다른 국소 신경학적 측위 징후 없이 발생한 전실어증 1예

송운욱,정두신,양광익,이태경,박형국,안무영 대한노인병학회 2001 대한노인병학회지 Vol.5 No.3

구연산과 칼슘이 치아침식증의 발생에 미치는 영향

송인경,이광희,김대업,양영숙 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

산성 음료의 치아침식증 유발력을 감소시키기 위한 연구의 일환으로, 0.1%, 0.3%, 0.5%, 1.0% 구연산용백의 5분, 15분, 30분, 60분간의 사람 소구치 법랑질의 치아침식증 유발력 및 구연산용액에 첨가되는 칼슘 0.05%, 0.1%, 0.2%에 따른 치아침식증 발생 억제효과를 표면미세경도를 측정하여 연구하였다. 전체적으로 볼 때, 구연산 농도가 높을수륵, 탈회시간이 길수록, 칼슘농도가 낮을수록 탈회후 경도가 하락하였다. 탈회 5분 후 경도는 칼슘 무첨가의 경우에 76~90%이었고 칼슘 첨가에 따른 5분간의 탈회억제량은 2~l5%이었다. 탈회 15분 후 경도는 칼슘 무첨가의 경우에 65~84%이었고 칼슘 첨가에 따른 15분간의 탈회억제량은 3~l7%이었다. 탈회 30분 후 경도는 칼슘 무첨가의 경우에 53~72%이었고 칼슘 첨가에 따른 30분간의 탈회억제랑은 6~22%이었다. 탈회 60분 후 경도는 칼슘 무첨가의 경우에 43~66%이었고 칼슘 첨가에 따른 60분간의 탈회억제량은 7~l9%이었다. 탈회억제량의 분포를 전체적으로 보면, 구연산 농도에서는 1.0%에서 가장 크게 나타났고, 칼슘농도에서는 0.2%에서 가장 크게 나타났으며, 탈회시간에서는 0,1% 구연산용액에서는 탈회시간이 증가함과 더불어 탈회억제량도 함께 커지는 경향을 보였으나, 0.3% 이상의 구연산용액에서는 30분에 가장 크고 60분에 약간 감소하는 경향을 보였다 이상의 결과는 구연산에 의한 치아침식증 발생에 칼슘이 억제효과를 나타낼 수 있음을 시사한다. The purpose of study was to observe the effect of calcium and citric acid on the dental erosion of human premolar enamel. Enamel specimens were demineralized in 0.1%, 0.3%, 0.5%, or 1.0% citric acid solutions with 0.05%, 0.1%, or 0.2% calcium for 5, 15, 30, and 60 minutes, and then the surface microhardness of the enamel was measured. The hardness decreased as the concentration of citric acid and the demineralization time increased. Hardness after 5 minutes was 76~90% in case of no calcium and the inhibition of dental erosion by calcium addition was 2~15%. Hardness after 15 minutes was 65~84% in case of no calcium and the inhibition of dental erosion by calcium addition was 3~17%. Hardness after 30 minutes was 53~72% in case of no calcium and the inhibition of dental erosion by calcium addition was 6~22%. Hardness after 60 minutes was 43~66% in case of no calcium and the inhibition of dental erosion by calcium addition was 7~19%. The inhibition was the highest in 1.0% citric acid and 0.2% calcium. In 0.1% citric acid the inhibition increased as the demineralization time increased, but in 0.3% to 1.0% citric acid the inhibition was most high at 30 minutes and decreased a little at 60 minutes. These results suggest that calcium has a inhibitory effect on the citric acid induced dental erosion.

Mandibular overclosed patient를 위한 oral rehabilitation

송창용,김광석,이상돈,백희선,박찬운 全北大學校 齒醫學硏究所 1985 전북치대논문집 Vol.3 No.1

작은 치아종으로 인한 맹출 장애

송지현,이광희,라지영,이동진 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.3

연구소 직무등급시스템의 개발과 활용 (JFSL 모형) : 인도네시아 과학기술평가청 사례

송계충,조영호,이광순 충남대학교 경상대학부설 경영경제연구소 1996 경영논집 Vol.12 No.2

기혼여성의 여가활동 참여빈도와 여가태도의 관계

송강영,양광희,김이정 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

The main purpose of this study is to investigate The Contribution Frequency of Leisure Participation to Leisure attitude among Married Women. The subjects of this study are married women residing in Seoul using a systematic stratified cluster random sampling. From our target sample of 500, excluding those who dropped out in the course of research or those questionnaires that were judged unreliable, the sample number used in actual analysis was 349 people. In order to analyze the data, this study used a SPSSWIN 11.0 program for statistical analysis. Correlation and Regression Analysis were conducted to examine hypothesis Based on the above research methods and procedures, this study produced the following results. The frequency of leisure participation influences leisure attitude. The higher the frequency of leisure participation the greater leisure attitude.

