S-528 : The Clinical Characteristics of Angioedema with Eosinophilia

( Hyo Jung Cho ),( Hye Soo Yoo ),( Mi Ae Kim ),( Yoo Seob Shin ),( Young Min Ye ),( Dong Ho Nahm ),( Joo Hee Kim ),( Jeong Hee Choi ),( Sun Young Park ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Angioedema with eosinophilia (AE) is a very rare allergy disease, case reports of which have been published sporadically since 1984. Here, we retrospectively analyzed the clinical features of 10 AE patients in Korea. Nine of the 10 subjects were young females, ranging from 23 to 38 years old. Twenty percent of the subjects had episodic-type AE with high serum IgM and eosinophil counts, while 80% were non-episodic type with normal serum IgM levels but high eosinophil counts. All patients had used systemic corticosteroids to control AE. One patient with refractory EAE was treated with anti-IgE antibody. This is the first study to evaluate the clinical characteristics of AE in a Korean population.

한방 다이어트 식품 HBM(Healthy Body Maker)의 체중감소 및 혈청 콜레스테롤 저하 효과

박재상,김애정,김선여 동아시아식생활학회 2001 동아시아식생활학회지 Vol.11 No.4

This study was performed to investigate the effects of HBM(Healthy Body Maker) on the weight loss and serum cholesterol level of rats. Twenty male Sprague-Dawley rats weighing 200±5g were grouped into 2. Rats were raised for 6 weeks with diet containing 0% and 5% of HBM. 1. There were no clinical signs for all the experimental period(6 weeks) in 0% and 5% groups. 2. At 3 and 6 weeks, body weight of 5% HBM group was significantly lower than that of control group. respectively (p<0.05, p<0.01). 3. At 4 weeks, the level of MCHC of 5% HBM group was significantly higher than that of control group(p<0.01). And at 6 weeks the level of RBC and Hct of 5% HBM group were significantly higher than those of control group(p<0.05). 4. At 6 weeks, the level of serum cholesterol of 5% HBM group was significantly lower than that of control group. 5. Absolute liver weight of 5% HBM group was significantly lower than that of control group(p<0.05). 6. Minor subaceous sickness of liver cell in the control group appeared but no symptom of liver cell in 5% HBM group, It is concluded that HBM was a safe and effective diet food which aided in inducing weight loss in rat without any observed harmful clinical side effects.

서울·경기지역 병원직원의 혈액매개 감염노출에 대한 다기관 조사연구

박미라,김정은,박은숙,최정실,정선영,송영구,홍성관,김준명,허애정,양동규,조영주 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

