한방 이화주의 미백 및 피부 주름 개선 효과

이상진(Sang-Jin Lee),권이영(Yi-Young Kwon),조성원(Sung-Won Cho),권희숙(Hee-Suk Kwon),신우창(Woo-Chang Shin) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4

본 연구에서는 한방이화주의 피부 생리기능 활성을 알아보기 위해 70% EtOH 추출물의 피부 미백, 주름 개선 및 항염증 효과를 조사하였다. HEE은 tyrosinase 활성 억제 및 tyrosine을 기질로 melanin이 형성되는 pathway에 관여하는 주요한 인자인 TRP-1과 TRP-2를 저해하는 작용 기전을 통해 피부 색소침착의 주요 원인 물질인 melanin 생합성을 농도 의존적으로 저해하는 것을 확인하였다. HEE은 피부진피 내 피부 탄력을 유지하는 elastin을 분해하는 효소인 elastase의 활성을 저해하였고, 피부의 keratinocyte가 생성분비하는 MMP-2와 MMP-9의 단백질 발현과 proteolytic 활성을 억제하여 노화에 따른 피부 주름 생성 억제할 수 있는 가능성을 확인하였다. 또한 세포 독성 없이 LPS에 의해 유도된 염증 반응을 50% 저해하는 HEE의 농도(IC50)는 24.9 μg/mL이며, 50 μg/mL 농도로 처리하였을 때 염증 반응 저해 효과가 70%로 높은 효과를 가지는 것을 확인하였다. 이상의 결과를 종합하면 HEE의 피부 미백, 주름 개선 및 항염증에 우수한 효과를 나타내고 있으므로 기능성 화장품의 주요한 소재로 이용 가치가 높을 것으로 사료된다. Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)- induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.

고랭지 농업 용수확보를 위한 소규모 빗물 이용시설 적용방안

전계원(Kye Won Jun)(全桂元),장창덕(Chang Deok Jang)(張昌德),정승권(Seung Kwon Jung)(鄭承權),전병희(Byong Hee Jun)(田炳熙) 위기관리 이론과 실천 2013 Crisisonomy Vol.9 No.8

최근 기후변화로 지난 2009년과 2012년에 강원도 태백시에서는 가뭄으로 인하여 엄청난 피해를 경험한 적이 있다. 또한 가뭄과 장마의 예측은 점점 더 어려워져 가는 실정이다. 특히 태백시의 87일간의 가뭄과 제한급수에 따른 피해액은 일상생활 134억원, 산업부문 338억원, 공공부문 47억원, 정신적ㆍ사회적 피해 1, 430억원 등 총 1, 949억원에 달하는 것으로 분석되었다. 태백시에 또 다른 큰 문제점은 가뭄으로 인한 고랭지 농업 피해로 인한 손실이다. 고랭지 배추를 생산하는 태백시는 우리나라 유일의 고산지역의 도시로서, 고랭지 농업이 특히 발달한 지역이다. 특히 태백 고랭지 배추는 태백시 농산품의 95.9%, 총 경지면적의 86.6%를 차지하고 있으므로, 배추의 생산성이 태백시 농산품 생산성을 대변한다고 할 수 있다. 본 연구에서는 태백시의 공공기관과 고랭지 농업 지역을 직접 방문하여 소규모 빗물 이용 시설에 대한 현황조사 및 시설의 상태를 점검하고 가뭄발생시 고랭지 농업지역의 피해를 최소화 할 수 있도록 소규모 빗물 이용 시설의 적용 방안 및 효과를 분석하였다. Recently, drought and rainy season are getting more serious. It is getting hard to forecast about drought because drought frequency is getting shorter than before. In 2009(winter) and 2012(summer), Taebaek-si was suffered from enormous damage due to the drought. Particularly, in 2009, cost of damage due to drought and restriction on water supply for 87days were estimated daily life sector 134 billion won, industry sector 338 billion won, the public sector 47 billion won, mental and social damage 1, 430 billion won. The other big issue of Taebaek is decrease in products of Highland Agricultural caused by the drought. Highland chinese cabbage which is the most important agricultural product in Taebaek-si account for 95.9% of all agricultural production of Taebaek-si and account for 86.6% of all gross area. For this reason, chinese cabbage of Taebaek-si is tropical agricultural product and is in charge of supply cabbage definitely. It is considered that if small scale rainwater harvesting system would be installed in highland agriculture area, it could reduce damage of drought at low cost and damage of cabbage would be decrease by system. For this study, We have researched regarding current status of Small Scale Rainwater Harvesting System of Highland Agriculture area in Taebaek-si and have compared with the amount of damage and installation cost in case of drought for the beneficial effects of Small Scale Rainwater Harvesting System, flexible supply of water and damage minimization of agricultural products.