인도네시아 연구기관의 인적자원관리 시스템 개발을 위한 목표모형

송계충,조영호,이광순 충남대학교 경상대학부설 경영경제연구소 1996 경영논집 Vol.12 No.2

흰쥐에서 음경발기 평가의 척도로서 음경해면체내압측정술 확립

송윤섭,김용준,이광우,김준모,문기혁,박영호,민영기,유형균,김형건 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Because studies about the control of penile erection at the entral nervous system was dependent on the animal experiments, establishment of measuring penile erection is important to evaluate the effects changes at the central nervous system on the penile erection. Intracavernous pressure measurement in rats has been introduced as a suitable index for the evaluation of penile erection but this method is invasive and technically difficult. So, we established the intracavernous pressure measurement in rats as the experimental index for penile erection. Materials and Methods: 42 male adult Sprague-Dawley rats (250-300gm) were divided to saline or papaverine treated group. Rats were placed on a heating table to maintain their body temparature and anesthetized with 50mg/kg of pentobarbital sodium by intraperitoneal injection. A cannula was inserted to the left carotid artery to measure systemic blood pressure. Saline (0.05, 0.1ml), papaverine(0.05, 0.1, 0.25, 0.5, 1.0, 2.0mg) were injected intracavernously via 26 guage needle filled with saline or papaverine which connected to pressure transducer and polygraph was inserted into the corpus cavernosum on one side to inject the drug and to measure intracavernous presure. Results: Properly executed insertion and intracavernous administration produced a instantaneous but transient rise in intracavernous pressure that substantially stabilized and maintained at 5.4±0.4mmHg. Intracavernous pressure and duration of penile blood flow following intracavernous injection of papaverine are increased comared to those of saline. Conclusions: Monitoring intracavernous pressure in rats represents a suitable index for the evaluation of penile erection in small laboratory animals.

Fe^++이 6-Hydroxydopamine에 의한 Synaptosome의 변성에 미치는 영향

송영명,이정수,이광수 중앙대학교 의과대학 의과학연구소 1986 中央醫大誌 Vol.11 No.3

Metal ions such as Fe^++ and Cu^++ are reactive cations which are know to catalyze eventual production of either hydroxyl radical(OHㆍ) or singlet oxygen(^10_2) In the Haber-Weiss reaction. These metal ions have been suggested to simulate the autoxidation of several autoxidizable compounds, among them catecholamines and hemoglobin. The autoxidation of 6-OHDA is also stimulated by metal ions and it is reported that neuronal damages caused by 6-OHDA are affected by metal ions. In the iron-catalyzed Haber-weiss reaction to produce OHㆍ the only function of 0^-_2 is to reduce Fe^+++ to Fe^++. This role or 0^-_2 may be replaced by other reducing agents and ascorbate may be one of such reducing agents occuring in bioiogical system. In the present study, the possible role of Fe^++ was investigated in the autoxidation of 6-OHDA and 6-OHDA induced inactivation of synaptoiomal Na^+-K+ ATPase and Mg^++ ATPase. These effects were studied with respect to generation of reactive oxygen species during autoxidation of 6-OHDA, lipid peroxidation and oxidation of sulfhydryl group. Also, the effect of ascorbate on inactivation of synaptosomal ATPase caused by 6-OHDA with and without Fe^++ was investigated. The synaptosomal Na^+- K^+ ATPase and Mg^++ ATPase activities were significantly reduced by S-OHDA, and this inactivation was effectively prevented by catalase, a scavenger of H_2O_2, SOD, a scavenger of 0^-_2 and histidine, a scavenger of ^1O_2. Generation of H_2O_2 and 0_2 during autoxidation of 6-OHDA and antoxidation were inhibited by catalase and SOD. Fe^++ stimulated the rate of autoxidation og 6-OHDA and enhance inactivation of ATPase caused by 6-0HDA. Inactivation of ATPase caused by Fe^++ and 6-0HDA was apparently inhibited by catalase, SOD and histidine. Fe^++ reacted with O^-_2 which was released during autoxidation of 6-OHDA and formed other reactive oxygen species including H_2O_2. When synaptosomes were incubated with 6-OHDA, both the production of malonyldiaidehyde from synaptosomes and the oxidation of sulfhydryl groups were increased with time, and these phenomena were further enhanced by Fe^++ or Cu^++ Generation of H_20_2 and inactivation of ATPases due to interaction of Fe^++ and 6-OHDA were faciliated by ascorbate. The results obtained suggest that reactive oxygen species which take pare in autoxidation of 6-OHDA or which were released primarily during autoxidation of 6-OHDA may be the less reactive oxygen species such as 0^-_2 and Immediate oxidants of destruction processes appear to be due to more reactive oxygen species such as ^1O_2 Fe^++ acted as catalyst for autoxidation of 6-0HDA and enhanced the inactivation of ATPases caused by 6-OHDA. These effects were further stimulated by ascorbate. It is therefore suggested that inactivation of ATPases caused by 6-OHDA or Fe^++ and 6-OHDA may be associated with lipid peroxidation and oxidation of sulfhydryl groups of synaptosomes, and these events may be attributable to O_2, H_2O_2 and particularly, ^1O_2.

