Analysis of Neck Trauma Patients Using the Korean National Emergency Department Information System

Jung Hun Kim,Sung Won Jung,Jin Suk Lee,Jong-Min Park,Han Deok Yoon,Jung Tak Rhee,김선월,Borami Lim,So Ra Kim,Il-Young Jung 대한외상중환자외과학회 2018 Journal of Acute Care Surgery Vol.8 No.1

Purpose: Trauma is a leading cause of death, even in previously healthy and disease-free individuals, and the mortality rate is very high in neck trauma patients. On the other hand, there have been few studies related to neck injuries. This study examined the characteristics and treatment results of trauma-related neck injuries using the data from Korean National Emergency Department Information System. Methods: Neck trauma patients were classified using the 6th Korean Standard Disease Classification system. The patients’ demographic factors, number of surgeries, and clinical results were investigated. Statistical analysis was conducted using SPSS to evaluate the annual differences in the demographic factors; mortality according to the site of injury and type of surgery; and mechanisms of injury. Results: From 2011 to 2014, 2,458 neck trauma patients were treated in hospitals in South Korea. The number of patients admitted to regional and local emergency medical centers was 883 (35.9%) and 1,502 (61.1%), respectively. No significant annual differences were observed in age, sex ratio, location of treatment center, mortality, and injury site (vascular, tracheal, or esophageal). In addition, no significant differences in the cause of injury, performed surgery (%), and mortality according to the injured organ were observed. Conclusion: This study revealed no annual changes in neck injury patients or differences in mortality according to injured organs. This study can be used as a basis for national research on organ-specific injuries, and may help predict the demand for future support projects for the establishment of regional trauma centers. (J Acute Care Surg 2018;8:7-12)

Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications

Nam, Jung Seung,Kang, Myeong-Gyun,Kang, Juhye,Park, Sun-Young,Lee, Shin Jung C.,Kim, Hyun-Tak,Seo, Jeong Kon,Kwon, Oh-Hoon,Lim, Mi Hee,Rhee, Hyun-Woo,Kwon, Tae-Hyuk American Chemical Society 2016 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.138 No.34

<P>Protein inactivation by reactive oxygen species (ROS) such as singlet oxygen (O-1(2)) and superoxide radical (O-2(center dot-)) is considered to trigger cell death pathways associated with protein dysfunction; however, the detailed mechanisms and direct involvement in photodynamic therapy (PDT). have not been revealed. Herein, we report Ir(III) complexes designed for ROS generation through a rational strategy to investigate protein modifications by ROS. The Ir(III) complexes are effective as PDT agents at low concentrations with low-energy irradiation (<= 1 J cm(-2)) because of the relatively high O-1(2) quantum yield (> 0.78), even with two photon activation. Furthermore, two types of protein modifications (protein oxidation and photo-cross-linking) involved in PDT were characterized by mass spectrometry. These modifications were generated primarily in the endoplasmic reticulum and mitochondria) producing a significant effect for cancer cell death. Consequently, we present a plausible biologically applicable PDT modality that utilizes rationally designed photoactivatable Ir(III) complexpi.</P>

고관절 수술 후 심혈관계 합병증의 위험 요소

서근택 ( Kuen Tak Suh ),이승준 ( Seung Joon Rhee ),이정섭 ( Jung Sub Lee ),김정일 ( Jeung Ii Kim ) 대한고관절학회 2012 Hip and Pelvis Vol.24 No.2

