임신중독증 태반에서 Apoptosis의 양상

이연혜(Yeun Hae Lee),이병석(Byung Suk Lee),이용희(Yong Hee Lee),최형민(Hyung Min Choi),유용균(Yong Gyun Yoo),조재성(Jae Sung Cho),이지원(Ji Won Yi),권혜경(Hae Kyung Kwon),양우익(Woo Ik Yang),박용원(Yong Won Park) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11

N/A The mechanism of apoptosis was first discovered at the end of the 19th century, but it was only recently that its importance was recognized. Not only in a pathologic environment but also in a normal environment, apoptosis has an important role in homeostasis. The number of cells is restricted by apoptosis which is controlled by several SlgBS lll VlVO. In pregnancy, the placenta regulates the maternal-fetal exchange of molecules and functions as a barrier for the protection of the fetus. As the pregnancy proceeds, changes occur in the number and components of placental cells. Observing the placental tissues, apoptosis was found in the syncytiotrophoblasts of early and late pregnancy. In particular, the fact that apoptosis observed in the placenta of late pregnancy supports the hypothesis that pmgrammed cell death is a normal sequence. Pregnancy-induced hypertension is usually accompanied by abnormal placenta and intrauterine growth restriction. In this study, using the TdT-FragEL DNA fragmentation detection kit, the changes in the nucleus by apoptosis in the placental tissues of 23 to 40 gestational weeks in preeclampsia and eclampsia were compared with normal placenta. Apoptosis was observed in the normal term placenta and in pregnancy-induced hypertension patients, regardless of whether vasculopathy was observed in Doppler ultrasound or confirmed by pathology, more apoptoses were observed aside from the number of gestational weeks.

국내(國內) 의류(衣類)브랜드 네임의 네임 스펙트럼 유형(類型) 및 특성(特性) -여성복(女性服)과 남(男),여(女) 공용복(共用服)을 중심(中心)으로-

권혜숙 ( Hae Sook Kwon ),오연정 ( Yeun Jung Oh ) 한국패션비즈니스학회 2005 패션 비즈니스 Vol.9 No.5

The purpose of this research is to investigate the types of name spectrum and their characteristics of domestic fashion brand names focusing on women` wear and bisex wear, and also studied the differences based on the sex of brand target. 224 of women`s wear brands and 99 of bisex wear brands were selected from ``2002 Korea Fashion Yearbook`` under the criterion that their brand names were made in Korea and they should engage in business in 2002. The data analysis quatitatively evaluate the frequency and qualitatively evalute the image of brand product and the meaning of brand name. The result as follows; 1.The domestic fashion brands for women`s and bisex wear appeared to have to three types of name spectrum ; the descriptive name was the most frequently used one, then followed by the arbitrary, and the suggestive name. There were only one coined brand name and no generic brand name. 2. The characteristics of descriptive brand name was that, in most cases, it used the name of designer. For the suggestive brand name, it implied the features or the image of its products. For the arbitrary brand name, some bear the ideology or the foundation belief of company itself. 3. For women`s wear, the discriptive name appeared most, and followed by arbitrary, and the suggestive name. For bisex wear, the suggestive brand name appeared most, and followed by arbitrary name, and the discriptive name. 4. For descriptive brand name, the names of designer were used most in women`s wear brands. Otherwise, the brand names that directly described the image or the characteristics of products were used most in bisex wear brands. For suggestive brand name, soft and feminine images were prevailed in women`s wear brand names but comfotable and casual images were dominent in bisexsual brand names. For arbitrary brand name, as the various types of languages were combined and the various meanings and words were mixed, and imply the various meanings in both cases, it was hard to classify the characteristics into some categories.

죽음에 관한 주관성 연구

정혜경,김경희,윤은자,류은정,염순교,정연강,권혜진 대한간호학회정신간호학회 1999 정신간호학회지 Vol.8 No.1

The purpose of this study is, by using Q-methodology, to classify the type of attitude for the general public about the death and to understand the specific characters of each type. Q-population was investigated by referring to relevant records and interviewing with the general public and the experts. The final 40 of Q-sample was selected and the data was collected through P-sample, randomly chosen 32 people around Seoul and Kyung-gi area. After analyzing, 4 types were found. Type 1 is aiming for the future life. They believe firmly the future life. They feel certain that eh death means starting for eternal life rather than being afraid of the death or having a despair. Type 2 is valuing reality. They do their best for the reality of life. They take up a positive attitude toward completing their life with responsibilities even at the situation of confronting death have a right to know when they will be dead. They should have enough time to prepare for death. Type 4 is devoting for society. Even though there is only one life, people think that devoting their life for justice is very important. Through the result of this study, people's agreement for nobility and importance of life were found same. It is reconfirmed that instead of being dead suddenly, if it's possible, they want to know the fact of dying to have time to prepare for their death. Also, the fact that everyone has the fear of death is confirmed.