상악 제1 및 제2소구치의 발치공간 폐쇄기전에 대한 3차원 유한요소 해석의 비교 연구

고신애,임원희,박선형,전윤식 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.6

교정 치료에서 발치공간 폐쇄는 치열을 이루는 모든 치아의 연속적인 이동으로 이루어지므로 그 기전은 복잡하다. 특히 전치부 치축을 적절히 유지하면서 구치부 고정원을 조절하는 과정은 정교함을 요하기 때문에 입체적 분석을 통한 치아이동 양상에 대한 이해가 필요하다. 지금까지의 유한요소 분석은 초기 응력분포를 관찰하여 치아 이동 양상을 예측해 보는데 그쳤지만 이러한 양상만으로 정확한 치아이동 결과를 추정하는 데에는 한계가 있었다. 따라서 본 연구에서는 3차원 유한요소 모델을 이용하여 상악 제1소구치 및 제2소구치 발치공간 폐쇄 시 전치부와 구치부의 입체적인 이동 양상을 단계별로 비교하여 그 기전을 규명하고자 하였다. 자연치의 크기 및 형태를 갖는 상악 치아들과 브라켓, 교정용 호선 및 치조골부를 3차원 레이저 스캐너로 스캐닝한 후 사면체 요소의 유한요소모델을 제작하였다. 0.017" x 0.025" 스테인레스 강 호선에 제작된 bull 루프 후방에 10˚의 gable bend를 부여하고 한 번에 2mm씩 12회 활성화시켜 발치공간을 폐쇄시켰다. 그 결과 제1소구치를 발치한 경우 제2소구치 발치에 비해 전치부의 후방 이동량이 많았으며 구치부의 전방 이동량은 더 적게 나타났다. 전치부에서는 제1, 2소구치 발치 모두 비슷한 미약한 정출을 동반하였고 치축의 변화량은 제1소구치 발치에서 더 크게 나타났다. 또한 제2소구치 발치 시 고정원의 협측 이동량이 더 크게 나타났다. Objective: The aim of this study was to compare the differences in closing extraction spaces between maxillary first premolar and second premolar extractions using 3-dimensional finite element analysis (FEA). Methods: Maxillary artificial teeth were selected according to Wheeler's dental anatomy. The size and shape of each tooth, bracket and archwire were made from captured real images by a 3D laser scanner and FEA was performed with a 10-noded tetrahedron. A 10˚ gable bend was placed behind the bull loop on a 0.017" x 0.025" archwire. The extraction space was then closed through 12 repeated activating processes for each 2mm of space. Results and Conclusions: The study demonstrated that the retraction of anterior teeth was less for the second premolar extraction than for the first premolar extraction. The anterior teeth showed a controlled tipping movement with slight extrusion, and the posterior teeth showed a mesial-in rotational movement. For the second premolar extraction, buccal movement of posterior teeth was highly increased.

병원의무기록과에서 생성되는 각종 통계와 그전산화율에 대한 조사

서승원,김광환,김석재,박석건,서진숙,신종연,이경미,최명애 대한의료정보학회 1999 Healthcare Informatics Research Vol.6 No.3

정확한 국가보건통계 데이터베이스는 보건정책의 기초가 되지만, 우리나라에서는 아직 신뢰할만한 통계를 생산해내지 못하고 있는 것이 사실이다. 의료보험자료를 기초로 해서 만드는 보건통계가 있지만 여러 면에서 신뢰도가 떨어진다는 의견들이 많다. 이에 저자들은 대안으로서 각 병원의 의무기록실에서 생성하고 있는 통계들이 국가보건통계의 기초가 될 수 있는 지를 알아보기 위해 78개 병원을 대상으로 통계 생성여부와 전산화 정도를 조사하였다. 설문은 병원표준화 심사와 서비스평가, OECD에서 요구하는 통계들을 참고로 하여 작성하였으며, 해당 통계를 생성하고 있는지, 통계생성 작업이 어느정도 전산화되어 있는지를 물었다. 응답한 병원의 50% 이상이 통계를 생성하고 있다고 하였으며, 통계를 생성하고 있는 병원에서 전산망을 이용하지 않고 수작업으로 하고있는 비율은 1.3%에서 7.7% 사이였다. 설문서에서 질문한 통계를 생성하지 않고 있다고 응답한 병원의 대부분은 전산화 되어있지 않았다. 이상의 결과로부터 각 병원의 의무기록실에서는 많은 부분 국가보건 통계에 필요한 각종 통계량들을 생성해 내고 있으며, 통계 생성 방법은 전산화 되어있고, 따라서 이를 수집, 가공하면 국가보건통계 데이터베이스를 구축할 수도 있을 것이라는 결론을 얻었다. 이를 위해서는 통계량을 정의하는 표준화 사업이 선행되어야 할 것이다 We surveyed the generation rate of health statistics by medical records offices of the 78 hospitals and its automation rate using computerized hospital information system. Structured questionnaire was given to one medical record officer of each hospital. Items in the questionnaire was selected from statistics required for hospital service evaluation or OECD health statistics. More than 50% of the medical record office generated questioned health statistics, and most of them was automated. Because many of the medical record offices of the hospitals are producing essential health statistics and automated, the is a possibility that we can collect and use these datas to build up national health database if adequate standardization procedure can be implemented.

