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HPLC용 형광유도체화제인 1-(N,N-dimethylamino)pyrene-6-sulfonyl chloride를 이용한 GABA와 Glutamate의 HPLC분석에 관한 연구
이윤중,김용희,강동호,박귀례 성균관대학교 약학연구소 1991 成均藥硏論文集 Vol.3 No.1
Abstract-Fluorescent derivatives of amino acid neurotransmitter such as GABA and glutamate were synthesized using 1-(N,N-dimethylamino)pyrene-6-sulfonyl chloride (DAPS-Cl) as a derivatizing reagent. GABA and glutamate were derivatized quantitatively into fluorescent compounds by reacting with DAPS-Cl. The optimal conditions for the derivatization of GABA and glutamate with DAPS-Cl were estimated such as pH, reaction temperature and time, and the amount of DAPS-Cl. The derivatives were separated on a reverse phase column with a gradient elution using the 30 mM phosphate buffer and acetonitrile, and monitored by fluorescence detector. Calibration curves for GABA and glutamate exhibited good linearty over 1∼5 pmol. GABA and glutamate in hippocampus of rat brain were determined. After postmortem of rat brain, GABA increasing and glutamate decreasing in hippocampus were prevented 3-mercaptopropionic acid and microwave application.
한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률
조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4
Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.
Kang, Tong Ho,Moon, Eunjung,Hong, Bin Na,Choi, Sang Zin,Son, Miwon,Park, Ji-Ho,Kim, Sun Yeou Pharmaceutical Society of Japan 2011 Biological & pharmaceutical bulletin Vol.34 No.9
<P>Diabetic neuropathy is characterized by axonal degeneration, demyelination, and atrophy in association with failed axonal regeneration, remyelination, and synaptogenesis. Recent reports suggest that reduced levels of nerve growth factor (NGF) may play a significant role in the pathogenesis of diabetic polyneuropathy. In this study, we investigated the regulation of NGF by steroid diosgenin (DG) in a diabetic neuropathy rodent model. We found that DG, the primary spirostane-type steroid in several <I>Dioscorea</I> species, increased NGF levels in the sciatic nerve of diabetic rats. Additionally, DG increased neurite outgrowth in PC12 cells and enhanced nerve conduction velocities in the diabetic neuropathy mouse model. DG-treated diabetic mice showed reduced disarrangement of the myelin sheath and increased area of myelinated axons by electron microscope studies and exhibited improvement in the damaged axons. Our data further suggest that DG increased the nerve conduction velocity through induction of NGF. Thus, our findings indicate that DG, a major sapogenin obtained from <I>Dioscorea nipponica</I>, reverses functional and ultrastructural changes and induces neural regeneration in a diabetic neuropathy model.</P>
Kang, Tong Ho,Oh, Hye Rim,Jung, Sun Moon,Ryu, Jong Hoon,Park, Mee Won,Park, Yong Kon,Kim, Sun Yeou Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.2
