영양 장애 환자에 대한 지질 영양 수액제 "Trive-1000^(R)"의 효과에 대한 연구

손기섭,배진선,장일성,노승무,박인근,김지연 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

The association between malnutrition and poor hospital course in surgical patients is well recognized, although it may not involve the causation. When the period of NPO is needed more than several weeks, adequate caloric intake is difficult to maintain, and nutritional status often worsens especially after the operation. Trive-1000^(R) is a ready to use industrial ternary mixture. It fulfills standard requirements for TPN and has a advantage to decrease the cost because of time saving in preparation by the pharmacist and cost saving in disposables(transter sets, bags, filters). It improves safety by less risk of contamination and of error from handling and labelling. A prospective study was undertaken to evaluate the efficacy of Trive-1000^(R) in 34 malnourished patients after the major operation and the results were summarized as follows ; 1) The hemoglobin was not changed and AST, ALT, and bilirubin were increased and BUN and alkaline phosphatase were slightly increased without significance. 2) Mild to moderate toxicities including fever and chill, hepatopathy, thrombophlebitis and hyperglycemia. The infusion was discontinued in one of thrombophlebitis and one of hepatopathy. There results suggest that Trive-1000^(R) is relatively effective and safe TPN agents but requires the large scaled prospective randomized study.

정신장애인의 재활의 위한 사회기술훈련의 효과성에 관한 연구

황태연,손덕순,백형의,박종원,김지현,이경화 용인정신의학연구소 1999 용인정신의학보 Vol.6 No.2

시각적 피드백을 병행한 어깨복합운동프로그램이 어깨비대칭 청년들의 어깨 근력과 정렬에 미치는 영향

강순희, 강은지, 목미경, 박지연, 손혜림, 연우정 한국교통대학교 2016 한국교통대학교 논문집 Vol.51 No.-

The purpose of this study was to identify whether shoulder complex exercise program with visual feedback could improve the shoulder muscular strength and postural alignment in adolescents with shoulder asymmetry. Twenty eight subjects were recruited from the K university and divided into three groups: experimental 1, 2group(Each n=10) and control group(n=8). For 4 weeks, the experimental group 1 performed shoulder muscle complex exercise program and the experimental group 2 performed shoulder complex exercise program with visual feedback. The control group did not perform exercises. The shoulder muscle strength and difference between the height of left and right shoulders were assessed before, after training using the hand-held dynamometer and Global Posture System. Subordination variables, general characteristics analysis, χ² test and Kruskal Wallis H test were conducted to evaluate differences between groups and training before, after changes were checked Wilcoxon signed rank test with using the PASW 18.0 statistical program. The results of the study were as follows. 1) Both the experimental 1, 2group showed improvements in muscle strength of several muscles following training (p<.01). The control group showed significant reduction in the left posterior deltoid (p<.05), and did not show significant changes in examining other muscles (p>.05). And there were differences among three groups in shoulder muscle strength (p<.001). Muscle strength changes in several muscles were greater in the experimental 1, 2group compared with the control group (p<.001). Muscle strength changes in the several muscles were greater in the experimental group 2 compared with the experimental group 1 (p<.001) 2) Both the experimental 1, 2group showed significant decreases in the difference between the left and right shoulder heights following training (p<.01). The control group did not show change (p>.05). Changes in the difference between the left and right shoulder heights were greater in the experimental 1, 2group compared with the control group (p<.001).