복막투석복막염 환자에서 발생한 창자벽공기증 1예

정선영,나지훈,최윤정,고성애,조규향,박종원,도준영,윤경우 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1

Peritonitis is a serious problem in patients undergoing peritoneal dialysis. Rarely pneumatosis intestinalis can occur as a complication of this infectious process. Pneumatosis intestinalis is a potential life threatening condition with a challenging management. The mortality of peritoneal dialysis patients with pneumatosis intestinalis secondary to mesenteric ischemia is almost 100%. We describe a rare case of pneumatosis intestinalis in a peritoneal dialysis patient who developed Staphylococcus aureus peritonitis which was initially treated with appropriate antibiotics. Since initial response to therapy was not achieved, an abdominal computerized tomography was done which revealed a pneumatosis intestinalis. A laparotomy was performed and small bowel necrosis was seen. A segmented resection with ileostomy, jejunostomy was done. Though surgical treatment was performed, the patient died in 2 weeks after admission. Pneumocystitis intestinalis in peritoneal dialysis peritonitis is a uncommon complication which requires prompt evaluation to rule out mesenteric ischemia as it carries a high mortality and its management will be surgical.

계획되지 않은 아동의 입원시 정보제공이 어머니 스트레스 대처에 미치는 효과

최명애,박승현,권원경,김선구,안혜영,김윤경 서울대학교 간호대학 간호과학연구소 1999 간호학 논문집 Vol.13 No.1

The purpose of this study was to explore the effect of informational intervention on coping of mother's stress in unplanned childhood hospitalization. Thirty four mothers of the hospitalized children, 24 months to 60 months old, were randomly assigned to experimental and control group. Child behavioral information and parental role information was given to experimental group by booklet and cassette tape. The state-trait anxiety was measured within 12 to 24 hours following hospitalization, the state anxiety was measured during from 24 hours to 48 hours, and the parent participation with care of children, and the parent support during invasive procedures was measured during 48 hours to 72 hours after hospitalization. The data was collected from May, 1997 to October, 1998 at B hospital in Seoul. Data was analyzed with X²-test, non paired t-test, ANCOVA test and Wilcoxon test using SAS program. Results were obtained as follows: 1. There were no difference in the state anxiety during the period of hospitalization and after discharging from hospital between experimental and control group. 2. Experimental group showed significantly higher scores on the parent participation with care of children than control group(P=0.03). 3. The parent support during invasive procedures of experimental group was significantly greater than that of control group(P=0.0167). The results suggest that information intervention regarding child behavioral information and parental role information may enhance both the parent participation with care of children and the parent support during invasive procedures.

마우스 골수세포의 액체배양에서의 세포화학적 염색성에 관한 연구

김현태,박애자,장선택 중앙대학교 의과대학 의과학연구소 1988 中央醫大誌 Vol.13 No.4

The mouse bone marrow cells were cultured in liquid culture system to investigate the correlation of cytochemical changes and the number of colony forming unit granulocyte/macrophage(CFU-GM) and colony-forming unit megakaryocyte(CFU-Meg) colonies with cell maturation and platelet formation. The following results are obtained; 1. Total colony counts are markedly increased during 4-6 days of culture and reach the maximum number by 7th day (262.33 ± 192.33/ml). The number of cells are increased in each colonies without increase of total colony number after 5 days. 2. The mean ratio of acetylcholinesterase positive megakaryocyte colonies are 13.70 ± 7.04% of total colonies formed with no remarkable changes during 9 days culture period. The number of megakaryocyte colonies reach maximum level by 7th day (31.37 ± 25.73/ml), while that of nonmegakaryocytic colonies reach maximum level by 9th day (230.51 ± 81.90/m1). 3. Platelet count in medium are 5,000 ± 3,490/ml with no remarkable changes during 9 days of culture periods. 4. In acetylcholinesterase positive megakaryocytic colonies, the PAS stain show weak positive in few megakaryocyte by 3rd day, however about 40% of megakaryocytes show rather strong positivity by 7th day. The positivity of non-specific esterase and acid phosphatase are less than 10% until 9th flay of culture. Specific esterase positivity was not found during 9 days period of culture. 5. Non-specific esterase and acid phosphatase stain show lower positivies (11%, 5%) than PAS and specific esterase stain (21%, 55%) in non megakaryocyte colonies. In summary, the number of CFU-GM and CPU-Meg colonies in liquid culture are increased gradually and reached maximum by 7th day, forming large colonies from 5th days on In megakaryocytic colonies, no evidence of platelet formation were observed during 9 days period of culture. It is suggesed that the majority of CFU -GM colonies in liquid culture are mixed colonies according to the cytochemical stainabilities.

