健康한 韓國人의 動脈血液 가스 및 酸一鹽基 平衡値에 對한 觀察

崔震守,曺方煥,朴喜淑,金顯承,金瑛,白正敏,徐錫助 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.3

The purpose of this paper is to make an attempt in this investigation to determine normal adult values of arterial blood gas and acid-base balance in 53 healthy Korean male and female subjects of varying age and then compare with the data obtained by others. Determinations of the acid-base status of the arterial blood were performed at 37℃ by the Astrup method using a radiometer instruments, consisted of BGA2A/3-MK 2 system. The mean and standard errors of each component were as follows: pH 7.42±0.043, oxygen saturation 96.96±0.089%, pO?? 97.66±0.91mmHg, pCO?? 37.08±0.68mmHg, CO?? content 24.29±0.43mM/L, bicarbonate 23.26±0.68mM/L, buffer base 46.56±0.66mEg/L, and base excess -0.024±0.001mEg/S. Compared with normal adult values in literatures, all the components of the data appear to be in the same range without any significant difference.

마산만의 하수기인 유기물 fecal sterol의 분포

최민규,문효방,김상수,이윤 한국환경과학회 2005 한국환경과학회지 Vol.14 No.5

Surface sediments and seawater were sampled at Masan and Haengam Bays of Korea, to evaluate contamination by sewage-derived organic matter using fecal sterols. Six stream-water samples into Masan and Haengam Bays were also sampled. Total concentrations of eight sterols (coprostanol, epichloestanol, epicoprostanol, cholesterol, cholestanol, brassicasterol, stigmasterol and β-sitosterol) were in the range of 1,274~4,768 ㎍/g dry weight in suspended particulate from the stream-water, 292-2,244 ㎍/g dry weight in suspended particulate from the seawater and 4.5~27.2 ㎍/g dry weight in the sediments. Although sterol compositions in sediments, seawater and stream-water were different, cholesterol was the predominant sterol in all samples. The proportion and concentration of coprostanol, a sewage tracer, in stream-water was much higher than those in sediment and seawater. The sterol levels including coprostanol in the sediments and seawater were higher at inner basin than at the outer bay. Some molecular indices and multivariate statistical analysis were used to assess the origin of these sterols and sewage contamination in the study area. The sterol composition patterns in stream-water were mainly associated with contamination by sewage-derived organic matters and those of seawater were associated with the activities of marine-originated organisms. Sterol levels in the sediments were both from the sewage input through stream-water and the marine-originated organisms. This survey suggests that the main source/route of sewage-derived organic matters in Masan Bay is the input of stream-water into the bay.

말기신질환을 동반한 다발성 골수종 1예에서 시행된 자가말초혈액 조혈모세포이식

유승민,박정우,이규훈,방수미,안정열,박필환,조은경,신동복,이종호,이재훈 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

본 환자는 혈액투석이 요구되는 말기신질환을 동반한 다발성골수종으로 진단받고 VAD 유도요법으로 초기 치료 후 부분관해를 보였으며, melphalan 투여 후 자가말초 조혈모세포이식을 시행하여 심각한 부작용 없이 완전관해를 보이고 그 효과가 1년간 유지되어 이를 보고하는 바이다. Multiple myeloma with monoclonal gammopathy of the lambda light chain, which initially manifested as end-stage renal disease, was diagnosed in a 50-year-old man. Induction chemothery with VAD (vincristine, adriamycin, and dexamethasone) failed to induce a complete response. Complete remission was obtained after high-dose therapy using melphalan (100 mg/m²) followed by autologous peripheral stem cell transplantation. Hemodialysis was performed every day or every other day during induction and high- dose therapy. The adverse events during transplantation consisted of mucositis and neutropenic fever. This case demonstrated that a sustained complete response can be achieved in multiple myeloma complicated by end-stage renal failure using hemodialysis and high-dose chemotherapy without serious toxicity.