肺癌에 있어서 職業과의 關聯性 硏究

김두희,박완섭,손지연,이종영,홍성철 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2

폐암에 대한 직업의 관련성을 밝히기 위하여 1993년 11월에서 1994년 8월까지 대구 시내 2개 종합병원에 입원하여 병리 조직학적으로 진단된 168명의 폐암 환자와 같은 병동에 있는 내과 환자를 연령군과 성별로 빈도 짝짓기하여 168명의 대조군으로 선정하였다. 직업력과 유해 물질의 폭로력, 거주 환경, 흡연에 관한 정보는 설문지를 통하여 얻었다. 흡연 상태를 보정하고 연령군과 성별에 대한 짝지은 자료에 대하여 직업과 산업 분류에 대한 폐암 발생의 상대 위험은 농업 종사자에서 유의하게 높았고(OR=1.84 ; 95% 신뢰구간 1.16-2.94) 생산직, 가내 수공업, 운수창고통신업, 숙박음식업, 건설업에서도 높게 나타났으나 유의하지 않았다. 그러나 가사(OR=0.31 ; 95% 신뢰구간 0.11-0.89), 관리직(OR=0.22 ; 95% 신뢰구간 0.08-0.61), 공공 행정업(OR=0.23, 95% 신뢰구간 0.08-0.66), 공공 사회및 개인 서비스직(OR=13 ; 95% 신뢰구간 0.03-0.56)에서는 폐암 발생의 상대 위험이 유의하게 낮았으며, 전문직, 도소매업에서도 낮게 나타났으나 유의하지 않았다. 거주 환경에 따른 폐암 발생의 상대 위험은 연탄난로 사용자(OR=3.00 ; 95% 신뢰구간 1.06-8.52)와 농약 사용시(OR=2.14 ; 95% 신뢰구간 1.36-3.37)에 통계학적으로 유의하게 높았고, 공장지대 거주자에서도 높게 나타났다(OR=1.97 ; 95% 신뢰구간 0.92-4.27) 그러나, 중앙집중식난방사용자(OR=0.5 ; 95% 신뢰구간 0.28-0.89)에서는 낮게 나타났으며 통계학적으로 유의하였다. 유해 물질 폭로에 따른 폐암 발생의 상대 위험은 농약(OR=2.07 ; 95% 신뢰구간 1.31-3.26)과 용접 및 흄(OR=10.56 ; 95% 신뢰구간 1.07-103.90)에 폭로시 유의하게 높게 나타났다. 흡연에 의한 폐암 발생의 상대 위험은 비흡연자에 비하여 흡연자(OR=3.98 ; 95% 신뢰구간 1.88-8.45)와, 과거흡연자(OR=4.50 ; 95% 신뢰구간 1.99-10.16)에서 높게 나타났다. 이상의 결과로 비록 흡연이 폐암의 중요한 원인이지만 흡연의 영향을 보정한 후에도 대기오염 및 직업과 폐암과 관련성이 있음을 보여주고 있으며, 앞으로 이러한 직업에서 어떠한 위험 요인이 있는지에 대한 추구가 필요하여 그에 대한 예방 대책을 밝히는 연구가 필요하다. The relationship between occupation and risk of lung cancer was analyzed in hospitalbased case-control study conducted in Taegu on 168 patients with histologically confirmed lung cancer and age group(30-39, 40-49,etc) and sex frequency-matched 168 controls admitted into hospitals for other internal medicine problems. A self adminstered questionnaire was used to obtain occupation, resident environment, smoking histories and specific agent exposure history. The conditional logistic regression was used to estimate oddsratio for age group and sex frequency matched, after controlling for smoking status(non smoker, exsmoker, current smoker) Significant association was observed for farmer[odds ratio(OR), 1.84 ; 95% confidence interval(CI), 1.16-2.94], briquette stove users[OR, 3.0 ; 95% CI, 1.06-8.25], agricultural chemicals users[OR, 2.14 ; 95% CI, 1.35-3.37], and welding/fume exposures[OR, 10.56 ; 95% CI, 1.07-103.90]. Although there were elevated risks associated with production, home industry, transportation/storage/communication, lodgement/food worker and construction, none were statistically significant. The effect of smoking was showed significantly increased risk for exsmoker [OR, 4.50 ; 95% CI, 1.99-10.16] and current smoker [OR, 3.98 ; 95% CI, 1.88-8.45]. As results, although smoking is important risk of lung cancer, occupation and resident environment are showing association of lung cancer. So further evaluation is necessary for occupation risk and take preventive measures.

다중주파수·다중성분 고막운동도에 관한 연구

소원섭,이지연,강희라,손원진,허승덕 대구대학교 특수교육재활과학연구소 2012 再活科學硏究 Vol.30 No.1

이 연구는 이학적·청각학적 정상 소견을 가진 성인들의 다중주파수 고막운동도(multi-frequency tympanogram, MFT)와 다중성분 고막운동도(multi-component tympanogram, MCT)의 특성을 알아보고자 하였다. 연구 참여자는 D대학교 재학 중인 19명(M:F=9:10, 만 19∼23세)으로 하였다. MCT는 각 성분(admittance; Y, susceptance; B, conductance; G)별 정점의 수를 확인하였고, MFT는 200 ㎐부터 2 ㎑ 순음에 대한 고막 긴장 및 이완상태에서 전도율을 통해 공명주파수와 ΔB, Δ∅를 각각 구하였다. MCT는 668 ㎐ 자극에 대해 47.4 %가 1Y1B1G를, 52.6 %가1Y3B1G를 보였고, MFT의 공명주파수는 829~1,213(1,021±192) ㎐, ΔB와 Δ∅의 평균은 각각 –0.18, -19.3으로 관 찰되었다. This study will be to confirm the characteristic of Multi-component tympanogram(MCT) and Multi-frequency tympanogram(MFT) of adults who have physical and audiological normal findings. Participants were 19 students(M:F = 9:10) who are attending D-university. MCT checked the number of peaks per each component(admittance; Y, susceptance; B, conductance; G) and MFT got the resonance frequency through the conductivity rate of tympanic membrane's tense and relaxation state, and ΔB, Δ∅ respectively. 47.4% of MCT showed 1Y1B1G about 668 ㎐ stimulus and 52.6% of that showed 1Y3B1G. Resonance frequency of MFT was 829~1,213(1,021±192) ㎐, and the average of ΔB and Δ∅ was observed -0.18, -19.3 respectively.