<P>Several neurological disorders such as Alzheimer's and Parkinson's diseases have been attributed to γ-aminobutyric acid (GABA) depletion in the brain. In order to provide a pharmacological basis for the neuroprotective actions of the enhanced accumulation of GABA in mulberry leaves (ML) against cerebral ischemia <I>in vitro</I> and <I>in vivo</I>, a process was developed to enhance the accumulation of GABA in mulberry leaves (GAML) as a result of the various anaerobic treatments. The GABA concentrations were changed by N<SUB>2</SUB> gas purging, the reaction temperature, reaction time, pH and the leaf size. GABA enhanced the potential of neuroprotection in the PC12 cells damaged by H<SUB>2</SUB>O<SUB>2</SUB>-induced oxidation. GAML reduced the cytotoxicity in the PC12 cells against oxygen glucose deprivation-induced cerebral ischemic condition. The neuroprotective effect of GAML was further demonstrated <I>in vivo</I> using middle cerebral artery occlusion brain injury model. GAML significantly decreased the infarct volume of the brain compared with than control group. Overall, these results suggest that the anaerobic treatment of ML makes GAML enhance the neuroprotection effect against <I>in vivo</I> cerebral ischemia such as <I>in vitro</I>.</P>
산약의 항당뇨 특성 연구(2) -NGF 유도 신경병증예방-
강동호 ( Tong Ho Kang ),최상진 ( Sang Zin Choi ),이태호 ( Tae Ho Lee ),손미원 ( Mi Won Son ),박지호 ( Ji Ho Park ),김선여 ( Sun Yeou Kim ) 한국식품영양학회 2008 韓國食品營養學會誌 Vol.21 No.4
The main cause of diabetic neuropathy, one of the most debilitating complications, is the chronic hyperglycemia, the increase sorbitol or the decrease of nerve growth factor(NGF). NGF, a protein, plays a major role in the development and maintenance of peripheral nervous system. Systemic administration of NGF prevents manifestations of neuropathy in rodent models of diabetic neuropathy. In the previous investigation, we report the hypoglycemia effect of Dioscorea rhizoma extract(DRE) in diabetic mice. The present study shows protective effect of DRE on diabetic neuropathy by induction of NGF protein. We investigated the NGF level in salivary gland and sciatic nerve of normal mouse and the effect of DRE on sciatic nerve conductivity and thermal hyperalgesia test in Type 2 db/db mouse. DRE increased endogenous NGF level in salivary gland and sciatic nerve of mouse. And sensory nerve conductivity velocity(SNCV), motor nerve conductivity velocity(MNCV) and thermal hyperalgesia increased in DRE treatment mice compared with control group. On the basis of our results, we conclude that DRE increase induction of endogenous NGF level and have protective effect on diabetic neuropathy by induction of NGF. Therefore, we propose that long-term use of DRE might help prevention of diabetes-associated complication; diabetic neuropathy.
Streptozotocin 투여 용량에 따른 당뇨병성 마우스의 신경전도도 변화에 대한 연구
강동호(Tong Ho Kang) The Research and Information Service 2006 남부대학교 논문집 Vol.6 No.-
본 연구는 streptozotocin 유발 type 1 당뇨병 mouse 동물 모델에서 당뇨병성 신경병증과 streptozotocin 용량과의 상관관계를 규명하고자 하였다. 구체적으로 streptozotocin의 용량을 50mg/kg, 100mg/kg, 150mg/kg 으로 투여하여 mouse에서 당뇨병을 유발하였고, 31일 경과 후 mouse 좌골신경에서 운동신 경 및 감각신경의 신경전달 속도를 측정 하여 당뇨병성 말초신경병증의 정도를 평가하였다. Streptozotocin 투여용량별 체중변화는 streptozotocin을 투여하지 않은 그룹과 비교하여 streptozotocin을 투여한 그룹들의 체중이 감소했고 streptozotocin의 용량증가에 따라 체중 감소율은 유의적으로 증가하였다. Streptozotocin 투여용량에 따른 평사 (non fasting)와 공복시(fasting) 의 혈당은 streptozotocin의 투여용량이 증가할수록 혈당은 증가하는 것으로 나타났다. Streptozotocin 투여용량에 따른 신경전달속도 변화를 평가 사streptozotocin 투여 31일 경과시 감각신경의 신경 전달속도는 의미 있는 차이가 나타나지 않았으나 운동신경의 신경전달속도는 streptozotocin올 투여한 그룹에서 유의미하게 감소를 나타냈고 streptozotocin 용량의존적으로 감소하는 경향을 보여주었다. 따라서 운동신경 및 감각신경 양자 모두에서 신경전달속도의 뚜렷한 감소를 확인하기 위해서 는 streptozotocin 투여 후 고혈당증의 지속기간이 좀 더 필요한 것으로 사료된다.