목적: 고관절 수술을 받은 환자군에서 심혈관계 합병증의 발생 빈도와 발생에 기여하는 위험요소를 분석하고자 한다. 대상 및 방법: 1998년부터 2008년까지 11년간 고관절 치환술과 고관절 골절 수술을 받은 1,390명의 환자들 중 심혈관계 합병증의 유무에 따라 질병군과 대조군으로 구분하여 연령, 성별, 수술 종류, 양측성 수술 여부, 술전 심혈관계 질환의 과거력 유무 등에 따라 비교 분석하였다. 수술 후 심혈관계 합병증은 술후 재원기간 이내에 심근경색, 심부전, 불안정성 협심증, 부정맥, 증상성저혈압, 폐색전증의 발생 여부를 기준으로 판단하였다. 결과: 총 1,390명 중 43명(3.1%)에서 심혈관계 합병증이 발생하였으며 합병증에 의하여 입원기간 중1명(0.07%)의 사망환자가 발생한 것으로 조사되었다. 환자의 연령이 증가할수록, 양측의 단계적 수술을 받은 환자에서, 술전 고혈압이나 관상동맥 폐쇄성 질환 또는 판막질환의 과거력이 있는 경우, ASA category 3에 해당되는 경우에 심혈관계 합병증의 발생률이 통계적으로 유의하게 높은 것으로 관찰되었다. 결론: 고령 환자들 및 양측의 단계적 고관절 수술 환자들의 술후 관리를 세심하게 하고 술전 고혈압조절과 관상동맥 폐쇄성 질환의 예방 및 약물치료를 철저히 하는 것이 고관절 술후 심혈관계 합병증의 빈도를 감소시키는데 도움이 될 것으로 판단된다. Purpose: This study was performed in order to analyze the incidence of postoperative cardiovascular complications in patients who had undergone hip surgery and to identify risk factors associated with these complications. Materials and Methods: A total of 1,390 patients who had undergone hip surgery from 1998 to 2008 were divided into case or control groups according to occurrence of postoperative cardiovascular complications. Both groups were sorted and analyzed by age, gender, mode of operation, bilaterality and history of preoperative cardiovascular disease. Postoperative cardiovascular complication was defined as having any condition including myocardial infarction, congestive heart failure, unstable angina, arrhythmia, hypotension, or pulmonary thromboembolism during the surgical admission period. Results: Forty three out of 1,390 patients (3.1%) experienced cardiovasucular complications and 1 patient (0.07%) died. Increasing patient age (P=0.001), history of bilateral hip surgery (P=0.000), hypertension (P=0.002), coronary artery disease (P=0.000) or valvular heart disease (P=0.010), and ASA category 3 (P=0.000) were all associated with significantly higher incidence of cardiovascular complications. Conclusion: Intensive preoperative management though adequate hypertension control and prevention of coronary artery occlusive disease for patients who are elderly or receiving bilateral operation will help decrease the incidence of postoperative cardiovascular complications after hip surgery.

SNP 조합 인자들의 진화적 학습 방법 기반 질병 관련 복합적 위험 요인 추출 (pp.62-63)

이제근(Je-Keun Rhee),하정우(Jung-Woo Ha),배설희(Seol-Hui Bae),김수진(Soo-Jin Kim),이민수(Min Su Lee),박근준(Keun-Joon Park),장병탁(Byoung-Tak Zhang) 한국정보과학회 2009 한국정보과학회 학술발표논문집 Vol.36 No.1

Green process development for apple-peel pectin production by organic acid extraction

Cho, Eun-Hi,Jung, Ho-Tak,Lee, Byung-Hoo,Kim, Hyun-Seok,Rhee, Jin-Kyu,Yoo, Sang-Ho Elsevier 2019 Carbohydrate Polymers Vol.204 No.-

<P><B>Abstract</B></P> <P>To extract pectin in food industry, HCl is generally used as the major extracting solvent for releasing the pectin from the plant tissues, however it has an environmental issue to use. In this study, food-grade tartaric-, malic, and citric acids were used to produce apple peel pectin as an eco-friendly protocol instead of HCl. Finely-ground lyophilized apple peel was applied as the raw material, and the pectin was extracted by organic acids at 85 °C. The pectin extracted with citric acid displayed greater molecular weight and apparent viscosity compared to other organic acid treatments. Analysis of degree of methyl esterification revealed that the pectins extracted with organic acids were highly methoxylated. From these results, it was suggested that organic acids could be utilized to extract apple peel pectin effectively as a green process. Especially, the extraction process with citric acid as the solvent showed great potential to produce high-viscosity apple peel pectin.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pectin was extracted by organic acid as an eco-friendly protocol to replace HCl. </LI> <LI> Organic acid-extracted pectin has higher molecular weight and viscosity. </LI> <LI> Citric acid-extracted apple peel pectin has high amount of methoxyl groups. </LI> <LI> Apple peel pectin extraction by organic acid has a potential to reduce and recycle apple waste. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