A Co-inhibitory Molecule, B7-H4, Synergistically Potentiates Oral Tolerance by Inducing CD4+CD25+FoxP3+ T Cells

Wen, Lanying,Yang, Sung-Yeun,Choi, Jae-Kyoung,Kim, Young-Hee,Kwon, Eun-Hee,Lee, Hyun-Ji,Jeoung, Hae-Young,Hwang, Du-Hyeon,Hwang, Dong-Jin,Choi, In-Hak The Korean Association of Immunobiologists 2008 Immune Network Vol.8 No.1

Background: A co-inhibitory molecule, B7-H4, is believed to negatively regulate T cell immunity by suppressing T cell proliferation and inhibiting cytokine production. However, the mechanism behind B7-H4-mediated tolerance remains unclear. Methods: Balb/c $(H-2^d)$ mice were fed with dendritic cell line, DC2.4 $(H-2^d)$ every day for 10 days. Meantime, mice were hydrodynamically injected with recombinant plasmid expressing B7-H4 fusion protein (B7-H4.hFc) or hFc via tail vein. One day after last feeding, mice were immunized with allogeneic B6 spleen cells. 14 days following immunization, mice were challenged with B6 spleen cells to ear back and the ear swelling was determined the next day. Subsequently, a mixed lymphocyte reaction (MLR) was also performed and cytokines profiles from the reaction were examined by sandwich ELISA. Frequency of immunosuppressive cell population was assayed with flow cytometry and mRNA for FoxP3 was determined by RT-PCR. Results: Tolerant mice given plasmid expressing B7-H4.hFc showed a significant reduction in ear swelling compared to control mice. In addition, T cells from mice given B7-H4.hFc plasmid revealed a significant hyporesponsiveness of T cells against allogeneic spleen cells and showed a significant decrease in Th1 and Th2 cytokines such as IFN-${\gamma}$, IL-5, and TNF-${\alpha}$. Interestingly, flow cytometric analysis showed that the frequency of CD4+CD25+FoxP3+ Tregs in spleen was increased in tolerant mice given recombinant B7-H4.hFc plasmid compared to control group. Conclusion: Our results demonstrate that B7-H4 synergistically potentiates oral tolerance induced by allogeneic cells by increasing the frequency of FoxP3+ CD4+CD25+ Treg and reducing Th1 and Th2 cytokine production.

Inheritance and Linkage of Some Polymorphic Isozymes in Ginkgo biloba L.

(Zin Suh Kim),(Hae Yeun Kwon) 한국임학회 2000 한국임학회 학술발표논문집 Vol.2000 No.-

도심 가로정원의 심리적 회복효과에 관한 연구

권현숙,함연경,김혜령,윤희연,Kwon, Hyun-Sook,Hahm, Yean-Kyoung,Kim, Hae-Ryung,Yoon, Hee-Yeun 한국조경학회 2017 韓國造景學會誌 Vol.45 No.1

Street gardens, a series of streetscape improvement projects led by Seoul City Government, are initiated for the purpose of providing aesthetic satisfaction and mental refreshment to pedestrians. In order to investigate whether street gardens indeed promote the psychological health of the users, questionnaire surveys were conducted on three selected street gardens - at Gangnam-daero, Digital-ro, and Teheranro - and their comparison sites located on the same streets, which have a similar physical environment but without a street garden. The survey questionnaires, based on Attention Restoration Theory, were composed of Perceived Restorativeness Scale-11 with the eleven individual questions grouped into four categories: 'Fascination', 'Being away', 'Coherence', and 'Scope'. The survey questionnaires also ask about physical components that promote psychological improvement in the aforementioned categories. The collected data was analyzed with factor analysis, reliability analysis, and independent t-test. The results suggested that street gardens had a relatively positive effect on the psychological restorativeness of the users. In particular, they gave fascination and interest to the users. However, they did not offer a feeling of being away to the users, which revealed the limitation in the psychological improvement effect of street gardens. The physical components of the street garden that have led the psychological restorativeness effect were wooden bench, tree, and flower. This result corresponds to an extant theory that natural factors have a positive effect on the psychological restorativeness within a hardscape. This research will shed light on the planning and design guidelines for the street garden project. 가로정원은 서울시 가로환경 개선 사업의 일환으로, 보행자들에게 심미적 만족과 심리적 안정감을 제공하기 위한 휴식공간으로 설치되었다. 본 연구에서는 실제 가로정원이 이용자의 심리적 향상을 돕는지 고찰하기 위해, 가로정원과 이에 상응하는 비교대상지를 선정하여 설문조사를 실시하고, 결과를 비교하였다. 서울시에 위치한 총 9개의 가로정원 중 강남대로, 디지털로, 테헤란로에 설치된 가로정원을 대상지로 선택하였으며, 비교대상지로는 동일 대로상에 위치하며 물리적 환경이 유사하나 가로정원 사업이 시행되지 않은 3개의 장소를 선정하였다. 설문은 주의회복이론(Attention Restoration Theory: ART)을 근거, '매력감(Fascination), '벗어남(Being away)', '짜임새(Coherence)', '규모(Scope)'를 중심으로 구성된 회복환경지각척도-11(Perceived Restorativeness Scale-11) 질문과, 심리적 회복을 유도한 설계 요소를 묻는 질문으로 구성하였고, 요인분석, 신뢰도 분석, 독립표본 t-검정을 이용하여 분석하였다. 분석 결과, 가로정원은 이용자들의 심리적 회복에 비교적 긍정적 효과를 미치며, 특히 이용자들에게 매력감과 흥미로움을 부여한다고 나타났다. 그러나 가로정원은 이용자들에게 고단한 현실에서 벗어나는 듯한 느낌을 주지 못하여 심리적 향상효과의 한계를 드러냈다. 심리적 회복효과를 유도한 가로정원의 물리적 요소는 나무벤치, 나무, 꽃으로 나타나, 자연적인 요소가 인공적 요소보다 심리적 회복에 긍정적 영향을 준다는 심리회복 이론에 부합하였다. 본 연구의 결과는 향후 가로정원 사업을 추진함에 있어 계획 및 설계 가이드라인 개발에 기여할 것으로 기대된다.

