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Ji Yeon Son,Yoon Jong Kang,Kyeong Seok Kim,Tae Hyung Kim,Sung Kwang Lim,Hyun Jung Lim,Tae Cheon Jeong,Dal Woong Choi,Kyu Hyuck Chung,Byung Mu Lee,Hyung Sik Kim 한국독성학회 2014 Toxicological Research Vol.30 No.2
Melamine-induced nephrotoxicity is closely associated with crystal formation in the kidney caused by combined exposure to melamine (Mel) and cyanuric acid (CA). However, there are few dosage-finding studies for toxicological evaluation of chronic co-exposure to Mel and CA. The objective of this study was to investigate the possible mechanism by which a Mel and CA mixture lead to renal toxicity in rats. Mel and CA were co-administered to rats via oral gavage for 50 days. Nephrotoxicity was determined by measuring blood urea nitrogen (BUN) and serum creatinine (sCr) levels. Relative kidney weights were significantly increased in rats after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg) mixtures. BUN and sCr levels were significantly increased after Mel and CA co-exposure. Taken together, significant increase in KIM-1, NGAL, and calbindin levels were observed in the urine of rats exposed to Mel+CA (63/6.3 or 630/6.3 mg/kg) compared with the corresponding control group. Histological analysis revealed epithelial degeneration and necrotic cell death in the proximal tubules of the kidney after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg). Our data suggest that Mel-mediated renal toxicity may be influenced by CA concentrations in Mel-contaminated milk or foods.
( Ji Yeon Son ),( Yoon Jong Kang ),( Kyeong Seok Kim ),( Tae Hyung Kim ),( Sung Kwang Lim ),( Hyun Jung Lim ),( Tae Cheon Jeong ),( Dal Woong Choi ),( Kyu Hyuck Chung ),( Byung Mu Lee ),( Hyung Sik Ki 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Melamine-induced nephrotoxicity is closely associated with crystal formation in the kidney caused by combined exposure to melamine (Mel) and cyanuric acid (CA). However, there are few dosage-finding studies for toxicological evaluation of chronic co-exposure to Mel and CA. The objective of this study was to investigate the possible mechanism by which a Mel and CA mixture lead to renal toxicity in rats. Mel and CA were co-administered to rats via oral gavage for 50 days. Nephrotoxicity was determined by measuring blood urea nitrogen (BUN) and serum creatinine (sCr) levels. Relative kidney weights were significantly increased in rats after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg) mixtures. BUN and sCr levels were significantly increased after Mel and CA co-exposure. Taken together, significant increase in KIM-1, NGAL, and calbindin levels were observed in the urine of rats exposed to Mel+CA (63/6.3 or 630/6.3 mg/kg) compared with the corresponding control group. Histological analysis revealed epithelial degeneration and necrotic cell death in the proximal tubules of the kidney after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg). Our data suggest that Mel-mediated renal toxicity may be influenced by CA concentrations in Mel-contaminated milk or foods.
Son, Ji Yeon,Kang, Yoon Jong,Kim, Kyeong Seok,Kim, Tae Hyung,Lim, Sung Kwang,Lim, Hyun Jung,Jeong, Tae Cheon,Choi, Dal Woong,Chung, Kyu Hyuck,Lee, Byung Mu,Kim, Hyung Sik Korean Society of ToxicologyKorea Environmental Mu 2014 Toxicological Research Vol.30 No.2
Melamine-induced nephrotoxicity is closely associated with crystal formation in the kidney caused by combined exposure to melamine (Mel) and cyanuric acid (CA). However, there are few dosage-finding studies for toxicological evaluation of chronic co-exposure to Mel and CA. The objective of this study was to investigate the possible mechanism by which a Mel and CA mixture lead to renal toxicity in rats. Mel and CA were co-administered to rats via oral gavage for 50 days. Nephrotoxicity was determined by measuring blood urea nitrogen (BUN) and serum creatinine (sCr) levels. Relative kidney weights were significantly increased in rats after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg) mixtures. BUN and sCr levels were significantly increased after Mel and CA co-exposure. Taken together, significant increase in KIM-1, NGAL, and calbindin levels were observed in the urine of rats exposed to Mel+CA (63/6.3 or 630/6.3 mg/kg) compared with the corresponding control group. Histological analysis revealed epithelial degeneration and necrotic cell death in the proximal tubules of the kidney after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg). Our data suggest that Mel-mediated renal toxicity may be influenced by CA concentrations in Mel-contaminated milk or foods.