하이퍼망 모델을 이용한 MircoRNA Strand 선택 예측

이지훈(Ji-Hoon Lee),하정우(Jung-Woo Ha),이제근(Je-Keun Rhee),장병탁(Byoung-Tak Zhang) 한국정보과학회 2010 한국정보과학회 학술발표논문집 Vol.37 No.1C

MicroRNA는 RNA로 전사된 유전자와의 상보결합을 통해 유전자 발현을 억제하는 조절인자이다. MicroRNA 생성과정에서 pre-microRNA의 3’ 또는 5’ 부근의 strand가 선택되어 mature 시퀀스가 되고 유전자 조절에 직접 작용하게 된다. 하지만 어떤 특징을 가진 strand가 선택 되는지에 대한 정확한 메커니즘은 아직 연구되어 있지 않다. 본 논문에서는 microRNA 시퀀스 정보를 바탕으로 하이퍼망을 구성하여 strand 선택 예측 모델을 구축하였다. 실험 결과 하이퍼망 학습을 통해 microRNA strand 선택에 중요한 영향을 미치는 시퀀스 특징을 찾을 수 있었고, strand 선택을 높은 정확도로 예측할 수 있음을 확인하였다.

Analysis of Abdominal Trauma Patients Using National Emergency Department Information System

( In-gyu Song ),( Jin Suk Lee ),( Sung Won Jung ),( Jong-min Park ),( Han Deok Yoon ),( Jung Tak Rhee ),( Sun Worl Kim ),( Borami Lim ),( So Ra Kim ),( Il-young Jung ) 대한외상학회 2016 大韓外傷學會誌 Vol.29 No.4

Purpose: To develop an inclusive and sustainable trauma system as the assessment of burden of injuries is very much important. The purpose of this study was to evaluate the estimates and characteristics of abdominal traumatic injuries. Methods: The data were extracted from the National Emergency Department Information System. Based on Korean Standard Classification for Disease 6th version, which is the Korean version of International Classification of Disease 10th revision, abdominal injuries were identified and abdominal surgeries were evaluated with electronic data interchange codes. Demographic factors, numbers of surgeries and clinical outcomes were also investigated. Results: From 2011 to 2014, about 24,696 patients with abdominal trauma were admitted to the hospitals annually in South Korea. The number of patients who were admitted to regional and local emergency medical centers was 8,622 (34.91%) and 15,564(63.02%), respectively. Based on National Emergency Department Information System, liver was identified as the most commonly injured abdominal solid organ (39.50%, 9,754/24,696, followed by spleen (17.57%, 4,338/24,696) and kidney (12.94%, 3,195/24,696). Conclusion: This study shows that the demand for abdominal trauma care is considerable in South Korea and most of the patients with abdominal trauma were admitted to regional or local emergency centers. The results of this study can be used as good source of information for staffs to ensure proper delivery of abdominal trauma care in trauma centers nationally. [ J Trauma Inj 2016; 29: 116-123 ]

Laser Isotope Separation of 176Yb for Medical Applications

Park Hyunmin,Han Jaemin,Jeong Do-Young,Kim Cheol-Jung,Kim Tak-soo,Kwon Duck-Hee,Nam Sungmo,Rhee Yongjoo,Yongho Cha 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.1

The radioisotope, 177Lu, is emerging as a promising isotope for a variety of medical applications such as cancer treatment. Enriched 176Yb can be used as a source material for the production of 177Lu in an atomic reactor. For these applications, we have developed a laser separation technology based on isotopic selective photoionization to enrich the stable 176Yb isotope. Our separation system consists of three dye lasers, a Yb vaporizer, and an ion-extraction system. Especially, we use a compact diode-pumped solid-state laser as the pumping source of the dye lasers. With the developed system, we succeeded in producing enriched 176Yb with an abundance of more than 97 %.