Fluoroquinolone계 항균제의 penicillin 내성 폐렴구균(Streptococcus pneumoniae)에 대한 항균력 비교

이광준,배송미,황규잠,이영희,김기상 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.3

목적 : 최근들어 penicillin 내성 폐렴구균의 급속한 증가와 전세계로의 확산은 심각한 문제를 야기하고 있다. 1990년대 들어 그람음성 세균뿐 아니라 그람 양성 세균에 대한 항균력이 향상된 많은 fluoroquinolones계 항균제의 개발에 힘입어 폐렴구균성 감염질환 치료시 사용이 증대되고 있으며 한편, 이와 더불어 이미 fluoroquinolone계 항균제에 대한 내성을 보이는 폐렴구균에 대한 보고가 증가하고 있는 실정이다. 이에 본 실험에서는 국내 임상 분리 폐렴구균 중 penicillin에 고도내성을 보이는 균주를 대상으로 하여 fluoroquinolones계 항균제에 대한 감수성 여부를 확인하고자 하였다. 방법 : 항균제 감수성 검사는 3% 말혈액이 첨가된 Mueller-Hinton broth를 사용한 액체배지 미량희석법을 이용하여 NCCLS에서 제시한 방법에 준하여 실시하였다. 결과 : MIC_90를 기준으로 하였을 때 본 실험에서 사용한 5가지의 fluoroquinolones계 한균제 중 gatifloxacin과 moxifloxacin(MIC_90, 0.5㎍/㎖)이 ciprofloxacin (MIC_90, 4㎍/㎖), levofloxacin (mic_90, 2㎍/㎖) sparfloxacin (MIC_90, 1㎍/㎖)에 비해 penicillin 내성 폐렴구균에 대한 항균력이 높게 나타났다. 결론 : 5가지의 fluoroquinolones계 항생제 중 최근들어 새로이 개발된 항생제인 moxifloxacin과 gatifloxacin이 ciprofloxacin, levofloxacin, sparfloxacin보다 폐렴구균에 대한 더 우수한 항균력을 가지고 있음을 확인하였다. 한편, 국내 페니실링 고도 내성 폐렴구균에서 fluoroquinolones에 대한 고도 내성을 보이는 균주의 출현은 fluoroquinolones 내성 균주의 급속한 증가와 확산에 대한 지속적인 감시와 대책 마련이 요구된다. Background : Recently the rapid increase and global spread of penicillin-resistant S. pneumoniae has become a serious problem. In the 1990s, a varisty of novel fluoroquinolones with enhanced activity against gram-positive bacteria have been developed and used for the treatment of pneumococcal infections. In such situations, the fluoroquinolone-resistance in S. pneumonaie has been reported from many countries. In this study, we compared the activity of ciprofloxacin, levofloxacin, sparfloxacin, gatifloxacin and moxifloxacin against 93 isolates of S. pneumoniae which were highly- resistant to penicillin (MIC 2~8㎍/㎖). methods : Antimicrobial susceptibilities were determined by the broth microdilution method in cation-adjusted Muller-Hinton broth supplemented with 3% lysed horse blood according to the guidelines of the National Committee for Laboratory Standards (NCCLS). Results : Based on MIC_90s, sparfloxacin and moxifloxacin were the most potent fluoroquinolone tested against penicillin-resistant S. pneumoniae and retained excellent activity comparable with ciprofloxacin and levofloxacin. The rank order of bactericidal activity was ciprofloxacin (least active)《 levofloxacin 〈 sparfloxacin 〈 gatifloxacin and moxifloxacin (most active). Conclusion : In this study, the newer fluoroquinolones (moxifloxacin, sparfloxacin)showed improved activity over that observed with ciprofloxacin, levofloxacin, and sparfloxacin. The emergence of highly resistance to fluoroquinolones among penicillin-resistant pneumococci in Korea call for continuous attention and strategies to prevent rapid increase and spread of these strains.