國産스테인레스鋼線系 矯正用線材의 開發과 物理的 性質에 關한 硏究

권오원,성재현,이기대,경희문 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.2

The physical properties of seven sizes of control groups and experimental group in stainless steel orthodontic wires were studied in tension, hardness, bending, torsion and observation of microstructure. The wires (0.40 - 0.90mm dia.) of round type were tested in the as-received condition. The wires of control groups were TRU-CHROME and REMANIUM, and experimental group was SK wire which was developed by ourselves and made in Korea. The results were as follows: 1. The chemical compositions of control groups and experimental group were austentie stainless steel wires of SOS 304. 2. Higher values of tensile and yield strength in tension were control group I, experimental group, control group II. Maximum tensile and yield strength of experimental group were 203.63 ±1.41kg/mm²in 0.70mm diameter and 148.96 ± 4.88kg/mm² in 0.60mm diameter, and maximum elongation was 5.20 ± 0.57% in 0.45mm diameter. 3. Hardness values of experimental group were similar to control groups. Maximum hardness values were 596.2 ± 13.66 Hv in 0.45mm diameter wire of control group I, 590.5 ± 20.08Hv in 0.50 mm diameter wire of control group II, and 563.6 ± 5.35 Hv in 0.70mm diameter wire of experimental group. 4. Torsion properties of experimental group were similar to control group I and more than control group II. Maximum torsion cycles were 31.8 ± 2.48 in 0.45mm diameter of control group I,17.4 ± 4.84 in 0.60mm diameter of control group II, and 24.6 ± 3.04 in 0.45mm diameter of experimental group. 5. Maximum bending cycles of experimental group were smaller than control groups. Maximum bending cycles were 9.00 ± 0.00 in 0.50mm diameter wire of control group I, 10.0 ± 0.82 in 0.40mm diameter wire of control group II, and 8.0 ± 1.26 in 0.50 mm diameter wire of experimental group. 6. Microstructures of experimental and control groups co-existed with martensited austenite structure and elongated austenite structure. 7. The direction of wire fracture was propagated parallel to torsion direction typically and there was no probability showing wire fracture at inclusions and surface scratches. 8. The type of wire fracture was brittle fracture at initiation site and ductile fracture at core.

부정교합 아동의 성장에 따른 연조직 측모의 변화

권오원,경희문,장병천,성재현,김정민 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.3

This investigation was undertaken to know how soft tissue facial profile could changed with age. The 3 serial lateral cephalometric roentgenograms of the twenty nine boys and twenty six girls between 9 and 13 years of age were studied and the findings seemed to warrant the following conclusions. 1. The author made the tables of means, standard deviations in each item, sex, age. 2. Soft tissue facial angle, soft tissue facial convexity including the nose tended to increase, but others tended to remain relatively stable. 3. Facial soft tissue thickness increased with age and the growth of facial soft tissue in the middle rgion (point A, LS, LI)was greater than others in the facial region. 4. In the soft tissue vertical proportions, GI'-Sn/Sn-Me' was 1.1, Sn-St/St-Me' was 0.51:1, Sn-LI/LI-Me' was 0.82.1 and those were stable with age.

도시근린공원의 편익비용분석 : 청주시를 대상으로 A Case of Chongju

권상준,명현,박구원,이만희 청주대학교 산업과학연구소 1993 産業科學硏究 Vol.11 No.-

As a consequence of this study, the analyses of urban community parks in Chongju are as follows; 1. The total benefit of three scenarios can be calculated at 200,031, 255,197, 368,411 million Won, respetively depending on the scenario, which of the percentage of indirect benefit is 57.7%, 49.3%, 53.3% respetively in the order of the scenario . 2. The total cost can be calculated at 231,840 million Won. 3. The ratio of Benefit and Cost comes out in the order of the scenario 3, 2, 1, depending on the relative importance factors according to the benefit. 4. The priority of developing community parks depends on the hiearchical order factors: location, developed area, scale of parks.