치면열구전색제의 조건에 따른 법랑질 결합강도에 관한 연구

이용근,이흥수,이성재,방기숙,최정민,류승호,강민석 대한치과기재학회 1997 대한치과재료학회지 Vol.24 No.1

In this study, the shear bond strengths and accompanying elastic modulus ratio, displacement at bond failure and work up to fracture of pit and fissure sealants to toothe enamel were analyzed by the following variables, those were acid etching, moisture content of the surface of enamel, dentin bonding agent(species and method), thermocycling, saliva contamination. One kind of chemically cured resin based pit and fissure sealant, two kinds of light cured resin based pit and fissure sealants and one kind of glass ionomer based pit and fissure sealant, and two kinds of dentin bonding agents were studied. The buccal surface of extracted premolars were ground flat with # 600 silicone carbide papers, and the ground surface was treated depending on the experimental conditions. After each treatment, each pit and fissure sealant was filled into plastic tube of 3mm diameter, which were laid on the surface of ground enamel surface, and were cured. Sealant bonded teeth specimens were immersed in 37℃ distilled water form 24 hours. The shear bond strength of sealant to enamel surface was measured with Universal testing machine with the cross head speed of 1mm/min. From the obtained load-deflection curves, modulus ratio, bond strength, displacement at bond failure and work up to fracture were analyzed. From this experiment, the following results were obtained : 1. Comparing the results of standard condition(i. e. acid etching, dry surface, no dentin bonding agent and 300 thermocyling), the elastic modulus ratio of chemically cured resinbased pit and fissure sealant was significantly higher than those of other materials(P<0.05), and the bond strength, displacement at bond failure and work up to fracture of glass ionomer based pit and fissure sealant were significantly lower than those of other materials(P<0.05). 2. The results of ANOVA with the variables of type of material, acid etching, moisture condition of the enamel surface, dentin bonding agents were as follows ; 1) variables showed significant main effect on the shear bond strength of pit and fissure sealant to enamel(P<0.01), 2) type of material, acid etching and moisture condition of enamel influenced the bond strength significantly(P<0.01), 3) type and application methods of dentin bonding agents influenced on the bond strength significantly(P<0.05). 3. There were statistically significant correlation between the work up to fracture and the bond strength, and between the work up to fracture and the displacement at bond failure(P<0.01), and in these cases the correlation coefficient was 0.87.

장기간 Risperidone 투여후 지연성으로 발생한 Neuroleptic Malignant Syndrome 1례

이헌정,조방현,김인,이민수 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

Risperidone은 비교적 최근에 개발된 항정신병약물이며, 그것이 가진 도파민 D2 수용체와 세로토닌2 수용체를 차단하는 작용기전, 추체외로 부작용과 지연성 운동장애가 적다는 점, 정신분열병의 음성증상에도 효과가 있다는 점에서 흔히 비전형적 약물로 불리운다. 그러나 이러한 비전형성에도 불구하고, 이미 전세계적으로는 15개 정도의 risperidone에 의한 신경이완제 악성증후군(neuroleptic malignant syndrome : NMS)의 보고가 있으며. 국내에서도 최근 하나의 증례가 보고되었다. 저자들은 정신분열병으로 장기간 risperidone으로 치료받던 젊은 남자 환자에서 치료 1년 9개월만에 발생된 NMS 1례를 경험하였기에 관련문헌의 고찰과 더불어 증례보고하고자 한다. Risperidone is a relatively new antipsychotic agent. It is often referred to as 'atypical', because it has a mechanism of action that blocks post synaptic dopamine-2 and serotonin-2 receptors, it is associated with fewer extrapyramidal side effects, it is not yet associated with tardive dyskinesia, and it may have some efficacy on negative symptoms of schizophrenia. In despite of its 'atypical' nature, there are already more than 15 reports of risperidone-induced neuroleptic malignant syndrome. Only one case of risperidone-induced NMS was reported recently in Korea. We report one case of delayed risperidone-induced neuroleptic malignant syndrome in young male patient and review the related articles.