김상아,곽연희,박웅섭,송재석,이상욱,박덕영,강명근 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1
This study was conducted to use for the Community Health Care Plan through analyzing the specific cause of death in Gangneung. The study subject were death in Gangneung that happened from January 1, to December 31 in 2000, and that were enrolled as the citizen of Gangneung. The causes of death were classified according to the 56 selected list for ranking of causes of death in Korean National Statistical Office in order to compare the data of nation. We also estimated Years of Potential Life Lost in order to evaluate the burden of disease in Gangneung.
김상아,곽연희,박웅섭,송재석,이상욱,강명근 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1
This study was conducted to use for the Community Health Care Plan through the demand-supply analysis of medical institution in Gangneung. The study data were obtained from the Korean National Health Insurance Corporation and the government of Gangneung. The major findings is follows; First, the hospital beds in Gangneung was 793 beds, but supply was 2,187 beds. Second, the demand of clinic in rural area was 43, and supply was 21. But demand of clinic in urban area was 115, and supply was 144. Third, the pubic medical institution in rural covered 4.7% of outpatient demand, and that in urban covered 0.9% of outpatient demand.
증가 분산을 보이는 오차하에서 Michaelis-Menten Kinetic 상수 추정치의 분석을 위한 5가지 방법들의 비교
김충원,김연웅,박중양 慶尙大學校 1987 論文集 Vol.26 No.1
Lineweaver-Burk 방법은 등분산 오차와는 달리 증가분산 오차인 경우 K?을 계사낳는 좋은 방법임을 앞의 결과들로 부터 알 수 있었다. 즉 기질농도 범위가 다른 방법에 비해 넓다. 그러나 정확도와 정도 모두 다른 방법에 비해 우수하였으며 오차의 크기에도 영향을 적게 받는다. Hanes-Woolf 방법은 추정치 K?의 C.V.가 기질 농도 범위 증가에 따라 급격히 증가하였고 이에 따른 정확도로 나빠졌다. 정확한 기질농도 범위를 선택한 경우 정확한 K?을 추정할 수 있으나(Table 2)그렇치 않은 경우는 매우 위험한 방법이었다. Woolf-Augustinsson-Hofstee 방법은 다른 방법들에 비해 K? 추정치의 C.V.가 가장 작은 방법이었으나 K?-K?의 분포가 각 실험에서 다른 나머지 방법에 비하여 크게 나타나 정확도가 좋지 않은 방법이었다. 이와 같은 결과가 실험 I과 실험 III에서 추정치들의 C.V.는 가장 작으나 K?-K? 분포가 가장 크게 나타났었다. 또한 Fig.5에서 보면 측정 오차가 커지면 K? 추정치는 실제값보다 작게 측정되는 경향이 있음을 볼 수 있었다. Wilkinson-Cleland 방법은 정확도에서 좋은 방법이었다.그러나 K? 추정치의 C.V.가 크며 (Table2)정확한 기질 농도 범위를 사용하지 않으면 실제값보다 작은 추정치를 가지는 경향이 있음을 알 수 있었다(Fig.2). 정확한 기질농도 범위에서 실험을 할 경우 정확도는 Hanes-Woolf 방법, Wilkinson-Cleland 방법, Lineweaver-Burk 방법,Direct linear 방법, Direct linear 방법, Woolf Augustinsson-Hofstee 방법의 순서로 양호하였다. 같은 효소에서 저해제나 활성제의 영향을 서로 비교할 때는 추정치들의 분산이 작은 Woolf-Augustinsson-Hofstee 방법이 좋다. 적정 기질농도 범위는 약 2 K?에 서 6K?사이로 각 방법에 따라 조금씩 차이가 있었으며 최소 필요 기질농도 수는 10개 내외가 적당하였다. The Michaelis-Menten equation was fitted to simulated data showing the increasing variance error by using three linear transformations(Lineweaver-Burk, Hanes-Woolf, Woolf-Augustinsson-Hofstee), and Cornsih-Bowen's direct linear plot and the method of Wikinson Cleland. The best method under the well definded conditions was those of Hanes-Wkklf's. The Woolf-Augustinsson-Hofstee plot appeared the worst method. The proper fanges of substrate concentration were different from each other between even-spaced within the defined range, were adequate.
김상아,박웅섭,이상엽,이승근,송재석,이상욱,곽연희,박성준 關東大學校 醫科大學 醫科學硏究所 2003 關東醫大學術誌 Vol.7 No.1
This study is conducted to established integrated principal framework for the effects of the Hospital Information System(HIS) specially Physician Order Entry system(POE), Laboratory Information System(LIS), and Picture Archiving and Communication System(PACS) on the performance of medical institute. We had reviewed and analyzed the literature of POE, LIS, and PACS, and then formulated principal framework. In conclusion, the implementation of HIS could improve the satisfaction of medical staff and reengineer the work process, and those leaded improving the quality of service, and that also leaded increasing the number of patients and case mix of disease, and then those leaded increasing the performance of medical institute.