난소에 발생한 원발성 소세포암종 : 2예 보고 Two cases reports

권계원,고은석,김희경 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Primary small cell carcinoma of the ovary is a rare, aggressive tumor of young women and has two subtypes. The pulmonary type small cell carcinomas of the ovary that resembled small cell carcinoma of the lung and differed from both clinically and pathologically from small cell carcinoma of the ovary, usually associated with hypercalcemia. The histogenesis of the primary ovarian small cell carcinoma has not been established. We have identified two cases of small cell carcinomas primary in the ovary. One has microscopic features of pulmonary type, and the other has hypercalcemic type. Pulmonary type small cell carcinoma patient was a 40-year-old woman. She was admitted due to known ovarian mass. She was well before this episode. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Gross examination revealed 15cm sized right ovarian mass which was mostly solid with multifocal necrosis. Histologically, the tumor was composed of small to medium sized round cells with scanty cytoplasm, hyperchromatic nuclei, inconspicuous nucleoli, numerous mitotic figures forming large sheets and diffuse pattern. Hypercalcemic type small cell carcinoma patient was a 43-year-old woman. She was also complained of right abdominal swelling and discomfort of 1 month duration. She was received total abdominal hysterectomy due to myoma in 3 years ago. The serum calcium levels was elevated. Right salpingo-oophorectomy and omentectomy was performed. Gross examination revealed 15cm sized huge ovarian mass which was mainly solid with small cystic components and hemorrhagic necrosis. The omentum showed several oval shaped metastatic nodules. Microscopic examination reveals closely packed tumor cells with scanty cytoplasm, vesicular nuclei that contains single nucleoli, and numerous mitotic figures. Many folliculoid spaces are present. Pulmonary type small cell carcinoma patient died 13 months after surgery. Hypercalcemic type small cell carcinoma patient was alive without evidence of disease 2 months after surgery but lost to follow up thereafter.

우리 나라 中等學校 科學敎育의 現況 및 改善方案

權五亨,高在杰,鄭遠佑,韓斗熙 경북대학교 과학교육연구소 1987 科學敎育硏究誌 Vol.11 No.-

In order to develop the intellective man power effectively, the educational processes are renewd by efforts of emphasizing the science education. We previewed the features, objects and doctrine of present science education. And dicussed the ideas of educational fields, poverty of experimental ability, the problems of educational environments in laboratory and relations between each science texts, and the college entrance examination system. With these discussions, we asserted the importance and improvemental devices of science education in terms of motivations of students, inquiry learning, laboratories, reeducation of science teacher, development of entrance examination system and national supports.

경북대학교 병원 교정과에 내원한 부정교합 환자의 분포 및 변동추이

권오원,경희문,곡덕부,성재현,박동옥 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.3

1795 patients who visited orthodontic department from 1979 to 1987, were surveyed on the yearly tendency of patient distribution and state of Angle's classification. The results were as follows: 1. There was increased visiting rate of patient per year and higher visiting rate in female than in male. 2. 8-15 age group was 70.3% in total visiting patients and over 20 age group was 10.8%, under 7 age group was 7.3%. 3, Class I malocclusion was 26.3%, Class II div 1 was 31.0%, Class II div 2 was 1.6% and Class III was 41.1% in total visiting pateint. 4. There was increased tendency to be received preventive treatment than fixed treatment and increased extracting rate per year in fixed treatment. 5. There was increased tendency for the number of the patient to be received orthognathic surgery.

면역억제제를 사용치 않은 동소성 간이식 실험견의 조직병리소견

조원현,최순옥,김인호,임태진,김성수,박준희,김우석,김현철,최규택,김진모,권건영 大韓移植學會 1994 Korean Journal of Transplantation Vol.8 No.1

한국인 성장기 아동에서 Angle씨 2급 1류 부정교합자의 골격 특징

경희문,권오원,김유경,성재현 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.3

This study was designed to investigate the difference of teeth and craniofacial complex between normal occlusion and Angle's Class II, div. 1 malocclusion in korean childern. The sample was divided into 2 groups, the 66 subjects with normal occlusion and 96 subjects with Angle's Class II, div.1 malocclusion in both sexes. The results obtained were as follows: 1. No significant differences were observed in ant. cranial base length & flexure(saddle angle) between normal occlusion & cranial Angle's Class II, div. 1 malocclusion group, but posterior cranial base length of Class II, div. 1 malocclusion group was larger than that of normal occlusion group. 2. No significant difference was observed in the anteroposterior position of Maxilla to cranial base between two groups, but mandibular position in Class II. div. 1 malocclusion was posterior and interior to that of normal occlusion. 3. The length of maxilla (ANS-PSN) was larger in Class II, div. 1 malocclusion than normal occlusion. The length of mandibular body(Go-Me) was nor differnet between Class II, div. 1 malocclusion and normal occlusion. 4. Maxillary incisor position of Class II, div. 1 malocclusion to cranial base was more protrusive than that of normal occlusion, but there was no difference in mandibular incisor position between two groups.