the hybrid surgery through a comparative analysis between the results of surgical thrombectomy and those of hybrid surgery, combining surgical methods and endovascular treatments. Methods: From January 2007 to December 2008, surgical thrombectomy had been done to 55 patients,whereas hybrid surgery had been done to 111 patients from January 2009 to December 2011. We have done a comparative analysis on the patency rate after the salvage operation for each group, retrospectively. Medical records were reviewed for patient information and radiographic data was used for checking the stenosis site in the hybrid surgery group. Results: There were no statistically significant differences between the two groups, including age, gender,diabetes status, hypertension, and vascular access site or type. The primary patency rate was significantly higher in arteriovenous fistulas (65%) compared with arteriovenous grafts group (55%), at 12 months (P<0.01). At one year after the salvage operation, the secondary patency rate was higher in the hybrid surgery group compared to the surgical thrombectomy group (43.8% vs. 23.7%, P<0.01). Conclusion: This study shows that hybrid surgery combining surgical methods and endovascular treatments can be more useful for the salvaging of thrombosed vascular access than performing only surgical thrombectomy.
Tiletamine/zolazepam 마취견에서 전침자극이 순환기계에 미치는 영향
강한샘,장환수,이문학,엄기동,장광호 한국임상수의학회 2003 한국임상수의학회지 Vol.20 No.2
This study was performed to evaluate the effect of electroacupuncture at some acupoint combinations on the cardiovascular system, especially on blood pressure. Electroacupuncture at acupoint combinations of GV20(+)/GV-16(-), 4(+)/GV16(-), KI1(+)/GV20(-), and HT9(+)/GV16(-) did not changed heart rates and blood pressure, but stimulation of HT1(+)/HT7(-) increased systolic, diastolic and mean arterial blood pressure significantly in dogs anesthetized with tiletamine/zolazepam.
Xylazine hydrochloride로 진정시킨 개에 대한 dexamethasone의 항구토 효과
양정훈,강한샘,배재성,송창현,김정은,진희경,장광호 한국임상수의학회 2005 한국임상수의학회지 Vol.22 No.2
This prospective study aimed to assess the efficacy of dexamethasone to prevent xylazine induced emesis in dogs. The antiemetic effect of graded, single high-dose intravenous dexamethasone against xylazine hydrochloride was studied. Clinically healthy mixed breed dogs that weighed 4.64±1.25kg were used in this study. Food and water were given 3 hours before the experiment. Venous blood specimens were collected from all experimental animals for hema-tological and blood chemical test pre- and post-experiment. Twenty-eight experimental animals were randomly divided into 4 groups; the group treated with 0.2ml/kg of normal saline (Control group), the groups treated with 1mg/ kg (D1 group), 2mg/kg (D2 group) and 4mg/kg of dexamethasone (D4 group). Three doses of the dexamethasone or normal saline was administered intravenousely to each group and after 5 minutes, xylazine (2.2mg/kg) was administered intramuscularly. The time until onset of the first emetic episode and rate of emesis were investigated. At the same time, the extent of sedation was scored subjectively 5, 15, 30 and 60 minutes after injection of xylazine hydrochloride using Visual Sedation Score. The time until onset of the first emetic episode was 203.25±11.35sec in Control group, 187.33±48.01sec in D1 group and 218.33±13.58 sec in D2 group. The rate of xylazine induced emesis were 57% in Control group and 43% in D1 and D2 group respectively. On the other hand, any emetic episodes were not observed in D4 group. At extent of sedation score, all experimental animals especially including the animals in D1 group were highly sedated at 15minutes after administration of xylazine hydrochloride. Hematological and blood chemical values showed normal ranges pre- and post-experiment. We concluded that prior treatment with 4mg/kg of dexamethasone hardly caused xylazine-induced emesis without disturbing the sedative effect of xylazine in dogs.