産業災害로 인한 手脂切斷 患者의 療養期間과 診療費의 變異

이종호,이종영,손지연,하영애,박순우,감신,이영숙,김건엽,강윤식 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.3

This study was conducted to analyze variation in patient days and medical care benefits among finger-amputated patients due to industrial injury. The 242 personal data on medical care for finger-amputated patients due to industrial injury(131 in 1994, 111 in 1995) of Regional Labor Office were analyzed. The major results of this study were as follows: Patient days per case were 69. And the ratio of the maximum and the minimum among patient days for case was 26.6. Patient days per case in university hospital were 134.8 and the longest than other medical facilites. The ratio of the maximum and the minimum among the patient days per case was higher in hospital(24.7) than in other medical facilities. Benefits per case were 1,258,000 Won. And the ratio of the maximum and the minimum among benefits of case was 232.0. Case benefits was higher in university hospital (2,685,000 Won) than in other medicl facilities. The ratio of the maximum and the minimum among the benefits per case was higher in hospital(232.0) than in other medical facilities. Variation in patient days and medical care benefits per finger-amputated patient in industrial injury was large. This study results indicated need for a new industrial injury compensation insurance policy initiative for efficient utilization of medical resources and quality assurance. And the author thought that the results of this study would influence the policy for the industrial injury compensation insurance policy.

아시아 지역 폐렴 구균의 항균제 내성 현황 및 변화 양상 : Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study

정숙인,김나영,손준성,기현균,고관수,서지연,장현하,김연숙,오원섭,백경란,이남용,송재훈,항생제 내성 감시를 위한 아시아 연합 (ANSORP) 대한감염학회 2004 감염과 화학요법 Vol.36 No.1