백서 대장암의 동종면역효과에 관한 연구 : Effect of Cancer Bearing Rat Serum

김형일,박애자,장선택 중앙대학교 의과대학 의과학연구소 1988 中央醫大誌 Vol.13 No.2

In recent years, there has been much interests in identification and characterization of numerous tumor relating substances including ectopic hormones, oncofetal antigens, or abnormal enzymes for the diagnosis and monitoring of malignant tumors. But, practically so called cancer antigen, such as AFP, CEA, or TPA, which has been never used toward manufacturing anti-cancer antibody, while only used to compete the cancer tissue type specificity. Nowadays, cancer antigen must be actually applied in the field of cancer treatment by means of the mediator or inducer for anti-cancer antibody formation. This study researched the alloimmunization effect of the serum components obtained from cancer developing animals, chemical carcinogen (NG: N-methyl-N'-nitroso-N-nitrosoguanidine) induced colon adenocarcinoma model, in 216 male rats, and gained following results: 1. In cancer producing rats, the CRP levels were maintained evenly high values althrough the experimental period, but serum TPA was gradually increased along sequential studies, while βCG and LDH were increased in early acute phase and sooner decreased in late phase. 2. The individuals, those were alloimmunized by the serum acquired from cancer bearing rats, represented significantly high cancer rejection rate, especially in the group which was infused the serum of conspicuously high TPA concentration. 3. In the long survivers and cancer resistance group, could observed neither high βCG level nor increased LDH value, however the early deaths revealed extremely higher βCG and LDH levels in contrast of relatively lower TPA concentration. 4. So, there was able to confirm the fact that not only cancer rejection antigenicity was presented in the serum of cancer developing individuals, but also could gained prominent allommunization effect utilizing such serum of high occurring TPA believing one of immunologic cancer rejectives by itself or mediation of antibody inducing effects.

대인관계성향 검사의 타당화 연구 (Ⅰ)

송인섭,박애선,신은영 숙명여자대학교 학생생활지도연구소 1999 學生生活硏究 Vol.21 No.-

본 연구는 자기자신의 대인관계특성을 이해하기 위하여 대인관계성향검사를 제작하는 것을 목적으로 한다. 이를 위하여 주로 남녀 대학생들을 지역별로 표집하여 수집된 자료를 예비검사(N=343) 하였다. 본 검사는 전국의 10개지역의 4년제 대학교와 전문대학의 남녀 대학생을 대상으로 하였고 최종 분석대상은 1531명이었다. 본 연구는 예비연구를 통하여 대인관계성향의 개념을 형성하는 차원을 요인분석을 통한 구인타당도와 내용타당도를 검증함으로써 대인관계성향 검사를 제작하였다. 최종검사의 문항은 요인분석 결과 8개 차원 91문항으로 나타났다. The purpose of this study was to investigate the construct validity of the interpersonal relations scale developed by factor analysis. The subjects of the pre- study were 343 college or university student randomly sampled and assigned. The subjects of main study were 1531 female and male college students and junior college students the 10 regions through out the country. Interpersonal Relations Disposition (IRDS) consists of 8 areas, there are Role disposition ares and Expressive areas - These major areas are further divided into eight sub-areas there are : Initiative - comformative, independant - non independant, responsibility - non responsibility, superiority - inferiority, agressive - non agressive, empathy - non empathy, mis trust - trust, competition - non competition.