은행나무의 몇가지 다형적 동위효소의 유전양식 및 연관

김진수,권해연 한국임학회 2000 한국산림과학회지 Vol.89 No.4

Isozyme variants of 15 enzyme systems were analyzed in megagametophytes of Ginkgo biloba L. Five enzyme systems (ADH, G6PD, IDH, MPI, and UGPP) appeared to be monomorphic. Only 11 isozyme zones observed in 10 enzyme systems were polymorphic : ACON-A, FST-B, GDH-A, GOT-B, MDH-B, MDH-C, MNR-A, PGI-B, PGM-A, 6PGD-B and SKDH-B. The segregation ratio and heterogeneity at most polymorphic zones suggested that each isozyme zone was controlled by a single locus with codominant alleles, but significant deviation from 1 : 1 segregation was observed at MDH-B in pooled data. Three pairs of isozyme loci (ACON-A : MDH-B, GOT-B : PGI-B, and MNR-A : SKDH-B) were found to be weakly linked. Recombination frequencies between them ranged from 0.38 to 0.40 (p$lt;0.05).

대구지역 경부선 철도주변의 소음실태와 특성

민경섭,송희봉,박연준,한개희,이명숙,김용혜,홍성희,권기홍 한국환경과학회 1997 한국환경과학회지 Vol.6 No.1

We investigated and analysed the actual conditions and characteristics of railroad noise levels for 17 sites in the vicinity of the Seoul-Pusan Line. The results are summarized. as follows : 1) Railroad noise level ranged to 64∼74 L_eq dB(A) at day time and ranged to 60∼72 L_eq dB(A) at night time. 2) Increased night noise level depend on the increase of trains passing at night time. 3) The major factor of increased noise level in the vicinity of stations are using loudspeakers and stream whistle on trains. 4) Decreased effect of noise according to distance is able to be described quantitatively using regression equations of multiplicative model. L_eq=78.59 X^-0.056 n=25, r=-0.994, s.e.=1.007 P_av =105.68X^-0073, n =25, r =-0.997, s.e. = 1.007 Also increased and decreased effect of noise according to floor in apartment is able to be described quantitatively using regression equations of multiplicative model. L_eq = 64.238 X^0.0567, n = 39, r = 0.787, s. e. = 1.004 P_av. = 79.963 X^0.0254 n = 39, r = 0.689, s. e. = 1.056 5) Average noise level in high floor is over 70L_eq dB(A) at day and night time, so more detailed soundproofing countermeasured in high floors apartment is required.

범이론 모형을 기초로 한 농촌지역 성인의 금연행위에 영향을 미치는 요인

안옥희(Ahn, Ok-Hee),윤은자(Yeun, Eunja),권성복(Kwon, Sung-Bok),정혜경(Chung, Hae-Kyung),류은정(Ryu, Eunjung) 한국간호과학회 2005 Journal of Korean Academy of Nursing Vol.35 No.7

노인이 지각한 건강에 대한 주관성 연구

정혜경,김경희,권혜진,윤은자,정연강,Chung, Hae-Kyung,Kim, Kyung-Hee,Kwon, Hye-Jin,Yeun, Eun-Ja,Chung, Yeoun-Kang 한국지역사회간호학회 1999 지역사회간호학회지 Vol.10 No.1

This study is to classify subjectification and the perceived health of the elderly according to Q-methodology and to provide basic materials for health promotion of the elderly. In this study, 28 elderly people residing in Seoul classified 33 selected statements in to 9 standards. The material taken from this process resulted in 4 types by the analysis using a PC QUANL program. Case 1 thought that religion was important for their health. Case 2 were go-getters they thought they felt healthy at work. Case 3 took a serious view of their relationships with other people. Case 4 centered around the couple, and thought it important to live with their life's companion.