목적 : 1980년대부터 페니실린을 비롯한 β-lactam 계열과 비 β-lactam 계열 항균제에 대한 폐렴구균의 항생제 내성이 급격하게 증가하여 국내 뿐 아니라 세계적인 문제로 대두되고 있다. ANSORP 에서는 아시아 지역에서 폐렴구균의 항균제 내성과 그 변화 추이, 내성의 기전 및 위험인자를 분석하고자 본 국제 공동 연구를 시행하였다. 재료 및 방법 : 1999년 11월부터 2001년 8월까지 아시아 지역 12개국의 14개 기관에서 폐렴구균 감염증 환자의 임상 검체로 분리된 침습성 폐렴구균을 대상으로 액체배지 미량희석법을 이용하여 16개 항생제의 MIC를 구하였다. 위험인자의 분석을 위하여 폐렴구균 감염증 환자를 대상으로 의무기록지를 조사하였다. Quellung 반응을 통해 혈청형을 결정하였다. 결과 : 총 685균주 중 52.4%가 페니실린에 대하여 비감수성(중등도 내성 22.9%, 내성 29.5%)을 보였고, 그 빈도는 베트남(92.1%), 스리랑카(85.7%), 홍콩(67.9%), 한국(64.5%)의 순이었다. Erythromycin에 대한 비감수성 비율은 베트남(92.1%), 대만(87.7%), 한국(80.6%), 홍콩(76.8%) 등에서 높게 나타났고, 베트남, 대만, 한국, 홍콩 등의 erythromycin의 MIC_(90)이 32㎍/mL를 넘는 고도내성을 보였다. 홍콩, 싱가포르, 대만, 인도에서는 fluoroquinolone에 대한 내성 균주가 출현하였다. 전체 균주 중 다제내성 균주의 비율은 47.7%였다. 혈청형은 19형과 23형이 가장 많았고, 그 외 6형, 14형 등이 있었다. 페니실린 비감수성 감염증의 위험인자로는 5세 미만(OR=1.7; 95%, CI, 1.2-2.4; P=0.002), 기관지폐질환(OR=2.0; 95%, CI, 1.3-3.1; P=0.003), 악성종양(OR=2.3; 95%, CI, 1.2-4.6; P=0.015), 스테로이드의 사용(OR=2.8; 95%, CI, 1.1-7.4; P=0.032)이 확인되었다. 결론 : 침습성 폐렴구균 균주를 대상으로 한 본 연구의 결과 아시아 국가들에서 페니실린, β-lactam 및 macrolide에 대한 폐렴구균의 내성률 및 내성 정도가 급증하고 있음을 확인하였다. Background : Emergence of pneumococcal resistance became a global issue since 1990s. According to the ANSORP studies with clinical isolates and carriage isolates between 1996 and 1999, some Asian countries showed alarmingly high prevalence of resistance to penicillin and other antimicrobial agents. To investigate the changing trends of pneumococcal resistance, ANSORP study group has performed a multinational surveillance study with invasive pneumococcal isolates from Asian countries. Methods : All isolates from various invasive pneumococcal diseases were prospectively collected from 14 centers in 12 countries between November 1999 to August 2001. Broth microdilution tests with 16 antimicrobial agents were performed according to the NCCLS procedures. Serotyping was performed by means of Quelling reaction with use of group-specific antisera. Results : A total of 685 isolates were collected. Overall, 52.4% of invasive isolates from Asian countries were not susceptible to penicillin (intermediate (1), 22.9%, Resistant (R), 29.5%). Vietnam showed the highest prevalence of penicillin non-susceptibility (1 20.6%, R 71.4%) followed by Sri Lanka (1 71.4%, R 14.3%), Hong Kong (1 24.1%, R 76%) and Korea (1 9.7%, R 54.8%). China (I 19.8%, R 23.4%) and Malaysia (1 9.1%, R 29.5%) also showed remarkable increase in penicillin resistance compared with previous ANSORP data, which were less than 10%. Vietnam (92.1%), Taiwan (87.7%), Korea (80.6%), and Hong Kong (76.8%) showed high prevalence of erythromycin resistance. MIG_(90)S for ciprofloxacin were 4 ㎍/mL (Hong Kong) and 2 ㎍/mL (11 Asian countries except Hong Kong), respectively. Conclusion : Compared with previous data from ANSORP studies, antimicrobial resistance among invasive pneumococcal isolates has markedly increased in Vietnam, Sri Lanka, Taiwan, China, and Malaysia. Continuous surveillance of pneumococcal resistance in Asia is strongly warranted.

Protein microarray를 이용한 Apin-단백질의 상호작용에 관한 연구

박주철,박선화,김흥중,박종태,윤성호,김지웅,이태연,손호현 대한치과보존학회 2007 Restorative Dentistry & Endodontics Vol.32 No.5

Resource-aware smart home management system by constructing resource relation graph

Ji-Yeon Son,Jun-Hee Park,Kyeong-Deok Moon,Young-Hee Lee IEEE 2011 IEEE TRANSACTIONS ON CONSUMER ELECTRONICS - Vol.57 No.3

<P>With the advent of smart home devices including Smart TV or smart appliances, home becomes smarter. Smart home is a complex environment where heterogeneous smart devices and appliances are connected to each other to provide various smart services. As the home environments become smarter and more complex, the need for an effective managing mechanism with minimum user's intervention is growing. However, just only putting together all the individual information of each resource is not enough, since it is very hard to catch out overall home situation without the relation information between the managed resources. In this paper, we propose a resource-aware management system with hierarchical smart home resource model, using the home context information which defines the information convergence model of heterogeneous home resources and builds a home knowledge by constructing a resource relation graph. The proposed system can accelerate deployment of advanced future smart home service features such as context-aware dynamic service composition, autonomous fault management systems. In addition, it allows cost effective remote maintenance system with highly convenient manageability. We implemented the prototype system of our proposed architecture and evaluated the performance on the query response time of home resources and relations in a real environment. Results showed that it has acceptable performance for navigating or control of home information and excellent improvements in terms of relation based search. We anticipate that the proposed system will bring the huge benefits not only to the consumers, home network service providers but also to the home network maintenance companies in terms of ease of management, and diagnostic effectiveness.</P>

Preclinical Quantitative MicroPET Imaging in Evaluation of Neuroprotective Drug Candidates

( Ji Yeon Son ),( Yu Kyeong Kim ),( Ji Sun Kim ),( Byung Chul Lee ),( Kyeong Min Kim ),( Tae Hyun Choi ),( Gi Jeong Cheon ),( Won Woo Lee ),( Sang Eun Kim ) 대한핵의학회 2007 핵의학 분자영상 Vol.41 No.5