Vitamin A와 Ethanol이 Dimethylnitrosamine에 의한 Mouse조직내의 DNA, RNA 및 단백질의 손상도에 미치는 영향

김재현,홍연탁,박정식,김승희,강태규,홍성렬,박창원,권오철,이동권,Kim, Jea-Hyun,Hong, Youn-Tak,Park, Jung-Sik,Kim, Seung-Hee,Kang, Tea-Gyu,Hong, Sung-Roul,Park, Chang-Won,Kweon, O-Cheol,Rhee, Dong-Kwon 생화학분자생물학회 1991 한국생화학회지 Vol.24 No.6

Dimethylnitrosamine(DMN)은 간 및 폐, 신장, 식도 등에 앙을 유발시키는 물질이며 정상인의 혈액 및 뇨에서도 0.1~1 ppb정도가 검출되고 있다. DMN은 DNA를 methylation시켜 비정상적인 adduct를 형성하여 암을 유발하게 된다. 본 연구는 ethanol 또는 vitamin A를 mouse에 전처리 하였을 때 $[^{14}C]$으로 표지된 DMN이 생체내의 DNA, RNA 및 단백질과 어느 정도 공유결함을 형성하여 손상을 주는지 측정하였다. 실험결과 DMN은 뇌 또는 췌장에서 보다는 간에 선택적으로 결합하였으며 이 때 간의 DNA와 결합하는 것이 단백질 또는 RNA와 결합하는 것보다 각각 1.4배와 1.75배 높았다. Ethanol을 전처리 하였을 때는 DMN이 ethanol을 투여하지 않은 군보다 간의 경우 RNA와 단백질이 각각 7.5배, 1.4배 정도 더 결합하였다. Ethanol을 전처리한 뇌의 DNA에 6.7배 많이 결합하였으나 RNA에는 오히려 대조군의 15.9% 정도로 크게 감소되었다. 또한, 췌장의 단백질에는 2.0배, RNA의 경우 1.7배 정도 각각 더 결합한 결과를 나타내었다. 반면에 vitamin A 전처리군에서 간 단백질의 adduct는 35% 유의성 있게 감소되었으나 뇌 DNA에서 는 유의성 있게 9.5배 증가하였다. Dimethylnitrosamine(DMN) has been shown to induce tumors of the liver, kidney, esophagus and lung. Furthermore low levels of DMN (0.1~1 ppb) have been detected in normal human blood as well as urine. The purpose of this study is to determine extent of the covalent binding of DMN to DNA, RNA and protein in ethanol- and vitamin A- pretreated mouse. Ethanol or vitamin A was administered for 3 weeks and $^{14}C$-labeled DMN was administered intraperitoneally. Then DNA, RNA and protein were isolated from liver, brain and pancreas and used for determination of radioactivity. DMN was bound selectively to liver DNA rather than brain or pancreas DNA. DNA damage in liver was 1.4 and 1.7 times greater than protein and RNA damage, respectively. Ethanol pretreatment and vitamin A pretreatment increased DNA damage in brain significantly upto 6.7 and 9.5 times, respectively, than the control group.

Depth of Interaction (DOI) Determination in Three-Layer Small Animal PET

( Sun Il Kwon ),( Seong Jong Hong ),( Mikiko Ito ),( Geon Song Lee ),( Kwang Souk Sim ),( Kwang Suk Park ),( Jung Tak Rhee ),( Jae Sung Lee ) 대한핵의학회 2007 핵의학 분자영상 Vol.41 No.5