넙치, Paralichthys olivaceus의 수온 자극 스트레스에 대한 사료첨가제 투여 효과

권문경,박상언,방종득,조병열,이상민,박수일 한국어병학회 2003 한국어병학회지 Vol.16 No.3

본 연구는 넙치의 수온 스트레스에 대한 사료첨가제 (미역 5%, 미역 10%, 어보산 0.5%, 고추냉이 잎 2%, 고추냉이 줄기 2%)의 영향을 혈액학적, 면역학적 측면과 Edwardsiella tanda를 사용하여 질병에 대한 저항성으로서 평가하였다. 혈장의 글루코즈와 콜티졸 농도는 1차 수온 변동 후 대조구에 비하여 미역 5%와 고추냉이잎 2% 첨가구에서 유의적으로 낮게 나타났다(P〈0.05). 1차 수온 변동 후 혈장 라이소자임 활성과 E. tarda의 공격 시험 후 생존율은 미역 5%첨가구에서 대조구에 비하여 유의적으로 높게 나타났다(P〈0.05). 본 실험 결과 미역 5% 첨가 사료 투여는 넙치의 스트레스 상태에서 질병 감염에 대한 저항성을 높일 수 있을 것으로 사료된다. The effect of each dietary supplements (Undaria 5%, Undaria l0%, Obosan 0.5%, Wasabi leaf 2%, Wasabi stem 2%) on the water temperature fluctuation in juvenile olive flounder (Puralichthys olivaceus) was investigated. The response to stress was assessed in terms of effects on haematological and immunological, and resistance against Edwurdsiella tarda infection. Plasma glucose and cortisol levels were significantly lower in 5% undaria and 2% wasabi leaf supplement groups than the controls after the first change of water temperature (P<0.05). The plasma lysozyme activities and the survival rates from E. tarda infection were significantly higher in the 5% undaria supplement groups than the control (P<0.05). These results suggest that the 5% undaria supplement seems to be contributable to the increased disease resistance on olive flounder.

Determination of biotin in foods for special dietary uses using HPLC with immunoaffinity column cleanup extraction

Soo Jin Bang,Bo Young Oh,Min Ji Ye,Soo Jung Hu,Hye Young Lee 한국분석과학회 2019 학술대회논문집 Vol.2019 No.11

Clinical Significance of Serum Exosomal miRNA in Liver Fibrogenesis of Non-alcoholic Fatty Liver Disease

( Soo Min Bang ),( Eun Jung Ko ),( Yoonseok Lee ),( Haein Bak ),( Sehwa Kim ),( Young-sun Lee ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Soon Ho Um ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Fatty liver disease in non-significant amount of alcoholic drinker (Non-alcoholic fatty liver disease (NAFLD)) is on the rise worldwide as obesity and diabetes increase. Among histologic changes, the degree of liver fibrosis is the most important factor for predicting long term outcomes. Although liver biopsy is the gold standard for diagnosis, it is difficult to be done in routine clinical practice due to the risk of serious complications and variabilities of sampling and interpretation. The aim of this study was to explore clinical significance of serum exosomal miRNA in liver fibrogenesis of NAFLD patients. Methods: A total of 41 biopsy-proven NAFLD patients were included. Exosomes were isolated from serum samples and exosomal miRNAs were analyzed with GeneChip miRNA 4.0 array (Affymetrix, U.S.A). Expression levels of miRNAs in liver tissues of the same patient who had been tested for serum exosomal miRNA were analyzed. To define the role of miRNA in liver fibrogenesis, hepatocytes or stellate cells were transfected with miRNA of interest. Results: NAFLD patients with significant fibrosis (Group 1) were older than those with non-significant fibrosis (Group 2). The percentage of patients who had metabolic syndrome was higher in Group 1. In addition, Group 1 patients had lower platelet counts and prolonged PT INR. A total of 86 serum exosomal miRNAs showed significant differences in expression between the two groups. Of these, 42 miRNAs showed significantly higher expression while 44 miRNAs showed significantly lower expression in Group 1 than in Group 2. MiR4668-5p, 3613-3p, 8075, 619-5p, 1184 showed higher expression levels in Group 1 than in Group 2. When human stellate cells (LX2 cells) were transfected with miR4668-5p inhibitors or miR4668-5p mimics, TGF-b, collagen1A1, and a-SMA mRNA expression levels were significantly decreased by miR 4668-5p inhibitors. However, their expression levels or significantly increased after transfections with miR4668-5p mimics. Conclusions: Serum exosomal miRNAs showed significantly altered expression in NAFLD patients with significant fibrosis. Although additional researches are required, serum exosomal miRNA might have a diagnostic value for advanced fibrosis or serve as therapeutic targets for liver fibrogenesis in NAFLD patients.

The Role of Genetic and Epigenetic Factors in Disease Development and Progression in Nonalcoholic Fatty Liver Disease

( Soo Min Bang ),( Young-sun Lee ),( Jeong-an Gim ),( Yoonseok Lee ),( Se Ryun Bae ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Soon Ho Um ),( Kwan Soo 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1

A Case of Left Supraclavicular Lymph Node Metastasis from Transitional Cell Carcinoma of the Bladder

Ryu, Soo Bang,Shin, Chul Soo,Park, Yang Il,Min, Byung Kap Chonnam National UniversityResearch Institute of 1991 Chonnam journal of medical sciences Vol.4 No.1